• Applied Microscopy
• /
• v.3 no.1
• /
• pp.45-54
• /
• 1973

The present study is to determine the toxicity of the fungi isolated from foodstuffs by observing the ultrastructural changes in the mouse liver cells. The results as follows: 1. The toxin-producing fungi were screened by the methods of toxin-screening test(cyto-toxicity test against to HeLa cells and thin layer chromatography). 2. All of the experimental animals treated with isolated fungi were observed the focal necrosis and inflammatory infiltration of liver parenchymal cells. 3. It showed the cytoplasmic changes, such as dilatation of rough endoplasmic reticulum (RER), swelling of mitochondria (mi). increased number of lipid droplet (li) and glycogen (gl), detachment of ribosomes (ri) by observing the electron microscopy. 4. Nuclear and nucleolar alteration were also noted the segregation of nucleolar element and irregularity of nuclear envelopes. 5. As a mass screening, the cytotoxicity test using HeLa cells and thin layer chromatography are feasible methods to detection of the mycotoxin producing fungi from various sources.

• Journal of Pharmaceutical Investigation
• /
• v.41 no.2
• /
• pp.75-82
• /
• 2011

LB71350 is an HIV protease inhibitor with poor aqueous solubility and extensive first pass effect. The purpose of the present study was to test the feasibility of solid dosage form of LB71350 with improved bioavailability utilizing solid dispersion. Three different compositions with varying ratio of (LB71350: Gelucire 44/14: Tween 20) were studied. Capsule filling of these solid dispersion compositions was tested using a semi-automatic capsule filling system. Oral bioavailability in dog was tested. Chemical and physical stability at 4, 25 and $40^{\circ}C$ was monitored by HPLC assay, dissolution test, powder XRD and microscopy. The capsule filling system yielded uniform products of drug loading up to 10%. Oral bioavailability in dog was improved compared to the aqueous suspension of crystalline LB71350. Capsules were chemically stable for up to 6 months at $40^{\circ}C$. However, there were temperature and composition dependent physical changes. Decrease in dissolution rates after storage at $40^{\circ}C$ was due to the polymorphic change. In conclusion, manufacturing process, bioavailability, and physico-chemical stability have been considered to propose a solid dispersion capsule formulation for the HIV protease inhibitor with poor physico-chemical properties. A new less soluble crystalline form identified during the physical stability test warrants further study.

• Journal of Korean Academy of Nursing
• /
• v.36 no.5
• /
• pp.813-820
• /
• 2006

Purpose: This study examined the effects of individual reminiscence therapy on older adults' depression, morale, and the quality of life. Methods: The design was a single-group pre-test and post-test study. Subjects consisted of 31 older adults from two senior centers and a welfare center in Seoul. Individual reminiscence therapy was applied to study subjects four times, once a week for an hour at each time. Measurement tools were the Geriatric Depression Scale Short Form Korea (GDSSF-K) for depression, Mun Ae-ri's (1996) scale for morale, and Medical Outcomes Study Short Form 36 (SF-36) for the quality of life. Data was analyzed using descriptive statistics, paired t-test, and pearson correlation. Results: The application of individual reminiscence therapy reduced older adults' depression (t=-5.65, p=.000), and enhanced older adults' morale (t=4.65, p=.000). The application of individual reminiscence therapy improved older adults' quality of life (t=5.00, p=.000). Conclusion: Findings of the study suggest that individual reminiscence therapy may be applied as a nursing intervention that contributesto the improvement of older adults' quality of life, reduces their depression, and enhances their morale.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2009.11a
• /
• pp.130-133
• /
• 2009

The sequence of the propellant supply is very important for the reliable and safe operation of a LRE combustion test. So combustion performance tests were performed to find an optimum test sequence by changing supply time of propellants and purge gas in the moment of ignition and extinction. The liquid rocket engine consisted of a catalytic ignitor and six swirl-coaxial injectors which used hydrogen peroxide and kerosene. Conclusively, an optimum sequence was found for stable combustion in the moment of ignition and extinction.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2006.03a
• /
• pp.147-152
• /
• 2006

In this study, we examined the applicability of three-dimensional electrical resistivity survey to detect underground cavities of ground subsidence area at the field test site, located at Yongweol-ri, Muan-gun in Korea. Underground cavities are widely present within the limesilicate bedrock overlain by the alluvial deposits in the area of the test site where the ground subsidences have occurred in the past. The limesilicate cavities are mostly filled with groundwater and clays in the test site. Thus, cavities have low electrical resistivity compared to the surrounding host bedrock. The results of the study have shown that the zones of low resistivity correspond to the zones of the cavities identified in the boreholes at the site, and that the three-dimensional electrical resistivity survey used are very effective to detect underground cavities.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
• /
• v.22 no.1
• /
• pp.27-34
• /
• 2016

Background: The purpose of this study was to investigate the immediate effects of neuro-dynamics technique (NDT) to the balance and gait for chronic stroke patients. Methods: This study was composed of the cross-sectional design. Nine patients with chronic stroke applied to NDT. Balance ability function was measured using the Good Balance System device for static balance, timed up and go test (TUG) and functional reach test (FRT) for dynamic balance. The 10 meter walk test (10MWT) and GAITRite device were used for measurement of gait ability for patients. Results: There were significant improvements were observed on dynamic balance ability (p<.05) and gait ability function (p<.05). Conclusions: This research shows that the NDT is immediate effective on dynamic balance and gait ability of the chronic stroke patients. Further studies may be needed to continuously intervention of NDT for more patients.

