• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.36 no.2
• /
• pp.137-143
• /
• 2010

Yuza (Citrus junos Sieb ex TANAKA) is a citrus fruit that is cultivated in northeast Asia. Citron is known for containing abundant antioxidants such as vitamin C, flavonoids, for example hesperidin and hesperetin, and terpenoids such as limononin. When mature citron is processed for tea or other beverage food products in Korea, massive amounts of seeds and pericarp are remained as waste. This study aimed to exploit the processed remnant of Citron for developing functional cosmetic applications. Ethanol extracts of Yuza seed and pericarp did not show significant radical scavenging activities measured by DPPH (2,2-diphenyl-1-picrylhydrazyl) method. But they contained significantly high phenolic compounds. Cultured human dermal fibroblasts and HaCaT keratinocytes were irradiated with 25 mJ UVB and the citron extracts were added to the medium of each culture. Cellular damages caused by UVB irradiation were prevented by the addition of the Yuza extract. In addition, the reduction of the enhanced MMP-1 expression after irradiation of UVB in human dermal fibroblasts was observed. Also the increased level of pro-inflammtory TNF-$\alpha$ in the UVB irradiated HaCaT cells was decreased. The collagen expression was enhanced by the extract. Yuza extract markedly inhibited melanin production from $\alpha$-MSH treated B16F1 melanoma cells. Melanin assay, tyrosinase zymography results indicated that Yuza extract had strong depigmenting activity. In conclusion, Yuza ethanol extracts have good anti-photoaging and strong anti-melanogenic efficacies.

• Journal of Gastric Cancer
• /
• v.15 no.1
• /
• pp.46-52
• /
• 2015

Purpose: The aim of this study was to compare the short-term surgical and long-term functional outcomes of Billroth I, Billroth II, and Roux-en-Y reconstruction after laparoscopic distal gastrectomy. Materials and Methods: We retrospectively collected data from 697 patients who underwent laparoscopic distal gastrectomy for operable gastric cancer between January 2009 and December 2012. The patients were classified into three groups according to the reconstruction methods: Billroth I, Billroth II, and Roux-en-Y. The parameters evaluated included patient and tumor characteristics, operative details, and postoperative complications classified according to the Clavien-Dindo classification. Endoscopic findings of the remnant stomach were evaluated according to the residue, gastritis, bile (RGB) classification and the Los Angeles classification 1 year postoperatively. Results: Billroth I, Billroth II, and Roux-en-Y were performed in 165 (23.7%), 371 (53.2%), and 161 patients (23.1%), respectively. Operation time was significantly shorter ($173.4{\pm}44.7$ minute, P<0.001) as was time to first flatus ($2.8{\pm}0.8$ days, P=0.009), time to first soft diet was significantly faster ($4.3{\pm}1.0$ days, P<0.001), and postoperative hospital stay was significantly shorter ($7.7{\pm}4.0$ days, P=0.004) in Billroth I in comparison to the other methods. Postoperative complications higher than Clavien-Dindo grade III occurred in 61 patients (8.8%) with no statistically significant differences between groups (P=0.797). Endoscopic findings confirmed that gastric residue, gastritis, bile reflux, and reflux esophagitis were significantly lower in Roux-en-Y (P<0.001) patients. Conclusions: Roux-en-Y reconstruction after laparoscopic distal gastrectomy for middle-third gastric cancer is beneficial in terms of long-term functional outcome, whereas Billroth I reconstruction for distal-third gastric cancer has a superior short-term surgical outcome and postoperative weight change.

• Restorative Dentistry and Endodontics
• /
• v.26 no.1
• /
• pp.77-85
• /
• 2001

