• Radiation Oncology Journal
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• 제34권3호
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• pp.193-201
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• 2016

Purpose: To assess the clinical outcomes of radiotherapy (RT) using two-dimensional (2D) and three-dimensional conformal RT (3D-CRT) for patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma to evaluate the effectiveness of involved field RT with moderate-dose and to evaluate the benefit of 3D-CRT comparing with 2D-RT. Materials and Methods: Between July 2003 and March 2015, 33 patients with stage IE and IIE gastric MALT lymphoma received RT were analyzed. Of 33 patients, 17 patients (51.5%) were Helicobacter pylori (HP) negative and 16 patients (48.5%) were HP positive but refractory to HP eradication (HPE). The 2D-RT (n = 14) and 3D-CRT (n = 19) were performed and total dose was 30.6 Gy/17 fractions. Of 11 patients who RT planning data were available, dose-volumetric parameters between 2D-RT and 3D-CRT plans was compared. Results: All patients reached complete remission (CR) eventually and median time to CR was 3 months (range, 1 to 15 months). No local relapse occurred and one patient died with second primary malignancy. Tumor response, survival, and toxicity were not significantly different between 2D-RT and 3D-CRT (p > 0.05, each). In analysis for dose-volumetric parameters, $D_{max}$ and CI for PTV were significantly lower in 3D-CRT plans than 2D-RT plans (p < 0.05, each) and $D_{mean}$ and V15 for right kidney and $D_{mean}$ for left kidney were significantly lower in 3D-CRT than 2D-RT (p < 0.05, each). Conclusion: Our data suggested that involved field RT with moderate-dose for gastric MALT lymphoma could be promising and 3D-CRT could be considered to improve the target coverage and reduce radiation dose to the both kidneys.

• 한국방사선학회논문지
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• 제15권7호
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• pp.983-989
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• 2021

본 연구에서는 환자상태가 좋지 않은 환자에게 적용하기 위하여 Fast MRCP 검사 방법를 이용한 2D TSE(RT)와 3D GRASE(BH) 기법에 적용하여 영상의 질을 평가하고 임상에 기초자료로 제공하고자한다. MRCP 검사를 시행한 환자 30명(남자 15명, 여자 15명, 평균나이 64±4.26)을 대상으로 데이터를 분석하였다. 사용된 장비는 Ingenia CX 3.0 T 장비를 사용하였고 Data 획득은 Ds anterior Coil을 사용하였다. 정량적 분석으로 각 영상의 SNR과 CNR을 측정하고 정성적 평가를 위해 5등급으로 나누어 영상의 질을 평가하였다. 영상평가는 paired t-test와 wilcoxon 검정을 하였으며 p 값이 0.05 이하 일 때 유의성이 있는 것으로 간주하였다. SNR과 CNR에 대한 정량적 분석 결과 2D TSE(RT) MRCP 와 3D GRASE(BH) 두 기법을 비교했을 때 3D GRASE(BH)가 높게 측정되었다(p<0.05). 정성적 분석결과는 담관의 선예도: 3D GRASE(BH):4.12 ± 0.03, 전반적인 영상의 질: 3D GRASE(BH):4.21 ± 0.91로 높게 나타났다(p=0.001). 담관의 움직임 인공물은 두 기법(2D TSE(RT): 4.41 ± 0.04, 3D GRASE(BH): 4.53 ± 0.14로 유의성 있는 차이를 보이지 않았다(p=0.067). 그러나 배경소거부분은 2D TSE(RT)가 4.14 ± 0.55로 유의성 있는 결과를 얻었다(p=0.001). 결론적으로, Fast MRCP 검사방법을 이용한 결과 3D GRASE (BH)로 획득한 MRCP 영상이 2D TSE(RT)를 사용한 MRCP 영상에 비해 우위의 결과를 얻었다. 그러나, 호흡을 참기 힘든 환자의 경우 2D TSE(RT) MRCP 기법이 유용성이 있는 결과가 있을 것이다.

