• 소성∙가공
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• 제22권7호
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• pp.383-388
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• 2013

Metal flow of the beam blank during H-beam rolling was examined in order to correlate the rolling defects with the beam blank configuration. For this purpose, H-beam rolling was performed on the beam blank where stainless steel bolts were inserted as the marker at the web and flange. The positional variation of the marker was monitored at each rolling pass, and the result was compared with the 3D FEM simulation employing the point tracking function. The simulation results were reasonably agreed with the experimental within the error of 0.5~1mm on both web and flange of the H-beam. It is anticipated that the 3D FEM simulation employing the point tracking function provides the guidance information on analyzing the correlation between the rolling defects and the beam blank configuration in H-beam rolling.

• Journal of Hospice and Palliative Care
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• 제13권2호
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• pp.89-97
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• 2010

목적: 본 연구는 호스피스 간호 요구도와 삶의 질을 파악하여 호스피스 간호 중재 방안을 모색하고자 시도 되었다. 방법: 자료수집기간은 2006년 10월부터 2007년 3월까지이며 전라북도 소재 1개 대학 병원에 입원한 암환자 127명을 대상으로 하였다. 연구도구는 Kang과 Kim이 개발한 암환자의 호스피스 간호 요구도 측정도구와 Tae 등이 개발한 삶의 질 측정도구를 이용하였다. 수집된 자료는 SPSS Win 12.0을 이용하였으며, 실수와 백분율, 평균, 표준편차 t-test, ANOVA, Pearson correlation을 이용하여 분석하였다. 결과: 대상자의 호스피스 간호 요구도는 4점 만점에 평점 3.11점이었으며 가족지지 영역이 3.15점으로 가장 높게 나타났으며 다음이 심리적 영역이 3.12점, 신체적 영역이 3.10점, 영적 영역이 3.05점의 순으로 나타났다. 대상자의 삶의 질은 10점 만점에 평점 5.25점이었으며 영적 영역이 5.84점으로 가장 높았고 다음 심리적 영역이 5.18점, 신체적 영역이 5.06점, 사회적 영역이 5.01점의 순이었다. 대상자의 호스피스 간호 요구도와 삶의 질은 호스피스 간호 요구도가 높을수록 삶의 질이 낮게 나타나는 역 상관관계를 보였으며(r=-0.395, P=0.000), 호스피스 간호 요구도 4개 영역 중 신체적 요구가 삶의 질과 가장 강한 역 상관관계를 보였다(r=-0.388, P= 0.000). 대상자의 특성별 호스피스 간호 요구도는 종교(t=6.02, P=0.016), 암 투병기간(F=3.45, P=0.019)에 따라 차이가 있었으며, 삶의 질은 월수입(F=3.38, P=0.021), 암 병기(F=8.10, P=0.000), 항암화학요법(t=6.09, P=0.015)에서 통계적으로 유의한 차이가 있었다. 결론: 결론적으로 암환자의 삶의 질을 향상시키기 위해서는 호스피스 간호 요구를 파악하여야 하며, 동시에 종교, 암 투병기간, 월수입, 암 병기 등과 같은 대상자의 특성을 고려하여야 함을 제안하다.

• 대한유전성대사질환학회지
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• 제13권2호
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• pp.104-110
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• 2013

Purpose: Phenylketonuria (PKU) is the first inherited metabolic disease of which treatment is known. We performed this study to find out clinical symptoms and prognosis of tetrahydrobiopterin (BH4) responsive PKU patients and genetic relation. Methods: Clinical, biochemical, genetic analysis were done retrospectively in 23 patients diagnosed BH4 responsive PKU in Soonchunhyang University Hospital from March 2000 to September 2012. Results: Patients were classified to mild hyperphenylalaninemia and mild phenylketonuria with initial plasma phenylalanine level below 20 mg/dL. After BH4 loading, blood phenylalanine decrease level ranged between 37% and 99%. Initial treatment with low phenylalanine formula or BH4 was started before 2 month after birth except 2 patients. And one of them resulted in developmental delay in language and social activity. The others showed satisfactory progress without developmental delay. In genetic analysis, of 46 allele, R241C allele mutation was identified most commonly (41%). R241C/A259T, R241C/R243Q, R241C/V388M, R241C/T278I was detected in 5 (21.7%), 3 (13%), 2 (8%), 2 (8%) patients, respectively. Conclusion: R241C mutation was detected most frequently in this study group and R243Q mutation which is known to be prevalent in Korean PKU patients was found in 4 patients (8.6%). Early diagnosis and treatment is important in PKU patients.

