• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.2979-2982
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• 2016

Background: High dose ionizing radiation can induce ovarian cancer, but the effect of low dose radiation on the development of ovarian cancer has not been extensively studied. We evaluated the effect of low dose radiation and total background radiation, and the radiation delivered to the ovaries during the treatment of rectosigmoid cancer and breast cancer on ovarian cancer incidence. Materials and Methods: Background radiation measurements are from Assessment of Variations in Radiation Exposure in the United States, 2011. Ovarian cancer incidence data are from the Centers for Disease Control and Prevention. Standardized incidence ratios (SIR) of ovarian cancer following breast cancer and rectosigmoid cancer are from Surveillance, Epidemiology, and End Results (SEER) data. Obesity data by US state are from the Centers for Disease Control and Prevention. Mean ages of US state populations are from the United States Census Bureau. Results: We calculated standardized incidence ratios (SIR) from Surveillance, Epidemiology, and End Results (SEER) data, which reveal that in 194,042 cases of breast cancer treated with beam radiation, there were 796 cases of ovarian cancer by 120+ months of treatment (0.41%); in 283, 875 cases of breast cancer not treated with radiation, there were 1,531 cases of ovarian cancer by 120+ months (0.54%). The difference in ovarian cancer incidence in the two groups was significant (p < 0.001, two tailed Fisher exact test). The small dose of scattered ovarian radiation (about 3.09 cGy) from beam radiation to the breast appears to have reduced the risk of ovarian cancer by 24%. In 13,099 cases of rectal or rectosigmoid junction cancer treated with beam radiation in the SEER data, there were 20 cases of ovarian cancer by 120+ months of treatment (0.15%). In 33,305 cases of rectal or rectosigmoid junction cancer not treated with radiation, there were 91 cases of ovarian cancer by 120+ months (0.27%). The difference in ovarian cancer incidence in the two groups was significant (p = 0.017, two tailed Fisher exact test). In other words, the beam radiation to rectum and rectosigmoid that also reached the ovaries reduced the risk of ovarian cancer by 44%. In addition, there was a significant inverse relationship between ovarian cancer in white women and radon background radiation (r = - 0.465. p = 0.002) and total background radiation (r = -0.456, p = 0.002). Because increasing age and obesity are risk factors for ovarian cancer, multivariate linear regression was performed. The inverse relationship between ovarian cancer incidence and radon background was significant (${\beta}=-0.463$, p = 0.002) but unrelated to age (${\beta}=-0.080$, p = 0.570) or obesity (${\beta}=-0.180$, p = 0.208). Conclusions: The reduction of ovarian cancer risk following low dose radiation may be the result of radiation hormesis. Hormesis is a favorable biological response to low toxin exposure. A pollutant or toxin demonstrating hormesis has the opposite effect in small doses as in large doses. In the case of radiation, large doses are carcinogenic. However, lower overall cancer rates are found in U.S. states with high impact radiation. Moreover, there is reduced lung cancer incidence in high radiation background US states where nuclear weapons testing was done. Women at increased risk of ovarian cancer have two choices. They may be closely followed (surveillance) or undergo immediate prophylactic bilateral salpingo-oophorectomy. However, the efficacy of surveillance is questionable. Bilateral salpingo-oophorectomy is considered preferable, although it carries the risk of surgical complications. The data analysis above suggests that low-dose pelvic irradiation might be a good third choice to reduce ovarian cancer risk. Further studies would be worthwhile to establish the lowest optimum radiation dose.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.20 no.3
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• pp.203-224
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• 2016

The heat and mass transfer characteristics of the unsteady hydromagnetic natural convection flow with Hall current and Soret effect of an incompressible, viscous, electrically conducting, heat absorbing and optically thin radiating fluid flow past a suddenly started vertical infinite plate through fluid saturated porous medium in a rotating environment are taken into account in this paper. Derivations of exact analytical solutions are aimed under different physical properties. The velocity, concentration and temperature profiles, Sherwood number and Nusselt number are easily examined and discussed via the closed forms obtained. Soret effect and permeability parameter tends to accelerate primary and secondary fluid velocities whereas hall current, radiation and heat absorption have reverse effect on it. Radiation and heat absorption have tendency to enhance rate of heat transfer at the plate. The results obtained here may be further used to verify the validity of obtained numerical solutions for more complicated transient free convection fluid flow problems.

