• 대한약리학회지
• /
• 제4권1호
• /
• pp.41-44
• /
• 1968

Pyrogallol is recently known to be a inhibitor of catechol-o-methyl transferase (COMT) and increase the action of epinephrine on the isolated rabbit atria. In this experiment, the author attempated to investigate the influence of pyrogallol on the effect of ephedrine and epinephrine on the blood pressure of the rabbit and isolated atria and excised intestine of the rabbit. The results obtained were summarized as follows; 1. Pyrogallol tends to increase the blood pressure and respiration of the rabbit. But it has no significant effect on the excised rabbit atria and intestine. 2. The effect of ephedrine on the blood pressure and respiration, isolated atria and excised intestine of the rabbit were not influenced by the pretreatment with pyrogallol. 3. The effect of epinephrine on the blood pressure and isolated atria of the rabbit is potentiated with pyrogallol pretreatment.

• Journal of Pharmaceutical Investigation
• /
• 제6권2호
• /
• pp.101-110
• /
• 1976

1. In the rabbit and the dog, the blood pressure response to water extract and methanol extract obtained from Atractylodes rhizoma alb'a was investigated. 2. Water extract and methanol extract, when administered into the rabbit and the dog by the route of vein, produced fall of the blood pressure. 3. The depressor response of the rabbit to water extract and methanol extract was not affected by $Avicel{\circledR}$, propranolol and atropine. 4. The depressor response by water extract and methanol extract in the rabbit was not affected by guanethidine, but water extract and methanol extract produced elevation of blood pressure in this rabbit. 5. Pretreatment of rabbit with chlorisendamine or phenoxybenzamine weakened the depressor response to water extract and methanol extract, and the both extracts produced secondary elevation of blood pressure in this rabbit. 6. The pressor response of the chlorisondamine-treated rabbit to water extract and methanol extract was not affected by atropine. 7. Water extract decreased the pressor action of tyramine and depressor action of pilocarpine and isoproterenol, but did not affect the blood pressure response of nor einephrine, angiotensin and dimethylpehnyl piperazinium iodide(DMPP).

• 약학회지
• /
• 제20권1호
• /
• pp.83-91
• /
• 1976

Effects of Alismatis water extract (AE) on the blood pressure were investigated in the rabbit and the dog. AE, when administered into the vein of rabbit and dog, into the lateral ventricle of rbbit, produced fall of blood pressure. The depressor response of the rabbits to intravenous AE was abolished by treatment with atropine, but not with chlorisondamine weakened the depressor effect of AE. Intravenous AE in this rabbit produced secondary elevation of the blood pressure. AE potentiated the pressor response of the rabbit to norepinephrine and tyramine, but nor to angiotensin, acetylcholine, and DMPP.

• 약학회지
• /
• 제23권2호
• /
• pp.69-80
• /
• 1979

Effects of Astragali Radix Water Extract (ARWE) on the blood pressure were investigated in the whole rabbit and the spinalized rabbit. ARWE, when administered into the ear-vein or lateral ventricle, produced a fall in the blood pressure in the whole rabbit, but intravenous ARWE in the spinalized rabbit did not elicite the hypotensive action. Pretreatments with chlorisondamine, guanethidine, phentolamine and cyproheptadine in the whole rabbit weakened the depressor action of ARWE. The hypotensive action of the whole rabbit to ARWE was not influenced by the pretreatment of the animals with diphennylhydramine, propranolol, and vagotomization, whereas inhibited by atropine. ARWE did not affect the pressor response by angiotensin. However, it enhanced the hypertensive action by norepineprine and reduced the elevation in the blood pressure by carotid occlusion in the whole rabbit. These experimental observations suggest that ARWE may cause the depressor response via mechanisms of the central sympathetic blocking action, cholinergic action by peripheral origin and serotonin-like action.

• Journal of Pharmaceutical Investigation
• /
• 제9권2호
• /
• pp.22-30
• /
• 1979

Effects of Akebiae Lignum, whose scientific name is Akebia quinata Decaisne, on the blood pressure were investigated with EtOH extract in whole and spinal rabbits. Akebia Lignum EtOH extract (AEE), when given intravenously, produced a fall in blood pressure not only in whole rabbit but also in spinal rabbit and AEE administered into a lateral cerebral ventricle of whole rabbit did not elicit a fall in blood pressure. The depressor responses of the whole rabbit to intravenous AEE were weakened by treatment of the animals with atropine and chlorisondamine but not by vagotominijation, phentolamine avil, and then the depressor action causing by AEE in the whole rabbit was not affected by pretreatment of physostigmine which is cholinesterase inhibitor and of hemicholinium which blocks acetylcholine synthesis by interfering with choline uptake in nerves. These observations suggest that the hypotensive action of AEE of which component is not affected by cholinesterase is due to direct action at parasympathetic receptor.

