• Genomics & Informatics
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• v.12 no.1
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• pp.35-41
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• 2014

Single-nucleotide polymorphisms (SNPs) have been emerging out of the efforts to research human diseases and ethnic disparities. A semantic network is needed for in-depth understanding of the impacts of SNPs, because phenotypes are modulated by complex networks, including biochemical and physiological pathways. We identified ethnicity-specific SNPs by eliminating overlapped SNPs from HapMap samples, and the ethnicity-specific SNPs were mapped to the UCSC RefGene lists. Ethnicity-specific genes were identified as follows: 22 genes in the USA (CEU) individuals, 25 genes in the Japanese (JPT) individuals, and 332 genes in the African (YRI) individuals. To analyze the biologically functional implications for ethnicity-specific SNPs, we focused on constructing a semantic network model. Entities for the network represented by "Gene," "Pathway," "Disease," "Chemical," "Drug," "ClinicalTrials," "SNP," and relationships between entity-entity were obtained through curation. Our semantic modeling for ethnicity-specific SNPs showed interesting results in the three categories, including three diseases ("AIDS-associated nephropathy," "Hypertension," and "Pelvic infection"), one drug ("Methylphenidate"), and five pathways ("Hemostasis," "Systemic lupus erythematosus," "Prostate cancer," "Hepatitis C virus," and "Rheumatoid arthritis"). We found ethnicity-specific genes using the semantic modeling, and the majority of our findings was consistent with the previous studies - that an understanding of genetic variability explained ethnicity-specific disparities.

• Journal of Ecology and Environment
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• v.34 no.2
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• pp.193-202
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• 2011

We studied temperature sensitivity characteristics of soil respiration during periods of rising and falling temperatures within a common temperature range. We measured soil respiration continuously through two periods (a period of falling temperature, from August 7, 2003 to October 13, 2003; and a period of rising temperature from May 2, 2004 to July 2, 2004) using an open-top chamber technique. A clear exponential relationship was observed between soil temperature and soil respiration rate during both periods. However, the effects of soil water content were not significant, because the humid monsoon climate prevented soil drought, which would otherwise have limited soil respiration. We analyzed temperature sensitivity using the $Q_{10}$ value and $R_{ref}$ (reference respiration at the average temperature for the observation period) and found that these values tended to be higher during the period of rising temperature than during the period of falling temperature. In the absence of an effect on soil water content, several other factors could explain this phenomenon. Here, we discuss the factors that control temperature sensitivity of soil respiration during periods of rising and falling temperature, such as root respiration, root growth, root exudates, and litter supply. We also discuss how the contribution of these factors may vary due to different growth states or due to the effects of the previous season, despite a similar temperature range.

• Transactions of the Korean Society of Mechanical Engineers
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• v.17 no.10
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• pp.2398-2406
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• 1993

Abdi's numerical method(ref.13) for representing a stress singularity by shifting the mid-side nodes of isoparametric elements is reviewed. A simple technique to obtain the optimal position of the mid-side nodes in quadratic isoparametric finite element is presented. From this technique we can directly obtain the position of the side-nodes adjacent to the crack tip. It is also observed that the present technique provides good accuracy for the expression of the opening displacement and the determination of the mid-side nodes for more wide range of material properties than that obtained by Abdicant the finite element method is applied to determine stress intensity factors for pressurized crack perpendicular to and terminating at the interface of two bonded dissimilar materials. A proper definition for stress intensity factors of a crack perpendicular to bimaterial interface is provided. It is based upon a near-tip displacement solutions on the crack surface for interface crack between two dissimilar materials. Numerical testing is carried out with the eight-node and six-node elements. The results obtained are compared with the previous solutions.

• Journal of the Korean Society of Combustion
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• v.8 no.1
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• pp.25-35
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• 2003

The objective of this research is to determine generally applicable design principles for the development of internally staged combustion devices. Utilizing a triple annulus combustor, the detailed combustion characteristics are studied. For this triple air staged combustor, the angular momentum weighted by it#s swirl number and air distribution ratio was observed to be the critical criteria of NOx emission. An internal recirculation zone which develops on the centerline of the flame immediately downstream of the burner entraps the fuel into a fuel rich eddy. Then sufficient heat must be transferred from the flame via radiation to the chamber heat transfer surfaces, such that the peak flame temperatures are suppressed when the second air is introduced. It is experimentally found out that the total NOx emission level in this type of burner is below 50ppm(3% Ref. O2) at optimum operating conditions.

• Journal of the Society of Naval Architects of Korea
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• v.33 no.2
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• pp.56-64
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• 1996

In this study, a review is made of the previous work(Ref. 1 and 5) for the development of the limit design method of the flat rectangular grillages under the lateral pressure. And the effect of the in-plane loads on the collapse theory is considered. The main part of the work is devoted in developing the standard design method of grillages under the criteria of minimum weight and minimum cost. In the final part, it was shown that Pareto solution methods can be easily applied to structural optimization with the multiple objectives, and the designer can have an appropriate choice from those Pareto optimal solutions.