• Industrial Engineering and Management Systems
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• 제12권4호
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• pp.380-388
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• 2013

Large variation in electrocardiogram (ECG) waveforms continues to present challenges in defining R-wave locations in ECG signals. This research presents a procedure to extract the R-wave locations by forward-backward (FB) algorithm and classify the arrhythmic beat conditions by using RR intervals. The FB algorithm shows forward and backward searching rules from QRS onset and eliminates lower-amplitude signals near the baseline using a statistical process control concept. The proposed algorithm was trained the optimal parameters by using MIT-BIH arrhythmia database (MITDB), and it was verified by actual Holter ECG signals from a local hospital. The signals are classified into normal (N) and three arrhythmia beat types including premature ventricular contraction (PVC), ventricular flutter/fibrillation (VF), and second-degree heart block (BII) beat. This work produces 98.54% accuracy in the detection of R-wave location; 98.68% for N beats; 91.17% for PVC beats; and 87.2% for VF beats in the collected Holter ECG signals, and the results are better than what are reported in literature.

• Journal of Microbiology and Biotechnology
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• 제8권4호
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• pp.388-398
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• 1998

A bacterium which is resistant to both mercury and cadmium, and also capable of utilizing phenol as a carbon and energy source, was isolated from the Kumho River sediments near Kangchang Bridge, Taegu, Korea. The isolate was labeled Pseudomonas sp. KM10 and characterized. The bacteria grew in 4 mM $CdCl_2$and in $70{\mu}M$ $HgCl_2$. The bacteria efficiently removed over 90% of 1 g/l phenol within 30 h. In the presence of 1.250 g/l phenol, the growth of the microorganism was slightly retarded and the microorganism could not tolerate 1.5 g/l phenol. Curing of plasmid from the bacteria was carried out to generate a plasmidless strain. Subsequent experiments localized the genes for phenol degradation in plasmid and the genes for mercury resistance and cadmium resistance on the chromosome. Dot hybridization and Southern hybridization under low stringent conditions were performed to identify the DNA homology. These results showed significant homologies between the some sequence of the chromosome of Pseudomonas sp. KM10 and merR of Shigella flexneri R 100, and between the some sequence of the chromosome of Pseudomonas sp. KM10 and cadA of Staphylococcus aureus pI258. The mechanism of cadmium resistance was efflux, similar to that of S. aureus pI258 cadA, and the mechanism of mercury resistance was volatilization, similar to that of S. flexneri R100 mer.

• 한국자원식물학회지
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• 제1권1호
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• pp.8-22
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• 1988

Vincristine and vinblastine isolated from Vinco spp. , and podophyllotoxine derivatives isolated from Podophyllum spp. are usefulas anticancerous components obtaned from higher plants. More thanten antineoplastic compounds are now following them as anticancerousagents from higher plants. In my laboratory, Sarcoma 180A has beenused as the first screening test. By this method, I have found outsome kinds of antineoplastic constituents from active plants extracts .For instance, bisaborane type compounds were isolated from Curcumaxanthorrhiza, one of Indonesian plants; a morphinane type compoundfromCocculus trilobus; cyclic hexapeptides from Rubia akane and R.cordiorta. Seven components having antineoplastic actirity wereisolated from Rubia spp. except. R. tinctoria. Their structures wereelucidated except RA-Vl by chemical reaction and variovs instrumentalanalysis as shown in Fig. Among of them, RA-Vll showed strong activityagainst P388 Lymphocytic leukemia, L2O, B16 melanoma, Lewis lungcarcinoma, colon 38 and Ehrlich carcinoma. RA-V revealed excellentactivity against MM2 mammary carcinoma. The· value of acute LD5O ofRA-ViI were 10. Omg/kg( iP) and 16.5mg/kg( po ) respectiveIy . Therapruticratio was 400, compared with 10 of mitomycin C. QSAR was also appliedto these compounds by elongation of ether and ester side chains atR'. Mechanism of action of RA-Vll was also investigated and wasassumed to be inhibition of protein biosynthesis .

