• Bulletin of the Korean Chemical Society
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• v.31 no.6
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• pp.1583-1588
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• 2010

A single step fabrication process of carbon nanotube/Prussian Blue (CNT/PB) paste electrodes based on screen printing technology has been studied as an amperometric sensor for the determination of hydrogen peroxide and free chlorine. Compared to the classical carbon paste (CP) electrode, the CNT paste electrode greatly enhanced the response in the presence of hydrogen peroxide due to the electrocatalytic activity of the CNT. Based on the CNT/binder paste, PB was also incorporated into a network of CNT paste and characterized. The best electroanalytical properties of PB-mixed sensors to hydrogen peroxide were obtained with PB ratio of 10 wt % composition, which showed fast response time ($t_{90}{\leq}5$ s; 0.2 - 0.3 mM), low detection limit of 1.0 ${\mu}M$, good linear response in the range from $5.0{\times}10^{-5}$ - $1.0{\times}10^{-3}$ mol $L^{-1}$ ($r^2$ = 0.9998), and high sensitivity of -8.21 ${\mu}AmM^{-1}$. In order to confirm the enhanced electrochemical properties of CNT/PB electrode, the sensor was further applied for the determination of chlorine in water, which exhibited a linear response behavior in the range of 50 - 2000 ppb for chlorine with a slope of 1.10 ${\mu}Appm^{-1}$ ($r^2$ = 9971).

• Computers and Concrete
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• v.2 no.6
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• pp.423-437
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• 2005

In this study two single-bay, three-storey space frames, one with brick masonry infill in the second and third floors representing a soft-storey frame and the other without infill were designed and their 1:3 scale models were constructed according to non-seismic detailing and the similitude law. The models were excited with an intensity of earthquake motion as specified in the form of response spectrum in Indian seismic code IS 1893-2002 using a shake table. The seismic responses of the soft-storey frame such as fundamental frequency, mode shape, base shear and stiffness were compared with that of the bare frame. It was observed that the presence of open ground floor in the soft-storey infilled frame reduced the natural frequency by 30%. The shear demand in the soft-storey frame was found to be more than two and a half times greater than that in the bare frame. From the mode shape it was found that, the bare frame vibrated in the flexure mode whereas the soft-storey frame vibrated in the shear mode. The frames were tested to failure and the damaged soft-storey frame was retrofitted with concrete jacketing and, subjected to same earthquake motions as the original frames. Pushover analysis was carried out using the software package SAP 2000 to validate the test results. The performance point was obtained for all the frames under study, therefore the frames were found to be adequate for gravity loads and moderate earthquakes. It was concluded that the global nonlinear seismic response of reinforced concrete frames with masonry infill can be adequately simulated using static nonlinear pushover analysis.

• Korean Journal of Medicinal Crop Science
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• v.8 no.4
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• pp.291-296
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• 2000

To evaluate the biological effects of boxthorn (Lycium chinense Mill.) extracts on the immune response systems, the mitogenic effects were tested by LPS (lipopolysaccharide) and Con A (concanavalin A) using water extracts from various parts of Lycium chinense Mill. The proliferation of B-lymphocytes which were activated by the mitogen, LPS, was markedly increased in the concentration of 0.1mg/ml to 0.5mg/ml, but inhibited in more than 0.5mg/ml. It increased only proliferation of B-lymphocytes but not that of T-lymphocytes by Con A. There was no difference between boxthorn species in immune response. Water extracts of various parts in boxthorn enhanced the humoral immune response which was related to B-lymphocytes.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.364-364
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• 2019

최근 전세계적으로 기후변화로 인한 국내외 가뭄에 대한 피해 및 발생 빈도가 점차 증가하고 있으며, 우리나라의 경우 2000년대 이후 가뭄 주기가 점점 짧아져 2013년 이후 매년 가뭄이 발생하고 있다. 북한은 자연재해에 취약한 국가이며 특히 가뭄으로 인한 식량난 문제가 대두되고 있지만, 북한의 제한적인 정보로 인해 북한 지역에서의 가뭄의 발생과 피해 정보는 한정적이고, 활용할 수 있는 자료의 경우 외국 기관의 정보에 의존하는 실정이다. 향후 농업부문에 대한 대북한 지원과 통일 후를 대비한 농업정책의 수립을 위하여 북한의 가뭄에 대하여 독자적으로 신속한 정보를 취득, 분석할 수 있는 능력을 확보하는 것이 필요하다. 위성영상을 이용한 원격탐사 기술은 접근이 용이하지 못한 지역의 주기적인 관측이 가능하며, 동일한 정확도로 기상자료의 획득이 가능하다. Vegetation Drought Response Index (VegDRI)는 위성영상기반의 가뭄지수인 정규식생지수(Nomalized Difference Vegetation Index, NDVI), 기상학적 가뭄지수를 활용한 기후적 요소, 토지피복 및 생태지역 등의 생물물리학적 요소를 활용한 가뭄지표이다. 본 연구에서는 MODerate resolution Imaging Spectroradiometer (MODIS) 위성의 MOD13Q1 영상자료의 NDVI (2001~2018년)를 이용하였으며, 북한의 기상자료를 이용한 표준강수지수 (Standardized Precipitation Index, SPI)와 파머가뭄심도지수 (Palmer Drought Severity Index, PDSI), 그리고 북한 지역의 토지피복 및 생태지역 등의 요소들을 활용한 VegDRI를 통하여 북한의 가뭄 시기에 따른 시도별 가뭄 특성에 대하여 분석하고자 한다.

