Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
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Study on Radioprotective Effects of Kamisagoonjatang, Kamijihwangtang and Kamigoonjajihwangtang

가미지황탕(加味地黃湯), 가미사군자탕(加味四君子湯) 및 가미군자지황탕(加味君子地黃湯)의 방사선(放射線) 부작용(副作用) 감소효과(減少效果)

  • Kim, Dong-hee (Department of Pathology College of Oriental Medicine, Taejon University) ;
  • Choi, Bong-gun (Department of Pathology College of Oriental Medicine, Taejon University) ;
  • Jo, Mun-jun (Chung-nam University) ;
  • Kim, Sung-hoon (Department of Pathology College of Oriental Medicine, Taejon University)
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 최봉균 (대전대학교 한의과대학 병리학교실) ;
  • 조문준 (충남대학교 의과대학 방사선과) ;
  • 김성훈 (대전대학교 한의과대학 병리학교실)
  • Published : 1999.09.01
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Abstract

To evaluate radioprotective effects of Kamisagoonjatang(KST), Kamijihwangtang (KJT) and Kamigoonjajihwangtang(KKJT), studies were done experimentally. The results were obtained as follows: 1. By FACS analysis after exposure to radiation by Liniac, T cell and T-helper cell were significantly increased in KST treated group and also B cell and macrophage in KJT treated group while splenocytes were significantly decreased in control group. 2. WBC, PLT were significantly increased in KKJT treated group as compared with control group after exposure to radiation by Liniac. 3. In histological changes of jejunum of $BALB{\backslash}C$ mice after after exposure to radiation by Liniac, exclusion and fusion of villi were decreased in all groups as compared with control group. 4. In the observation of morphological changes by SEM and TEM after radiation by Liniac, KKJT, KJT and KST inhibited demage of internal structures such as mitochondria, ESR and golgi of jejunum cells in order as compared with control group. From above results it was concluded that KJT, KST and KKJT could be usefully applied for protection from damage by radiotherapy to cancer.

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