• 대한약리학회지
• /
• 제1권1호
• /
• pp.63-65
• /
• 1965

Rabbit blood pressure showed gradual fall by intraventricular guanethidine (5mg). The pressure rise by carotid occlusion was markedly inhibited or abolished by the guanethidine, while it was enhanced by small dose (2mg). The intraventricular guanethidine did not affect norepinephrine pressor effect, but caused marked inhibition or abolishment of depressor action of serotonin.

• 생약학회지
• /
• 제7권3호
• /
• pp.215-220
• /
• 1976

1. Nepetae Herba water extract (NHW) produced a fall of blood pressure in the rabbit. 2. The depressor effect of NHW was inhibited by atropine, but was not affected by propranolol, hexamethonium and diphenhydramine. 3. NHW showed pressor response in the rabbit treated with atropine. 4. The pressor response in the atropine treated rabbit was inhibited by phentolamine and guanethidine.

• 대한약리학회지
• /
• 제1권1호
• /
• pp.53-61
• /
• 1965

Effects of intraventricular norepinephrine (NE) on rabbit blood pressure and heart rate were investigated. 1) Blood pressure was little affected by small doses of NE (below $500{\mu}g$) but showed marked rise by 1 mg. 2) Heart rate was decreased by intraventriccular NE $(200{\sim}500{\mu}g)$. One mg of NE caused less pronounced bradycardia than with smaller doses. The bradycardia could not be observed in vagotomized or atropinized animals. 3) Intraventricular NE potentiated reflexive bradycardia produced by 5-hydroxytryptamine. 4) Cord-sectioned rabbit showed different responses; the smaller doses $(100{\sim}200{\mu}g)$ produced transitory bradycardia and depression of blood pressure, which followed by tachycardia and pressure rise. The transitory bradycardia and depressor effects were not observed in cord-sectioned and vagotomized rabbit. 5) Treatment of animals with reserpine, guanethidine and hexamethonium changed the effects of intraventricular NE on blood pressure, i.e., in these cases the smaller doses of NE caused maked elevation of blood pressure. 6) From these observations it was inferred that central NE caused stimulation of cardioinhibitory and vasomotor center. The former seemed to be more sensitive to NE than the latter. Susceptibility of the vasomotor center to NE seemed to be influenced by peripheral sympathetic tone.

• 대한한방내과학회지
• /
• 제11권1호
• /
• pp.109-120
• /
• 1990

In order to investigate the therapeutic effects on blood pressure and hyper cholesteremia, aqueous extract of Chin Gan Sik Pung Tang were studied. The result of the total cholesterol contents in serum and blood pressure of each group were as follows, 1. The aqueous extract of Chin Gan Sik Pung Tang inhibited increased Total cholesterol in serum of rabbits administrated with cholesterol rich diet. 2. Blood pressure manifested gradual response by the fall of 4, 3, 9.2, 19.9 percent in proportion to the administration of 10, 30, 100 mg/kg of Chin Gan Sik pung Tang, respectively 3. Administration of Chin Gan Sik Pung Tang to the rabbit pretreated with Vagotomy, Atropine and Regitine did not show any significant difference in the blood pressure, compare with that of the control group. 4. Administration of Chin Gan Sik Pung Tang to the rabbit pretreated with propranolol show significant difference in the blood pressure, compare with that of the control group. From the above results, it is suggested that Chin Gam Sik Pung Tang has the action on adrenergic ${\beta}-receptor$ and can he used therapeutic effect on the hypertension, and inhibit the increase of Total Cholesterol contents in serum.

• 생약학회지
• /
• 제6권1호
• /
• pp.39-42
• /
• 1975

Influence of Eucommiae Cortex in Korea on the blood pressure of the rabbit was examined, 1) The intravenous injection of 3 mg/kg, 10 mg/kg and 30 mg/kg of the water extract to the rabbit decreased its blood pressure to $9.7\;{\pm}\;1.9,\;26.4\;{\pm}\;1.7\;and \;35.5\;{\pm}\;2.7\;mmHg$. respectively. 2) The intravenous injection of 10 mg/kg of the water extract did not show any remarkable influence to the blood pressure caused by the intravenous injection of acetylcholine $10^{-8}\;g/kg\; and \;10^{-7}\;g/kg$. 3) The intravenous injection of the water extract after the intravenous injection atropine 2mg/kg did not show any remarkable change to the blood pressure 4) The intravenous injection of the water extract after the intravenous injection of propranolol 2mg/kg slightly decreased the blood pressure.