• Journal of the Korean Society for Nondestructive Testing
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• v.21 no.6
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• pp.658-662
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• 2001

The classification of surface flaw types was performed on the basis of angular dependence of backscattered ultrasound. The copper line adhered on the surface, cower line filled in groove, pure groove and the normal edge were adopted as various surface flaw patterns of glass specimen. A backward longitudinal profile was formed probably by the longitudinal wane scattering at and near 1st critical angle. The wave trains at the peak angles of the backward radiation profiles showed different shapes according to the superposition ratio of scattered and leaky waves. The asymmetry of the backward radiation profile arose due to the scattering effect of flaw. The additive resonance effect of copper line appeared in the left side of the profile. The peak angles of both the longitudinal and radiation profiles were shifted toward small angle by the scattering effect.

• Fire Science and Engineering
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• v.28 no.3
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• pp.20-28
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• 2014

Effect of radiation models on the suppression limits in counterflow $CH_4$/air diffusion flame was numerically investigated with fundamental experiments for the numerical validation. $N_2$ and $CO_2$ were considered as extinguishing agents. The differences in extinguishing concentration between OTM and SNB radiation models which have different accuracy levels were examined. As a result, there is no considerable difference in extinguishing concentration for the $N_2$ dilution as the radiation models with different accuracy levels were used. As the $CO_2$ having strong radiative effect was diluted in the low strain flames, however, the radiation model with high predictive accuracy such as SNB should be used. In particular, the $CO_2$ dilution in fuel stream leads to the significant difference in extinguishing concentration between OTM and SNB models. Therefore, it is necessary that the radiation model should be reasonably chosen with the consideration of numerical accuracy and computational time for the prediction of extinguishing concentration.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.23 no.8
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• pp.1040-1047
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• 1999

The characteristics of flame propagation in inert particle-laden $H_2$/Air premixed gas are numerically investigated on this study. The 2nd order TVD scheme is applied to numerical analysis of governing equations and multi-step chemical reaction model and detailed transport properties are sued to solve chemical reaction terms. Radiation heat transfer is computed by applying the finite volume method to a radiative transfer equation. The burning velocities against the mole fractions of hydrogen agree well with results performed by different workers. The inert particles play significant roles in the flame propagation on account of momentum and heat transfer between gas and particles. Gas temperature, pressure and flame propagation speed are decreased as the loading ratio of particle is increased. Also the products behind flame zone contain lots of water vapor whose absorption coefficient is much larger than that of unburned gas. Thus, the radiation effect of gas and particles must be considered simultaneously for the flame propagation in a mixture of $H_2$/Air and inert particles. As a result, it is founded that because the water vapor emits much radiation and this emitted radiation is released at boundaries as radiant heat loss as well as reabsorbed by gas and particles, flame propagation speed and flame structure are altered with radiation effect.

• Korean Journal of Environmental Agriculture
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• v.19 no.4
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• pp.328-331
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• 2000

Maize (Zea mays L. cv. kosungjaerae and cv. youngwoljaerae) seeds were irradiated with the dose of $0.5{\sim}20$ Gy by $^{60}Co\;{\gamma}-ray$ radiation to investigate the effect of the low dose ${\gamma}-ray$ radiation on the germination rate, early growth and yield. The low dose radiation was able to improve the germination rate and early growth in maize, but the optimal radiation doses were different depended on kinds of cultivars. High stimulatory effect in early growth of maize was observed in 2 Gy irradiation group of kosungjaerae cultivar and in 12 Gy irradiation group of youngwoljaerae cultivar. The optimal radiation dose for the enhancement of yield and yield components in maize was 8 Gy in kosungjaerae cultivar and $4{\sim}12$ Gy in youngwoljaerae cultivar.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.20 no.1
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• pp.161-166
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• 2016

We studied the effect of $Co^{60}$ gamma-radiation on the FBGs by a variation of grating the fabrication parameters. The FBGs were fabricated in a different UV KrF laser intensity using the same boron co-doped photo-sensitive fiber and exposed to gamma-radiation up to a dose of 33.8 kGy. According to the experimental data and analysis results, We confirmed that the laser intensity for grating inscription has a highly effect on the radiation sensitivity of the FBGs and the radiation-induced Bragg wavelength shift by the change of laser process condition showed a difference more than about 30 %.

