• Molecules and Cells
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• v.41 no.9
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• pp.842-852
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• 2018

Notch signaling is an evolutionarily conserved pathway and involves in the regulation of various cellular and developmental processes. Ligand binding releases the intracellular domain of Notch receptor (NICD), which interacts with DNA-bound CSL [CBF1/Su(H)/Lag-1] to activate transcription of target genes. In the absence of NICD binding, CSL down-regulates target gene expression through the recruitment of various corepressor proteins including SMRT/NCoR (silencing mediator of retinoid and thyroid receptors/nuclear receptor corepressor), SHARP (SMRT/HDAC1-associated repressor protein), and KyoT2. Structural and functional studies revealed the molecular basis of these interactions, in which NICD coactivator and corepressor proteins competitively bind to ${\beta}-trefoil$ domain (BTD) of CSL using a conserved ${\varphi}W{\varphi}P$ motif (${\varphi}$ denotes any hydrophobic residues). To date, there are conflicting ideas regarding the molecular mechanism of SMRT-mediated repression of CSL as to whether CSL-SMRT interaction is direct or indirect (via the bridge factor SHARP). To solve this issue, we mapped the CSL-binding region of SMRT and employed a 'one- plus two-hybrid system' to obtain CSL interaction-defective mutants for this region. We identified the CSL-interaction module of SMRT (CIMS; amino acid 1816-1846) as the molecular determinant of its direct interaction with CSL. Notably, CIMS contains a canonical ${\varphi}W{\varphi}P$ sequence (APIWRP, amino acids 1832-1837) and directly interacts with CSL-BTD in a mode similar to other BTD-binding corepressors. Finally, we showed that CSL-interaction motif, rather than SHARP-interaction motif, of SMRT is involved in transcriptional repression of NICD in a cell-based assay. These results strongly suggest that SMRT participates in CSL-mediated repression via direct binding to CSL.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.41 no.3
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• pp.176-185
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• 2018

With the recent development of manufacturing technology and the diversification of consumer needs, not only the process and quality control of production have become more complicated but also the kinds of information that manufacturing facilities provide the user about process have been diversified. Therefore the importance of big data analysis also has been raised. However, most small and medium enterprises (SMEs) lack the systematic infrastructure of big data management and analysis. In particular, due to the nature of domestic manufacturing companies that rely on foreign manufacturers for most of their manufacturing facilities, the need for their own data analysis and manufacturing support applications is increasing and research has been conducted in Korea. This study proposes integrated analysis platform for process and quality analysis, considering manufacturing big data database (DB) and data characteristics. The platform is implemented in two versions, Web and C/S, to enhance accessibility which perform template based quality analysis and real-time monitoring. The user can upload data from their local PC or DB and run analysis by combining single analysis module in template in a way they want since the platform is not optimized for a particular manufacturing process. Also Java and R are used as the development language for ease of system supplementation. It is expected that the platform will be available at a low price and evolve the ability of quality analysis in SMEs.

• Korean Chemical Engineering Research
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• v.49 no.4
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• pp.498-504
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• 2011

In this research, hollow fiber membranes were used in order to investigate to permeation and selectivity of the $CH_4$ and $N_2$. Polyimide and polyethersulfone hollow fiber membrane were prepared by the dry-wet phase inversion method and the module was manufactured by fabricating fibers after surface coating with silicone elastomer. The scanning electron microscopy (SEM) studies showed that the produced fibers typically had an asymmetric structure. The permeance of $CH_4$ and $N_2$ were increased with pressure and temperature. However, the selectivity was decreased with increasing temperature. The permeances of $CH_4$ and $N_2$ were decreased with increasing the air gap and the effect of post-treatment on membrane showed the increase in permeance up to 3.2~7.0 times.

• Journal of Convergence for Information Technology
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• v.10 no.1
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• pp.139-148
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• 2020

As the internet and computer technology are developed, there is a need for service of traditional culture that can effectively search and create culture, history, and tradition-related materials in online contents. In this paper, we developed an RDF-based ontology retrieval service platform and verified usability and validity. This platform is divided into triple search, keyword search, network graph search, story search and management, curation management module. Based on this, the search results can be visualized based on the relationship between data, network graph search and story search can be used to easily understand the relationship between the keywords. An platform evaluation was conducted for verification, and it was evaluated that an intelligent search that can easily identify the relationship between information and shorten the analysis and search time than the existing search function.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.38 no.1
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• pp.69-78
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• 2001

