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The Therapeutic Effect of Angiotensin II Receptor Antagonist in Idiopathic Pulmonary Fibrosis (특발성 폐섬유화증 환자의 치료에서 Angiotensin II Receptor Antagonist의 치료효과)

  • Woo, Duck Soo;Seol, Won Jong;Kyung, Sun Young;Lim, Young Hee;An, Chang Hyeok;Park, Jeong Woong;Jeong, Sung Hwan;Lee, Jae Woong
    • Tuberculosis and Respiratory Diseases
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    • v.55 no.5
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    • pp.478-487
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    • 2003
  • Background : There have been several studies showing that the angiotensin II and angiotensin converting enzyme(ACE) contributes to the apoptosis of alveolar epithelial cells in idiopathic interstitial pneumonia and the activation of fibroblasts during the process of pulmonary fibrosis. These results suggest that the pulmonary fibrosis can be inhibited by the angiotensin II receptor antagonist(AGIIRA). This study was performed to identify the therapeutic effect of AGIIRA in idiopathic pulmonary fibrosis(IPF). Method : Thirteen patients with IPF, who were diagnosed with an open lung biopsy(6 patients) and furfilling the ATS criteria(7 patients) between March 1999 and October 2001 at the Gachon medical center, were enrolled in this study. Of these patients, eight patients were treated with a regimen including AGIIRA(AT group), and five were treated without AGIIRA(NT group). The pulmonary function tests and dyspnea(ATS scale) were measured at diagnosis and 1 year after treatment. All the data was collected to analyze the therapeutic effect of AGIIRA on the patients with IPF. Results : The AT group contained 8 patients(M:F=4:4) and the NT group contained 5 patients(M:F=3:2). There was no significant difference in the serum angiotensin II level between the two groups($202.5{\pm}58.5$ vs $163.7{\pm}47.3pg/ml$, p>0.05). The AT group showed an upward trend in TLC(+3%), FVC(+4%), FEV1(+3%) and DLco(+2%) compared to the NT group(TLC(-14%), FVC(-3%), FEV1(-4%) except for DLco(+5%)). The dyspnea score in the AT group improved significantly but not in the NT group. Conclusion : These results suggest that the angiotensin II receptor antagonist may have an effect on stabilizing IPF.

Studies on the improvement of Nursery method for Late-seasonal Cultivation of Rice Varieties (Indica × Japonica) (통일계(統一系) 수도품종(水稻品種)의 만식재배(晩植栽培)를 위(爲)한 육모방법(育苗方法) 개선(改善)에 관(關)한 연구(硏究))

  • Choi, B.Y.;Jo, J.S.;Lee, J.C.
    • Korean Journal of Agricultural Science
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    • v.3 no.1
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    • pp.11-16
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    • 1976
  • This experiment was carried out to determine the most adequate type and period of nursery for the late seasonal cultivation of the new varieties of rice, Yusin and Josaengtongil. The results obtained are summarized as follows: 1. Semi-hot up-land nursery was much effective for the increase of the number of tillerings and the roots of rise seedlings compared with the semi-hot low-land nursery. The number of tillerings and roots was increased in 60 days seedlings compared with 50 or 60 days seedlings. 2. The abnormal heading has not appeared at the variety Yusin at all. The seedlings of Josaengtongil grown over 50 days at the semi-hot low-and nursery showed the abnormal heading, but the abnormal heading was not checked out at the seedlings of same variety grown for 60 days on the semi-hot upland nursery. 3. On the nursery not to cause the abnormal heading, earlier seeding was much effective for the hastening of the heading time and the hastening effect of heading time by earlier seeding was significantly greater at the variety Josaengtongil than Yusin 4. The number of ears per hill was significantly increased in the seedlings from the semi-hot up-land nursery compared with the semi-hot low-land nursery. 5. When the growing period of rice seedlings was not considered, the semi-hot up-land nursery resulted in higher yield of rice than the semi-hot low-land nursery. Considering the growing periods of rice seedlings, 40 days seedlings showed high yield at the semi-hot low-land nursery, however, at the semi-hot up-land nursery, 60 days seedlings showed higher yield of rice.

