• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3403-3408
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• 2012

The molecular mechanisms involved in the progression of clear cell renal cell carcinomas (ccRCCs) are still unclear. The aim of this study was to analyse the relationships between expression of RALYL and clinical characteristics. In 41 paired samples of ccRCCs and adjacent normal tissues, we used real-time qPCR to evaluate the expression of RALYL mRNA. RALYL protein levels were determined in 146 samples of ccRCC and 37 adjacent normal tissues by immunohistochemistry. Statistical analysis was used to explore the relationships between expression of RALYL and the clinical characteristics (gender, age, tumor size, T stage, N stage, M stage, survival times and survival outcome) in ccRCC. In addition, these patients were follow-up period 64 months (range: 4~116months) to investigate the influence on prognosis. We found significantly differences between ccRCC tissues and normal tissues (p<0.001, paired-sample t test) in mRNA levels of RALYL. Immunohistochemistry analyses in 146 ccRCC samples and 37 adjacent normal tissues showed significantly lower RALYL protein levels in ccRCC samples (${\chi}^2$-test, p<0.001), inversely correlating with tumour size (p=0.024), T stage (0.005), N stage (p<0.001) as well as M stage (p=0.019), but not age (p=0.357) and gender (p=0.348). Kaplan-Meier survival analysis demonstrated that people with lower level of RALYL expression had a poorer survival rate than those with a higher level of RALYL expression, significantly different by the log-rank test (p=0.011). Cox regression analysis indicated that RALYL expression (p=0.039), N stage (p=0.008) and distant metastasis (p<0.001) were independent prognosis factors for the overall survival of ccRCC patients. We demonstrated that the expression of RALYL was significantly low in ccRCC and correlated with a poor prognosis in a large number of clinical samples. Our findings showed that RALYL may be a potential therapeutic target as well as a poor prognostic factor.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8419-8423
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• 2016

Purpose: Anti-cancer activity evaluation of aqueous extract of CRUEL (herbomineral formulation) capsules on renal cell carcinoma cell lines, and exploration of mechanisms of cell death. Materials and Methods: To detect the cytotoxic dose concentration in renal cell carcinoma (RCC) cells, MTT assays were performed and morphological changes after treatment were observed by inverted microscopy. Drug effects against RCC cell lines were assessed with reference to cell cycle distribution (flow cytometry), anti-metastatic potential (wound healing assay) and autophagy(RT-PCR). Results: CRUEL showed anti-proliferative effects against RCC tumor cell lines with an IC50 value of ${\approx}4mg/mL$ in vitro., while inducing cell cycle arrest at S-phase of cell cycle and inhibiting wound healing. LC3 was found to be up-regulated after drug treatment in RT-PCR resulting in an autophagy mode of cell death. Conclusions: This study provides the experimental validation for antitumor activity of CRUEL.

• Computers and Concrete
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• 제27권5호
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• pp.437-445
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• 2021

Retrofitting of structures has gained importance over the recent years. Particularly, Reinforced Cement Concrete (RCC) column strengthening has become a challenge to the structural engineers, owing to the risks and complexities involved in it. There are several methods of RCC column strengthening viz. RCC jacketing, steel jacketing and Fiber Reinforced Polymer (FRP) wrapping etc., FRP wrapping is the most promising alternative when compared to the others. The large research database shows FRP wrapping, through lateral confinement, improves the axial load carrying capacity of the columns under concentric loading. However, its confining efficiency reduces under eccentric loading. Hence a relative newer technique called Near Surface Mounting (NSM), in which Carbon FRP (CFRP) strips are epoxy grouted to the precut grooves in the cover concrete of the columns, has been thrust domain of research. NSM technique strengthens the column nominally under concentric load case while significantly under eccentric case. A novel configuration of NSM in which the vertical NSM (VNSM) strips are being connected by horizontal NSM (HNSM) strips was numerically investigated under both concentric and eccentric loading. It was found that the configuration with 6 HNSM strips performed better under eccentric loading than under concentric loading, while the configuration with 3 HNSM strips performed better under concentric loading than under eccentric loading. Hence an optimum of 4 HNSM strips is recommended as strengthening measure for the given column specifications. It was also found that Aluminum alloy cannot be used instead of CFRP in NSM applications owing to its lower mechanical properties.

