• Journal of Genetic Medicine
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• v.12 no.1
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• pp.49-56
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• 2015

We herein report an analysis of a female baby with a de novo dup(10p)/del(10q) chromosomal aberration. A prenatal cytogenetic analysis was performed owing to abnormal ultrasound findings including a choroid plexus cyst, prominent cisterna magna, and a slightly medially displaced stomach. The fetal karyotype showed additional material attached to the terminal region of chromosome 10q. Parental karyotypes were both normal. At birth, the baby showed hypotonia, upslanting palpebral fissures, a nodular back mass, respiratory distress, neonatal jaundice and a suspicious polycystic kidney. We ascertained that the karyotype of the baby was 46,XX,der(10)($pter{\rightarrow}q26.3::p11.2{\rightarrow}pter$) by cytogenetic and molecular cytogenetic analyses including high resolution GTG-and RBG-banding, fluorescence in situ hybridization, comparative genomic hybridization, and short tandem repeat marker analyses. While almost all reported cases of 10p duplication originated from one of the parents with a pericentric inversion, our case is extraordinarily rare as the de novo dup(10p)/del(10q) presumably originated from a rearrangement at the premeiotic stage of the parental germ cell or from parental germline mosaicism.

• IMMUNE NETWORK
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• v.11 no.2
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• pp.123-133
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• 2011

Background: Mycobacterium tuberculosis (Mtb) heparin binding hemagglutinin (HBHA) is an Ag known to evoke effective host immune responses during tuberculosis infection. However, the molecular basis of the host immune response to HBHA has not been fully characterized. In this study, we examined the molecular mechanisms by which HBHA can induce the expression of proinflammatory cytokines in macrophages. Methods: HBHA-induced mRNA and protein levels of proinflammatory cytokines were determined in bone marrow-derived macrophages (BMDMs) using RT-PCR and ELISA analysis. The roles of intracellular signaling pathways for NF-${\kappa}B$, PI3-K/Akt, and MAPKs were investigated in macrophage proinflammatory responses after stimulation with HBHA. Results: HBHA robustly activated the expression of mRNA and protein of both TNF-${\alpha}$ and IL-6, and induced phosphorylation of NF-${\kappa}B$, Akt, and MAPKs in BMDMs. Both TNF-${\alpha}$ and IL-6 production by HBHA was regulated by the NF-${\kappa}B$, PI3-K, and MAPK pathways. Furthermore, PI3-K activity was required for the HBHA-induced activation of ERK1/2 and p38 MAPK, but not JNK, pathways. Conclusion: These data suggest that mycobacterial HBHA significantly induces proinflammatory responses through crosstalk between the PI3-K and MAPK pathways in macrophages.

• Journal of Intelligence and Information Systems
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• v.14 no.3
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• pp.41-57
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• 2008

U-Publication, the Tag-Embedded publication, is one of U-Media. U-Media is defined as a media where human creates and consumes content through not only human cognitive and perceptual processes but also through the interactions between surrounding digital systems. U-Media provides information by generating, collecting, and attaching the content itself and the related information based on the interaction of the bio-systems incorporating digital information and devices embedded in humans, and surrounding objects including external digital devices. Using U-Publication, readers consume its content not only in offline but also online through a mobile RFID reader which touches and connects the URLs embedded in the RFID tags attached to it. Readers can consume the additional content though the hyperlinks attached to U-Publication and perform commercial activity as well as consumer the printed content. This paper defines the RFID-Tagged publication, proposes its related business models, and evaluates the alternative business models through a simulation study.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.1 no.2
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• pp.159-168
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• 1997

This paper presents a mechanism which supplies tasks with fast turn-around time on real-time multimedia environments. Tasks are classified into periodic and aperiodic tasks according to their executing period, and the types of them are classified into three groups : critical tasks, essential tasks and common tasks by the degree of its urgency. In the case of periodic tasks, we defer the execution of it within the extent to keep the deadline as long as possible and serve the aperiodic tasks, and provide aperiodic tasks with fast turn-around time. Changing the priority of each task is allowed within the same type and it is scheduled by using the dynamic priority. The emergency tasks are executed within deadline in any circumstances, and the least laxity one is served first when many real-time tasks are waiting for execution. The result of simulation shows that the proposed mechanism is better than the EDZL, known as suboptimal in multiprocessor systems, in the point of rum-around time.

• Resources Recycling
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• v.22 no.6
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• pp.55-63
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• 2013

In this study, a electrochemical-chemical combined dissolution technology was conducted by electro-generated chlorine to obtain ruthenium solution from ruthenium metal. To find out the optimum leaching conditions of ruthenium in chloride solution, this leaching process was carried out on the variation of pH, reaction time, temperature and applied voltage at the electro-generated chlorine system in the reaction bath. Also, ozone generator was used to obtain ruthenium(III) chloride solution to increase the leaching rate. The optimum condition was observed at pH 10.0, $40^{\circ}C$ within 1 hr of reaction time that more than 88% of ruthenium(III) chloride dissolved.

