• Journal of Microbiology and Biotechnology
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• v.28 no.11
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• pp.1908-1915
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• 2018

Upon viral infection, the host cell recognizes the invasion through a number of pattern recognition receptors. Melanoma differentiation associated gene 5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) recognize RNA molecules derived from invading viruses, activating down-stream signaling cascades, culminating in the induction of the type I interferon. On the other hand, viruses have evolved to evade type I interferon-mediated inhibition. Hepatitis E virus has been shown to encode a few antagonists of type I interferon and it is not surprising that viruses encode multiple mechanisms of viral evasion. In the present study, we demonstrated that HEV PCP strongly down-regulates MDA5-mediated activation of interferon ${\beta}$ induction in a dose-dependent manner. Interestingly, MDA5 protein expression was almost completely abolished. In addition, polyinosinic polycytidylic acid (poly(I:C))- and Sendai virus-mediated activation of type I interferon responses were similarly abrogated in the presence of HEV PCP. Furthermore, HEV PCP down-regulates several molecules that play critical roles in the induction of type I IFN expression. Taken together, these data collectively suggest that HEV-encoded PCP is a strong antagonist of type I interferon.

• Textile Coloration and Finishing
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• v.12 no.6
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• pp.361-371
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• 2000

The problematic effects of fly creation on circular knitting machines during the knitting process were investigated in order to develop a new method for tackling the problem. A new idea, i.e. coating the yarn surface with a polymer film, was studied. Important physical properties of the coated yarm were studied and compared with normal yarn. A new test-rig was designed to measure the coefficient of friction and the degree of shedding of yarn. Yarns were coated with seven polymer materials and the performance of the coated yarns was tested and the results are discussed.

• Proceedings of the KSME Conference
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• 2000.11b
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• pp.453-460
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• 2000

A test rig is developed for performance test of 1 stage axial-type turbine which is designed by meanline analysis, streamline curvature method, and blade design method using configuration parameters. The purpose of this study is to find the best configuration parameters for designing a high efficiency axial-type turbine blade. To measure the efficiency of turbine stage, a dynamo-meter is installed. Two different stators which are manufactured as an integrated type are developed, and a rotor blade and 5 sets disc are developed for setting different stagger angle. The tip and hub diameters of the test turbine are 300 and 206.4mm, respectively. The rotating speed is 1800RPM, and the extracted power is 2.5kW. Flow coefficient is 1.68 and the reaction factor at meanline is 0.373. The number of stator and rotor of test turbine are 31 and 41, respectively. The Mach number of stator exit flow near hub is 0.164.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.806-811
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• 2001

Since the characteristics of combustion and pollutant in Diesel engines were mainly effected by the characteristics of in-cylinder gas flow and fuel spray, an understanding of those was essential to the design of the D.I. Diesel engines. The improvement of volumetric efficiency of air charging into combustion chamber is a primary requirement to obtain better mean effective pressure of an engine. Since parameters such as the air resistances in intake and exhaust flow passages, valve lift and valve shape influence greatly to the volumetric efficiency, it is very important to investigate the flow characteristics of intake and exhaust port which develops air motion in the combustion chamber. In this study, two approach methods were used for design intake and exhaust port; experiment and computation which were made by using steady flow test rig and commercial CFD code. This paper presents the results of an experimental and analytical investigation of steady flow through the prototype cylinder head ports and valves of the HHI's H21/32 HIMSEN Engine.

• Journal of Digital Contents Society
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• v.11 no.2
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• pp.177-184
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• 2010

These days, as digital producing technique has been developed, 3D imaging technique is used in high-tech computer and T.V. Also study for 3D producing technique is actively in progress. Moreover, as James Cameron's movie, 'Avatar' released in 2009 was a box office hit, the issue about 3D image came to the fore again. At this point, I decided to study the effect of the visual depth caused by the color correction during the post-production stage. The purpose of this study is to offer information about processing effective images through data about the effect of the visual depth that applies the color correction during the post-production stage. Basically, I supposed that color and contract would have effects on depth of 3D image. As a result, I could find out the changes of visual depth, space perception and sense of depth throughout the experiment. Applying this result,, I produced the 15 minutes of 3D advertisement movie and I found out that the color correction during the post-production stage was very effective for 3D depth. The left image and the right image by beam splitter based rig and parallel rig were used for this study. Also I adjusted the strong contrast by the color correction during the post-production stage after correcting convergence and visual depth during editing. As a result, I could produce images which had strong sense of space and sense of depth.

• International Journal of Fluid Machinery and Systems
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• v.4 no.1
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• pp.140-149
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• 2011

For a certain operating point of a horizontal shaft bulb turbine (i.e. volume flow, net head, blade angle, guide vane angle) the efficiency for different pressure levels (i.e. different Thoma-coefficient ${\sigma}$) is calculated using a commercial Computational Fluid Dynamics (CFD-)-code including two-phase flow and a cavitation model. The results are compared with experimental results achieved at a closed loop test rig for model turbines. The comparison of the experimentally and numerically obtained efficiency and the visual impression of the cavitation show a good agreement. Especially the drop in efficiency is calculated with satisfying accuracy. This drop in efficiency in combination with the visual impression is of high practical importance since it contributes to determine the admissible cavitation in a bulb-turbine. It is seen that the incipient cavitation in Kaplan type turbines has no major importance in determing this admissible amount of cavitation.

