• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.12 no.1
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• pp.57-61
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• 1982

The author has made a study on the classification of the mandibular 3rd molars of Korean youths through dental radiography by means of Pell & Gregory's classification and on the prevalence of the dental caries of distal surface of the mandibular 2nd molar adjacent to the mandibular 3rd molars turned anteriorly. The results are as follow; 1. It was found that the largest case number was class I (272 cases, 52.9%) in the relation of the tooth to the ramus of the mandible and 2nd molar. 2. The mesio-angular position was the largest number (239 cases, 46.5%) in the relation of the long axis of the impacted mandibular 3rd molar to the long axis of the 2nd molar. 3. The mesio-angular position of class I was the largest number (140 cases, 27.2 %) in the relation of the tooth to the ramus of the mandible and 2nd molar and the long axis of the impacted mandibular 3rd molar to the long axis of the 2nd molar. 4. The average angle of the long axis of mandibular 3rd molar in mesioangular position or horizontal position to the occlusal plane was 143° 5. Mandibular 3rd molar with lesion such as dental caries or pericoronitis was 73 cases (14.2). 6. The caries incidence rate of the distal surface of the 2nd molar was about 3.1%.

• Journal of the Korean Chemical Society
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• v.55 no.5
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• pp.830-834
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• 2011

This paper is on the industrial synthesis process of anti-oxidant RD ((2,2,4-trimethyl-1,2-dihydroquinoline polymer $(C_{12}H_{15}N)_n$. n=2-4)).The content of dimer, trimer and tetramer of RD as the inspection targets, using the orthogonal design method - take the ratios of keto-amine, the reaction time, the reaction temperatures and the ratios of catalyst acid-amine as inspect factors - to optimized the reaction condition. The results indicate that the best ratio of keto-amine is 2:1, the time of salification and condensation is 3 hours and 7.5 hours. The range of temperature of salification and condensation is $135^{\circ}C$ and $120-125^{\circ}C$, and that the best ratio of acid-amine is 0.2: 1 (the proportion is the concentration ratio for mole). Under the optimization conditions, the yield of RD was stabilized and content of RD more than 45%.

• YAKHAK HOEJI
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• v.57 no.1
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• pp.37-42
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• 2013

In this present study, we determined the immunoregulatory activity of ginsenoside Rd extract from Panax ginseng. To determine the activity, we tested Rd against $CD4^+$ Th cells in a murine model of type 1 diabetes, which involves Th1-dominant immunity. The type 1 diabetes was caused by streptozotocin (STZ) and the severity of the diabetes was evaluated by measuring the degree of hyperglycemia, a major symptom of diabetes. The data resulting from experiments showed that ginsenoside Rd induced a greater level of Th1 type cytokines [IFN-${\gamma}$ & IL-2] than Th2 type [IL-4 & IL-10] (P<0.05), which was determined by cytokine profile analysis. In the animal model of diabetes, the depletion of $CD4^+$ Th cells by a treatment of anti-CD4 mAb resulted in considerably lower values of blood-glucose levels than those of the mAb-untreated mice, which indicates that the Th1 immune response from $CD4^+$ Th cells are responsible for diabetes. Based on these observations, the effect of Rd on diabetes was examined in the same animal model. Results showed that Rd-treated mice groups had increased levels of blood glucose compared to Rd-untreated mice groups that were used as a negative control (P<0.05). In other words, Rd aggravated the diabetes via the Th1 immune response. In conclusion, ginsenoside Rd had an immunoregulatory activity of Th1-dominant immunity.

• Bulletin of the Korean Chemical Society
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• v.27 no.1
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• pp.59-64
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• 2006

Unlike other viral polymerases, HCV RNA-dependent RNA polymerase (RdRp) has not been successfully inhibited by nucleoside analogues presumably due to its strong substrate specificity for RNA. Thus, in order to understand the RNA-specificity of HCV RdRp, the structural characteristics of the active site was investigated. The hereto unknown 2-OH binding pocket at the active site of RdRp provides invaluable implication for the development of novel anti-HCV nucleoside analogues.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.03a
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• pp.801-810
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• 2010