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Effect of Enzymes Application in Feed with Reduced Concentrations of Energy and Crude Protein in Broiler Chickens (육계에서 에너지 및 조단백질 저감 사료 내 효소제의 적용 효과)

  • Kim, Woong Lae;Kwon, So Hee;Kim, Kwan Eung;Kim, Eun Jib;An, Su Hyun;Kong, Changsu;Kim, Soo Ki;An, Byoung Ki
    • Korean Journal of Poultry Science
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    • v.47 no.3
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    • pp.143-151
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    • 2020
  • This study investigated the effects of the addition of commercial enzyme products to broiler feed with reduced levels of metabolizable energy and crude protein on the growth performance, blood profiles, and cecal microflora. A total of 750 seven-day-old male Ross 308 broiler chicks were randomly allotted to five treatment groups with six replicates (25 birds/replicate) for 28 days. A corn-wheat-soybean meal-based diet was formulated to meet or exceed the nutrient recommendations and used as the control diet. Experimental diets with metabolizable energy reduced by 100 kcal/kg and crude protein by 1% were formulated containing four different commercial enzyme products. Feed intake and weight gain were not affected by the dietary treatments; however, feed conversion ratios were significantly lower (P<0.01) in the control group than in the other treatment groups during the entire experimental period. There were no significant differences in the blood profiles and cecal microflora between the dietary treatments. However, the viscosity of jejunal contents in chicks fed a diet with enzyme B was significantly lower than that in the other groups. The tentative marketing age was unaffected by any of the dietary treatments, and ranged from 26.39 d to 26.84 d. Collectively, the use of commercial enzymes contributed to a similar weight gain as that in chicks fed diets with reduced energy and crude protein levels; however, it failed to maintain the feed conversion ratio.

Treatment of $Smilax$ $china$ L. Root Extract for Improvement of Storage Stability of $Mang-gae$ Rice Cake (망개떡의 저장성 향상을 위한 청미래덩굴 뿌리 추출물의 첨가)

  • Ko, Yu-Jin;Kim, Jin-Yong;Kim, Eun-Jung;Kim, Eun-Ja;Seol, Hui-Gyeong;Park, Geun-Hye;Chung, Gwon-Yong;Ryu, Chung-Ho
    • Food Science and Preservation
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    • v.19 no.2
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    • pp.167-172
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    • 2012
  • The antimicrobial activities of $Smilax$ $china$ L. against spoilage bacteria isolated from $Mang-gae$ rice cake were investigated and the storage stability of the $Mang-gae$ rice cake was enhanced. Spoilage bacteria, which cause $Mang-gae$ rice cake to rot, were isolated from commercial $Mang-gae$ rice cake, and most of the isolated strains were identified as $Bacillus$ sp. After the leaves, roots, shoots, and stalks of the $Smilax$ $china$ L. were extracted using 50% ethanol as the solvent, their antimicrobial activities were investigated using the paper disc method by treating them with 50 ${\mu}L$ of $Bacillus$ $cereus$, which is known as a major pathogenic micro-organism in foods that contain starch, as the test organism. The antimicrobial activities of the extracts were compared according to the size of the clear zones around the paper discs. The root extract showed significant antimicrobial activities. When red beans, which are used as stuffing for $Mang-gae$ rice cake, were treated with the root extract of the $Smilax$ $china$ L., the viable cell count of the $Mang-gae$ rice cake was 5.04 Log CFU/g after 48-hr storage, and the cake showed significantly slower growth of bacteria than with commercial products. These results show that treatment of red beans with $Smilax$ $china$ root extract could improve the storage stability of $Mang-gae$ rice cake.

