• 한국철도학회:학술대회논문집
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• 한국철도학회 2003년도 춘계학술대회 논문집
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• pp.388-392
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• 2003

In this study, various railroad geotechnical informations were standardized. The standardization was progressed by classifying the informations as basic properties, railroad vibrations and design plans. Basic informations included soil properties(27), dynamic property(1), geophysical prospecting(1), and elastic wave prospecting(4). Specification for 'human exposure to whole-body vibration' was used to construct the information of railroad vibration. And in the case of the information of design plan, the way to save by graphic files was chosen. Thus standardized informations examined their application by setting up database. Entity-Relation(E-R) model was used in the design of database and by this, the database system was constructed. This database system will be able to serve the performance enhancement of railroad system.

• 한국자원식물학회지
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• 제5권2호
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• pp.73-84
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• 1992

Many types of compounds have been isolated from higher plants till now, that is, alkaloids, terpenes, lignans, steroids and so on. One of them, named as RA series Cyclic hexapeptides isolated from Rubia akane and R. cordijofia also have strong antineoplastic activity against various types of tumors. Till now 10 kinds ofRA series compounds were isolated and named as RA - I, II, III, IV, V, VI, VII, VIII, IX and X. Moreover,monogl-ucoside of RA - V newly Isolated from same plant. Many kinds of derivatives including natural RAcompounds were tested for QSAR, and one of them, RA - VII was screened up as a most suitable substance asan antitumor agent. RA - VII(=RA-700) has strong cytotoxic activity against KB cells, P388 Iymphocyticleukemia and MM2 mammary carcinoma cells. RA - VII has been under investigation for Phase I clinical trials.

• 한국작물학회지
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• 제49권6호
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• pp.546-551
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• 2004

사전에 수행된 델파이 조사의 기초자료를 이용하여 경종작물분야 미래유망기술들을 AHP방법을 사용하여 우선순위를 설정하였다. 8명의 전문가가 응답한 설문조사에서는 평가대항목중 공공성이 0.390으로 가장 중요하게 나타났으며, 그 다음으로는 기술성이 0.388,시장성은 0.223으로 나타났다 각 평가소항목의 세부적 중요도는 기술성 측면에서는 기술실현성, 기술파급성, 기술독창성 순으로, 시장성 측면에서는 시장성장성, 투자수익성, 시장규모성 순으로,공공성 측면에서는 국가전략과의 부합성, 산업파급성. 사회영향성 순으로 중요하게 나타났다. 각 기술군 중 중요도가 가장 높은 기술은 I군의 기술 중에서는 '친환경 저투입, 생산비절감 작물 재배기술이 개발된다'의 기술이 중요도가 0.836으로 가장 높게 나타났다. II군의 기술 중에서는 '생명공학기술을 이용한 작물의 유전자 탐색, 형질전환 및 상업화기술이 개발된다'의 기술이 중요도가 0.772로 가장 높게 나타났다.

• 수산해양기술연구
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• 제49권4호
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• pp.368-376
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• 2013

Fishing experiments were carried out in the adjacent sea of Yeongil Bay, the eastern cost of Korea from 2003 to 2004 using the dome-shaped pots with different five mesh sizes (17.1, 24.8, 35.3, 39.8, and 48.3mm) in order to determine the size selectivity of pots for the whelk, Buccinum opisthoplectum. The catch species were composed of Buccinum opisthoplectum (45.4%), Buccinum striatissimum (30.1%), Pandalopsis japonica (9.3%), Chionoecetes opilio (8.9%), and so on. The shell height (l) of Buccinum opisthoplectum caught in the experimental fishing pots was measured. The SELECT (Share Each Length's Catch Total) analysis method was applied with fishing data to obtain master selection curve. The model with the estimated split parameter was found to fit the catch data best. The master selection curve was estimated to be s (R)〓exp (7.833R-10.871)/[1 + exp (7.833R-10.871], where R is the ratio of shell height to mesh size. The relative shell length for 50% retention was 1.388, and the selection range was 0.281. It means that the pots of larger mesh size allow more whelks of small size to escape.