Until now, design of Earth Retaining is practiced by 2nd dimensional analysis for convenience of analysis and time saving. However, the construction field is 3rd dimension, in this study, practised the 3rd dimensional analysis which can reflect the field condition more exactly the scope of earth retaining wall, and researched about the effective and economical way of design, compared and reviewed with the results, by practising both the 2nd and 3rd dimensional analysis. existing 2nd dimension. the depth of excavation, depth of embedded and soil condition. As result, under the whole conditions, more displacement came to appear to the value as result of 3rd dimensional analysis more than the result of 2nd dimensional analysis. Accordingly, the displacement by the 2nd dimension analysis is underestimated. Moreover, results of 2nd and 3rd dimensional analysis, there is no difference at displacement, when the depth of embedded is 0.5H, 1.0H and 1.5H, but Displacement of 1.5H is smaller than 0.5H, 1.0H. That is, the bigger the depth of embedded becomes, the displacement of Earth Retaining Wall appeared smaller. The displacement of earth retaining wall according to depth of excavation appeared bigger, when the depth of excavation is increased. In the meantime, when the soil condition is different, in the 2nd dimensional analysis, the displacement appeared biggest, in case of the clay layer, but in the 3rd dimensional analysis, in the beginning of excavating, the displacement of earth retaining wall appeared bigger in case of clay layer, but as excavating is in progress, the displacement of both compound soil layer and sand layer appeared big.

• Journal of the Korean Wood Science and Technology
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• v.12 no.1
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• pp.31-37
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• 1984

For the modification of kiln drying schedule, relations between resistance to drying Rd and the moisture content or drying times were found for 4/4, 6/4 and 8/4 green Douglas fir heartwood by the mild drying schedule and the severe drying schedule until the average moisture content was about 10 percent. The results of this study were as follows. 1. Resistance to drying of thicker lumber was higher than that of thinner lumber and resistance to drying of three different thicknesses were negligible between the mild-and the severe drying schedule. The relationships between resistance to drying and two schedules or three thicknesses of lumber were $Rd_1=1.830{\times}10^5\;M^{-2.24}$ for 4/4 lumber by the mild drying schedule, $Rd_2=1.822{\times}10^5\;M^{-2.25}$ for 4/4 lumber by the severe drying schedule, $Rd_3=2.352{\times}10^5\;M^{-2.14}$ for 6/4 lumber by the mild drying schedule, $Rd_4=3.457{\times}10^5\;M^{-2.27}$ for 6/4 lumber by the severe drying schedule, $Rd_5=1.317{\times}10^6\;M^{-2.56}$ for 8/4 lumber by the mild drying schedule, $Rd_6=8.267{\times}10^5\;M^{-2.40}$ for 8/4 lumber by the severe drying schedule. 2. Thinner lumber exhibited lower level of moisture content and shorter drying time required at intersection point between the moisture content and resistance to drying as a function of drying time than those of thicker lumber. Drying time of mild drying was longer than that of severe drying and similar to the level of moisture content at intersection point.

• Journal of Nutrition and Health
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• v.1 no.1
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• pp.9-18
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• 1968

Dividing into six(6) experimental groups; Stock Diet(SD) Group, Rice Diet(RD) Group, Rice Diet supplemented with Barley(RD-BD) Group, Barley Diet(BD) Group, Rice Diet supplemented with Millet(RD-MD) Group, and Millet Diet(MD) Group, biochemical and nutritional effects of rice, barley, and millet on rats are studied. The grains used in this experiment are polished ones and purchased from market. Six(6) weaning male albino rats are housed into the individual cages in each group and fed with each experimental diet and water ad libitum for 21 weeks. The composition of the experimental diets are shown in Table 1. At the end of experiment, the appearences of rats are observed and the bloods are sampled by heart puncture method following ether anesthesia for determinations of serum protein and serum cholesterol. And the livers are sampled immediately right after heart after heart puncture for determinations of liver weight, liver nitrogen, liver fat, and liver glycogen. And also liver tissues are observed histologically. The result of growth experiment is shown in Table 2 and Figure 7. The results of blood analysis are shown in Table 3 and the results of liver analysis are shown in Table 4. And the histological observations of liver tissue are shown in Figures 1, 2, 3, 4, 5, and 6. According to the above results, it could be summarized as follows; 1) The normal appearences are observed at SD Group and BD Group. Alopecia is observed at RD, RD-­BD, RD-MD, and MD groups and the wet appearences of hair are observed at RD-MD and MD groups. The color of hair is changed to yellowish white at RD, RD-MD groups. The maximum growth inhibition, is observed at MD group and the growths of RD, RD-BD, BD, and RD-MD groups are significantly lower than that of SD group. The growth of RD group is lower than those of RD-BD and BD groups, though this difference is not significant. 2) At the blood analysis, the highest serum protein content is shown at SD group and the lowest serum protein is observed at MD group. The serum cholesterol contents are not significantly different among the six(6) experimental groups. 3) The highest liver weight is observed at SD group and the lowest weight is shown at MD group. However, oppositely the highest liver weight per 100 grams of body weight at MD group and the lowest liver weight per 100 grams of body weight at SD group are observed as shown in Table 6. 4) The differences of liver nitrogen contents of RD, RB-BD, BD, RD-MD, and MD Groups are not significant except SD group showing the highest content. 5) The significant highest content of liver fat is observed at RD group and the lowest content of liver fat is shown at SD group. And no significant differences in contents of liver glycogen are observed among the six(6) experimental groups. 6) No significant abnormal histological changes of liver tissue are observed at SD, RD-BD, and BD groups. However, the fat metamorphosis at peripheral zone of liver tissue is observed at RD Group and the some histological abnormal changes are observed at RD-MD and MD groups. According to the above summaries, the followings might be estimated and recommended; 1) The BD group shows histological normality of liver tissue, improvement of liver fat and liver nitrogen, normality of appearence, and better growth compared with RD Group. This could be indicated that barley is nutritionally and biochemically better than rice as the feeding diet on rat. And it might be considered that there might be the species speciality for nutritionary evaluation of food. 2) Recently, Marshall indicated that the high consumption of carbohydrate causes fatty liver and Kondo reported that the higher consumption of rice causes the more heart disease and the shorter life span. Considering these reports, the higher consumption of rice as a main dish in our country should be considered as an important national nutritional problem. And this might be improved by supplementing with barley or other grains to rice.