Weed Occurrence and Yield of Rice in Transplanting Rice Culture with Paper Mulching (종이멀칭 이앙재배에서 잡초발생과 벼의 생육 및 수량)

  • Lee, B.W.;Cui, R.X.;Lee, H.L.
    • Korean Journal of Weed Science
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    • v.17 no.4
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    • pp.368-374
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    • 1997
  • Investigated ware the decomposition of mulch paper, weed occurrence, and rice growth and yield in transplanting rice culture with paper mulching in 1996 and 1997. The mulch paper were developed from domestic old corrugated container. In the experiment of 1996 where 25 percent of nitrogen fertilizer was applied as tillering fertilizer at 15 days after transplanting, it took about 28 to 40 days for the mulch paper to reach 50 percent decomposition according to types of mulch paper and fertilizer amount. The decomposition was faster in 18kg N/10a fertilization plot than in 12kg N/10a fertilization plot, and slower in the mulch paper treated with polyamidepolyamine epichlorohydrin resin(PPE) for the reinforcement of wet strength than in the mulch paper without PPE. In the experiment of 1997 where nitrogen fertilizer was not applied at tillering stage and instead 70 percent of nitrogen fertilizer was supplied as basal fertilizer, it took more than 42 days for the mulch paper(PPF treated) to reach 50 percent decomposition. Paper mulching was found to be very effective in controlling the paddy weeds at early stage of rice growth, but the efficacy, of weed control decreased especially in the mulch paper without PPE at later stage of rite growth due to the occurrence of Ludwigia prostrata in 1996. Few weeds occurred even in non-mulched plot without herbicide in 1997, rending difficulties in evaluating the efficacy of mulch paper in weed control, However, it could be deduced from the durability of mulch paper that paper mulching would have had sufficient efficacy of weed control. Rice yield was only 185kg/10a in the plot without mulching and weed control, but 657kg/10a and 771kg/10a in the paper(PPE treated) mulching plot with 12kgN/10a and 18kgN/10a, respectively, in 1996. The paper mulching plot showed rice yield similar to the weed control plot with herbicide in 1997. It would be concluded that paper mulching could ensure effective weed control and as high yield as the conventional rice cultivation with herbicidal weed control if the corresponding amount of basal nitrogen fertilizer is increased instead of omitting the nitrogen fertilizer at tillering stage.

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Regionality and Variability of Net Primary Productivity and Rice Yield in Korea (우리 나라의 순1차생산력 및 벼 수량의 지역성과 변이성)

  • JUNG YEONG-SANG;BANG JUNG-HO;HAYASHI YOSEI
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.1 no.1
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    • pp.1-11
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    • 1999
  • Rice yield and primary productivity (NPP) are dependent upon the variability of climate and soil. The variability and regionality of the rice yield and net primary productivity were evaluated with the meteorological data collected from Korea Meteorology Administration and the actual rice yield data from the Ministration of Agriculture and Forestry, Korea. The estimated NPP using the three models, dependent upon temperature(NPP-T), precipitation(NPP-P) and net radiation(NPP-R), ranged from 10.87 to 17.52 Mg ha$^{-1}$ with average of 14.69 Mg ha$^{-1}$ in the South Korea and was ranged 6.47 to 15.58 Mg ha$^{-1}$ with average of 12.59 Mg ha$^{-1}$ in the North Korea. The primary limiting factor of NPP in Korea was net radiation, and the secondary limiting factor was temperature. Spectral analysis on the long term change in air temperature in July and August showed periodicity. The short periodicity was 3 to 7 years and the long periodicity was 15 to 43 years. The coefficient of variances, CV, of the rice yield from 1989 to 1998 ranged 3.23 percents to 12.37 percents which were lower than past decades. The CV's in Kangwon and Kyeongbuk were high while that in Chonbuk was the lowest. The prediction model based on th e yield index and yield response to temperature obtain ed from the field crop situation showed reasonable results and thus the spatial distributions of rice yield and predicted yield could be expressed in the maps. The predicted yields was well fitted with the actual yield except Kyungbuk. For better prediction, modification should be made considering radiation factor in further development.

