• Journal of the Korean Solar Energy Society
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• v.33 no.1
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• pp.15-23
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• 2013

In this study, thermodynamic performance of R435A is examined both numerically and experimentally in an effort to replace HFC134a used in the refrigeration system of domestic water purifiers. Even though HFC134a is used predominantly in such a system these days, it needs to be phased out in the near future in Europe and most of the developed countries due to its high global warming potential. To solve this problem, cycle simulation and experimental measurements are carried out with a new refrigerant mixture of 20%R152a/80%RE170 using actual domestic water purifiers. This mixture is numbered and listed as R435A by ASHRAE recently. Test results show that the system performance with R435A is greatly influenced by the amount of charge due to the small internal volume of the refrigeration system of the domestic water purifiers. With the optimum amount of charge of 21 to 22 grams, about 50% of HFC134a, the energy consumption of R435A is 11.8% lower than that of HFC134a. The compressor discharge temperature of R435A $8^{\circ}C$ lower than that of HFC134a at the optimum charge. Overall, R435A, a new long term environmentally safe refrigerant, is a good alternative for HFC134a requiring little change in the refrigeration system of the domestic water purifiers.

• Proceedings of the Korean Society of Developmental Biology Conference
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• 2003.10a
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• pp.83-83
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• 2003

The lutropin/choriogonadotropin receptor (LHR) is a member of the rhodopsin-like subfamily of G protein coupled receptor (GPCRs), that has been shown to mediate the internalization of its two naturally occurring agonist, lutropin and choriogonadotropin (CG). The clustered agonist-receptor complex is internalized by a dynamin-dependent pathway and traverses the endosomal compartment without agonist dissociation Dissociation of the agonist-receptor complex occurs in the lysosomes, where both the agonist and receptor are degrade. Recently, constitutively activating mutations of the receptor have been identified that are associated with familial male-precocious puberty (FMPP). A FMPP is a form of sexual precocious puberty in boys in which testosterone levels are elevated independent of changes in luteinizing hormone-releasing hormone and serum luteinizing hormone levels, We have now analyzed two naturally occurring, constitutively active mutants of the human LHR. These mutations were introduced into the rat LHR (rLHR) and are designated L435R and D556Y. Cells expressing rLHR-D556Y bind human choriogonadotropin (hCG) with normal affinity, exhibit a 25-fold increase in basal cAMP and respond to hCG with a normal increase in cAMP accumulation. Cells expressing rLHR-L435R also bind hCG with normal affinity, exhibit a 47-fold increase in basal cAMP, and do not respond to hCG with a further increase in cAMP accumulation. This mutation enhances the internalization of the free and agonist-occupied receptors ~2- and ~17- fold, respectively We conclude that the state of activation of the rLHR can modulate its basal and/or agonist-stimulated internalization. Since the internalization of hCG is involved in the termination of hCG actions, we suggest that the lack of responsiveness detected in cells expressing rLHR-L435R is due to the fast rate of internalization of the bound hCG. The finding that membranes expressing rLHR-L435R respond to hCG with an increase in adenylyl cyclase activity supports this suggestion. Autonomous Leydig cell activity in FMPP is caused by a constitutively activating LH/CGR.

• Korean Journal of Environmental Agriculture
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• v.28 no.4
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• pp.435-441
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• 2009

In the present study, we analyzed the defensin protein deduced from Korean radish (Raphanus sativus L.) seeds.To express the genes in E. coli, we constructed a recombinant expression vector with a defensin gene, named rKRs-AFP gene isolated from Korean radish seeds. Over expressed rKRs-AFP proteins was separated by SDS-PAGE to determine the purity, and protein concentration was determined by the Bradford method. Antifungal activity was assessed by disk assay method against the tested fungi. As a result, when 500 mL of cell culture were disrupted by sonicator, 32.5 mg total proteins were obtained. The purified protein showed a single band on SDS-PAGE with estimated molecular weight about 6 KDa, consistent with the molecular mass calculated from the deduced amino acid sequence. The purified rKRs-AFP protein showed remarkable antifungal activities against several fungi including Aspergillus niger, Botrytis cinerea causing the gray mold disease, and Candida albicans. In field tests using the purified rKRs-AFP protein, the protein showed the reducing activity of disease spot and the mitigating effect of spreading of disease like agrichemicals. The immuno-assay of rKRs-AFP protein showed that the purified protein entirely accumulated at B. cinerea cytoplasm through the hyphal septa shown by fluorescence imaging. There was no fluorescence inside the cell, when the hypha was incubated without the protein. These all results indicate that the recombinant rKRs-AFP proteins can be utilized as a potential antifungal drug to control harmful plant fungal pathogens.

• Communications for Statistical Applications and Methods
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• v.11 no.3
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• pp.435-446
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• 2004

In this paper we introduced a new score generating function for the rank dispersion function in a multiple linear model. Based on the new score function, we derived the asymptotic relative efficiency, ARE(11, rs), of our score function with respect to the Wilcoxon scores for the generalized F distributions which show very flexible distributions with a variety of shape and tail behaviors. We thoroughly explored the selection of r and s of our new score function that provides improvement over the Wilcoxon scores.

