• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.20-20
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• 2016

본 연구는 레이더를 이용한 강우 추정 시 과소 추정하는 문제를 해결하기 위해 기상청에서 실시간으로 생산하고 있는 레이더 반사도를 AWS로 보정한 RAR (RADAR-AWS Rain rate) 자료의 수문 분석을 통한 적용성을 평가하는데 그 목적이 있다. 대상유역을 한탄강홍수조절댐 유역으로 선정하고 9개 소유역에 대한 시간 단위 지상 관측 자료와 RAR 자료의 유역평균 강우량을 산정 및 비교하였다. 분석 결과 미계측 유역이 80%가 넘는 1번 소유역에서 지상 관측 자료와 RAR 자료의 유역평균 강우량은 상관성이 낮게 분석되었다. 두 자료의 유역평균 강우량을 이용하여 2012년부터 2015년까지 홍수기간에 대한 저수지 모의 유입량과 관측 유입량을 비교한 결과 RAR 자료의 모의 유입량이 관측 유입량과 높은 상관성 및 정확도를 나타내었다. RAR 자료는 기존 레이더 강우의 과소 추정 문제를 보완할 수 있으며, 지상 관측이 어려운 지역에서 강우자료로 활용이 가능할 것으로 판단된다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.1-7
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• 2017

The RAR (Reinforced Abutment for Railways) is an economical abutment to reduce the settlement of a transitional zone and horizontal displacement of an abutment by constructing backfill before the abutment. In this paper, the performance of the RAR depending on the pile installation was evaluated using 2D (Dimensional) finite element analysis and compared with the existing abutment (with 5 rows pile). Numerical analysis showed that increasing pile installation is more effective in reducing horizontal displacement and earth pressure than settlement of the transitional zone. The horizontal displacement and earth pressure of the RAR was approximately 26~37% and 59~83% compared to the existing abutment by changing the pile installation. More pile installation led to a greater reduction of the horizontal displacement and earth pressure of the RAR. In addition, the horizontal earth pressure of RAR is influenced considerably by the reinforcement, pile, foundation, and stiffness of the ground.

• Journal of Korea Water Resources Association
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• v.44 no.9
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• pp.721-730
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• 2011

The objective of this study is to assess the availability of streamflow simulation using Radar-AWS Rain rate (RAR) data which is produced by KMA on real-time. Chuncheon dam upstream basin is selected as study area and total area is 4859.73 $km^2$. Mean Areal Precipitation (MAP) using AWS and RAR are calculated on 5 subbasin. The correlationship of hourly MAPs between AWS and RAR is weak on ungauged subbasins but that is relatively high on gauged ones. We evaluated the simulated discharge using the MAPs derived from two data types during flood season from 2006 to 2009. The simulated discharges using AWS on Chuncheon dam (gauged basin) are well fitted with measured ones. In some cases, however, discharges using AWS on Hwacheon dam and Pyeonghwa dam with some ungauged subbasins are overestimated on the other hand, ones using RAR in the same case are well fitted with measured ones. The hourly RAR data is useful for the real-time river forecast on the ungauged basin in view of the results.

• Journal of the Korean Society of Safety
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• v.16 no.4
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• pp.134-139
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• 2001

The Risk assessment regulation(RAR) is one of the essential articles of the Occupational safety and health law for the construction industry along with safety and health management expense and safety organization regulation. However, arguments regarding the working time of the safety assessment documents, the person in charge of documentation, weakness in legislative enforcement etc. are ongoing. Thus this study aims to analyze the effectiveness of RAR for the guidance of enhancing the effectiveness of RAR. The findings are; 1) the effectiveness of RAR is recognized, however the indirect effectiveness ie, enforcement of safety activities, previewing of drawings etc. are bigger than the direct effectiveness of accident prevention, 2) to enhance the effectiveness of RAR site inspection procedure has to be utilized, 3) further research for identifying and getting rid of negative factors in RAR is recommended.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.11
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• pp.7949-7956
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• 2015

This paper introduced the RAR(Reinforced Abutment for Railroads) to reduce settlement of transitional zone and horizontal displacement of abutment by constructing backfill before abutment. We expect that it has more economical and better performance which was validated by numerical analyses. First, transitional zone settlements and horizontal displacements of existing abutment were evaluated for various heights and ground conditions by using finite element analysis program. Then, numerical analyses of it under the same conditions were performed and its results were compared with existing abutment's ones. From the numerical analysis, we found that the responses(settlement and horizontal displacement) of transitional zone of the RAR is about 20% and 34% of one of existing abutment due to the effect of backfill stabilizing. We expected that the RAR having small foundations could be economic way to construct abutment with the control of responses such as, settlement, horizontal displacement, and earth pressure.