The purpose of this in vitro study was to compare the apical leakage in extracted teeth filled with gutta-percha subsequent to dressing with one of three different calcium hydroxide preparations. Thirty six extracted teeth with single canal were used in this study. After working length determination, canals were prepared with K flexo files to a #40 at the working length. Step-back flaring was produced by using #45, #50 K flexo files and #2, #3, #4 Gates Glidden burs. The teeth were randomly divided into 3 groups of 10 each : the remaining six teeth were used for negative and positive leakage control: Group 1, dressed with pure calcium hydroxide powder (Sigma, USA) mixed with distilled water; Group 2, dressed with Metapaste (Metadent, Korea) ; Group 3, dressed with Vitapex (Neo Dental, Japan). Teeth were sealed with Caviton (GC, Japan) and incubated in 100% humidity, at 37$^{\circ}C$ for 1 wk. All kinds of calcium hydroxide were removed from the canal with a MAF and 5% NaOCl. The canals were filled with AH-26$^{\circledR}$ sealer and gutta-percha using lateral condensation technique, incubated in 100% humidity, at 37$^{\circ}C$ for 2 days for the sealer to be set. The teeth were coated twice with nail varnish except for an area of approximately 2mm surrounding the apical foramen. All specimens were placed in 2% methylene blue solution for 2 days. The root were sectioned longitudinally, the amount of apical leakage was measured to the most coronal part of the root canal to which the dye had penetrated. The independent measurements were made for each root using a stereomicroscope ($\times$40 magnification) and the average was recorded for statistical analysis. The results were as follows ; 1. The mean of apical leakage in group of pure calcium hydroxide ranged 0.102$\pm$0.156mm, in Metapaste$^{\circledR}$ ranged 0.062$\pm$0.069mm, and in Vitapex$^{\circledR}$ ranged 0.067$\pm$0.072mm. 2. Group of pure calcium hydroxide exhibited more leakage than those of 2 manufactured calcium hydroxide preparations, but it was not statistically significant. 3. Group of water-based Metapaste$^{\circledR}$ showed lesser leakage than that of oil-based Vitapex$^{\circledR}$, but it was not statistically significant.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.34 no.1 s.114
• /
• pp.92-106
• /
• 2006

The process of designing Cheonggyecheon Entrance Plaza began with researching four keywords: plaza, restoration. modernity and icon. The outcome of the research was reinterpreted into and informed the design. An urban plaza must not only be a stage for civic life but should also be a portrait of the city to which it belongs. Many Korean plazas, however, are treated as if they are parks. Yeouido Park, which was originally a vast urban void, and Seoul Plaza, recently paved with grass, are good example. The strong 'green myth' can hinder socio-political activities. Cheonggyecheon cannot be said to have been 'restored', since it is still disconnected from its origin and upper streams, and the water is circulated by electricity. So it is better understood as an artificial urban waterfront, rather than an ecologically restored stream. This fact might diminish its ecological value, but not its recreational one. The entrance plaza therefore should reflect that the new stream brings back an 'experience', not only water itself. At the same time, the catch phrase of this restoration project was 'post-modern'. The demolished Cheonggye Expressway represents the 'economy drive' of the 1970s, so the newly opened Cheonggyecheon serves as a perfect counterpart to it. But modernity in Korea is the spirit that made many of the good things, not only its shortcomings, we have now. And from the philosophy of this restoration project, we can see that it is still an ongoing attitude in a way. Remnant of Cheonggye Expressway can evoke our nostalgia for the era. There are plenty of symbols in Seoul, both as architecture and objects. But none of them provide citizens with experience, other than the experience of looking at them. Cheonggyecheon Entrance Plaza is a good place to serve as an icon for a dynamic Seoul. From the research, the designer concluded that this plaza should commemorate the incomparable horizontal experience of Cheonggyecheon and the old expressway, amid the vertical metropolis. The Pedestrian Sculpture, which people can stroll on and look out over Cheonggyecheon, is to be made of steel cladding with a core structure and represents the dynamism of the stream, Seoul and contemporary Korea. The choice of material and the steel structure are also ways of creating the icon. The Water Plaza, the space underneath the ramp, will accommodate people and their urban activities, providing an opportunity to play with water. The Waterblades will be a device for the dramatic beginning of the stream, simultaneously camouflaging ugly openings in the outlets. The Wall of Archaeology is to be made with pre-fab resin blocks, translucent enough so that people can see through any archaeological findings of the site. The strong water-resistant character of resin makes the wall steady throughout the flood season as well. Cheonggyecheon restoration project is an effort to combine contemporary urban demand with the once-existing physicality by evoking our nostalgia for it. The project itself shows many socio-political issues of present-day Korea. The entrance plaza design thus is focused on suggesting an icon for the metropolis, simultaneously celebrating the stream itself. Within this space, people will be exposed to a unique experience that any 'green myth' cannot offer.