• Journal of Korean Medical Science
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• 제33권51호
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• pp.325.1-325.10
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• 2018

Background: To evaluate survival outcomes and prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received sunitinib (SU) and pazopanib (PZ) as first-line therapy in real-world Korean clinical practice. Methods: Data of 554 patients with mRCC who received SU or PZ at eight institutions between 2012 and 2016 were retrospectively reviewed. Based on the targeted therapy, the patients were divided into SU (n = 293) or PZ (n = 261) groups, and the clinicopathological variables and survival rates of the two groups were compared. A multivariable Cox proportional hazard model was used to determine the prognostic factors for OS. Results: The median follow-up was 16.4 months (interquartile range, 8.3-31.3). Patients in the PZ group were older, and no significant difference was observed in the performance status (PS) between the two groups. In the SU group, the dose reduction rate was higher and the incidence of grade 3 toxicity was more frequent. The objective response rates were comparable between the two groups (SU, 32.1% vs. PZ, 36.4%). OS did not differ significantly between the two groups (SU, 36.5 months vs. PZ, 40.2 months; log-rank, P = 0.955). Body mass index, Eastern Cooperative Oncology Group PS > 2, synchronous metastasis, poor Heng risk criteria, and liver and bone metastases were associated with a shorter OS. Conclusion: Our real-world data of Korean patients with mRCC suggested that SU and PZ had similar efficacies as first-line therapy for mRCC. However, PZ was better tolerated than SU in Korean patients.

• Structural Monitoring and Maintenance
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• 제6권1호
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• pp.67-84
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• 2019

Digital Image Correlation technique (DIC) is a non-contact optical method for rapid structural health monitoring of critical infrastructure. An innovative approach to DIC is presented using QR (Quick Response) code based random speckle pattern. Reinforced Cement Concrete (RCC) beams of size $1800mm{\times}150mm{\times}200mm$ are tested in flexure. DIC is used to extract Moment (M) - Curvature (${\kappa}$) relationships using random speckle patterns and QR code based random speckle patterns. The QR code based random speckle pattern is evaluated for 2D DIC measurements and the QR code speckle pattern performs satisfactorily in comparison with random speckle pattern when considered in the context of serving a dual purpose. Characteristics of QR code based random speckle pattern are quantified and its applicability to DIC is explored. The ultimate moment-curvature values computed from the QR code based random speckled pattern are found to be in good agreement with conventional measurements. QR code encrypts the structural information which enables integration with building information modelling (BIM).

• International journal of advanced smart convergence
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• 제9권4호
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• pp.42-51
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• 2020

In this paper, the authors propose the pseudo complex correlation coefficient (PCCC) of the two complex random variables (RV), because the four real correlation coefficients (RCC) of the corresponding four real RVs cannot be obtained only from the complex correlation coefficient (CCC) of given two complex RV. Such observation is motivated by the general statement; "The complex jointly-Gaussian random M-vector cannot be completely described by the complex covariance matrix, even though the real Gaussian random 2M-vector can be completely descried by the real covariance matrix. Therefore, in order to describe completely the complex jointly-Gaussian random M-vector, we need an additional matrix, namely the complex pseudo-covariance matrix, along with the complex covariance matrix." Then, we apply PCCC to correlated information sources (CIS) for non-orthogonal multiple access (NOMA) in 5G system, and investigate impact of the proposed PCCC on the achievable data rate of the stronger channel user in the conventional successive interference cancellation (SIC) NOMA with CIS. It is shown that for the given same CCC, the achievable data rates with the different PCCC are different, because the corresponding RCC are different. We also show that as the absolute value of the same CCC increases, the impact of the different PCCC becomes more significant.