• Journal of the Korea Computer Industry Society
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• v.2 no.7
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• pp.975-982
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• 2001

In this study, a solid-state laser system adopting a new real time multi-discharge (RTMD) method in which three flashlamps are turned on consecutively was designed and fabricated to examine the pulse width and the pulse shape of the laser beams depending upon the changes in the lamp rum-on time. That is, this study shows a technology that makes it possible to make various pulse shapes by turning on three flashlamps consecutively on a real-time basis with the aid of a PIC one-chip microprocessor. With this technique, the lamp turn-on delay time can be varied more diversely from 0 to 10 ms and the real-time control is possible with an external keyboard, enabling various pulse shapes. In addition, longer pulses can be more widely used for industrial processing and lots of medical purposes

• Journal of English Language & Literature
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• v.57 no.2
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• pp.339-365
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• 2011

Charlotte $Bront{\ddot{e}}^{\prime}s$ novel Jane Eyre has long been doted on as one of the canonized texts of British literature since its publication. Seemingly, this romantic novel has nothing to do with plantation based on slave trade. However, paying a keen attention to the fact that Jane's enormous inheritance results from wine plantation at a colony, this essay re-interprets Bertha's drinking and madness as evidence of imperialism. For the porter/jin Bertha and Grace Poole enjoy might have some suspicious connection with wine, the very root of Jane's great expectations. Jean Ryes' Wide Sargasso Sea, writing Jane Eyre back, records Bertha as "a white resident of the West Indies, a colonizer of European descent" (326). However, Jane Eyre, in my interpretation, describes Bertha pretty much as a black Creole. At any rate, the view that the white West Indians are tainted by miscegenation proves contemporary racism and is reflected in the text through Bertha and her mother's intemperate drinking and madness. Drinking and madness are stigmatized as the evidence of the so-called "bad blood"; embodying the stereotypes of drinking, madness, and sexual corruption, Creoles, the very inescapable product of imperialism, provide a convenient excuse for justifying imperialism for purity, civilization, and moral cleanness. In this way, Jane Eyre needs to be re-interpreted politically and historically in the context of colonialism. British imperialism pursues a tremendous amount of profits through grape plantation and wine trades; however, it cleverly leaves in the colony the associated images such as intemperate drinking and madness. Bertha, transferred from Jamaica to Britain, takes in these negative images of "savageness." Transcending the narrow confines of feminist criticism obsessed with doubling between Bertha and Jane, this essay, accordingly, reads Bertha the prisoner in the attic as the captive for perpetuating imperialism. This reading hinges upon interpreting Rochester and St John as colonizers bearing the so-called "white men's burden" to cultivate and civilize savages much like crops such as grapes and sugarcane in the colonial plantation.

• Korean Journal of Family Medicine
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• v.39 no.6
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• pp.347-354
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• 2018

Background: BMI alone may not serve as an index of obesity because it does not reflect body composition. The present study aimed to compare arterial stiffness as assessed by the brachial-ankle pulse wave velocity (ba-PWV) among groups defined by body fat percentage (pBF) and BMI. Methods: This cross-sectional study was based on 1,700 participants (1,044 men and 656 women) who completed a health screening examination at a national hospital between January 2011 and February 2016. Participants were divided into four groups according to BMI and pBF: normal fat and normal weight (NFNW); excessive fat and normal weight (EFNW); normal fat and obese (NFO); and excessive fat and obese (EFO). The ba-PWV and other cardiometabolic factors were compared among the four groups in men and women separately. Results: For both sexes, the NFNW group had a lower metabolic risk compared to that in the other groups (EFNW, NFO, and EFO). After adjusting for multiple variables, the NFO males had a significantly lower ba-PWV compared to those in the other groups, including NFNW males. The NFO group had significantly more skeletal muscle mass and muscle mass compared the other groups (P<0.05). Among women, the NFNW group had a significantly lower ba-PWV compared the other groups, even after adjusting for multiple variables. Conclusion: Lower pBF in obese men may be associated with improved cardiovascular risk.

• Journal of the Korea Convergence Society
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• v.10 no.6
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• pp.243-249
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• 2019

This study was conducted on elderly women in their 60s and 70s, and the results of the study were as follows when line dancing for 60 minuctes every three times a week for 12 weeks on dementia and aging-related hormones. After 12 weeks of line dancing programs, BDNF, DHEA-s, and estrogen increased, but no statistically significant differences with control groups emerged. In addition, after 12 weeks of line dancing, Apolipoprotein B decreased in line dancing group but showed no statistically significant difference from control group. Although significant differences between groups were not identified in the results of this study, positive effects on preventing and aging of dementia were identified in the group applying the line dance program, and further studies considering the new target and hign kinetic strength, frequency, time, and athletic genre are needed to identify the distinct effects of line dancing in the future.

• Safety and Health at Work
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• v.10 no.1
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• pp.103-108
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• 2019

Background: This study was designed to provide logical backgrounds for the revision of biological exposure indices (BEIs) for styrene exposure in Korea. In order to investigate the correlation between airborne styrene and biological exposure indices, we measured urinary mandelic acid (MA) and phenylglyoxylic acid (PGA) in workers exposed to styrene occupationally, as well as airborne styrene at workplaces. Methods: Surveys were conducted for 56 subjects. The concentrations of airborne styrene and urinary metabolites of styrene were measured in 36 workers who were occupationally exposed to styrene, and in 20 controls. Air samples were collected using personal air samplers and analyzed by gas chromatography. Urine samples were collected at the end of the shift and analyzed by high performance liquid chromatography. Results: The geometric mean concentration of airborne styrene was 9.6 ppm. The concentrations of urinary MA, PGA, and MA+PGA in the exposure group were 267.7, 143.3, and 416.8 mg/g creatinine, respectively. The correlation coefficients for correlation between airborne styrene and MA, PGA, and MA+PGA were 0.714, 0.604, and 0.769, respectively. The sum of urinary MA and PGA corresponding to an exposure of 20 ppm styrene was 603 mg/g creatinine. Conclusion: The correlation of the sum of urinary MA and PGA with airborne styrene was better than the correlation of each individual urinary determinant. It is considered appropriate to amend the concentration of urinary MA+PGA to 600 mg/g creatinine as a BEI, which corresponds to an airborne styrene concentration of 20 ppm in Korea.