• Journal of Advanced Marine Engineering and Technology
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• v.37 no.6
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• pp.623-630
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• 2013

This study was to evaluate hydrodynamic performance evaluation between an abroad product, a developed inflatable kayak and new developed kayaks. In order to test, inclining and turning trial test were carried out in the Ocean engineering Basin. Also, resistance test was carried out using a reduced scale model in the circulating water channel. In conclusion, stability of KONA was evaluated was the most greatest, the coefficient of resistance and center of gravity from RD-FK-12 were considerable, and turning performance of RD-FK-11 was greater than this of KONA and RD-FK-12.

• Journal of Ginseng Research
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• v.37 no.2
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• pp.201-209
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• 2013

Ginsenoside, one of the active ingredients of Panax ginseng, has a variety of physiologic and pharmacologic effects. The purpose of this study was to explore the effects of ginsenoside Rd (G-Rd) on melastatin type transient receptor potential 7 (TRPM7) channels with respect to the proliferation and survival of AGS and MCF-7 cells (a gastric and a breast cancer cell line, respectively). AGS and MCF-7 cells were treated with different concentrations of G-Rd, and caspase-3 activities, mitochondrial depolarizations, and sub-G1 fractions were analyzed to determine if cell death occurred by apoptosis. In addition, human embryonic kidney (HEK) 293 cells overexpressing TRPM7 channels were used to confirm the role of TRPM7 channels. G-Rd inhibited the proliferation and survival of AGS and MCF-7 cells and enhanced caspase-3 activity, mitochondrial depolarization, and sub-G1 populations. In addition, G-Rd inhibited TRPM7-like currents in AGS and MCF-7 cells and in TRPM7 channel overexpressing HEK 293 cells, as determined by whole cell voltage-clamp recordings. Furthermore, TRPM7 overexpression in HEK 293 cells promoted G-Rd induced cell death. These findings suggest that G-Rd inhibits the proliferation and survival of gastric and breast cancer cells by inhibiting TRPM7 channel activity.

• The korean journal of orthodontics
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• v.17 no.2
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• pp.321-333
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• 1987

The purpose of this study was to observe the changes of the lower 3rd molars following the extraction of the lower 2nd molars by Lateral Cephalograms and Orthopantomograms. The subjects consisted of twenty malocclusion, 7 males 13 females, were 19 year 5 month old at the removal of the lower 2nd molars, 19 year 1 month old at the end of the orthodontic supervision after the removal of the lower 2nd molars (mean age) The obtained results were as follows, 1 It is recommended to extract the lower 2nd molars when the lower 3rd molars are Nolla's Stage 4 or 5 2 With the pre-extraction variables obtained by factor analysis, it was possible to predict the long axis of the lower 3rd molars after 2nd molar extraction. 3 There were no impacted 3rd molars.