• Toxicological Research
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• 제30권3호
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• pp.211-220
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• 2014

Resveratrol has received considerable attention as a polyphenol with various biological effects such as anti-inflammatory, anti-oxidant, anti-mutagenic, anti-carcinogenic, and cardioprotective properties. As part of the overall safety assessment of HS-1793, a novel resveratrol analogue free from the restriction of metabolic instability and the high dose requirement of resveratrol, we assessed genotoxicity in three in vitro assays: a bacterial mutation assay, a comet assay, and a chromosomal aberration assay. In the bacterial reverse mutation assay, HS-1793 did not increase revertant colony numbers in S. typhimurium strains (TA98, TA100, TA1535 and TA1537) or an E. coli strain (WP2 uvrA) regardless of metabolic activation. HS-1793 showed no evidence of genotoxic activity such as DNA damage on L5178Y $Tk^{+/-}$ mouse lymphoma cells with or without the S9 mix in the in vitro comet assay. No statistically significant differences in the incidence of chromosomal aberrations following HS-1793 treatment was observed on Chinese hamster lung cells exposed with or without the S9 mix. These results provide additional evidence that HS-1793 is non-genotoxic at the dose tested in three standard tests and further supports the generally recognized as safe determination of HS-1793 during early drug development.

• 한국안전학회지
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• 제27권6호
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• pp.192-204
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• 2012

For a severe accident of nuclear power plant, an approach to estimation of the radiological source term using a severe accident code(MELCOR) has been proposed. Although the MELCOR code has a capability to estimate the radiological source term, it has been hardly utilized for the radiological consequence analysis mainly due to a lack of understanding on the relevant function employed in MELCOR and severe accident phenomena. In order to estimate the severe accident source term to be linked with the radiological consequence analysis, this study proposes 4-step procedure: (1) selection of plant condition leading to a severe accident(i.e., accident sequence), (2) analysis of the relevant severe accident code, (3) investigation of the code analysis results and post-processing, and (4) generation of radiological source term information for the consequence analysis. The feasibility study of the present approach to an early containment failure sequence caused by a fast station blackout(SBO) of a reference plant (OPR-1000), showed that while the MELCOR code has an integrated capability for severe accident and source term analysis, it has a large degree of uncertainty in quantifying the radiological source term. Key insights obtained from the present study were: (1) key parameters employed in a typical code for the consequence analysis(i.e., MACCS) could be generated by MELCOR code; (2) the MELOCR code simulation for an assessment of the selected accident sequence has a large degree of uncertainty in determining the accident scenario and severe accident phenomena; and (3) the generation of source term information for the consequence analysis relies on an expert opinion in both areas of severe accident analysis and consequence analysis. Nevertheless, the MELCOR code had a great advantage in estimating the radiological source term such as reflection of the current state of art in the area of severe accident and radiological source term.

• Nuclear Engineering and Technology
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• 제34권3호
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• pp.232-241
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• 2002

A safety assessment is carried out for the near-surface radioactive waste disposal in the reference engineered vault facility. The analysis is mainly divided into two parts. One deals with the release and transport of radionuclide in the vault and unsaturated zone. The other deals with the transport of radionuclide in the saturated zone and radiological impacts to a human group under well drinking water scenario. The parameters for source-term, geosphere and biosphere models are mainly obtained from the site specific data. The results show that the annual effective doses are dominated by long lived, mobile radionuclides and their associated daughters. And it is found that the total effective dose for drinking water is far below the general criteria of regulatory limit for radioactive waste disposal facility.

• Nuclear Engineering and Technology
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• 제35권2호
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• pp.108-120
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• 2003

In assessing the long term post closure radiological safety assessment of a potential HLW repository in Korea, three categories of uncertainties exist. The first one is the scenario uncertainty where series of different natural events are translated into written statements. The second one is the modeling uncertatinty where different mathematical models are applied for an identical scenario. The last one is the data uncertainty which can be expressed in terms of probabilistic density functions. In this analysis, three different scenarios are seleceted; a small well scenario, a radiolysis scenario, and a naturally discharged scenario. The MASCOT-K and the AMBER, probabilistic safety assessment codes based on connection of sub-modules and a compartment theory respectively, are applied to assess annual individual doses for a generic biosphere. Results illustrate that for a given scenario, predictions from two different codes fairly match well each other But the discrepancies for the different scenarios are significant. However, total doses are still well below the guideline of 2 mRem/yr. Detailed analyses with model and data uncertainties are underway to further assure the safety of a Korean reference dispsoal concept.