• Structural Engineering and Mechanics
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• 제55권1호
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• pp.137-160
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• 2015

The one-way (two-way) flexural strength of RCC prisms (circular slabs) reinforced with glass fiber textiles is addressed. To this end, alkaline-resistant glass fiber textiles with three surface weights were used in the composite, the matrix concrete was designed with zero/nonzero slump, and the textiles were used with/without an intermediate layer provided by epoxy resin and sand mortar. Prisms were tested under a four-point loading apparatus and circular slabs were placed on simple supports under a central load. Effects of the amount and geometry of reinforcement, matrix workability, and the intermediate layer on the ultimate load and deflection were investigated. Results revealed that, with a specific reinforcement amount, there is an optimum textile tex for each case, depending on the matrix mix design and the presence of intermediate layer. Similar results were obtained in one-way and two-way bending tests.

• Asian-Australasian Journal of Animal Sciences
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• 제27권6호
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• pp.886-897
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• 2014

The aim of the present study was to get a total physical and chemical characterization and comparison of the principal components in Bangladeshi buffalo (B), Holstein cross (HX), Indigenous cattle (IC) and Red Chittagong Cattle (RCC) milk. Protein and casein (CN) composition and type, casein micellar size (CMS), naturally occurring peptides, free amino acids, fat, milk fat globule size (MFGS), fatty acid composition, carbohydrates, total and individual minerals were analyzed. These components are related to technological and nutritional properties of milk. Consequently, they are important for the dairy industry and in the animal feeding and breeding strategies. Considerable variation in most of the principal components of milk were observed among the animals. The milk of RCC and IC contained higher protein, CN, ${\beta}$-CN, whey protein, lactose, total mineral and P. They were more or less similar in most of the all other components. The B milk was found higher in CN number, in the content of ${\alpha}_{s2}-$, ${\kappa}$-CN and ${\beta}$-lactalbumin, free amino acids, unsaturated fatty acids, Ca and Ca:P. The B milk was also lower in ${\beta}$-lactoglobulin content and had the largest CMS and MFGS. Proportion of CN to whey protein was lower in HX milk and this milk was found higher in ${\beta}$-lactoglobulin and naturally occuring peptides. Considering the results obtained including the ratio of ${\alpha}_{s1}-$, ${\alpha}_{s2}-$, ${\beta}$- and ${\kappa}$-CN, B and RCC milk showed best data both from nutritional and technological aspects.

• Biomolecules & Therapeutics
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• 제11권4호
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• pp.232-237
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• 2003

The present study examined functional effects of a new selective phosphodiesterase type 5 inhibitor, 1-[4-ethoxy-3-(6,7-dihydro-1-methyl-7-thioxo-3-propyl-1H-pyrazolo[ 4,3]pyrimidin-5-yl)phenylsulphonyl]-4-methyl piperazine (KJH-1002), in the isolated rabbit corpus cavernosum (RCC). Relaxing effects of KJH-1002 were also compared with those of sildenafil, which is currently used as an oral therapy for penile erectile dysfunction. In the isolated RCC precontracted with phenylephrine, both KJH-1002 and sildenafil in the concentration range of 1 to 1000 nM, produced a comparable potentiation of the electical field stimulation-induced relaxation in a concentration-dependent manner. In the sodium nitroprusside (SNP)-induced relaxation, the $IC_{50}$/ values, concentrations of SNP required to produce a 50％ relaxation of the phenylephrine-induced contraction, were significantly decreased to the similar extent by treatments with KJH-1002 and sildenafil. The results suggest that a new selective phosphodiesterase type 5 inhibitor, KJH-1002, has an augmentative effect on penile erection comparable to that of sildenafil and can be useful for the treatment of erectile dysfunction.

• Structural Engineering and Mechanics
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• 제47권1호
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• pp.1-25
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• 2013

A combined thermal and mechanical action in roller compacted concrete (RCC) dam analysis is carried out using a three-dimensional finite element method. In this work a numerical procedure for the simulation of construction process and service life of RCC dams is presented. It takes into account the more relevant features of the behavior of concrete such as hydration, ageing and creep. A viscoelastic model, including ageing effects and thermal dependent properties is adopted for the concrete. The different isothermal temperature influence on creep and elastic modulus is taken into account by the maturity concept, and the influence of the change of temperature on creep is considered by introducing a transient thermal creep term. Crack index is used to assess the risk of occurrence of crack either at short or long term. This study demonstrates that, the increase of the elastic modulus has been accelerated due to the high temperature of hydration at the initial stage, and consequently stresses are increased.