• Archives of Pharmacal Research
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• v.20 no.3
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• pp.212-217
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• 1997

Induction of an adaptive response to ionizing radiation in mouse lymphoma (EL4) cells was studied by using cell survival fraction and apoptotic nucleosomal DNA fragmentation as biological end points. Cells in early log phase were pre-exposed to low dose of ${\gamma}$-rays (0.01 Gy) 4 or 20 hrs prior to high dose ${\gamma}$-ray (4, 8 and 12 Gy for cell survival fraction analysis; 8 Gy for DNA fragmentation analysis) irradiation. Then cell survival fractions and the extent of DNA fragmentation were measured. Significant adaptive response, increase in cell survival fraction and decrease in the extent of DNA fragmentation were induced when low and high dose .gamma.-ray irradiation time interval was 4 hr. Addition of protein or RNA synthesis inhibitor, cycloheximide or 5,6-dichloro-1-.betha.-d-ribofuranosylbenzimidazole (DRFB), respectively during adaptation period, the period from low dose ${\gamma}$-ray irradiation to high dose ${\gamma}$-ray irradiation, was able to inhibit the induction of adaptive response, which is the reduction of the extent DNA fragmentation in irradiated EL4 cells. These data suggest that the induction of adaptive response to ionizing radiation in EL4 cells required both protein and RNA synthesis.

• Journal of the Korean Solar Energy Society
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• v.35 no.1
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• pp.9-19
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• 2015

Pyranometer have many uncertainty factors (sensitivity function, thermal offset, other spectral effect, geometric, environment, and equipment etc.) than pyrheliometer. The solution for most of the uncertainty factors have been researched, but the problem for thermal offset is being continued research so far. Under the clear sky, due to the thermal offset of pyranometer, the diffuse and global radiation have been negative value for the nighttime and lower value for the daytime, respectively. In order to understand the uncertainty of the thermal offset effect, solar radiation are observed and analyzed using Ji and Tsay method and data from modified pyranometer. As a result of performing temperature correction using the modified pyranometer, the slope (dome factor; k) and intercept ($r_0$) from a linear regression method are 0.064 and $3.457g{\cdot}m^{-2}{\cdot}k^{-1}$, respectively. And the solar radiation is decreased significantly due to the effect of thermal offset during nighttime. The solar radiation from modified pyranometer increased approximately 8% higher than its observed by general pyranometer during daytime. By the way, these results did not generalize because its result is for only single case in clear sky. Accordingly, it is to required for accurate results obtained by the various cases (clear, cloudy and rainy) with longterm observations.

• Journal of the Korean Physical Society
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• v.73 no.10
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• pp.1495-1501
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• 2018

We have developed an extended three-dimensional free-electron laser (3D FEL) code with source-dependent expansion to calculate the intensity of the radiation field and the spot size in a free-electron laser oscillator. The effect of the wiggler field errors was evaluated for the case of a planar wiggler generated by a magnet stack with parabolic shaped pole faces by using the extended three-dimensional equations in a free-electron laser oscillator based on the proposed FEL facility which is to be operated in the far-infrared and the infrared regions. The radiation spot size due to the wiggler field errors also have been analyzed for wiggler errors of ${\Delta}B/B=0.0$, 0.03, 0.06 and 0.09% at z = 1 m and z = 2 m. The effect of the diffraction of radiation field due to the wiggler field errors of ${\Delta}B/B=0.0$ and ${\Delta}B/B=0.09%$ at 200 passes was evaluated by using the extended 3D code that we developed. The variation of the curvature of the phase front and the effect of the radiation field intensity due to the wiggler field errors were also evaluated for B = 0.5 T and B = 0.7 T with the wiggler error of ${\Delta}B/B=0.09%$ at 200 passes and the results were compared to those of without errors. The intensity of the radiation, behavior of the radiation spot size and the variation of the curvature of the phase were highly sensitive to the wiggler error of ${\Delta}B/B$ > 0.09%, but were less sensitive to the wiggler errors for ${\Delta}B/B$ < 0.09% in a free-electron laser (FEL) oscillator based on the proposed FEL facility.