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Analysis of Influential Factors from Rainfall to Stream Water Quality in Small Forested Watershed - pH, dissolved oxygen, electrical conductivity - (산림유역내(山林流域內) 강수(降水)로부터 계류수질(溪流水質)에 미치는 영향인자(影響因子) 분석(分析) - pH, 용존산소(溶存酸素), 전기전도도(電氣傳導度) -)

  • Park, Jae-Hyeon;Woo, Bo-Myeong
    • Journal of Korean Society of Forest Science
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    • v.86 no.4
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    • pp.489-501
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    • 1997
  • This research was conducted to analyze the influence of the environmental factors on water quality such as pH, dissolved oxygen, and electrical conductivity of rainfall, throughfall, soil water(A and B layer), and stream water quality at a small forested watershed. Rainfall, throughfall, soil water(A and B layer), and stream water were sampled at the study sites in Kwanak Arboretum, Seoul National University in Mt. Kwanak for 14 months(Jul. 1, 1996~Aug. 31, 1997). Average rainfall pH value was 6.06(ranged from 5.02 to 6.60). Acid rain frequency(less than pH 5.6) was 16.7%. The lowest rainfall pH value was 5.02. Average of pH values in hydrological processes were decreasing in the following order, stream water>soil water [Prunus serrulata var, spontanea(B layer>A layer)]>throughfall(Prunus serrulata var. spontanea)>soil water [Carpinus laxiflora(B layer >A layer)]>throughfall(Carpinus laxiflora)>rainfall>soil water [Pinus rigida(B layer>A layer)]>throughfall(Pinus rigida). pH values of throughfall in Prunes serrulata var. spontanea and Carpinus laxiflora were higher in Pines rigida. Average of dissolved oxygen values in hydrological processes were decreasing in the order, stream water>throughfall(Carpinus laxiflora>Prunus serrulata var, spontanea>Pines rigida)>rainfall>soil water [Prunes serrulata var. spontanea(A layer)>Pines rigida(A layer)>Carpinus laxiflora(A layer)>Prunes serrulata var. spontanea(B layer)>Pines rigida(B layer)>Carpinus laxiflora(B layer)]. And average electrical conductivity values in hydrological processes were decreasing in the order, soil water (B layer>A layer)>throughfall(Pinus rigida>Prunes serrulata var, spontanea>Carpinus laxiflora)>stream water>rainfall. Multiple regression equations of electrical conductivity and $Mg^{2+}$, $Na^+$, total amount of cation, total amount of ion, and no. of before non-rain days in rainfall, throughfall, soil and stream water shows high significance(Multi R; 0.84).

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Comparison of Thatch Accumulation in Warm-Season and Cool-Season Turfgrasses under USGA and Mono-layer Soil Systems (USGA 지반 및 약식지반에서 난지형과 한지형 잔디의 대취축적 비교)

  • Kim, Kyoung-Nam;Kim, Byoung-Jun
    • Journal of the Korean Institute of Landscape Architecture
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    • v.38 no.1
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    • pp.129-136
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    • 2010
  • This study was initiated to investigate thatch accumulation in several turfgrasses grown under two soil systems. The 45 centimeter deep USGA system was constructed with rootzone, intermediate and drainage layers. The mono-layer system, however, was made with only a 30cm rootzone layer. Turfgrasses used in the study were comprised of 3 varieties from Korean lawngrass of Warm-Season Grass(WSG) and 3 blends and 3 mixtures from Cool-Season Grass(CSG). A total of 9 turfgrass treatments were replicated three times in RCBD in both systems. Cultural practices for the research plot followed a typical maintenance program for highly managed turf. Treatment differences for thatch accumulation were observed among the turfgrasses in both soil systems. Thatch under the USGA system was 9% greater than under the mono-layer system due to its more favorable conditions for turf growth. Higher thatch depth was found with Korean lawngrass, 34~87% in the USGA system and 16~75% in the mono-layer system when compared with CSG. Among WSG, the Joongji variety was the highest in thatch layer under both the USGA and mono-layer systems. Kentucky bluegrass(KB) was the greatest among CSG, since it is a rhizomatous-type in growth habit, resulting in faster production of organic matter over bunch-type of tall fescue and perennial ryegrass. Proper depth in the thatch layer was known to be beneficial by enhancing the resiliency and wear tolerance of the turf in athletic fields. Thus, KB was considered to be a very excellent turfgrass in terms of turf quality, environmental performance, physical properties and soccer player safety. However, disadvantages such as poor water-holding properties, more inclined to injury from environmental stresses and severe diseases and insect injury were also expected where thatch was excessively accumulated. Therefore, these results demonstrate that more frequent measures for controlling thatch such as vertical mowing, topdressing or coring should be employed for soccer fields with Korean lawngrass and KB over other turfgrasses.

