• 제목/요약/키워드: Radiation pathology

검색결과 438건 처리시간 0.025초

Mini-Pig Model Simulating Radiation Accidents for Evaluation of Acute Radiation Syndrome

  • Lee, Seung-Sook;Jang, Won-Suk;Kim, Jin;Ryoo, Baek-Youl;Lee, Jae-Chul;Kim, Mi-Suk;Ji, Young-Hoon;Lee, Sun-Joo;Jeon, Kwang-Hye;Lee, Jung-Eun;Lee, Hyun-Jung;Kim, Min-Suk;Koh, Jae-Soo;Cho, Soo-Yeon;Jang, Yoon-Hwan;Lim, Sang-Moo
    • 한국수의병리학회:학술대회논문집
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    • 한국수의병리학회 2005년도 Proceedings of The 2nd Asian Society of Veterinary Pathology Symposium(Vol.2) and 2005 Annual Meeting of The Korean Society of Veterinary Pathology(Vol.9)
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    • pp.80-81
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    • 2005
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Evaluation of apoptosis after ionizing radiation in feeding and starving rats

  • Lee, Jae-Hyun;Cho, Kyung-Ja;Hong, Seok-Il;Park, Min-Kyung
    • 한국수의병리학회지
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    • 제2권1호
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    • pp.37-46
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    • 1998
  • It has been known that $\gamma$-irradiation usually induces cell death in regenerating stem cell in normal tissues like skin, intestine and hematopoietic organ. The experiment were carried out to evaluate the early response of radiation injury in radiosensitive and intermediate radiosensitive tissues in feeding and starving rats with the doses of 3.5 and 7.0 Gy. The results of the study showed that the histological phenomenon was apoptosis in the doses of the radiation as the early response of tissue injury. Apoptosis were showed organ-specific and cellular specific responses suggesting that the selection of apoptosis be exactly focused on highly renewal organs and cells. It was interesting that the rats starved for 72 hours prior to irradiation induced less apoptosis in liver than fed rats. As for cellular responses it appeared that apoptotic cells were mostly distributed in ductal or periportal cells in liver of feeding rats unlikely in liver of Starving rots which showed no difference in zonal distribution. In salivary gland apoptotic cells in fed rats were highly induced in intercalating and ductal cell population than in acinar cell population although unlikely in starved rats. This study showed the value of apoptosis using the detection system of TUNEL for evaluating cellular damage after radiation injury and the diminished effect of starvation on cell damage after ionizing irradiation.

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Merkel cell carcinoma in the community setting: a case report

  • Callaghan, Cameron M.;Amornmarn, Rumpa
    • Radiation Oncology Journal
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    • 제36권2호
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    • pp.163-170
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    • 2018
  • Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin initially believed to arise from the Merkel cells. In the community setting a general radiation oncologist may only encounter this pathology in a handful of cases over the course of their career. Due to the low incidence of this malignancy, few prospective randomized controlled trials have ever been conducted and therefore guidelines are based on relatively lower levels of evidence upon which the clinical recommendations are made. We discuss the case of a female in her 90s presenting with a classic MCC primary lesion, as well as satellite lesions proximal to both the primary and the draining regional lymph nodes with no evidence of nodal involvement. Here we discuss the presentation, management, treatment planning, underlying pathology, results and sequelae of treatment. We also review new treatment modalities, and the most current staging systems and guidelines.

총 방사선 조사량이 잡종 백색 마우스의 정상 척수에 미치는 영향 (The Effect of Total Radiation Dose on Normal Spinal Cord of Hybrid Mice -Early Pathological Changes-)

  • 손승원;김명세;최원희
    • Radiation Oncology Journal
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    • 제4권2호
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    • pp.107-113
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    • 1986
  • 방사선에 의한 척수의 손상은 매우 드물기는 하나 치명적인 불가역성의 손상을 일으킬 수 있는, 치료방사선 분야에서 가장 심각한 합병증의 하나이다. 동물실험 및 임상보고를 통하여 많은 연구가 있었음에도 실제의 임상에서와 같은 조사방법을 사용한 계통적인 보고는 거의 없는 실정이다. 이에 저자는 전 조사량에 대한 초기의 급성 변화를 병리조직학적으로 관찰 분석하여 불가역성의 척수손상이 올 수 있는 최저선량을 추정하기 위하여 250KV의 X선 치료기를 사용하여 총 110마리의 마우스를 $2\times3cm$의 조사야로 고식적 분할조사를 실시하였으며 그 결과는 다음과 같다. 경한 모세혈관의 울혈, 염증성 세포의 부분적 침윤과 함께 축색돌기의 부종이 1,000 rad 군에서 관찰되기 시작하였다. 백질의 스폰지 변성은 2,000 rad 군에서 보이기 시작하였다. 연막과 지주막의 부분적 비후는 3,000rad 군에서 관찰되었다. 국소 괴사는 3,500rad군에서 관찰되기 시작하였고 신경조직의 단열과 신경원의 국소 손실은 4,000 rad군에서 관찰되기 시작하였다. 이제까지 용인되어온 척수의 내성선량인 5,000 rad/5wk.는 완전히 안전하지는 못하다고 생각되나 이는 만성 변화에 대한 추적실험을 통하여 확인되어야 할 것이다.

