• Steel and Composite Structures
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• v.27 no.3
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• pp.327-335
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• 2018

This paper presents structural assessment of a steel railway bridge for current condition using modal parameter to upgrade finite element modeling in order to gather accurate result. An adequate monitoring, such as acceleration, displacement, strain monitoring, is important tool to understand behavior and to assess structural performance of the structure under surround vibration by means of the dynamic analysis. Evaluation of conditions of an existing steel railway bridge consist of 4 decks, three of them are 14 m, one of them is 9.7 m, was performed with a numerical analysis and a series of dynamic tests. Numerical analysis was performed implementing finite element model of the bridge using SAP2000 software. Dynamic tests were performed by collecting acceleration data caused by surrounding vibrations and dynamic analysis is performed by Operational Modal Analysis (OMA) using collected acceleration data. The acceleration response of the steel bridge is assumed to be governing response quantity for structural assessment and provide valuable information about the current statute of the structure. Modal identification determined based on response of the structure play significant role for upgrading finite element model of the structure and helping structural evaluation. Numerical and experimental dynamic properties are compared and finite element model of the bridge is updated by changing of material properties to reduce the differences between the results. In this paper, an existing steel railway bridge with four spans is evaluated by finite element model improved using operational modal analysis. Structural analysis performed for the bridge both for original and calibrated models, and results are compared. It is demonstrated that differences in natural frequencies are reduced between 0.2% to 5% by calibrating finite element modeling and stiffness properties.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7737-7740
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• 2014

Background: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of mortality in patients with pancreatic, colorectal, lung, gastric cancer and renal cell carcinoma. The aim of this study was to determine the relationship between pathological complete response (pCR) and pretreatment NLR values in locally advanced breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT). Materials and Methods: Datawere collected retrospectively from the Akdeniz University School of Medicine Database for locally advanced BC patients treated with NACT between January 2000-December 2013. Results: A total of 78 patients were analyzed. Sixteen (20%) patients achieved pCR. Estrogen receptor (ER) positivity was lower in pCR+ than pCR-cases (p=0.011). The median NLR values were similar in both arms. The optimum NLR cut-off point for BC patients with PCR+ was 2.33 (AUC:0.544, 95%CI [0.401-0.688], p=0.586) with sensitivity, specificity, positive predictive value and negative predictive value (NPV) of 50%, 51,6%, 21,1%, and 80%, respectively. Conclusions: This study showed no relationship between the pCR and pretreatment NLR values. Because of a considerable high NPV, in the patients with higher NLR who had luminal type BC in which pCR is lower after NACT, such treatment may not be recommended.

• International Journal of High-Rise Buildings
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• v.1 no.3
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• pp.181-194
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• 2012

Chile is characterized by the largest seismicity in the world which produces strong earthquakes every $83{\pm}9years$ in the Central part of Chile, where it is located Santiago, the capital of Chile. The short interval between large earthquakes magnitude 8.5 has conditioned the Chilean seismic design practice to achieve almost operational performance level, despite the fact that the Chilean Code declares a scope of life safe performance level. Several Indexes have been widely used throughout the years in Chile to evaluate the structural characteristics of concrete buildings, with the intent to find a correlation between general structural conception and successful seismic performance. The Indexes presented are related only to global response of buildings under earthquake loads and not to the behavior or design of individual elements. A correlation between displacement demand and seismic structural damage is presented, using the index $H_o/T$ and the concrete compressive strain ${\varepsilon}_c$. Also the Chilean seismic design codes pre and post 2010 Maule earthquake are reviewed and the practice in seismic design vs Performance Based Design is presented. Performance Based Design procedures are not included in the Chilean seismic design code for buildings, nevertheless the earthquake experience has shown that the response of the Chilean buildings has been close to operational. This can be attributed to the fact that the drift of most engineered buildings designed in accordance with the Chilean practice falls below 0.5%. It is also known by experience that for frequent and even occasional earthquakes, buildings responded elastically and thus with "fully operational" performance. Taking the above into account, it can be said that, although the "basic objective" of the Chilean code is similar to the SEAOC VISION2000 criteria, the actual performance for normal buildings is closer to the "Essential/Hazardous objective".