• The Korean Journal of Physiology and Pharmacology
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• 제5권5호
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• pp.381-388
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• 2001

This work describes the pharmacological inhibition by KR 31378 and its acetyl metabolite, KR 31612, of the apoptotic cell death induced by $H_2O_2$ in the A7r5 cells. Exposure of A7r5 cells to $H_2O_2$ (0.5 mM) induced a concentration-dependent cytotoxicity in association with oligonucleosomal DNA fragmentation. $H_2O_2-induced$ cell death was potently suppressed by KR 31378, KR 31612, ${\alpha}-tocopherol$ or trolox. Additionally, the apoptotic death of A7r5 cells (DNA ladders on electrophoresis) was also strongly suppressed by KR 31378 and KR 31612, but to a less degree by ${\alpha}-tocopherol$ and trolox. As a mechanistic study, incubation with $H_2O_2$ markedly showed a decreased Bcl-2 level and, in contrast, increased Bax protein and cytochrome C release, which were significantly and concentration-dependently reversed by KR 31378 and KR 31612 as well as by ${\alpha}-tocopherol$ and trolox. KR 31378 and ${\alpha}-tocopherol$ significantly reduced lipid peroxidation in accordance with reduced intracellular ROS and peroxyl radical. These results suggest that KR 31378 has a therapeutic potential against the apoptotic injury via mediation of anti- oxidative stress.

• 대한통합의학회지
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• 제7권4호
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• pp.265-272
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• 2019

Purpose : Excessive computer use frequently results in musculoskeletal disorders of the neck and shoulder such as forward head posture (FHP). The purpose of this study was to investigate effects of neck and shoulder exercise program on spino-pelvic alignment and the correlation between change in head and neck posture and spino-pelvic alignment in FHP. Methods : The study included 44 participants with FHP. The participants performed the exercise for correction of FHP 2-3 times a week for 4 weeks. We examined whole spine X-ray images in the lateral standing position with both arms crossed. We measured anterior head translation distance (AHT), craniovertebral angle (CVA), cervical lordosis (CL), thoracic kyphosis (TK), lumbosacral lordosis (LSL), sacral slope (SS), pelvic tilt (PT), and pelvic incidence (PI) of the subjects. The association between change in AHT and each spino-pelvic parameter was also subjected to Pearson's correlation coefficient analysis. Results : There were statistically significant differences before and after exercise in the parameters of AHT, CVA, and SS (p<.05). Significant negative correlation was observed between the change in AHT and CVA (r=-.768, p<.001), and CL (r=-.388, p<.05). There was significant positive correlation between the change in AHT and SS (r=.328, p<.05), and PI (r=.333, p<.05). However, no significant correlation was observed in change in AHT with that of TK, LSL, and PT. Conclusion : Based on the above results, we conclude that there is a relationship between change in AHT, which is a parameter associated with forward displacement of the head, and that of CVA, CL, SS, and PI after exercise in cases of FHP.

• 대한화장품학회지
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• 제30권3호
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• pp.385-388
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• 2004

최근에 천연성분의 화장품 응용에 대한 관심이 높아지고 식물에 함유하고 있는 피토에스트로겐(Phytoestrogen)의 항노화 물질 연구가 중요해지고 있다. 태국 식물 Pueraria mirifica 추출물을 $4\%$ 함유한 크림제제(PM 크림)를 추출물 성분이 제외된 플라시보 크림과 비교하여 총 30명 여성을 대상으로 16주간 임상시험을 수행하였다. 피부 모사판을 제작하여 주름 측정을 하였고, 피부 탄력과 보습을 기기 평가하였다. 특히 피부 탄력도는 placebo 크림 사용군 대비 추출물 함유 크림 사용군이 통계적으로 유의하게 탄력도가 증가하였다. 주름이나 보습평가는 특이할 만한 결과를 나타내지는 못했다. Pueraria mirifiaca는 피부 탄력 개선을 주는 항노화 화장품 개발에 응용될 수 있을 것이라 기대된다.