• Korean Journal of Adult Nursing
• /
• v.26 no.2
• /
• pp.171-180
• /
• 2014

Purpose: This study was to investigate the effects of upper meridian massage on cerebral blood flow, emotions, and sleep of the institutionalized elderly. Methods: This study was a nonequivalent control group pre- and post-test design. The participants were 50 elderly (26 in the experimental group; 24 in the control group) living in the institutions. Data were collected between July 9 and September 1, 2011. The data were analyzed using descriptive statistics, t-test, and $x^2$-test, Repeated Measures ANOVA, and Cronbach's ${\alpha}$ coefficient. Each participant in the experimental group received the upper meridian massage for 10 minutes, 4 times per week for 2 weeks. Each participant's cerebral blood flow and self-reported questionnaires were tested before treatment, after 1 week and 2 weeks during treatment sessions. Results: There were significant differences in sleep and emotions after 1 week and 2 weeks during treatment sessions. But cerebral blood flow measured by common carotid artery pulsatility index (CCA PI) and common carotid artery resistance index (CCA RI) demonstrated significant differences in 2 week point in time. Conclusion: These results indicated that upper meridian massage could be an effective intervention for improving cerebral blood flow, emotions, and sleep of the institutionalized elderly.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2009.09a
• /
• pp.1017-1024
• /
• 2009

In the past few decades, the rockfill embankment dam, which has superior workability and economy, has become a major trend. In Korea, most of the embankment dams are rockfill dams, but recently, in response to the demand for sustainable development and environmentally-friendly water resource development, the sand and gravel in streams has become a major construction material for dams, rather than the non-economic rockfill, and its application examples have also increased. In this study, a large triaxial test was performed, with construction samples of different maximum sizes, in parallel with the grading method at the 'B Dam' construction site in Korea, and the effects of the different maximum sizes on the strain of the dam construction material and on the shear strength characteristics were analyzed to provide the basic data for determining the strength characteristics of the coarse-grained materials by the maximum size.

• PNF and Movement
• /
• v.8 no.3
• /
• pp.1-8
• /
• 2010

Purpose : The purpose of this study was to investigate the effects of virtual exercise training programs on the improvement of balance in the elderly women. Methods: The subjects were fifteen female citizens, 67 years of age or older living in G city, the subjects were randomly divided into groups; Virtual exercise training group(n=9), control group (n=6). After treatment measured balance by Berg Balance scale test and One-leg stand test during virtual exercise training program at pre-intervention and post-intervention. Results : The results of this study were as follows : Virtual Exercise Training Program (Wii fit) after applying the Berg balance test scores and One-Legged Stance Test, the evaluation results showed significant results(p<05). Conclusion : Virtual exercise training programs can be used to improve the balance of the elderly, as it has been shown to increase Berg balance test and one-leg stand results conducted after virtual training programs. Virtual Exercise Programs(Wii fit) were applied to demonstrate the effecting the balance of the elderly to promote more research on the impact of the ADL survey.

• PNF and Movement
• /
• v.16 no.2
• /
• pp.287-294
• /
• 2018

Purpose: The neurodynamic test used to implicate symptoms arising from the nerve is proposed to selectively increase the strain of the nerve without increasing the strain of adjacent tissue, although this has not yet been established in the time of nerve tension application. This study aimed to investigate the acute effects of nerve stretching time on nerve excitability using compound nerve action potential (CNAP) analysis. Methods: Thirty healthy young adults (mean age=23.10 years) with no medical history of neurological or musculoskeletal disorder voluntarily participated in this study. Nerve excitability was assessed using the median nerve conduction velocity test. The amplitude of the CNAP was measured under three conditions: resting phase (supra-maximal stimulus, without nerve stretching), baseline phase (two-thirds of the supra-maximal stimulus, without nerve stretching), and stretch phase (two-thirds of the supra-maximal stimulus, with 1-5 minutes nerve stretching). One-way repeated measures ANOVA was conducted to compare the latency and amplitude of CNAP. A post-hoc test was analyzed using the contrast test. Results: The latency was significantly delayed after 1 min. of nerve stretching in comparison with the baseline test. However, no significant difference was found during the nerve stretching (1-5 min.). The amplitude was significantly increased by nerve stretching. Conclusion: Nerve stretching can induce nerve excitability without any nerve injury. Based on the results, more than 1 min. of nerve stretching as a neurodynamic test can be a useful method in the clinical setting.