• Molecules and Cells
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• v.39 no.4
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• pp.299-309
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• 2016

We have previously reported the role of miR-217 in anti-cancer drug-resistance. miRNA array and miRNA hybridization analysis predicted miR-30a-3p as a target of miR-217. miR-30a-3p and miR-217 formed a negative feedback loop and regulated the expression of each other. Ago1 immunoprecipitation and co-localization analysis revealed a possible interaction between miR-30a-3p and miR-217. miR-30a-3p conferred resistance to anti-cancer drugs and enhanced the invasion, migration, angiogenic, tumorigenic, and metastatic potential of cancer cells in CAGE-dependent manner. CAGE increased the expression of miR-30a-3p by binding to the promoter sequences of miR-30a-3p, suggesting a positive feedback loop between CAGE and miR-30a-3p. miR-30a-3p decreased the expression of p53, which showed the binding to the promoter sequences of miR-30a-3p and CAGE in anti-cancer drug-sensitive cancer cells. Luciferase activity assays showed that p53 serves as a target of miR-30a. Thus, the miR-30a-3p-CAGE-p53 feedback loop serves as a target for overcoming resistance to anti-cancer drugs.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.1270-1275
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• 2004

Flow condensation heat transfer coefficients(HTCs) of R22 and R134a were measured on horizontal aluminum multi-channel tube. The experimental apparatus was composed of three main parts ; a refrigerant loop, a water loop and a water-ethylene glycol loop. The test section in the refrigerant loop was made of aluminum multi-channel tube of 1.4 mm hydraulic diameter and 0.53 m length. The refrigerant was cooled by passing cold water through an annulus surrounding the test section. The data scan vapor qualities $(0.1{\sim}0.9)$, mass flux ($200{\sim}400$ $kg/m^{2}s$) and heat flux ($7.3{\sim}7.7$ $kW/m^{2}$) at $40{\times}0.2^{\circ}C$ saturation temperature in small hydraulic diameter tube. It was found that some well-known previous correlations were not suitable for multichannel tube. So, It must develop new correlations for multi-channel tubes.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.3
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• pp.397-403
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• 2016

Generally, an electrical distribution configuration is a radial system with one-way current in a distribution management system (DMS). All feeders in a DMS have tie-switches to make radial system. Sometimes, DMS should change a tie-switch for operation. In that case, the tie-switch has to be closed first; then a switch is opened as another tie-switch in order to prevent blackout for customers. At the moment when the tie-switch is closed, distribution system is operated in a loop state, not radial. Before the loop operation, DMS operator has to check any expected events for stable distribution system operation; and the most important event is a mis-operation of a protection relay. In addition, DMS operator should check voltage profile violation but a calculation method of section voltages had not been used. Thus, this paper proposes a calculation method of section voltages at a loop operation in a DMS. The proposed calculation algorithm is verified by Matlap Simulink.

• Nuclear Engineering and Technology
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• v.52 no.2
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• pp.271-278
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• 2020

The investigation into a full-scale 27 m high, by 6 m wide, thermosyphon loop. The simulation model is based on a one-dimensional axially-symmetrical control volume approach, where the loop is divided into a series of discreet control volumes. The three conservation equations, namely, mass, momentum and energy, were applied to these control volumes and solved with an explicit numerical method. The flow is assumed to be quasi-static, implying that the mass-flow rate changes over time. However, at any instant in time the mass-flow rate is constant around the loop. The boussinesq approximation was invoked, and a reasonable correlation between the experimental and theoretical results was obtained. Experimental results are presented and the flow regimes of the working fluid inside the loop identified. The results indicate that a series of such thermosyphon loops can be used as a cavity cooling system and that the one-dimensional theoretical model can predict the internal temperature and mass-flow rate of the thermosyphon loop.

• East Asian mathematical journal
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• v.36 no.3
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• pp.365-376
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• 2020

Nonalcoholic fatty liver is a type of fatty liver in which fat accumulates in the liver without alcohol. In the accumulation, Nrf1 and miR-378 genes play very important role, so called negative feedback loop, in which the two genes suppress the other's production. In other words, Nrf1 activates fatty acid oxidation which promotes fat consumption in the liver, while miR-378 deactivates fatty acid oxidation. Thus, both genes regulate nonalcoholic fatty liver. In this paper, the negative feedback loop of Nrf1 and miR-378 are expressed by a system of ordinary differential equations. And, bifurcation simulation shows the change in the amount of each gene with significant parameter range changes. Bifurcation simulation has also used to determine the thresholds for transit between disease and steady state.