• Molecules and Cells
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• v.23 no.1
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• pp.1-10
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• 2007

Invading pathogens are recognized by diverse germline-encoded pattern-recognition receptors (PRRs) which are distributed in three different cellular compartments: extracellular, membrane, and cytoplasmic. In mammals, the major extracellular PRRs such as complements may first encounter the invading pathogens and opsonize them for clearance by phagocytosis which is mediated by membrane-associated phagocytic receptors including complement receptors. The major membrane-associated PRRs, Toll-like receptors, recognize diverse pathogens and generate inflammatory signals to coordinate innate immune responses and shape adaptive immune responses. Furthemore, certain membrane-associated PRRs such as Dectin-1 can mediate phagocytosis and also induce inflammatory response. When these more forefront detection systems are avoided by the pathogens, cytoplasmic PRRs may play major roles. Cytoplasmic caspase-recruiting domain (CARD) helicases such as retinoic acid-inducible protein I (RIG-I)/melanoma differentiation-associated gene 5 (MDA5), mediate antiviral immunity by inducing the production of type I interferons. Certain members of nucleotide-binding oligomerization domain (NOD)-like receptors such as NALP3 present in the cytosol form inflammasomes to induce inflammatory responses upon ligand recognition. Thus, diverse families of PRRs coordinately mediate immune responses against diverse types of pathogens.

• Journal of the Daesoon Academy of Sciences
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• v.21
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• pp.1-28
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• 2013

The intention of this article is to check for the believers in Daesoonjinrihoe how to perceive the gods who they believe in. For that intention, I explained how the perception of gods in Daesoonjinrihoe is different from the perception of gods in other religions. To make a long story short, because of its polytheism the idea of god in Daesoonjinrihoe is different from monotheism such as Christianity, Islam. In addition, in spite of its polytheism it is different from other polytheism such as the religion in ancient India, especially rig-vedicreligion. In this article it is said that the believers in Daesoonjinrihoe have understood the distinction between Shin(神) and Shinmyung(神明). Nowadays Shin that has been used in Korea, China, Japan, is the word that was translated from English god. Therefore we need to reappraise the meaning of the word Shin. Anyway Shin that is being used in general means Shinmyung in Daesoonjinrihoe. Instead when they say the name of functional gods and the name to which the meaning of its origin affixed, the word Shin is used. Meanwhile, it has the advantage of classifying the ideas of god, but we can't explain all of them through the use of those classifications. I checked some classifications in this article and tried to apply the idea of gods in Daesoonjinrihoe. As a result, each classification has some critical points. There fore in this article I explained the distinguishing ideas of god in Daesoonjinrihoe from that in other religions, instead of the explaining fitted those classifications.

• Transactions of The Korea Fluid Power Systems Society
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• v.4 no.1
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• pp.18-24
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• 2007

The continuously variable transmission (CVT) of which speed ratio can change continuously in a fixed range has the benefits of low fuel consumption and exhaust gas because it enables the engine of a vehicle to operate in a high efficiency range regardless of vehicle speed. The speed ratio of belt type CVT is controlled by adjusting line pressure. The one of the line pressure control methods, mechanical-hydraulic control is usually adopting VDT's control method, in which the secondary solenoid valve has two functions both a regulator and a line pressure controller. However, this control method could not show the high performance of CVT with optimal driving capability because of the limitation of simple control algorithm, and it could not gain market share sufficiently in spite of the advantage of CVT with low fuel consumption. On the other hand, the electro-hydraulic control method gives the enhancement of power performance and low fuel consumption by implementing various driving mode using the proportional control or PWM control. The key of CVT technique is to develop a control algorithm of the electro-hydraulic solenoid valve in order to implement the speed ratio efficiently. In this paper, the line pressure control algorithm is proposed and the hydraulic system is controlled using metal belt type CVT test rig and the embedded ECU platform.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.9
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• pp.1276-1283
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• 2002

Recently, HSDI (High Speed Direct Injection) diesel engine has been spotlighted as a next generation engine because it has a good potential for high thermal efficiency and fuel economy. This study was carried out to investigate the in-cylinder flow characteristics generated in a 4-valve small diesel cylinder head with a tangential and helical intake port. The flow characteristics such as coefficient of flow rate(Cf), swirl ratio (Rs), and mass flow rate (ms) were measured in the steady flow test rig using the impulse swirl meter and the analysis of in-cylinder flow field was conducted by experiment using the PIV and calculation using the commercial CFD code. As the results from steady flow test indicate, the mass flow rate of the cylinder head with a short distance between the two intake ports is increased over 13% than that of the other head. However, the non-dimensional swirl ratio is decreased approximately 15%. From in-cylinder flow characteristics obtained by PIV and CFD calculation, we found that the swirl center was eccentric from the cylinder center and the velocity distribution became uniform near the TDC. In addition, the results of the calculation are good agreement with the experimental results.