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Value of imaging study in predicting pelvic lymph node metastases of uterine cervical cancer

  • Jung, Wonguen;Park, Kyung Ran;Lee, Kyung-Ja;Kim, Kyubo;Lee, Jihae;Jeong, Songmi;Kim, Yi-Jun;Kim, Jiyoung;Yoon, Hai-Jeon;Kang, Byung-Chul;Koo, Hae Soo;Sung, Sun Hee;Cho, Min-Sun;Park, Sanghui
    • Radiation Oncology Journal
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    • 제35권4호
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    • pp.340-348
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    • 2017
  • Purpose: To evaluate the diagnostic accuracy of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) in predicting pelvic lymph node (LN) metastases in patients with cervical cancer. Materials and Methods: From January 2009 to March 2015, 114 patients with FIGO stage IA1-IIB uterine cervical cancer who underwent hysterectomy with pelvic lymphadenectomy and took CT, MRI, and PET/CT before surgery were enrolled in this study. The criteria for LN metastases were a LN diameter ${\geq}1.0cm$ and/or the presence of central necrosis on CT, a LN diameter ${\geq}1.0cm$ on MRI, and a focally increased FDG uptake on PET/CT. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for pelvic LN metastases were estimated. Results: The sensitivity, specificity, PPV, NPV, and accuracy for detection of pelvic LN metastases were 51.4%, 85.9%, 41.3%, 90.1%, and 80.3% for CT; 24.3%, 96.3%, 56.3%, 86.8%, and 84.6% for MRI; and 48.6%, 89.5%, 47.4%, 90.0%, and 82.9% for PET/CT, respectively. The sensitivity of PET/CT and CT was higher than that of MRI (p=0.004 and p= 0.013, respectively). The specificity of MRI was higher than those of PET/CT and CT (p=0.002 and p=0.001, respectively). The difference of specificity between PET/CT and CT was not statistically significant (p=0.167). Conclusion: These results indicate that preoperative CT, MRI, and PET/CT showed low to moderate sensitivity and PPV, and moderate to high specificity, NPV, and accuracy. More efforts are necessary to improve sensitivity of imaging modalities in order to predict pelvic LN metastases.

천연 우라늄 독성에 관한 치료 연구 (Study on therapeutic application of toxicity of Uranylnitrate in rats)

  • 유용운;이진오;윤택구
    • Journal of Radiation Protection and Research
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    • 제12권2호
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    • pp.9-18
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    • 1987
  • 천연 우라늄의 주독성이 중금속독성인지 혹은 방사성장해독성인지를 알기 위하여 질산납과 질산우라늄을 투여하여 변동되는 혈중 BUN, Creatinine, C-AMP 및 $PGE_2$의 활성도를 측정 비교하였다. 질산우라늄 투여시 비호소계인 질산대사의 임상적 지표인 BUN 및 Creatinine값은 질산납 투여군에 비교하여 예민한 반응을 나타났으나 C-AMP의 활성도에는 의의있는 변화가 없었다. 한편 질산 우라늄의 농도 변화에 따른 $PGE_2$ 활성도의 변동은 질산납 투여와 달리 현저하게 증가 되는 것을 관찰하였다. 이 결과는 천연우라늄의 저준위 방출 방사선이 세포막에 반응하여 $PGE_2$농도에 변화를 주는 것으로 사료된다. 질산 우라늄의 투여로 증가된 혈중 $PGE_2$의 농도를 감퇴시킴에 있어 Glucagon, Aldosterone 및 Furosemide를 사용하였다.

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가미지황탕(加味地黃湯), 가미사군자탕(加味四君子湯) 및 가미군자지황탕(加味君子地黃湯)의 방사선(放射線) 부작용(副作用) 감소효과(減少效果) (Study on Radioprotective Effects of Kamisagoonjatang, Kamijihwangtang and Kamigoonjajihwangtang)

  • 김동희;최봉균;조문준;김성훈
    • 혜화의학회지
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    • 제8권1호
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    • pp.115-129
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    • 1999
  • To evaluate radioprotective effects of Kamisagoonjatang(KST), Kamijihwangtang (KJT) and Kamigoonjajihwangtang(KKJT), studies were done experimentally. The results were obtained as follows: 1. By FACS analysis after exposure to radiation by Liniac, T cell and T-helper cell were significantly increased in KST treated group and also B cell and macrophage in KJT treated group while splenocytes were significantly decreased in control group. 2. WBC, PLT were significantly increased in KKJT treated group as compared with control group after exposure to radiation by Liniac. 3. In histological changes of jejunum of $BALB{\backslash}C$ mice after after exposure to radiation by Liniac, exclusion and fusion of villi were decreased in all groups as compared with control group. 4. In the observation of morphological changes by SEM and TEM after radiation by Liniac, KKJT, KJT and KST inhibited demage of internal structures such as mitochondria, ESR and golgi of jejunum cells in order as compared with control group. From above results it was concluded that KJT, KST and KKJT could be usefully applied for protection from damage by radiotherapy to cancer.

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