• Radiation Oncology Journal
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• v.34 no.3
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• pp.230-238
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• 2016

Purpose: Hypoxia can impair the therapeutic efficacy of radiotherapy (RT). Therefore, a new strategy is necessary for enhancing the response to RT. In this study, we investigated whether the combination of nanoparticles and RT is effective in eliminating the radioresistance of hypoxic tumors. Materials and Methods: Gold nanoparticles (GNPs) consisting of a silica core with a gold shell were used. CT26 colon cancer mouse model was developed to study whether the combination of RT and GNPs reduced hypoxia-induced radioresistance. Hypoxia inducible $factor-1{\alpha}$ ($HIF-1{\alpha}$) was used as a hypoxia marker. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining were conducted to evaluate cell death. Results: Hypoxic tumor cells had an impaired response to RT. GNPs combined with RT enhanced anti-tumor effect in hypoxic tumor compared with RT alone. The combination of GNPs and RT decreased tumor cell viability compare to RT alone in vitro. Under hypoxia, tumors treated with GNPs + RT showed a higher response than that shown by tumors treated with RT alone. When a reactive oxygen species (ROS) scavenger was added, the enhanced antitumor effect of GNPs + RT was diminished. Conclusion: In the present study, hypoxic tumors treated with GNPs + RT showed favorable responses, which might be attributable to the ROS production induced by GNPs + RT. Taken together, GNPs combined with RT seems to be potential modality for enhancing the response to RT in hypoxic tumors.

• Korean Journal of Head & Neck Oncology
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• v.14 no.2
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• pp.151-155
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• 1998

Background and Objectives: Numerous studies were conducted to develop radiosensitizers to increase antitumor effect and decrease systemic toxicity of ionizing radiation. In current study, the authors tested the synergistic effect of mutant $TNF-{\alpha}(M_3S)$ with radiation therapy on heterotransplanted hypoparyngeal squamous cell carcinoma. Materials and Method: SNU-1041 cell line was heterotransplanted to nude mice. When the tumors grew up to $70mm^3$ or more, the animals were randomly placed into 4 groups(n=10/group). Group I : 0.1ml of normal saline injected intraperitoneally once a day for 5 days. Group II : 10ug of $TNF-{\alpha}$ injected intraperitoneally once a day for 5 days. Group III : a single radiation dose of 10 Gy per animal delivered. Group IV : single radiation dose of 10 Gy was delivered 1 hour after intraperitoneal injection of $TNF-{\alpha}$ 10 ug. Results: Four weeks after treatment, group IV showed the least tumor growth during the 4 weeks follow up and the relative tumor growth rate(RTG) of each groups after 4 weeks were 31, 5.8, 10, and 3.2 respectively(p<0.05). Conclusion: These study suggests that pretreatment with $TNF-{\alpha}$ can significantly enhance the effects of radiation therapy and further studies may be needed for clinical trials of combination treatment of $TNF-{\alpha}$ and radiation.

• Korean Journal of Environmental Biology
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• v.17 no.3
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• pp.257-261
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• 1999

Effect of low dose gamma radiation on the growth of groundnut (Arachis hypognea L.) were investigated with respect to germination rate, seedling development and yield. Seeds of “Palpal” cultivar were irradiated with 0.5~20 Gy of ${\gamma}$ radiation in order to determine the hermetic effect of low dose radiation. The germination rate of ${\gamma}$-ray irradiation group was lower than that of the control but the seedling height of groundnut grown from seeds irradiated with low dose ${\gamma}$-ray was slightly higher than that of the control. The number of pod and kernels, and the seed yield increased by 27%, 17% and 19 %, respectively, in the 12.0 Gy irradiation group compared to that in the control group. The 100 seed weight was 87.2 g in the 4.0 Gy irradiation group, which was 11% heavier than 78.3 g in the control group. Low dose radiation showed an enhancement effects on the growth and yield components of groundnut.