• Journal of Microbiology and Biotechnology
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• 제15권2호
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• pp.388-394
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• 2005

In order to investigate the distribution of dominant Bifidobacterium species in intestinal microflora of Korean adults and seniors, SDS-PAGE profiles of whole cell proteins were used for the identification of bifidobacteria. To confirm the reliability of SDS-PAGE, the Bifidobacterium species identified by SDS-PAGE of whole cell proteins were validated by using 16S rDNA sequencing analysis. The results of SDS­PAGE corresponded well with those determined by the analysis of 16S rDNA sequencing. Based on the analysis of SDS-PAGE patterns on unidentified fecal strains which showed positive in fructose-6-phosphate phosphoketolase activity, B. adolescentis, B. longum, and B. bifidum were identified in the feces of adults, and B. adolescentis, B. longum, B. bifidum, B. breve, and B. dentium were identified in those of seniors. In most of the fecal samples tested, the predominant Bifidobacterium species consisted of only a few species, and differences in the distribution and numbers of Bifidobacterium species were observed between adults and seniors. B. adolescentis and B. longum were found to be the most common species in feces of adults, but not in seniors. Accordingly, the distribution and abundance of bifidobacteria in the human intestinal microflora varied depending on the age of hosts.

• Molecules and Cells
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• 제37권5호
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• pp.383-388
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• 2014

Renal cell carcinoma (RCC) is associated with a high frequency of metastasis and only few therapies substantially prolong survival. Honokiol, isolated from Magnolia spp. bark, has been shown to exhibit pleiotropic anticancer effects in many cancer types. However, whether honokiol could suppress RCC metastasis has not been fully elucidated. In the present study, we found that honokiol suppressed renal cancer cells' metastasis via dual-blocking epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) properties. In addition, honokiol inhibited tumor growth in vivo. It was found that honokiol could upregulate miR-141, which targeted ZEB2 and modulated ZEB2 expression. Honokiol reversed EMT and suppressed CSC properties partly through the miR-141/ZEB2 axis. Our study suggested that honokiol may be a suitable therapeutic strategy for RCC treatment.

• 대한원격탐사학회지
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• 제22권5호
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• pp.385-388
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• 2006

The land surface temperature (LST) can be defined as a weighted average temperature of components which constitute a pixel. The coefficients of split-window algorithm for MTSAT-1R were obtained by means of a statistical regression analysis from radiative transfer simulations using MODTRAN 4.0 for a wide range of atmospheric, satellite viewing angle (SVA) and lapse rate conditions. 6 types of atmospheric profile data imbedded in the MODTRAN 4 are used for the radiative transfer simulations. The RMSE is clearly larger on warm and humid profiles than cold and dry profiles, especially when the satellite viewing angle and lapse rate are large. The derivation of LST equations according to the atmospheric profiles clearly decreased the RMSE without regard to the SVA and lapse rate. The bias and RMSE are decreased as the more controls factors included. This preliminary result indicates that the characteristics of atmosphere, SVA and lapse rate should be included in the LST equation.

• 한국분말재료학회지
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• 제26권5호
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• pp.383-388
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• 2019

To improve the mechanical properties of aluminum, graphene has been used as a reinforcing material, yielding graphene-reinforced aluminum matrix composites (GRAMCs). Dispersion of graphene materials is an important factor that affects the properties of GRAMCs, which are mainly manufactured by mechanical mixing methods such as ball milling. However, the use of only mechanical mixing process is limited to achieve homogeneous dispersion of graphene. To overcome this problem, in this study, we have prepared composite materials by coating aluminum particles with graphene by a self-assembly reaction using poly vinylalcohol and ethylene diamine as coupling agents. The scanning electron microscopy and Fourier-transform infrared spectroscopy results confirm the coating of graphene on the Al surface. Bulk density of the sintered composites by spark plasma sintering achieved a relative density of over 99% up to 0.5 wt.% graphene oxide content.