• Journal of the Korean Geographical Society
• /
• v.41 no.4 s.115
• /
• pp.404-417
• /
• 2006

In order to clarify some characteristics of hydrological cycle in the subalpine zone of Mt. Halla, water balance has been analysed using hydrological data of a first-order drainage basin around Mansedongsan and meterological data of Odeung AWS. The experimental basin extends from 1,595 m to 1,645 m in altitude and has an catchment area of 1.34 ha. It is largely underlain by trachybasalt and covered with sasa bamboo and sedges. Hydrological observations were carried out every 20 minutes from April 15 to September 19, 2004. The basin shows the total precipitation of 3,074 m that is 1.6 to 3 times of those in coastal and intermontane regions. Surface runoff amounts to 850 mm that is equivalent to 27.6% of the precipitation. By contrast, evapotranspiration only accounts for 14.2% of the precipitation, and the remnant of 1,790 m penetrates underground through a basement. The basin is located in the subalpine zone and then it has a high rainfall intensity as well as a large rainfall due to frequent orographic precipitation. But surface runoff usually dose not exceed 30% of the rainfall while Percolation demonstrates about 2 times of the runoff. Compared with granite or gneiss basins in Korea Peninsula, the experimental basin is characterized by a higher portion of percolation in water balance. And it is probably related to the highly permeable basaltic lavas in Jeju Island which are also overlain by porous volcanic soils.

• Journal of Wetlands Research
• /
• v.8 no.3
• /
• pp.29-38
• /
• 2006

Digital Elevation Model (DEM) of intertidal flat can be widely used not only for scientific fields, coastal management, fisheries, ocean safety, military, but also for understanding natural and artificial topographic changes of the tidal flat. In this study, we generated DEM of the Ganghwado southern intertidal flat, the largest tidal flat in the west coast of the Korean Peninsula, using waterline method and interferometric synthetic aperture radar (InSAR). Constructed DEM which applied waterline method to the Landsat-5 TM and Landsat-7 ETM+ images closely expresses overall topographic relief of tidal flat. We found that the accuracy was determined by the number of waterlines which reflect various tidal conditions. The application of InSAR to the ERS-1/2 and ENVISAT images showed that only ERS-1/2 tandem pairs successfully generated DEM in the part of northern Yeongjongdo, but construction of DEM in the other areas was difficult due to the low coherence caused by a lot of surface remnant waters. In the near future, Kompsat-2 will provide satellite images having multi-spectral and high spatial resolution within a relatively short period at different sea levels. Application of waterline method to these images will help us construct a high precision tidal flat DEM. Also, we should develop DEM generation method using single-pass microwave satellite images.

• Journal of Veterinary Clinics
• /
• v.25 no.6
• /
• pp.482-487
• /
• 2008

This study was performed to investigate the ophthalmic findings of the Korean traditional 'Sapsaree' dogs, and to provide ophthalmic references. Five hundred forty-seven Sapsaree dogs were randomly chosen without any criteria preference. Ophthalmic examination was performed bilaterally using ocular equipments, including slit-lamp biomicroscope, tonometer, direct and indirect ophthalmoscope. The obtained data for ophthalmic findings were analysis by the multivariate linear regression model to identify effects of sex, age and hair coat type. For congenital conditions, the incidence of persistent pupillary membrane (PPM) was the most common defect and there was present 8.8 % whereas for acquired ophthalmic diseases, cataract was the most commonly observed (3.7 %) in Sapsaree dog. Other frequent ocular finding included persistent hyaloid vessel remnant (PHVR, 6.2 %) in congenital conditions, and postinflammatory retinal degeneration (PIRD, 3.1 %) and corneal dystrophy (2.4 %) in acquired ophthalmic diseases. Only one significant effect was age of the Sapsaree for PIRD (P=0.040). There are no any significant effect for sex and hair coat types. This study will provide useful guidelines to clinicians and breeders for the basic ophthalmic information on this breed.