• Journal of IKEEE
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• v.2 no.2 s.3
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• pp.178-184
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• 1998

Optical fiber coupler is a crucial optical passive component for optical transmission systems. In this paper, we fabricate wavelength insensitive optical coupler(WIC), of two types for which the processing procedures are complicate and difficult. These couplers are fabricated by two optical fibers having either different fiber parameters or different cladding diameters. To clarify the validity, we measure the optical characteritics and compare to the data of theoretical simulation. The experiment results ref#eat that it has uniformity of about 1.0 dB and excess loss of less than 0.1 dB in the range of $1310{\pm}40nm\;and\;1550{\pm}40nm$.

• Culinary science and hospitality research
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• v.8 no.1
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• pp.71-94
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• 2002

The food service industry has grown up without an affection of economic collapse, and its kinds are being diversified and focused on many different aspects from physical taste to many other elements such as atmosphere, service quality, sanitation and etc.. Now it appeals to even familiarity. These Facts are well ref looted to Family Restaurant which has not been very popular so far, but now it takes its space in the market, and its management system is being introduced to other countries. The purpose of this study is to see how to satisfy them to make maximum business profit, and one possibility is "incentive". To accomplish research, theoretical and practical studies have been done and surveys have taken placed for substantial studies. The subjects were limited to employees in Family Restaurant in Seoul from February 20th to March 20th, 2001. Data, reliableness, and propriety were analyzed by SAS(Statistical Analyzed System). Sampling mode was randomness, and validation mode was limited to 223 papers. The followings are the results of this analysis First, Satisfaction of incentive were made by stability, impartiality and suitability regardless difference on companies, ages, departments, and authority of an employees. Second, Satisfaction on incentive for employees in Family Restaurants were not well received. Although these necessary demand, there is not yet incentive system operation to most of business. Especially, it is not even studied on Family Restaurants. This study should have been studied on more customers and spotted employees to be objective. It is strongly recommended to do this study without limitation and further studies is considered on this subjects.

• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.224-227
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• 1999

A high power deep-water sonar transducer of FFR (Free Flooded Ring) type has been designed using a coupled FE-BEM. The present sonar transducer is composed of rectangular piezoelectric ceramics and pie-shaped steels (or the advantage of simple fabrication. The dynamics of the sonar transducer is modelled in three dimensions and is analyzed with external electrical excitation conditions. Different results are available such as steady-state frequency response for TX and RX displacement modes, directivity patterns, back-scattering patterns, bandwidths, transmitting voltage responses and receiving sensitivity responses. The TV response shows a very high acoustic pressure of 150 dB/lV (ref $1{\mu}Pa$ at 1m) at 1900 Hz. This ultra high power response of the sonar transducer indicates a new possibility of the sonar transducer development.

• Bulletin of the Korean Chemical Society
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• v.32 no.2
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• pp.524-530
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• 2011

In the present study, we demonstrate that SRM LC-MS/MS method developed by Luo et al. (ref. 10) can be successfully applied to the quantitative analysis of intracellular metabolites in E. coli that are collected at the exponential and stationary growth phases. A focus is given on measuring the changes in the concentrations of intracellular metabolites in batch cultures, which were induced during both the dynamically changing exponential and stationary growth phases. The following intracellular metabolites are quantified in the exponential and stationary phases of E. coli growth, using the SRM mode of a triple quadrupole mass spectrometer: glucose-1-phosphate, fructose-1,6-bisphosphate, phosphoenolpyruvate, pyruvate, acetyl-coenzyme A, 6-phosphogluconate, ribulose-5-phosphate, xylulose-5-phosphate, erythrose-4-phosphate. The determined intracellular metabolite concentration profiles are shown to be in a good agreement with the growth profiles of E. coli, which clearly indicates that SRM LC-MS/MS can be successfully used for following the metabolite changes induced at different growth stages.

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2003.11a
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• pp.151-155
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• 2003

The requirements for harsh environment electronic controllers in automotive applications have been steadily becoming more and more stringent. Electronic substrate technologists have been responding to this challenge effectively in an effort to meet the performance, reliability and cost requirements. An effect of the plasma cleaning at the alumina substrate and the IMC layer between $Sn-37wt\%Pb$ solder and Ag-Pd thick film conductor after reflow soldering has been studied. Organic residual carbon layer was removed by the substrate plasma cleaning. So the interfacial adhesive strength was enhanced. As a result of AFM measurement, Ag-Pd conductor pad roughness were increased from 304nm to 330nm. $Cu_6Sn_5$ formed during initial ref]ow process at the interface between TiWN/Cu UBM and solder grew by the succeeding reflow process so the grains had a large diameter and dense interval. A cellular-shaped $Ag_3Sn$ was observed at the interface between Ag-Pd conductor pad and solder. The diameters of the $Ag_3Sn$ grains ranged from about $0.1\~0.6{\mu}m$. And a needle-shaped $Ag_3Sn$ was also observed at the inside of the solder.