• Title/Summary/Keyword: RESPONSE 2000

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Differences in Larvicidal Activity of Complement and Chemiluminescent Response of Phagocytes in Carp (Cyprinus carpio), Crucian carp (Carassius auratus) and False Dace (Pseudorasbora parva) against Excysted Metacercariae of Clonorchis sinensis (간흡충 탈낭유충에 대한 잉어, 붕어, 참붕어의 보체 살충능 및 식세포 Chemiluminescent 반응 차이)

  • Kim, Ki-Hong;Hwang, Yoon-Jung;Kwon, Se-Ryun;Cho, Jae-Bum
    • Journal of fish pathology
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    • v.13 no.2
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    • pp.137-142
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    • 2000
  • Differences in larvicidal activity of complement and chemiluminescent response of phagocytes in carp (Cyprinus carpio), crucian carp (Carassius auratus) and false dace (Pseudorasbora parva) against excysted metacercariae of Clonorchis sinensis were investigated. The prevalence of C. sinensis metacercariae of false daces caught at Nakdong river (NR) was 100%. However, no C. sinensis metacercariae were found in false daces, which were collected at a reservoir in Chinyoung (CY), crucian carps and carps. The sera of false dace, which were intensively infected with C. sinensis metacercariae, killed excysted metacercariae of C. sinensis more readily than that of carp. However, the serum obtained from C. sinensis metacercariae-free false dace showed the lowest larvicidal ability. The larvicidal ability of sera collected from each fish species completely disappeared when the complement was inactivated by heating. When supernatant of excysted metacercariae homogenate were added to phagocytes of each species, the chemiluminescent responses were significantly (p<0.05) diminished in false dace and carp. The inhibition ratio of chemiluminescent responses by the supernatant was 22.9% in false dace, 9.6% in crucian carp and 12.4% in carp.

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Optimized Image-Based Surrogate Endpoints in Targeted Therapies for Glioblastoma: A Systematic Review and Meta-Analysis of Phase III Randomized Controlled Trials

  • Chong Hyun Suh;Ho Sung Kim;Seung Chai Jung;Choong Gon Choi;Sang Joon Kim;Kyung Won Kim
    • Korean Journal of Radiology
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    • v.21 no.4
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    • pp.471-482
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    • 2020
  • Objective: We aimed to determine the optimized image-based surrogate endpoints (IBSEs) in targeted therapies for glioblastoma through a systematic review and meta-analysis of phase III randomized controlled trials (RCTs). Materials and Methods: A systematic search of OVID-MEDLINE and EMBASE for phase III RCTs on glioblastoma was performed in December 2017. Data on overall survival (OS) and IBSEs, including progression-free survival (PFS), 6-month PFS (6moPFS), 12-month PFS (12moPFS), median PFS, and objective response rate (ORR) were extracted. Weighted linear regression analysis for the hazard ratio for OS and the hazard ratios or odds ratios for IBSEs was performed. The associations between IBSEs and OS were evaluated. Subgroup analyses according to disease stage (newly diagnosed glioblastoma versus recurrent glioblastoma), types of test treatment, and types of response assessment criteria were performed. Results: Twenty-three phase III RCTs published between 2000 and 2017, including 8387 patients, met the inclusion criteria. OS showed strong correlations with PFS (standardized β coefficient [R] = 0.719), 6moPFS (R = 0.647), and 12moPFS (R = 0.638). OS showed no correlations with median PFS and ORR. In subgroup analysis according to types of therapies, PFS showed the highest correlations with OS in targeted therapies for cell cycle pathways (R = 0.913) and growth factor receptors and their downstream pathways (R = 0.962). 12moPFS showed the highest correlation with OS in antiangiogenic therapy (R = 0.821). The response assessment in neuro-oncology criteria provided higher correlation coefficients between OS and IBSEs than the Macdonald criteria. Conclusion: Overall, PFS is an optimized IBSE in targeted therapies for glioblastoma; however, 12moPFS is optimal in antiangiogenic therapy.

Review on Adaptability of Rice Varieties and Cultivation Technology According to Climate Change in Korea (기후변화에 따른 국내 벼 품종과 재배기술의 적응성에 관한 고찰)