• 한국인터넷방송통신학회논문지
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• 제23권6호
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• pp.139-143
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• 2023

본 논문에서는 CT영상을 구성하는 RT 알고리즘에 비해 원추형 CB-CT 시스템에서 이용할 수 있는 TPSM 알고리즘을 적용하여 기존의 RT보다 빠르게 3D CT 영상 구성을 할 수 있도록 하였으며 두 개의 알고리즘에 대한 영상속도를 비교분석 하였다. 이를 위하여 원추형 CB-CT 시스템에서 이용할 수 있는 TPSM 알고리즘을 적용하여 3D CT 영상구성에 있어서 실시간 처리가 가능하도록 하였다. 실험결과 TPSM을 이용하여 구성된 단면 영상은 중심점에서 멀어질수록 빈 화소에 의해 영상의 질이 미소하게 감소하지만 TPSM 회전 기반법의 경우에서 영상 구성 속도는 RT알고리즘보다 월등하게 우수하다는 것을 알 수 있었다.

• BMB Reports
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• 제35권3호
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• pp.262-266
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• 2002

A non-isotopic neutravidin-based reverse transcriptase (RT) assay adapted for high throughput screening of HIV activity is described. Using a 96-well microtitre plate, HIV particles are lysed and the RT enzyme released into a reaction mixture containing poly(A) RNA, biotinylated oligo d(T) and fluorescein-labelled dUTP (FI-dUTP). With poly(A) as a template and oligo d(T) as primer, the viron RT incorporates FI-dUTP into an elongating DNA strand. The resulting product is captured on a neutravidin-coated 96-well plate and the unincorporated nucleotides removed by a series of washing steps. A simple ELISA is subsequently performed using a monoclonal antifluorescein antibody conjugated to alkaline phosphatase. Quantification of RT activity is facilitated by a colorimetric readout. The assay was validated in the context of a diagnostic HIV-1 phenotyping assay. Using supernatants from HIV-1 infected lymphocyte cultures the assay was shown to be as sensitive as a radioactive assay and the RT activity correlated well with levels of cell-asociated HIV-p24. Importantly, even minor reductions of RT activity by virus variants with reduced fitness could be distinguished.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2001년도 총회 및 춘계학술발표회
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• pp.120-123
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• 2001

To evaluate the biodegradability of contaminants in an aquifer, computer modeling with RT3D model (Clement, 1997) was used. The RT3D model simulates the biodegradation of organic contaminants using a number of aerobic and anaerobic electron acceptors. The RT3D model was applied to a well-studied petroleum hydrocarbon plume in a shallow unconfined aquifer in Uiwang, Korea. The results of this study demonstrate tile importance of biodegradation processes in the monitored natural attenuation and in reducing contaminant concentrations in a shallow aquifer. The modeling results tell that the amount of electron acceptors is the key factor affecting biodegradation of TEX, the petroleum hydrocarbon contaminant in shallow groundwater

• Radiation Oncology Journal
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• 제34권2호
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• pp.145-155
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• 2016

Purpose: Radiation therapy targeting axilla and groin lymph nodes improves regional disease control in locally advanced and high-risk skin cancers. However, trials generally used conventional two-dimensional radiotherapy (2D-RT), contributing towards relatively high rates of side effects from treatment. The goal of this study is to determine if three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), or volumetric-modulated arc therapy (VMAT) may improve radiation delivery to the target while avoiding organs at risk in the clinical context of skin cancer regional nodal irradiation. Materials and Methods: Twenty patients with locally advanced/high-risk skin cancers underwent computed tomography simulation. The relevant axilla or groin planning target volumes and organs at risk were delineated using standard definitions. Paired t-tests were used to compare the mean values of several dose-volumetric parameters for each of the 4 techniques. Results: In the axilla, the largest improvement for 3D-CRT compared to 2D-RT was for homogeneity index (13.9 vs. 54.3), at the expense of higher lung $V_{20}$ (28.0% vs. 12.6%). In the groin, the largest improvements for 3D-CRT compared to 2D-RT were for anorectum $D_{max}$ (13.6 vs. 38.9 Gy), bowel $D_{200cc}$ (7.3 vs. 23.1 Gy), femur $D_{50}$ (34.6 vs. 57.2 Gy), and genitalia $D_{max}$ (37.6 vs. 51.1 Gy). IMRT had further improvements compared to 3D-CRT for humerus $D_{mean}$ (16.9 vs. 22.4 Gy), brachial plexus $D_5$ (57.4 vs. 61.3 Gy), bladder $D_5$ (26.8 vs. 36.5 Gy), and femur $D_{50}$ (18.7 vs. 34.6 Gy). Fewer differences were observed between IMRT and VMAT. Conclusion: Compared to 2D-RT and 3D-CRT, IMRT and VMAT had dosimetric advantages in the treatment of nodal regions of skin cancer patients.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 2003년도 춘계학술대회 논문집
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• pp.428-432
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• 2003