• Journal of Korean Biological Nursing Science
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• v.25 no.4
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• pp.306-315
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• 2023

Purpose: This study aimed to evaluate the rest-activity circadian rhythm (RAR) using data obtained from wearable actigraph devices in hospitalized older adults with mild cognitive impairment (MCI), and to investigate its relationship with salivary alpha amylase (sAA). Methods: This secondary data analysis used data from the Hospitalized Older Adults' Cognition and Physical Activity Study. Actigraph data for 3-4 days were analyzed for RAR. RAR indices such as interdaily stability (IS), intradaily variability (IV), activity level during the most active 10-hour period and during the most least active 5-hour period, and relative amplitude (RA) were calculated. Data on sAA collected in the morning and general characteristics, including body mass index (BMI), were analyzed. Results: Data from 92 hospitalized older adults with MCI were analyzed. The IS, IV, RA were 0.23, 0.73, 0.88, respectively. The average level of sAA was 77.02 U/mL, and a higher level of sAA was significantly associated with better IS and RA in the regression analysis, while age, BMI, and cognitive level were not. BMI showed positive correlations with IS and RA. Conclusion: RAR in the hospitalized older adults with MCI was attenuated, showing especially low IS, which implies they failed to maintain regular and repetitive 24-hour RAR. Increased sAA and BMI were associated with robust RAR. Nurses need to pay attention to maintain robust RAR in hospitalized older adults with MCI, and strategies should be developed to improve their RAR.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10937-10941
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• 2015

Pathogenesis of lung cancer is a complicated biological process including multiple genetic and epigenetic changes. Since cigarette smoking is confirmed as the most main risk factor of non-small cell lung cancer (NSCLC), the aim of this study was to determine whether tobacco exposure plays a role in gene methylation. Methylation of the RAR-${\beta}$ gene were detected using methylation-specific polymerase chain reaction in DNA from 167 newly diagnosed cases with NSCLC and corresponding 105 controls. A significant statistical association was found in the detection rate of the promoter methylation of RAR-${\beta}$ gene between NSCLC and controls ($x^2$=166.01; p<0.01), and hypermethylation of the RAR-${\beta}$ gene was significantly associated with smoking status (p=0.038, p<0.05). No relationship was found between RAR-${\beta}$ gene methylation and pathologic staging including clinical stage, cell type, gender and drinking (p>0.05), and the methylation of RAR-${\beta}$ gene rate of NSCLC was slightly higher in stages III+IV (80.0%) than in I+II (70.8%). Similar results were obtained for methylation of the RAR-${\beta}$ gene between squamous cell carcinoma (77.9%) and other cell type lung cancer (73.9%). These results showed that the frequency of methylation increased gradually with the development of clinical stage in smoking-associated lung cancer patients, and tobacco smoke may be play a potential role in RAR-${\beta}$ gene methylation in the early pathogenesis and process in lung cancer, particularly squamous cell carcinoma. Aberrant promoter methylation is considered to be a promising marker of previous carcinogen exposure and cancer risk.

• Journal of Life Science
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• v.26 no.1
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• pp.42-49
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• 2016

The retinoic acid (RA) plays an important role in the growth and development of many cells, and bioactive RA concentration is regulated by several enzymes, including CYP26A1. The expression of the CYP26A1 gene is regulated by RA, and the CYP26A1 gene is one of the candidates for RA-responsive genes. Although CYP26A1 genes are cloned from several animals, cloning of the CYP26A1 gene from cows has not been reported yet. The promoter region of CYP26A1 from cows was cloned by PCR and analyzed by sequence alignment with human and mouse CYP26A1. The RA-responsive element (RARE), DR-5 (ttggg), was located in this region and was perfectly conserved. The promoter region of bovine CYP26A1, which contains DR-5, was ligated to the luciferase reporter gene on transient transfection assays. The expression of CYP26A1-Luc promoter was activated by ATRA treatment in lung-derived mtCC cells. Co-transfection with RAR-α or -β with ATRA significantly activates the expression of CYP26A1-Luc promoter; however, it was less effective with either RAR-γ or RXR-γ. In addition, the endogenous gene expressions measured by Q-RT-PCR in mtCC cells were not significantly affected by ATRA treatment for 2 days; however, the expression of the endogenous CYP26A1 gene was diminished sharply at day 3 with ATRA treatment. In conclusion, the promoter region of bovine CYP26A1 contains conserved DR-5 RARE, which functions as a binding site for RAR-α or -β, and it is involved in the regulation of CYP26A1 gene expression and the control of RA signaling in mtCC cells.