• 여성건강간호학회지
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• 제4권3호
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• pp.388-401
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• 1998

The purpose of this study is to investigate the relationship between the eating disorder, physical symptoms and mood status among college women. Data has been analyzed by SPSS/PC using frequency, percentage, mean, standard deviation, t-test, Pearson correlation coefficient. The results of this study are as follows : 1. The mean of body weight and height of the subjects were 52.74kg, 163.10cm. 2. Depending upon BMI, the obesity subjects were very rare(2.2%) and the rest(97.8%) were underweight or normal. 3. The total mean score of anorexia nervosa was higher than bulimia nervosa. 4. The total mean score of perceived physical symptoms was 20.68 and subjects in this study showed the tendency giving the highest core on the item of autonomic nerve system and mensural status. 5. The total mean score of mood status was 58.49. 6. The scores of eating behavior differed significantly by the BMI : The score was highest in the group of normal body weighted(t=5.75, p<.05). 7. The scores of physical symptoms differed significantly by the BMI : The score was highest in the group of the underweight(t=7.35, p<.01). 8. No significant difference was found on over all mood status scores according to the BMI. 9. There was high positive correlation between BMI and eating disorder(r=.1633, p<.01), between eating disorder and physical symptoms(r=.2497, p<.0001), between eating disorder and mood status(r=.2328, p<.0001), and between symptoms and mood status(r=.5051, p<.0001). From the results of this study, the eating disorder among college woman was very serious and the perception of their body weight was distorted. Therefore, to prevent the eating disorder, professional intervention is needed.

• Molecules and Cells
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• 제45권6호
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• pp.388-402
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• 2022

Malignant meningiomas often show invasive growth that makes complete tumor resection challenging, and they are more prone to recur after radical resection. Invasive meningioma associated transcript 1 (IMAT1) is a long noncoding RNA located on Homo sapiens chromosome 17 that was identified by our team based on absolute expression differences in invasive and non-invasive meningiomas. Our studies indicated that IMAT1 was highly expressed in invasive meningiomas compared with non-invasive meningiomas. In vitro studies showed that IMAT1 promoted meningioma cell invasion through the inactivation of the Krüppel-like factor 4 (KLF4)/hsa-miR22-3p/Snai1 pathway by acting as a sponge for hsa-miR22-3p, and IMAT1 knockdown effectively restored the tumor suppressive properties of KLF4 by preserving its tumor suppressor pathway. In vivo experiments confirmed that IMAT1 silencing could significantly inhibit the growth of subcutaneous tumors and prolong the survival period of tumor-bearing mice. Our findings demonstrated that the high expression of IMAT1 is the inherent reason for the loss of the tumor suppressive properties of KLF4 during meningioma progression. Therefore, we believe that IMAT1 may be a potential biological marker and treatment target for meningiomas.

• 한국작물학회지
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• 제53권4호
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• pp.388-393
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• 2008

광범위한 지역의 재배면적과 생산량을 신속하고 경제적으로 모니터링 할 수 있는 광학(LANDSAT) 중해상도 위성 영상을 활용하여 벼 재배면적, 생육 및 수량을 모니터링 할 수 있는지를 검토하였다. 1. 식생지수와 수량과의 관계를 살펴보면, EVI를 제외한 모든 식생지수와 수량간에는 정의 상관관계를 보였으며, NDVI_SWIR이나 EVI_SWIR과는 유의성이 없었다. NDVI가 RVI보다 수량과의 상관도가 다소 높았으며, 수량과 가장 밀접한 식생지수는 $NDVI_R$(r = 0.68)이었다 2. LANDSAT 단일시기 영상(2004년 7월 29일)을 활용하여 서산간척지 지역내 벼 수량을 모니터링한 결과 $NDVI_R$와 백미수량간에는 1차 직선관계($R^2$ = 0.46)가 성립하였으며, 필 지중에서 면적이 다소 적거나 주변에 반사특성에 영향하는 요인이 있는 지역을 제외하여 살펴본 결과 추정도가 다소 높아졌다($R^2$ = 0.66). 3. 논구역 벡터를 사용하여 논구역 정보를 추출하는 기존의 방법 대신 raster 기반의 논구역 masking을 제작하여 논 구역 정보를 추출하였는데 이 방법을 통해 쉽고 빠르게 논구역 정보를 추출할 수 있었다. 4. 연차별 지역적용가능성을 검토하기 위해 1994년 7월 26일 경기도내 7개 시군의 논구역 masking을 제작하여 NDVIred를 추출하고 $NDVI_R$-수량관계식을 이용하여 수량을 추정한 결과 1:1 line에 근접하여 비교적 잘 일치되었다.