  • Seo, Myung-Chul;Kim, Joon Hwan;Choi, Kyeong Jin;Lee, Yun-Ho;Sang, Wan-Gyu;Cho, Hyeon Suk;Cho, Jung-Il;Shin, Pyeong;Baek, Jae Kyeong
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.65 no.4
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    • pp.327-338
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    • 2020
  • In recent years, the temperature of Korea has been rapidly increasing due to global warming. Over the past 40 years, the temperature of Korea has risen by about 1.26℃ compared to that in the early 1980s. By region, the west region of the Gangwon Province was the highest at 1.76℃ and the Jeonnam Province was the lowest at 0.96℃. As the temperature continues to rise, it is expected that the rice yield will decrease in the future using the current standard cultivation method. As a result of global warming, the periods in which rice cultivation could be possible in regions each year has increased compared those to the past, showing a wide variety from 110 days in Taebaek to 180 days in Busan and Gwangyang. In addition, the transplanting time was delayed by 3-5 days in all regions. The average annual yield of rice showed an increasing trend when we analyzed the average productivities of developed varieties for cooked rice since the 1980s, especially in the early 1990s, which showed a rapid increase in productivity. The relationship between the average temperature at the time of development and the rice yield was divided into the periods before and after 1996. The higher the average temperature, the lower the yield of the developed varieties until 1996. However, since 1996, the increase in the average temperature did not show a trend in the productivity of the developed varieties. The climate change adaptability of developed rice varieties was investigated by analyzing the results of growing crops nationwide from 1999 to 2016 and the change in the annual yields of developed varieties and recently developed varieties as basic data to investigate the growth status of the crops in the country. As a result of annual comparisons of the yields of Taebongbyeo (2000) and Ungwangbyeo (2004) developed in the early 2000s for Odaebyeo, which was developed in the 1980s, the annual yields were relatively higher in varieties in the 2000s despite the increase in temperature. The annual yields of Samgwangbyeo (2003) and Saenuribyeo (2007), which were recently developed as mid-late-type varieties, were higher than those of an earlier developed variety called Chucheongbyeo, which was developed in the 1970s. Despite the rapid increase in temperature, rice cultivation technology and variety development are well adapted to climate change. However, since the biological potential of rice could reach its limit, it is necessary to develop continuous response technology.

Image Compression Based on Wavelet Transform Using Shffling and Bit Plane Correlation (부호변환 및 비트 평면 상관도를 이용한 웨이블릿 기반 영상 압축)

  • 김승종;정제창;최병욱
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.25 no.4B
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    • pp.743-754
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    • 2000
  • In this paper, we propose wavelet transform image compression method using shuffling and bit plane correlation. Proposed method is that original image decompose into multiresolutions using biorthogonal wavelet transform with linear phase response property and decomposed subbands are classified by maximum classification gain. And classified data sets in each subband are quantized using arbitrary set optimum bit allocation method. Quantized data sets in each subband are shuffled and context based bit plane arithmetic encoded .In context based bit plane arithmetic encoding, the context for each subband is not assigned uniformly, but assigned according to maximum correlation direction. Our results are comparable, or superior for some images at low rates, to published state-of-the-art coders.

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Photopatch Tests of recent three years at Kyoto University Hospital

  • Katoh, Mayumi;Kitoh, Akihiko;Otoshi, Eriko;Arima, Yaeno;Nishigori, Chikako;Miyachi, Yoshiki
    • Journal of Photoscience
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    • v.9 no.2
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    • pp.497-499
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    • 2002
  • We experienced 29 cases of tentative photo allergic disorders from April 2000 to March 2002. For those 29 patients, photopatch tests have been done to explore possible causative photoallergens. We performed photopatch tests with photo-related allergens and possible causative products that the patients brought to us. After applications for 48hrs, one test site was irradiated with half of MRD or 6.0 J/cm$^2$ of UVA. Readings were evaluated according to the reading criteria of the ICDRG. Photoallergens were suggested in 20 cases (69.0%). Among them, we could find out the causative products in 7 cases (24.1%). Photopatch tests, performed by an appropriate method, are useful in some cases not only for diagnosis of photocontact dermatitis but also diagnosis of systemic photoallergic disorders.

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A Study on the Social Cleavage Structure of Welfare Politics : Beyond the Limitations of Class Theories, towards a New Theoretical Framework (복지정치의 사회적 균열구조에 관한 연구 : 계급론의 한계와 새로운 분석틀)

  • Ahn, Sang-Hoon
    • Korean Journal of Social Welfare
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    • v.43
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    • pp.193-221
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    • 2000
  • The conventional framework of welfare politics, based on class concepts, tends to fail in explaining the recent social changes. Theoretical response from the social science diverges into two blocs. One is the postmodernist approach that denies possibility of structural cleavage; the other is the alternative trial that seeks to find various kinds of cleavages. The former approach is to be rejected because there is few empirical supports for it. The latter is too sparse to be applied to the studies of welfare politics that requires a comprehensive analysis. This study starts from critical investigation of such approaches, aiming at providing a theoretical framework that combines merits of existing studies on welfare politics. The theoretical framework of three statuses of welfare rights and duties, which is to be presented as an alternative to the conventional class counterpart, does not only underscore the expansion of welfare rights but also the burden of welfare duties. Hence, it can comprehensively subsume complex existence of interest cleavages of welfare politics. To make a long story short, individual interest, related to the welfare state, will effect individual attitudes toward the welfare state and their ways of political support.