• Archives of Pharmacal Research
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• v.26 no.11
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• pp.943-950
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• 2003

In the present studies, the acute toxic effects of 2-bromopropane (2-BP) and its analog, 1,2-dibromopropane (1,2-DBP), were investigated in female BALB/c mice. The mice were treated orally with either 2-BP at 2000 and 4000 mg/kg or 1,2-DBP at 300 and 600 mg/kg. Four days before necropsy, the mice were immunized intraperitoneally with sheep red blood cells (SRBCs). 1,2-DBP reduced the weights of the spleen and thymus weights and decreased the number of splenic cells. In addition, treatment with 1,2-DBP suppressed the antibody response to SRBCs. Meanwhile, only the antibody response was significantly suppressed by treatment with 2-BP. In the subsequent studies, the time course effects of 2-BP and 1 ,2-DBP on the hepatotoxic parameters were compared in female BALB/c mice. When mice were treated orally with either one of these chemicals for 6, 12, 24 and 48 h, the activities of serum alanine aminotransferase and aspartate aminotransferase elevated significantly only with 1,2-DBP 24 h after the treatment. The hepatic content of glutathione was reduced by 1,2-DBP. Meanwhile, these parameters were increased by 2-BP. The present results suggest that 1,2-DBP in the Solvent 5200 also contributes to the immnunotoxicity, although 2-BP is a major component.

• Clinical and Experimental Pediatrics
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• v.60 no.6
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• pp.167-174
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• 2017

Mycoplasma pneumoniae pneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children and adolescents. Outbreaks of MPP occur in 3- to 7-year cycles worldwide; recent epidemics in Korea occurred in 2006-2007, 2011, and 2015-2016. Although MPP is known to be a mild, self-limiting disease with a good response to macrolides, it can also progress into a severe and fulminant disease. Notably, since 2000, the prevalence of macrolide-resistant MPP has rapidly increased, especially in Asian countries, recently reaching up to 80%-90%. Macrolide-resistant Mycoplasma pneumoniae (MRMP) harbors a point mutation in domain V of 23S rRNA with substitutions mainly detected at positions 2063 and 2064 of the sequence. The excessive use of macrolides may contribute to these mutations. MRMP can lead to clinically refractory pneumonia, showing no clinical or radiological response to macrolides, and can progress to severe and complicated pneumonia. Refractory MPP is characterized by an excessive immune response against the pathogen as well as direct injury caused by an increasing bacterial load. A change of antibiotics is recommended to reduce the bacterial load. Tetracyclines or quinolones can be alternatives for treating MRMP. Otherwise, corticosteroid or intravenous immunoglobulin can be added to the treatment regimen as immunomodulators to downregulate an excessive host immune reaction and alleviate immune-mediated pulmonary injury. However, the exact starting time point, dose, or duration of immunomodulators has not been established. This review focuses on the mechanism of resistance acquisition and treatment options for MRMP pneumonia.

• Proceedings of the Korea Society of Poultry Science Conference
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• 2000.11a
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• pp.81-84
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• 2000

Effects of different photoperiod regimens on the cellular and humoral immunity in broiler chickens were studied(Exp 1). Total one hundred ninety two one-day-old commercial broiler chicks(Cobb$\times$Cobb) were raised between constant lighting(CL) and intermittent lighting (1h light: 3h darkness(IL; 1l; 3D) Body weight, feed intake and feed conversion were measured for seven week. Peripheral blood and splenic lymphocyte activities were tested at 3 and 5 wk of age by performing a mitogen cellproliferation assay with a polyclonal T-cell mitogen, concanavalin A (Con A), and B-cell mitogen, lipopolysaccharide (LPS). To investigate the effect of photoperiod on the humoral immunity, chicks were immunized with sheep red blood cell(SRBC) and iinactivated Newcastle disease virus(NDV) vaccine. Total immunoglobulin G(IgG) concentration was also determined. Diurnal change of melatonin was tested in sera. In experiment 2, 0.1ml melatonin were subcutaneously injected from three to five weeks old if immunomodulation effect of lighting regimen was due to the melatonin or not. Injections of melatonin were made at 0700h and the dosage was 10ng (M2), 100ng(M3), 1$\mu\textrm{g}$(M4) per bird daily, respectively. control were quivalent injections of vehicle(M1). Lymphocyte activities were tested and humoral immunities were examined at 5 weeks of age. Blood melatonin concentration was determined at 0h, 1, h, 2h, and 3h posterior to injection at five weeks old. It was higher in CL chicks than IL chickens during the subsequent period of 3 to 5 wk of age. However, weight gain of chicks raised IL were significantly higher at 6 wk of age than CL(P<0.05). Antibody response to NDV was not affected by both photoperiod regimens and melatonin injection, whereas anti-SRMB titer and IgG concentration were enhanced. Lymphocyte activity of chickens raised under IL was sighificantly higher than those of chickens raised under CL. Melatonin injection also increased lymphocyte activity. When peripheral blood lymphocytes were used, proliferation response to LPS and Con A were significantly increased in M2 and respectively. The results of this experiments suggest that IL improved host immune response and melatonin have immunomodulatory roles.