• Nuclear Engineering and Technology
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• 제55권1호
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• pp.238-247
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• 2023

The present work represents a technical guideline for decommissioning a disused teletherapy machine model Theratron-780 and contains category one ⁶⁰Co radioactive source. The first section predicts the dose rate from the source in case of normal and radiological emergency situations via FLUKA-MC simulation code. Moreover, the dose assessment for the occupational during the whole process is calculated and compared to the measured values. A suggested cordoned area for safety and security in a radiological emergency is simulated. The second section lists the whole process's technical procedures, including (preview, dismantle, securing, transport and storage) of the disused teletherapy machine. Results show that the maximum obtained accumulated dose for occupational were found to be 24.5 ± 4.9 μSv in the dismantle and securing process in addition to 3.5 ± 1.8 μSv during loading on the transport vehicle and unloading at the storage facility. It was found that the measured accumulated dose for workers is in good agreement with the estimated one by uncertainty not exceeding 5% in normal operating conditions.

• 방사성폐기물학회지
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• 제17권1호
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• pp.95-106
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• 2019

원전 해체를 준비함에 있어 정성적 또는 정량적 위험도 평가는 필수요소이다. 해체 공정간 발생하는 방사선학적 및 비방사선학적 위험요소는 해체 작업자 및 대중의 안전을 보장하기 위해 사전에 평가되어야 한다. 현재 해체 경험이 많은 미국의 기존 사업자들 및 NRC의 경우 위험의 중대성만 평가하는 결정론적 위험도 평가에 집중하고 있다. 하지만 최근 IAEA는 위험도 매트릭스를 활용한 위험도평가를 결정론적 위험도 평가의 대체안으로 제안하고 있다. 따라서 본 연구에서는 위험도평가에 앞서 해체 공정 별 해체 활동을 Risk Breakdown Structure에 맞추어 정리하였고, 미국 20여개 해체 원전에서 해체 공정별 위험도 평가 시행 중 선정한 해체 활동간 잠재적 사고를 해체 활동에 맞게 체계적으로 정리하였다. 그리고 복합 리스크 매트릭스를 개발 및 활용하여 해체 공정간 방사선학적 및 비방사선학적 위험요소의 위험도를 평가하여 정량적으로 수치화 하였다.

• 한국방사선학회논문지
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• 제17권4호
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• pp.565-572
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• 2023

본 연구에서는 국내 공공 부문에서 실시하고 있는 의료기관 평가 중 영상검사와 관련된 현황을 살펴보고 개선 방향을 제시하고자 하였다. 의료기관 평가 중 영상검사와 관련된 주요 평가는 의료기관 인증평가와 영상검사 적정성 평가가 있으며, 의료기관 인증평가에서는 영상검사 운영과정, 정확한 결과 제공, 안전관리 절차 준수 등을 평가하고 있다. 영상검사 적정성 평가에서는 인력, 장비와 관련된 구조 지표, 환자평가 실시율, 피폭 저감 프로그램 등이 포함되어 있었다. 하지만 좀 더 안전하고 질 높은 영상검사를 위해서는 의료기관의 인증평가 참여율을 높이는 방안 마련이 필요하며, 영상검사 적정성 평가의 인력지표 개선과 인센티브 지급에 대한 고려도 필요하다. 마지막으로 국가 차원의 방사선 노출 통합관리도 함께 병행되어야 할 것이다.

• 방사성폐기물학회지
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• 제19권1호
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• pp.113-121
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• 2021

A safety assessment of radioactive waste repositories is a mandatory requirement process because there are possible radiological hazards owing to radionuclide migration from radioactive waste to the biosphere. For a reliable safety assessment, it is important to establish a parameter database that reflects the site-specific characteristics of the disposal facility and repository site. From this perspective, solubility, a major geochemical parameter, has been chosen as an important parameter for modeling the migration behavior of radionuclides. The solubilities were derived for Am, Ni, Tc, and U, which were major radionuclides in this study, and on-site groundwater data reflecting the operational conditions of the Gyeongju low and intermediate level radioactive waste (LILW) repository were applied to reflect the site-specific characteristics. The radiation dose was derived by applying the solubility and radionuclide inventory data to the RESRAD-OFFSITE code, and sensitivity analysis of the dose according to the solubility variation was performed. As a result, owing to the low amount of radionuclide inventory, the dose variation was insignificant. The derived solubility can be used as the main input data for the safety assessment of the Gyeongju LILW repository in the future.

• 방사선산업학회지
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• 제17권2호
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• pp.209-217
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• 2023

The biosphere has important function in the safety assessment of a radioactive waste disposal facility. A biosphere model in the safety assessment needs various input data that contain significantly inherent uncertainties. This paper reviews the effects of the input data on the radiological impact assessment from main radionuclides such as ¹⁴C and ⁹⁹Tc in the biosphere model. In addition, it is confirmed that the safety criteria is met, when the conservative input data for the intake rate, soil to plant concentration ratio, and distribution coefficients of the radionuclides are applied and probabilistic analysis are conducted in the biosphere model. Nevertheless, it is required to generate site-specific input data for the confidence building and reduce excessive conservatism in the biosphere model.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2005년도 추계 학술대회 논문집
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• pp.185-186
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• 2005