This paper presents the design and FPGA implementation of a FLEX PSP(Protocol Signal Processor) for the portable high speed paging system. In this approach, two algorithms are newly proposed for implementing the PSP which provides capabilities of the maximum 6,400bps at speed, high-channel throughput, real time error correction and an effective frame search function. One is an accurate symbol synchronization algorithm which is applied for synchronizing the interleaved 4-level bit symbols which are received at input stage of A/D converter, and the other is a modified fast decoding algorithm which is provided for realizing double error correction of (31,21)BCH signal. The PSP is composed of six functional modules, and each module is modelled in VHDL(VHSIC Hardware Description Language). Both functional simulation and logic synthesis have performed for the proposed PSP through the use of Synopsys$^{TM}$ tools on a Axil-320 Workstation, and where Altera 10K libraries are used for logic synthesis. From logic synthesis, we can see that the number of gates is about 2,631. For FPGA implementation, timing simulation is performed by using Altera MAX+ PLUS II, and its results will be also given. The PSP which is implemented in 6 FPGA devices on a PCB has been verified by means of Logic Analyzer.r.

• Journal of Digital Contents Society
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• v.18 no.2
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• pp.403-410
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• 2017

In this paper, the fire extinguisher maintenance system using smart NFC communication and the real-time pressure measurement is proposed. The proposed system consists of three steps in the flow of information. The first step is to identify the fire extinguisher through NFC tagging in the fire extinguisher module using the smart device. The fire extinguisher appearance check and the real-time pressure measurement is performed in the second step, and the last step sends the check status information to the management server. In particular, the actual pressure value is calculated based on the angle of the green area and the indicating needle. Some experiments are conducted so as to verify the proposed system, and as a result, the proposed system shows that the administrator can effectively control the status information of fire safety check.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.44 no.2 s.314
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• pp.1-10
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• 2007

Branch prediction accuracy is critical for the overall system performance. Branch miss-prediction penalty is the one of the significant performance limiters for improving processor performance, as the pipeline deepens and the instruction issued per cycle increases. In this paper, we propose "Dynamic Per-Branch History Length Fitting Method" by tracking the data dependencies among the register writing instructions. The proposed solution first identifies the key branches, and then it selectively uses the histories of the key branches. To support this mechanism, we provide a history length adjustment algorithm and a required hardware module. As the result of simulation, the proposed mechanism outperforms the previous fixed static method, up to 5.96% in prediction accuracy. Furthermore, our method introduces the performance improvement, compared to the profiled results which are generally considered as the optimal ones.

• Korean Journal of Optics and Photonics
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• v.16 no.1
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• pp.50-55
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• 2005

A method for measuring the wavefront error and the modulation transfer function(MTF) of large aperture optics using an unequal path interferometer is presented. A bidirectional shearing interferometer is used for collimation testing of the measurement system. A large aperture Fizeau interferometer with long optical path difference measures the wavefront error of the optics under test by using a $\Phi$ 400 mm off-axis parabolic mirror. The MTF is also measured at the wavelength of the interferometer by changing the laser light into partially incoherent light. Test results of a $\Phi$ 300 mm Cassegrain type satellite telescope made in Korea are presented.

• Korean Journal of Optics and Photonics
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• v.16 no.1
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• pp.56-62
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• 2005

Because of the wide plane and the curved field of CRT rear projection high definition television, its MTF(modulation transfer function) can't be easily measured by the usual forward testing method. Then we propose a backward testing method for the MTF so that the object plane and the image analyzer of forward testing are located at positions opposite each other. We prefer to use the backward testing method because the forward testing method has poor accuracy caused by very small numerical aperture, low spatial resolutions, and long depth of focus. We found that the backward testing method was very easy to align and had high repeatability. We confirmed the confidence of results obtained by the backward testing method in comparison with designed results.

• Journal of Korea Society of Industrial Information Systems
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• v.19 no.5
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• pp.103-115
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• 2014

Mobile-Office is the IT office that enables people handle their business anywhere and anytime without going to head office. It has propagated rapidly in domestic and foreign companies as the users who use mobile terminal such as smartphone have increased sharply. Mobile-Office is emerging as a new way of conducting business. It requires business environment to be changed to improve business efficiency, as fast-growing mobile-based economies emerges. Small and medium-sized companies's utilization ability for advanced IT technology is insufficient, and limitations exist on capacity of building and investment. They need different development methodologies and utilization methods. The purpose of this study is not only to consider the previous business environment problem on accessibility, mobility, effectiveness, complexity and consolidation, but to search more efficient methods for introducing applications to utilize various smart devices and websites with minimum investment in R&D.