• Journal of The Korean Society of Integrative Medicine
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• v.3 no.4
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• pp.37-42
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• 2015

Purpose: This study was conducted to test the impact of The Dynamic Visual-Motor integration training has effect on the visual perception reaction velocity. Dynavision were used to measure data from the participating 24 students(K college). Method : The participants were the 24 students of 'K' College in Busan in there twenties. They were divided into the The Dynamic Visual-Motor integration training group and the control group. To know if the Dynamic Visual-Motor integration training has effect on the visual perception reaction velocity, the Dynamic Visual-Motor integration training was implemented triweekly for 4 weeks. In Dynamic Visual-Motor integration training the ball should be grasped with one hand and threw by an arm. Only the balls threw beyond the objective point were counted. The visual perception reaction velocity and the number of response were measured before and after experiment by Dynavision. Result : Firstly, the visual perception reaction velocity was increased in Dynamic Visual-Motor integration training group compared with control group. Secondly, the number of response was also increased in Dynamic Visual-Motor integration training group compared with control group. Conclusion : As a result of The Dynamic Visual-Motor integration training has an effect on the visual perception reaction velocity and the number of response. The Dynamic Visual-Motor integration training seems to be effective for cerebral apoplexy patient who has visual perceptional disability or cerebral palsy child in training for visual perceptional development or daily living activities development. Study participated by more detailed and practical patients in hospital is needed.

• Journal of KIISE:Computing Practices and Letters
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• v.6 no.1
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• pp.68-81
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• 2000

CORBA Trader Service is to locate appropriate objects that provide the desired functionality at runtime. To provide this service, the Trader Service federates a local trader and remote traders by considering the Traders or Link policies, and it returns the service offers that are requested by the importer. This traditional way of trading reveals a performance problem due to the low response time. The response time largely depends on the amounts of service offers of the Importer's request and the frequency of federations with the other trader. The performance is a key factor for evaluating the Trader Service performance.In order to overcome the low response time and to provide the high-quality services, we propose new policies of Import and Trader, and present a PUTS(Push Trader Service) model which implements this new advanced trader service. We present the design and implementation of the PUTS's major modules, also make a comparison between PUTS system and traditional trader system in terms of performance and functionality through case studies.

• Proceedings of the Microbiological Society of Korea Conference
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• 2000.10a
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• pp.78-82
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• 2000

The AIDS epidemic continues unabated in many part of the world. After near two decades, no vaccine is available to combat the spread of this deadly disease. Much of the HIV -1 vaccine effort during the past decade has focused on the viral envelope glycoprotein, largely because it is the only protein that can elicit neutralizing antibodies (Nabs). Eliciting broadly cross-reactive Nabs has been a primary goal. The intrinsic genetic diversity of the viral envelope, however, has been one of the major impediments in vaccine development. We have recently completed a comprehensive study examining whether it is possible to elicit broadly acting Nabs by immunizing monkeys with mixtures of envelope proteins from multiple HIV -1 isolates. We compared the humoral immune responses elicited by vaccination with either single or multiple envelope proteins and evaluated the importance of humoral and non-humoral immune response in protection against a challenge virus with a homologous or heterologous envelope protein. Our results show that (1) Nab is the correlate of sterilizing immunity, (2) Nabs against primary HIV -1 isolates can be elicited by the live vector-prime/protein boost approach, and (3) polyvalent envelope vaccines elicit broader Nab response than monovalent vaccines. Nonetheless, our findings clearly indicate that the increased breadth of Nab response is by and large limited to strains included in the vaccine mixture and does not extend to heterologous non-vaccine strains. Our study strongly demonstrates how difficult it may be to elicit broadly reactive Nabs using envelope proteins and sadly predicts a similar fate for many of the vaccine candidates currently being evaluated in clinical trials. We have started to evaluate other vaccine candidates (e.g. genetically modified envelope proteins) that might elicit broadly reactive Nabs. We are also exploring other vaccine strategies to elicit potent cytotoxic T lymphocyte responses. Preliminary results from some of these experiments will be discussed.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.1B
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• pp.61-70
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• 2010

This research presents a methodology to define and apply appropriate index that can measure the risk of regional flood damage. Pressure-State-Response structure has been used to develop the Flood Risk Index(FRI), which allows for a comparative analysis of flood risk assessment between different sub-basins. FRI is a rational assessment method available to improve disaster preparedness and the prevention of losses. The pressure and state index for flood at 117 sub-basins from the year 1980s until the t 10s showed proportional relations, but state index did not decrease even though response index increased. This shows that pressures for flood damage relatively exceed countermeasure for flood. Thus this means we need to strengthen design criteria for flood countermeasure in the future. The FRI is gradually going down in consequence of continuous flood control projects. Flood risk of Han River and Nakdong River area is relatively lower than that of Geum, Seumjin, and Youngsan River area.