• Earthquakes and Structures
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• v.17 no.4
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• pp.373-385
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• 2019

In this article, different frequently adopted modeling aspects of linear and nonlinear dynamic soil-structure interaction (SSI) are studied on a pile-supported integral abutment bridge structure using the open-source platform OpenSees (McKenna et al. 2000, Mazzoni et al. 2007, McKenna and Fenves 2008) for a 2D domain. Analyzed approaches are as follows: (i) free field input at the base of fixed base bridge; (ii) SSI input at the base of fixed base bridge; (iii) SSI model with two dimensional quadrilateral soil elements interacting with bridge and incident input motion propagating upwards at model bottom boundary (with and without considering the effect of abutment backfill response); (iv) simplified SSI model by idealizing the interaction between structural and soil elements through nonlinear springs (with and without considering the effect of abutment backfill response). Salient conclusions of this paper include: (i) free-field motions may differ significantly from those computed at the base of the bridge foundations, thus put a significant bias on the inertial component of SSI; (ii) conventional modeling of SSI through series of soil springs and dashpot system seems to stay on the safer side under dynamic conditions when one considers the seismic actions on the structure by considering a fully coupled SSI model; (iii) consideration of abutment-backfill in the SSI model positively affects the general response of the bridge, as a result of large passive resistance that may develop behind the abutments.

• Journal of Ginseng Research
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• v.43 no.4
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• pp.666-675
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• 2019

Background: Korean Red Ginseng (KRG) has been widely used as an herbal medicine to normalize and strengthen body functions. Although many researchers have focused on the biological effects of KRG, more studies on the action mechanism of red ginseng are still needed. Previously, we investigated the proteomic changes of the rat spleen while searching for molecular signatures and the action mechanism of KRG. The proteomic analysis revealed that differentially expressed proteins (DEPs) were involved in the increased immune response and phagocytosis. The aim of this study was to evaluate the biological activities of KRG, especially the immune-enhancing response of KRG. Methods: Rats were divided into 4 groups: 0 (control group), 500, 1000, and 2000 mg/kg administration of KRG powder for 6 weeks, respectively. Isobaric tags for relative and absolute quantitation was performed with Q-Exactive LC-MS/MS to compare associated proteins between the groups. The putative DEPs were identified by a current UniProt rat protein database search and by the Gene Ontology annotations. Results: The DEPs appear to increase the innate and acquired immunity as well as immune cell movement. These results suggest that KRG can stimulate immune responses. This analysis refined our targets of interest to include the potential functions of KRG. Furthermore, we validated the potential molecular targets of the functions, representatively LCN2, CRAMP, and HLA-DQB1, by Western blotting. Conclusion: These results may provide molecular signature candidates to elucidate the mechanisms of the immune response by KRG. Here, we demonstrate a strategy of tissue proteomics for the discovery of the molecular function of KRG.

• Korean Journal of Community Nutrition
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• v.27 no.5
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• pp.373-386
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• 2022

Objectives: This study examined the perception of the vegan trend of millennials and their future needs. Methods: This study was conducted online from June 21, 2021, to July 15, 2021, targeting 425 adult men and women born between 1980 and 2000. The contents of the survey were divided into four categories: general information, awareness of vegetables, awareness of vegan trends, and future needs for vegan trends. Results: Most respondents recognized the importance of eating vegetables and perceived vegetarianism and veganism as a lifestyle. Regarding the perception of the vegan trend, the highest response rate was 'The vegan trend is to be satisfied with my life regardless of other people', while the lowest response rate was 'The vegan trend is only a temporary fad'. The reasons for purchasing vegan products with high response rates were 'interest in the earth and environment', 'protection of animal rights', and 'thinking about health'. The type of vegan product wanted in the future was delicious food, and convenience level was in the order of 'completely cooked', 'half-cooked', and 'pre-processed'. Among the sustainable vegetarian types that millennials responded, 'semi-vegetarian', which can consume most animal products excluding red meat, showed the highest response rate. Conclusions: The positive perceptions about vegetables are expected to increase. Efforts should be made to develop convenient meals using vegetables and provide reasonable prices to expand vegetable intake.