The technical combination of RP and RT has a potential for rapid manufacturing of three-dimensional parts. In the present work a new RP system, $VLM-_{ST}$, is proposed to manufacture net shapes of 3D prototypes. ㅁ human head shape and a kob shape are manufactured by the $VLM-_{ST}$ apparatus. In addition, a new RT technology, which utilizes a RTV molding technique and a triple reverse process technique, is proposed to manufacture net shapes of 3D plastic parts using prototypes of $VLM-_{ST}$. A plastic part of the knob shape os produced by the proposed RT technology. The combination of the proposed RP and RT enables the manufacturing of a plastic knob within two days.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2001년도 춘계학술대회 논문집
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• pp.16-19
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• 2001

Rapid Prototyping (RP) and Rapid Tooling (RT) were introduced to reduce time-to-market and cost by shortening not only the development phase but also the production phase of the manufacturing process. RP generally builds up a prototype layer by layer, rapidly generating a fully three-dimensional free form shape. RT enables the manufacture of production tools. The integration of RP and RT has the potential for rapid net shaping of thee-dimensional parts, which have geometrical complexity. In this study, net shaping techniques for making three-dimensional parts using RP and RT are described and a sample part are shown. A three-dimensional metal part is manufactured by a new RP process, Variable Lamination Manufacturing by using Expandable Polystyrene Foam (VLM-S), and its application to RT for making a clover punch. In addition, we discussed the technology fusion between metal forming md RP/RT.

• 소성∙가공
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• 제11권4호
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• pp.323-331
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• 2002

The combination of rapid prototyping(RP) and rapid tooling(RT) has a potential for rapid manufacturing of three-dimensional parts. In the present study, a new RP system transfer type Variable Lamination Manufacturing using Expandable Polystyrene Foam (VLM-ST), is proposed to fabricate net shapes of three-dimensional prototypes. Various three-dimensional parts, such as a knob shape and a human head shape, are manufactured by the VLM-ST apparatus. In addition, a new rapid tooling technology, which utilizes a room temperature vulcanizing (RTV) molding technique and a triple reverse process technique, is proposed to manufacture net shapes of three-dimensional plastic parts using the prototypes of VLM-ST. A plastic part of the knob shape is produced by the proposed RT technology. The combination of the proposed RP and RT enables the manufacture of a plastic knob within two days.

• 한국항행학회논문지
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• 제19권3호
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• pp.199-206
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• 2015

IGS에서는 실시간 정밀 측위에 사용할 수 있도록 궤도 예측값인 IGU (IGS Ultra-rapid)와 실시간 궤도 추정값인 RTS (real-time service) 보정정보를 제공한다. IGU는 데이터 지연시간이 없지만, RTS는 5~30 초의 지연시간을 갖기 때문에 실시간으로 사용하기 위해선 지연시간만큼 예측이 필요하다. 본 논문에서는 실시간 사용 측면에서 RTS와 IGU의 성능 분석을 수행하였다. 한반도 내에서 RTS 제공 비율을 파악하기 위하여 한반도에서 관측되는 위성 대비 RTS 제공 비율을 계산하였으며 그 결과 99.3%로 나타났다. RTS의 정확도를 확인하기 위해 보정정보를 방송궤도력에 적용하여 오차를 분석하였으며 이 때 3D 궤도 RMS 오차는 0.043 m으로 나타났다. 실시간 사용 측면에서 RTS와 IGU를 비교하였는데, 실시간으로 가정하였기 때문에 IGU는 예측 정보만 이용하였고, RTS는 데이터 지연시간동안 다항식 모델로 예측을 수행하였다. RTS와 IGU를 1초 간격으로 각각 외삽, 보간을 수행하였고 그 결과 궤도 예측 성능은 비슷하였으며 시계 예측 성능은 RTS가 0.13 m 더 뛰어났다.