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Dynamic Responses Characteristics of Steel Box Railway Bridges Subjected to Train Loading (열차주행에 따른 강박스 철도교의 동적응답특성)

  • Park, Sun-Joon;Kang, Sung-Hoo;Jo, Eun-Pyung
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2009.10a
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    • pp.772-778
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    • 2009
  • By rising the interests of the railroad, It has been required the research about railroad structure. And since 2000, the study about railway bridges caused by steel box railway bridges has been only 0.2%. So I was hard to find out about steel box railway bridges. In this study, I evaluate and analyze 4 types(KTX, Saemaeul, Mugunghwa, Freight) of dynamic caused by train loading, natural frequency and damping ratio, verticality deflection and verticality acceleration, end slope deflection, impact factor for dynamic characteristics analysis. natural frequency was measured 2.45Hz~3.34Hz and damping ratio revealed for 1.26~2.84%. Maximum verticality deflection(4.86mm) was sufficiently satisfied the design criteria(30.1mm), but in the case of verticality acceleration's respond, design criteria BRDM(Bridge Design Manual) & CTRL presentation derive rail limit value 0.35g be more than value 6 time recorded, maximum was measured 0.49g in 3 kinds of train(KTX, Saemaeul, Mugunghwa), except for Freight. Survey impact factor of Experiment bridge was 0.20 which is measured when the KTX(15:04) was driving. impact factor is enough contended with design criteria 0.29 which is presented in domestic railway design criteria and thoroughly guarantee the dynamic stability.

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Static and dynamic responses of Halgavor Footbridge using steel and FRP materials

  • Gunaydin, M.;Adanur, S.;Altunisik, A.C.;Sevim, B.
    • Steel and Composite Structures
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    • v.18 no.1
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    • pp.51-69
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    • 2015
  • In recent years, the use of fiber reinforced polymer composites has increased because of their unique features. They have been used widely in the aircraft and space industries, medical and sporting goods and automotive industries. Thanks to their beneficial and various advantages over traditional materials such as high strength, high rigidity, low weight, corrosion resistance, low maintenance cost, aesthetic appearance and easy demountable or moveable construction. In this paper, it is aimed to determine and compare the geometrically nonlinear static and dynamic analysis results of footbridges using steel and glass fiber reinforced polymer composite (GFRP) materials. For this purpose, Halgavor suspension footbridge is selected as numerical examples. The analyses are performed using three identical footbridges, first constructed from steel, second built only with GFRP material and third made of steel- GFRP material, under static and dynamic loadings using finite element method. In the finite element modeling and analyses, SAP2000 program is used. Geometric nonlinearities are taken into consideration in the analysis using P-Delta criterion. The numerical results have indicated that the responses of the three bridges are different and that the response values obtained for the GFRP composite bridge are quite less compared to the steel bridge. It is understood that GFRP material is more useful than the steel for the footbridges.

CONSCIOUS SEDATIVE DRUGS: A CLINICAL STUDY (의식하 진정에 사용된 약물에 관한 임상적 연구)

  • Kim, Sang-Ryul;Kim, Su-Gwan;Yeo, Hwan-Ho
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.22 no.4
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    • pp.436-441
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    • 2000
  • The purpose of this retrospective study is to investigate the effects of conscious sedation in an outpatient setting. Data from 292 patients (154 males, 138 females), sedated for minor oral surgery, were studied using various parameters including age and sex distribution, as well as according to procedures and each drug group. Results show that this intravenous conscious sedation technique is a safe and effective method of controlling behaviour, but one has to be prepared to deal with any emergencies or complications. The specific results are as follows: 1. Most procedures (265/292) were used to Valium mixed with Demerol and Midazolam mixed with Demerol. 2. Valium revealed a high incidence of pain upon injection and symptoms limited to daily activity and thrombophlebitis. 3. Nausea and vomiting manifested in the procedure using Demerol. 4. The patient manifested comfort similar in response to the same drugs used in another treatment.

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Investigation of Fluorescent Shape Memory Polyurethanes Grafted with Various Dyes

  • Chung, Yong-Chan;Choi, Jae-Won;Lee, Seung-Hwan;Chun, Byoung-Chul
    • Bulletin of the Korean Chemical Society
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    • v.32 no.spc8
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    • pp.2988-2996
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    • 2011
  • Shape memory polyurethane (SMPU), grafted with a fluorescent dye (Rhodamine, Mehylene violet, or Fluorescein) through an allophanate linking, was tested for the fluorescence and the shape recovery effect. The main chain of SMPU was composed of 4,4'-methylenebis(phenylisocyanate) (MDI), poly(tetramethyleneglycol) (PTMG), and 1,4-butanediol (BD), and a fluorescent dye was connected through a second MDI linked to the carbamate moiety of the main chain. Three series of SMPU, differing according to their dye content, were prepared to compare their shape recovery and fluorescence properties. In tensile mechanical property, maximum stress increased up to 350% compared to the linear SMPU, and strain remained above 2000%. Shape recovery went to as high as 97%, and remained almost same after repetitive shape recovery test cycles. Finally, the fluorescence emission of SMPU was demonstrated in the luminescence spectrum and fluorescent light emission pictures. In addition, the response of SMPU to external stimuli such as metal ions was investigated.