• Journal of the Earthquake Engineering Society of Korea
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• v.6 no.6
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• pp.33-39
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• 2002

Response Modification Factor(R-factor) approach is currently implemented to reflect inelastic ductile behavior of the structures and to reduce elastic spectral demands from earthquakes to the design level. However R factors were set empirically and simply based on the professional committee consensus on observed performance of building structures during past earthquakes. Consequently some major shortcomings linked to the current R factor approach have been pointed out. Using reinforced concrete intermediate moment-resisting frames(RC IMRFs), an analytical procedure is presented in this paper to establish R factor rationally. To this end, analytical R values were evaluated based on N2 Method and compared with the values recommended by IBC 2000. Overall, the analytical results correlated well with the code values. However the results also revealed that R factor might strongly depend on the system fundamental period. As evidenced by the interstory drift index(IDI) analysis results of this study, current R-factor based(or, Life Safety based) design tends to fail in fulfilling other implicit and hopeful performance objectives such as immediate Occupancy and Collapse Prevention. Performance based design(PBD) appears to be a promising approach to meet the multi level seismic performance objectives assigned to the building structures of nowadays.

• The Journal of the Acoustical Society of Korea
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• v.35 no.1
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• pp.63-73
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• 2016

It is widely acknowledged that the human auditory system is organized tonotopically and people generally listen to sounds as a function of frequency distribution through the auditory system. However, it is still unclear how acoustic features of speech sounds are indicated to the human brain in terms of speech perception. Thus, the purpose of this study is to investigate whether two sounds with similar high-frequency characteristics in the acoustic analysis show similar results at the level of auditory brainstem. Thirty three young adults with normal hearing participated in the study. As stimuli, two Korean monosyllables (i.e., /ja/ and /cha/) and four frequencies of toneburst (i.e., 500, 1000, 2000, and 4000 Hz) were used to elicit the auditory brainstem response (ABR). Measures of monosyllable and toneburst were highly replicable and the wave V of waveform was detectable in all subjects. In the results of Pearson correlation analysis, the /ja/ syllable had a high correlation with 4000 Hz of toneburst which means that its acoustic characteristics (i.e., 3671~5384 Hz) showed the same results in the brainstem. However, the /cha/ syllable had a high correlation with 1000 and 2000 Hz of toneburst although it has acoustical distribution of 3362~5412 Hz. We concluded that there was disagreement between acoustic features and physiology outcomes at the auditory brainstem level. This finding suggests that an acoustical-perceptual mapping study is needed to scrutinize human speech perception.

• Radiation Oncology Journal
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• v.22 no.4
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• pp.247-253
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• 2004

Purpose: Hypopharyngeal cancer is diagnosed at the advanced stage in most cases, which the prognosis known to be poor. Thus, the efficacy of induction chemotherapy followed by radiotherapy, with regards to the response and survival rate for stage IV hypopharyngeal cancer patients, was examined. Materials and Methods: From July 1998 to February 2000, 18 cases were diagnosedas AJCC stage IV hypopharyngeal cancer without distant metastasis. These patients were treated with induction chemotherapy followed by radiotherapy, and the results retrospectively analyzed. The regimen of the induction chemotherapy was the 5-FU and cisplatincombination, at 3-week intervals for, 2 cycles. The total radiation dose for the primary lesion and metastatic lymph nodes was $68.4\~72.0$Gy (median: 70.2 Gy). Results: The: The median follow up period was 28 months, ranging from 7 to 99 months. The 3-year overall survival and disease-free survival rate were 41.7 and $31.1\%$, respectively. In 6 cases ($33.3\%$), conservation of the larynx for over 3 years was possible. After the induction chemotherapy there were 16 partial responses ($88.8\%$), 1 complete response and 1 with no response ($5.6\%$ each), therefore, 17 of the 18 cases ($94.6\%$) showed responses. After the completion of the induction chemotherapy and radiotherapy, a complete response was noted in 13 cases ($72.2\%$), a partial response in 5 ($27.8\%$), with an overall response rate of $100\%$. In the analysis of the prognostic factors influencing the survival rate, the 3-year and disease-free survival rates for the complete and partial response groups were 43.1, and $20.0\%$, and 39.6, and $20.0\%$, respectively (p=0.0003, p=0.002). Only the final response after treatment completion was statistically significant. Conclusion: For stage IV hypopharyngeal cancer, induction chemotherapy followed by radiotherapy was an effective treatment, with no severe side effects.