• Journal of Mechanical Science and Technology
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• v.16 no.12
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• pp.1725-1732
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• 2002

Combined convection and radiation heat transfer in a circular tube with circumferential fins and circular disks is investigated for various operating conditions. Using a finite volume technique for steady laminar flow, the governing equations are solved in order to study the flow and temperature fields. The P- 1 approximation and the weighted sum of gray gases model (WSGGM) are used for solving the radiation transport equation. The results show that the total Nusselt number of combined convection and radiation is higher than that of pure convection. If the temperatures of the combustion gas and the wall in a tube are high, radiation becomes dominant. Therefore, it is necessary to evaluate the effect of radiation on the total heat transfer.

• Advances in nano research
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• v.16 no.6
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• pp.579-591
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• 2024

This study explained the effects of radiation, magnetic field, and nanoparticle shape on the peristaltic flow of an Upper-Convected Maxwell nanofluid through a porous medium in an asymmetric channel for a better understanding of cooling and heating mechanisms in the presence of magnetic fields. These phenomena are modeled mathematically as a system of non-linear differential equations, that are solved under long-wavelength approximation and low Reynolds number conditions using the perturbation method. The results for nanofluid and temperature described the behavior of the pumping characteristics during their interaction with (the vertical position, thermal radiation, the shape of the nanoparticle, and the magnetic field) analytically and explained graphically. Also, the combined effects of thermal radiation parameters and some physical parameters on pressure rise, pressure gradient, velocity, and heat distribution are pointed out. Qualitatively, a reverse velocity appears with combined high radiation and Grashof number or combined high radiation and low volume flow rate. At high radiation, the spherical nanoparticle shape has the greatest effect on heat distribution.

• Radiation Oncology Journal
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• v.8 no.2
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• pp.145-150
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• 1990

Mesna has been used with ifosfamide to prevent urotoxicity in the treatment of testicular cancers. This drug also protected the toxicities of adriamycin without compromising cytostatic activity. With an idea of radioprotective role of sulfhydryl group of radioprotectors and of mesna decreasing the toxic effect of adriamycin which produces free radicals, mesna and radiation were administered to mice to study the protective effect of this drug and to identify the difference in regenerative capacity of the germ cells in the testis between radiation-treated and both mesna-and radiation-treated groups. The shape and numbers of spermatogenic cells in the seminiferous tubules were examined every week after irradiation. In both groups, initial reduction and later recovery in germ cell numbers and shape was observed. The lowest germ cell number was found around three weeks after irradiation. Mean germ cell number of the mesna-treated group was significantly higher than radiation-treated group at all observed periods (p<0.05). More competent regeneration was present in mesna-treated group. These results suggest that mesna protect the testis from radiation injury. Further study will be necessary to identify whether mesna protects other tissues from radiation and it does not hamper tumor control.

• Radiation Oncology Journal
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• v.30 no.2
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• pp.78-87
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• 2012

Purpose: Troglitazone (TRO) is a peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) agonist. TRO has antiproliferative activity on many kinds of cancer cells via G1 arrest. TRO also increases $Cu^{2+}/Zn^{2+}$-superoxide dismutase (CuZnSOD) and catalase. Cell cycle, and SOD and catalase may affect on radiation sensitivity. We investigated the effect of TRO on radiation sensitivity in cancer cells in vitro. Materials and Methods: Three human cervix cancer cell lines (HeLa, Me180, and SiHa) were used. The protein expressions of SOD and catalase, and catalase activities were measured at 2-10 ${\mu}M$ of TRO for 24 hours. Cell cycle was evaluated with flow cytometry. Reactive oxygen species (ROS) was measured using 2',7'-dichlorofluorescin diacetate. Cell survival by radiation was measured with clonogenic assay. Results: By 5 ${\mu}M$ TRO for 24 hours, the mRNA, protein expression and activity of catalase were increased in all three cell lines. G0-G1 phase cells were increased in HeLa and Me180 by 5 ${\mu}M$ TRO for 24 hours, but those were not increased in SiHa. By pretreatment with 5 ${\mu}M$ TRO radiation sensitivity was increased in HeLa and Me180, but it was decreased in SiHa. In Me180, with 2 ${\mu}M$ TRO which increased catalase but not increased G0-G1 cells, radiosensitization was not observed. ROS produced by radiation was decreased with TRO. Conclusion: TRO increases radiation sensitivity through G0-G1 arrest or decreases radiation sensitivity through catalase-mediated ROS scavenging according to TRO dose or cell types. The change of radiation sensitivity by combined with TRO is not dependent on the PPAR ${\gamma}$ expression level.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.627-633
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• 2015