• 제어로봇시스템학회:학술대회논문집
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• 2001.10a
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• pp.156.5-156
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• 2001

Stabilized tracking platform in a missile consisting of a flat planar antenna, pitch/yaw gimbals, gear trains, and current controlled DC drive motors for pitch and yaw gimbal must have a capability to track a target as an inertial sensor in the presence of missile body motion such as maneuvering and vibration. Because of this reason, tracking a target from dynamic platform requires a servo architecture that includes a outer tracking loop(position loop) and inner rate loop that stabilizes the line of sight(LOS). This paper presents a gimbaled platform model including nonlinear phenomena due to viscous and Coulomb friction based on experimental data and torque equilibrium equation, the design concept for the inner tacholoop having P controller structure ...

• Proceedings of the KIPE Conference
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• 2003.07b
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• pp.965-968
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• 2003

This paper describes the PWM-VSI controller of three-phase UPS system using stationary reference frame. This controller meets the specification the UPS inverter output voltage even under the unbalanced or nonlinear load. This controller is also constructed with duble control loop of the outer voltage control loop and the inner current control loop. For the fast response of the output voltage control, yhr inner current control loop of the capacitor current os used. To get the good property against overshoot, the If controller us used. The outer voltage controller is designed with P controller and the high gain transfer function is used for the zero steady state error. All control gains of both controller is designed base on the CDM method.

• Proceedings of the Korean System Dynamics Society
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• 2004.02a
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• pp.19-52
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• 2004

This study aims to grasp invisible yet dynamic systemic structure that influences the general procedure of national R＆D investment system in Korea using "system dynamic methods and to suggest policy lever. Various conflicting situations, 'R＆D investment paradoxes' in myopia investment and principal-agent problems etc, arise when the government decides R＆D investment area and makes indispensable choice. Difficulty in the decision can be amplified due to misalignments among decision on adequate amount of R＆D investment ("strategic loop"), R＆D system ("structural loop") and acceptance and realization by R＆D laboratories and theirs researcher ("efficacy loop"). Results of modeling and simulation of korea national R＆D investment system with consideration of three causal loops show the switching pattern dynamically, in which form of technologies shifts from one to another stage like paradigm shift, when the R＆D investment reaches a certain stork. R＆D investment increases are directly not liked to R＆D productivities because of delays and side effects during transition periods between different stages of technology development. Thus, It is necessary to develope strategies in order to enhance efficiency of technological development process by perceiving the switching pattern.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.25 no.2
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• pp.180-186
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• 2001

The condensation heat transfer coefficients of pure refrigerants R-22, R-134a, and a binary refrigerant mixture R-410A flowing in a small diameter tube were investigated. The experiment apparatus consists of a refrigerant loop and a water loop. The main components of the refrigerant loop consist of a variable-speed pump, a mass flowmeter, an evaporator, and a condenser(test section). The water loop consists of a variable-speed pump, an isothermal tank, and a flowmeter. The condenser is a counterflow heat exchanger with refrigerant flowing in the inner tube and water flowing in the annulus. The test section consists of smooth, horizontal copper tube of 3.38mm outer diameter and 1.77mm inner diameter. The length of test section is 1220mm. The refrigerant mass fluxes varied from 450 to 1050kg/(㎡$.$s) and the average inlet and outlet qualities were 0.05 and 0.95, respectively. The main results were summarized as follows ; in the case of single-phase flow, the heat transfer coefficients increase with increasing mass flux. The heat transfer coefficient of R-410A was higher than that of R-22 and R-134a, and the heat transfer for small diameter tubes were about 20% to 27% higher than those predicted by Gnielinski. In the case of two-phase flow, the heat transfer coefficients also increase with increasing mass flux and quality. The condensation heat transfer coefficient of R-410A was slightly higher than that of R-22 and R-134a. Most of correlations proposed in the large diameter tube showed significant deviations with experimental data except for the ranges of low quality and low mass flux.

• Kyungpook Mathematical Journal
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• v.28 no.1
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• pp.51-62
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• 1988

In this work we study properties of five identities of Bol-Moufang type (1). We establish a necessary and sufficient condition for a loop to be an RC-loop. A corollary to this is the condition for a Bol loop to be an RC-loop. Some proerties of a generalization of RC-loops are discussed. We also state the relationship between the supernucleus M(G) of a loop G and the nucleii of loops which do not have the inverse property. Finally, we give two tables of non-associative RC-loops of order 16, which are not Bol loops.