• Asian-Australasian Journal of Animal Sciences
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• v.2 no.3
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• pp.435-438
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• 1989

• Bulletin of the Korean Mathematical Society
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• v.37 no.3
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• pp.429-435
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• 2000

Our main goal is to show that if there exist Jordan derivations D, E and G on a noncommutative 2-torsion free prime ring R such that$(G^2(x)+E(x))D(x)=0\ or\ D(x)(G^2(x)+E(x))=0\ for\ all\ x\inR$, then we have D=o or E=0, G=0.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.08a
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• pp.317-326
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• 2004

This study investigated tile local austenite grain size (AGS) distribution In rolling of SCM435 steel which is commonly used for high strength bolt. To investigate AGS distribution, round-oval (R-O) and square-diamond (S-D) rolling experiments were carried out with pilot mill. In round-oval rolling, local AGS has a tendency to increase when it goes to outward. In square-diamond rolling, local AGS has a tendency to increase when it goes to free surface. To investigate relation between AGS and process parameter, three dimensional FE analysis was carried out along with rolling experiment. To validate accuracy of FE analysis, we compared deformed geometry with FE result. The AGS prediction combined AGS model with numerical analysis was also carried out for center node of S-D rolling. Although this study brought experimental observation and its qualitative analysis into focus and quantitative AGS prediction will be done as a further work.

• Parasites, Hosts and Diseases
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• v.57 no.4
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• pp.435-437
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• 2019

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and is endemic in many Latin American countries. Diagnosis is based on serologic testing and the WHO recommends two or more serological tests for confirmation. Acidic ribosomal P protein of T. cruzi showed strong reactivity against positive sera of patients, and we cloned the protein after fragmenting it to enhance its antigenicity and solubility. Twelve positive sera of Chagas disease patients were reacted with the fragmented ribosomal P protein using western blot. Detection rate and density for each fragment were determined. Fragments F1R1, F1R2, and F2R1 showed 100% rate of detection, and average density scoring of 2.00, 1.67, and 2.42 from a maximum of 3.0, respectively. Therefore, the F2R1 fragment of the ribosomal P protein of T. cruzi could be a promising antigen to use in the diagnosis of Chagas disease in endemic regions with high specificity and sensitivity.

• Kyungpook Mathematical Journal
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• v.53 no.3
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• pp.435-457
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• 2013

Using the Lukasiewicz 3-valued implication operator, the notion of an (${\alpha},{\beta}$)-intuitionistic fuzzy left (right) $h$-ideal of a hemiring is introduced, where ${\alpha},{\beta}{\in}\{{\in},q,{\in}{\wedge}q,{\in}{\vee}q\}$. We define intuitionistic fuzzy left (right) $h$-ideal with thresholds ($s,t$) of a hemiring R and investigate their various properties. We characterize intuitionistic fuzzy left (right) $h$-ideal with thresholds ($s,t$) and (${\alpha},{\beta}$)-intuitionistic fuzzy left (right) $h$-ideal of a hemiring R by its level sets. We establish that an intuitionistic fuzzy set A of a hemiring R is a (${\in},{\in}$) (or (${\in},{\in}{\vee}q$) or (${\in}{\wedge}q,{\in}$)-intuitionistic fuzzy left (right) $h$-ideal of R if and only if A is an intuitionistic fuzzy left (right) $h$-ideal with thresholds (0, 1) (or (0, 0.5) or (0.5, 1)) of R respectively. It is also shown that A is a (${\in},{\in}$) (or (${\in},{\in}{\vee}q$) or (${\in}{\wedge}q,{\in}$))-intuitionistic fuzzy left (right) $h$-ideal if and only if for any $p{\in}$ (0, 1] (or $p{\in}$ (0, 0.5] or $p{\in}$ (0.5, 1] ), $A_p$ is a fuzzy left (right) $h$-ideal. Finally, we prove that an intuitionistic fuzzy set A of a hemiring R is an intuitionistic fuzzy left (right) $h$-ideal with thresholds ($s,t$) of R if and only if for any $p{\in}(s,t]$, the cut set $A_p$ is a fuzzy left (right) $h$-ideal of R.

• Journal of the Korean Mathematical Society
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• v.49 no.2
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• pp.435-447
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• 2012

Let G be a group. Let R be a G-graded commutative ring with identity and M be a G-graded multiplication module over R. A proper graded submodule Q of M is semiprime if whenever $I^nK{\subseteq}Q$, where $I{\subseteq}h(R)$, n is a positive integer, and $K{\subseteq}h(M)$, then $IK{\subseteq}Q$. We characterize semiprime submodules of M. For example, we show that a proper graded submodule Q of M is semiprime if and only if grad$(Q){\cap}h(M)=Q+{\cap}h(M)$. Furthermore if M is finitely generated then we prove that every proper graded submodule of M is contained in a graded semiprime submodule of M. A proper graded submodule Q of M is said to be almost semiprime if (grad(Q)$\cap$h(M))n(grad$(0_M){\cap}h(M)$) = (Q$\cap$h(M))n(grad$(0_M){\cap}Q{\cap}h(M)$). Let K, Q be graded submodules of M. If K and Q are almost semiprime in M such that Q + K $\neq$ M and $Q{\cap}K{\subseteq}M_g$ for all $g{\in}G$, then we prove that Q + K is almost semiprime in M.