• Korean Journal of Remote Sensing
• /
• v.26 no.5
• /
• pp.497-510
• /
• 2010

In this study, comparisons of the backscattering coefficients and the coherence values which had been extracted from SAR (Synthetic Aperture Radar) images such as JERS-1, ENVISAT and ALOS satellites with surface roughness, surface geometric and soil moisture content were carried out. As the results of analysis using the backscattering coefficient and coherence values from SAR images, the coherence was shown high in the region containing more of mud fraction due to higher viscosity of fine grain-size. A lot of tidal channels were well developed in the Ganghwa tidal flat, affecting the drainage of seawater and subsequent soil moisture content by exposure time of tidal flat. The backscattering coefficient. consequently, appeared to be lower in sand flat and mix flat with decrease of soil moisture. In contrast, most mud flats were distributed at high elevation so that soil moisture was not much influenced by seawater. The backscattering coefficient in mud flat seemed to have a relationship with the density of tidal channel. In addition, lowering backscattering coefficients in the all Ganghwa tidal flat was observed when surface remnant water increased according to the amount of rainfall. The correlation between backscattering coefficient, coherence and sediment environment factors in the Ganghwa tidal flat was investigated. In the future, more quantitative spatial analysis will be helpful to well understand the sedimentary influence of various sediment environment factors.

• Annals of Surgical Treatment and Research
• /
• v.95 no.6
• /
• pp.303-311
• /
• 2018

Purpose: OncoHepa test is a multigene expression profile test developed for assessment of hepatocellular carcinoma (HCC) prognosis. Multiplication of ${\alpha}$-FP, des-${\gamma}$-carboxy prothrombin (DCP) and tumor volume (TV) gives the ${\alpha}$-FP-DCP-volume (ADV) score, which is also developed for assessment of HCC prognosis. Methods: The predictive powers of OncoHepa test and ADV score were validated in 35 patients who underwent curative hepatic resection for naïve solitary HCCs ${\leq}5cm$. Results: Median tumor diameter was 3.0 cm. Tumor recurrence and patient survival rates were 28.6% and 100% at 1 year, 48.6% and 82.9% at 3 years, and 54.3% and 71.4% at 5 years, respectively. The site of first tumor recurrence was the remnant liver in 18, lung in 1, and the peritoneum in 1. All patients with HCC recurrence received locoregional treatment. OncoHepa test showed marginal prognostic significance for tumor recurrence and patient survival. ADV score at 4log also showed marginal prognostic difference with respect to tumor recurrence and patient survival. Combination of these 2 tests resulted in greater prognostic significance for both tumor recurrence (P = 0.046) and patient survival (P = 0.048). Conclusion: Both OncoHepa test and ADV score have considerably strong prognostic power, thus individual and combined findings of OncoHepa test and ADV score will be helpful to guide postresection surveillance in patients with solitary HCCs ${\leq}5cm$.

• Korean Chemical Engineering Research
• /
• v.56 no.6
• /
• pp.832-840
• /
• 2018

In this study, both of the concentration of benzo(a)pyrene in 5 species (total 50 samples) of medicinal herbs and their transfer ratios in the preparation steps of water extract(decoction) and soft extract, were measured by HPLC/FLD. The calibration curve of benzo(a)pyrene shows excellent correlation over the concentration range of 3~40 ng/mL with the correlation coefficient ($R^2$) of 1.000. The detected benzo(a)pyrene concentrations from the medicinal herbs ranged from non-detection to $37.54{\mu}g/kg$, and their average was $6.73{\mu}g/kg$. Among the total samples, 15 samples (i.e., 30%) exceeded the limit of herbal medicine benzo(a)pyrene criteria (i.e., $5{\mu}g/kg$) according to the notification No. 2009-302 from Ministry of Food and Drug Safety. In particular, the concentration of benzo(a)pyrene in Coptidis Rhizome was turned out to be the highest of $37.54{\mu}g/kg$. The detected benzo(a)pyrene concentrations from water extract(decoction), soft extract and remnant after boiling, ranged from non-detection to $2.31{\mu}g/kg$, non-detection to $2.28{\mu}g/kg$, and 2.18 to $21.91{\mu}g/kg$, respectively. In preparation of water extract(decoction) and soft extract, transferred benzo(a)pyrene was not detected or, if transferred, the maximal transfer ratios of benzo(a)pyrene were shown to be 8.9% and 9.8%, respectively. Therefore, the content of benzo(a)pyrene in the samples of herbal medicine used in this study, were reduced by more than 90% in preparation steps of water extract (decoction) and soft extract.