A Study on Trust Transfer in Traditional Fintech of Smart Banking (핀테크 서비스에서 오프라인에서 온라인으로의 신뢰전이에 관한 연구 - 스마트뱅킹을 중심으로 -)

  • Ai, Di;Kwon, Sun-Dong;Lee, Su-Chul;Ko, Mi-Hyun;Lee, Bo-Hyung
    • Management & Information Systems Review
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    • v.36 no.3
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    • pp.167-184
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    • 2017
  • In this study, we investigated the effect of offline banking trust on smart banking trust. As influencing factors of smart banking trust, this study compared offline banking trust, smart banking's system quality, and information quality. For the empirical study, 186 questionnaire data were collected from smart banking users and the data were analyzed using Smart-PLS 2.0. As results, it was verified that there is trust transfer in FinTech service, by the significant effect of offline banking trust on smart banking trust. And it was proved that the effect of offline banking trust on smart banking trust is lower than that of smart banking itself. The contribution of this study can be seen in both academic and industrial aspects. First, it is the contribution of the academic aspect. Previous studies on banking were focused on either offline banking or smart banking. But this study, focus on the relationship between offline banking and online banking, proved that offline banking trust affects smart banking trust. Next, it is the industrial contribution. This study showed that offline banking characteristics of traditional commercial banks affect the trust of emerging smart banking service. This means that the emerging FinTech companies are not advantageous in the competition of trust building compared to traditional commercial banks. Unlike traditional commercial banks, the emerging FinTech is innovating the convenience of customers by arming them with new technologies such as mobile Internet, social network, cloud technology, and big data. However, these FinTech strengths alone can not guarantee sufficient trust needed for financial transactions, because banking customers do not change a habit or an inertia that they already have during using traditional banks. Therefore, emerging FinTech companies should strive to create destructive value that reflects the connection with various Internet services and the strength of online interaction such as social services, which have an advantage over customer contacts. And emerging FinTech companies should strive to build service trust, focused on young people with low resistance to new services.

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Factors that affect the Behavior on the Radiation Safety Management for Dental Hygienists (치과위생사들의 방사선 안전관리행위에 영향을 미치는 요인)

  • Jeong, Young-Hee;Kwon, Yang-Ok;Lee, Ji-Young;Heo, Seong-Eun;Yoon, Young-Suk
    • Journal of dental hygiene science
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    • v.11 no.6
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    • pp.471-479
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    • 2011
  • This research, which was conducted for dental hygienists, intended to check out what factors have an influence on their behaviors by measuring the level of self-efficacy and consciousness on the use of radiation, knowledge and attitude on radiation safety management(RSM). The subjects were 235 of the dental hygienists and this study performed a survey 8 May to 17 June, 2011. The survey results were as follows. 1. As a result of comparing the average of the self-efficacy according to the general characteristics, a statistically meaningful difference(p<0.05) was found according to health condition, protection facilities condition. 2. As a result of comparing the average of consciousness about radiation use according to the general characteristics, a statistically meaningful difference(p<0.05) was found according to medical institute type, protection facilities conditions. 3. As a result of comparing the average of the behaviors for RSM according to the general characteristics, a statistically meaningful difference(p<0.05) was found according to monthly income, medical institute type, whether or not education on radiation was conducted, the number of education, education type, and protection facilities condition. 4. As a result of analyzing what factors have an influence on the behaviors for RSM by employing the points of those behaviors as a dependent variable and self-efficacy, consciousness, knowledge and attitude as an independent variable in order to investigate those factors, it turned out that the factors which had a relatively larger influence on the point of behaviors were attitude and self-efficacy by that order(p<0.05). In conclusion, we believe that a variety of programs should be offered to provide knowledge on RSM as a prerequisite for improving the level of RSM behaviors by dental hygienists.