Background: To study the effect of parecoxib, a novel cyclooxygenase-2 selective inhibitor, on the radiation response of colorectal cancer (CRC) cells and its underlying mechanisms. Materials and Methods: Both in vitro colony formation and apoptosis assays as well as in vivo mouse xenograft experiments were used to explore the radiosensitizing effects of parecoxib in human HCT116 and HT29 CRC cells. Results: Parecoxib sensitized CRC cells to radiation in vitro with a sensitivity enhancement ratio of 1.32 for HCT116 cells and 1.15 for HT29 cells at a surviving fraction of 0.37. This effect was partially attributable to enhanced apoptosis induction by parecoxib combined with radiation, as illustrated using an in vitro apoptosis assays. Parecoxib augmented the tumor response of HCT116 xenografts to radiation, achieving growth delay more than 20 days and an enhancement factor of 1.53. In accordance with the in vitro results, parecoxib combined with radiation resulted in less proliferation and more apoptosis in tumors than radiation alone. Radiation monotherapy decreased microvessel density (MVD) and microvessel intensity (MVI), but increased the hypoxia level in xenografts. Parecoxib did not affect MVD, but it increased MVI and attenuated hypoxia. Conclusions: Parecoxib can effectively enhance radiation sensitivity in CRC cells through direct effects on tumor cells and indirect effects on tumor vasculature.

• 한국연소학회:학술대회논문집
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• 2006.10a
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• pp.79-85
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• 2006

Radiative heat transfer is very important in many combustion systems since they are operated in high temperature. Fluid flows in most of the combustion systems are turbulent to promote fast mixing of the hydrocarbon fuel and oxidant. Major combustion products are $CO_2$ and $H_2O$. The turbulent flow is modeled by using the standard ${\kappa}-{\epsilon}$ model and the radiation transfer is modeled by using the discrete ordinates method where the radiative gas properties are calculated by using the weighted sum of gray gases model with a gray gas regrouping(WSGGM-RG). Effect of the radiation on the combustion characteristics in a three-dimensional rectangular enclosure is studied by changing the equivalence ratio. Results show that the radiation plays a significant role on the heat transfer in the combustion systems by resulting in a temperature drop of 16% as compared to that obtained without radiation. The equivalence ratio also affects the combustion by different contribution of the radiative transfer with different gas compositions.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2001.09a
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• pp.21-21
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• 2001

The objective of this investigation was to evaluate of dose-incidence relationships on the prenatal effects of gamma-radiation. Pregnant ICR mice were exposed on day 11.5 after conception, coincident with the most sensitive stage for the induction of major congenital malformations, with 0.5-4.0 Gy of gamma-radiations. The animals were sacrificed on day 18 of gestation and the fetuses were examined for mortality, growth retardation, change in head size and any other morphological abnormalities. With increasing radiation dose, incidence of small head, growth retarded fetus, cleft palate, dilatation of cerebral ventricle and abnormalities of the extremities in live fetuses rose. The threshold doses of radiation that induced cleft palate and dilatation of cerebral ventricle, and abnormal extremities were between 1.0 and 2.0 Gy, and between 0.5 and 1.0 Gy, respectively.