• Journal of Gastric Cancer
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• v.8 no.4
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• pp.182-188
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• 2008

Purpose: Transcriptional factors of CREB (cAMP response element binding protein) are involved in regulating the gene expression in response to a variety of signaling pathways. The proteins produced by the CREB genes play key roles in many physiological processes, including memory and long-term potentiation. The retinoic acid receptor (RAR) axis mediates epithelial cell differentiation and proliferation in many tissues. This study examined the expressions of RAR and CREB and their relationship with the clinicopathologic factors and their significance. Materials and Methods: The levels of the RAR and CREB expressions were measured in 150 gastric adenocarcinomas by performing immunohistochemical staining. Results: 1. An RAR protein expression was found in 63.3% of the adenocarcinomas (95/150) and a CREB expression was found in 60.7% (91/150) of the adenocarcinomas. 2. An RAR protein expression was found in 72.2% (78/108) of the intestinal type adenocarcinomas and in 40.5% (17/42) of the diffuse type adenocarcinomas (P<0.05). Based on the depth of invasion, an RAR protein expression was found in 58.3% (14/24) of the T1 adenocarcinomas, in 61.9% (13/21) of the T2 adenocarcinomas, in 63.5% (61/96) of the T3 adenocarcinomas, in 77.8% (7/9) of the T4 adenocarcinomas and in 74.7% (62/83) of the adenocarcinomas with lymph node metastasis and in 49.2% (33/67) of the adenocarcinomas without lymph node metastasis (P<0.01). 3. A CREB expression was found in 69.4% (75/108) of the intestinal type and in 38.1% (16/42) of the diffuse type (P>0.05). Based on the depth of invasion, a CREB expression was found in 50% (12/24) of the T1 adenocarcinomas, in 52.4% (11/21) of the T2 adenocarcinomas, in 64.6% (62/96) of the T3 adenocarcinomas, in 66.6% (6/9) of the T4 adenocarcinomas, in 71.1% (59/83) of the adenocarcinomas with lymph node metastasis and in 47.8% (32/67) of the adenocarcinomas without lymph node metastasis (P<0.01). 4. The RAR protein and CREB expressions coincided in 71.4% of the gastric adenocarcinomas and a significant correlation between them was found (P<0.05). Conclusion: We found a significant relationship between the expression of RAR and CREB and the histology and lymph node metastasis of gastric cancer. Further studies are needed to confirm their biologic meaning in gastric carcinogenesis.

• Tuberculosis and Respiratory Diseases
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• v.59 no.6
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• pp.631-637
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• 2005

Background : Transcriptional factors of the CREB(cAMP Response Element Binding Protein) are involved in the regulation of gene expression in response to a variety of signaling pathways. Proteins produced by the CREB genes play key roles in many physiological processes, including memory and long-term potentiation. The retinoic acid receptor (RAR) axis mediates epithelial cell differentiation and proliferation in many tissues including the lung. Material and method : The RAR and CREB expression levels were examined in 60 adenocarcinomas and 60 squamous cell carcinomas of the lung using immunohistochemical staining. Results : 1) RAR protein expression was found in 58.3%(35/60) of adenocarcinomas and 36.7%(22/60) of squamous cell carcinomas(P<0.05). 2) RAR protein expression was found in 80%(16/20) of well differentiated adenocarcinomas, 60%(12/20) of moderately differentiated adenocarcinomas, and 35%(7/20) of poorly differentiated adenocarcinomas (P<0.01). 3) RAR protein expression was found in 45%(9/20) of well differentiated squamous cell carcinomas, 35%(7/20) of moderately differentiated squamous cell carcinomas, and 30%(6/20) of poorly differentiated squamous cell carcinomas (P>0.05). 4) CREB expression was found in 61.7%(37/60) of adenocarcinomas and 40%(24/60) of squamous cell carcinomas( P<0.05). 5) CREB expression was found in 85%(17/20) of well differentiated adenocarcinomas, 60%(12/20) of moderately differentiated adenocarcinomas, and 40%(8/20) of poorly differentiated adenocarcinomas (P<0.01). 6) CREB expression was found in 45%(9/20) of well differentiated squamous cell carcinomas, 35%(7/20) of moderately differentiated squamous cell carcinomas, and 35%(8/20) of poorly differentiated squamous cell carcinomas(P>0.05). 7) RAR and CREB expression was found in 68.5% of lung cancers, and there was a significant correlation between them(P<0.05). Conclusion : RAR and CREB expression can be used to indirectly determine the malignant potentiality of a cell.