• Journal of Microbiology and Biotechnology
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• 제31권2호
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• pp.181-188
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• 2021

Bacillus subtilis and Enterococcus faecium are commonly used probiotics. This study aimed to identify the effect of live combined Bacillus subtilis R0179 and Enterococcus faecium R0026 (LCBE) on obesity-associated hyperlipidemia and gut microbiota in C57BL/6 mice. Forty male C57BL/6 mice were divided into four groups: normal group (N group), model group (M group), low-dose group (L group), and high-dose group (H group). Mice were gavaged with LCBE at 0.023 g/mice/day (L group) or 0.23 g/mice/day (H group) and fed with a high-fat diet for 8 weeks. In vitro E. faecium R0026 showed an ability to lower the low-concentration of cholesterol by 46%, and the ability to lower the high-concentration of cholesterol by 58%. LCBE significantly reduced the body weight gain, Lee index, brown fat index and body mass index of mice on a high-fat diet. Moreover, LCBE markedly improved serum lipids (including serum triglyceride, total cholesterol, low-density lipoprotein and high-density lipoprotein) while also significantly reducing liver total cholesterol. Serum lipopolysaccharide and total bile acid in L and H groups decreased significantly compared with M group. PCR-DGGE analysis showed that the composition of gut microbiota in the treatment groups was improved. Akkermansia muciniphila was found in H group. The PCA result indicated a similar gut microbiota structure between LCBE treatment groups and normal group while the number of bands and Shannon diversity index increased significantly in the LCBE treatment groups. Finally, qPCR showed Bifidobacterium spp. increased significantly in H group compared with M group, LCBE alleviated liver steatosis and improved brown adipose tissue index.

• Tuberculosis and Respiratory Diseases
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• 제67권3호
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• pp.183-190
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• 2009

Background: Repeated arousals during sleep have been known to be associated with excessive daytime sleepiness and cardiovascular complications. We investigated the relationship between arousal indices and clinical parameters. Methods: We retrospectively reviewed medical records of 41 patients who performed polysomnography for a diagnosis of obstructive sleep apnea syndrome. We defined total arousal index (TAI) as the number of arousals per hour and respiratory arousal index (RAI) as the number of arousals associated with apnea or hypopnea per hour. Results: There were significant positive correlations between arousal indices and apnea-hypopnea index (AHI) (RAI vs. AHI, r=0.958, p<0.001; TAI vs. AHI, r=0.840, p<0.001). RAI and mean oxygen saturation showed a significant negative correlation with each other (r=-0.460, p=0.002). TAI revealed a significant positive correlation with mean systolic blood pressure (MSBP) and mean diastolic blood pressure (MDBP) (TAI vs. MSBP, r=0.389, p=0.014; TAI vs. MDBP, r=0.373, p=0.019). There was no significant correlation between arousal indices and parameters of sleepiness. RAI had a significant positive correlation with body mass index (BMI) and neck circumference (NC) (RAI vs. BMI, r=0.371, p=0.017; RAI vs. NC, r=0.444, p=0.004). When partial correlation analysis was performed to adjust for other variables, there was significant correlation between RAI and AHI (r=0.935, p<0.001). Conclusion: This study shows that respiratory arousal index could be a useful index reflecting of severity of obstructive sleep apnea syndrome. Arousal during sleep would be concerned in the development of cardiovascular complication of obstructive sleep apnea. And some anthropometric factors would contribute to the development of arousals during sleep. Further studies are needed to clarify any cause-effect relationship.

• 산업경영시스템학회지
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• 제32권2호
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• pp.29-37
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• 2009

National R&D programs play an important role in the development of a country in this age of the knowledge economy. Since many numbers of R&D programs compete for limited resources such as national R&D budget, the R&D program evaluation problem is a challenging decision-making problem faced by decision makers that deal with R&D management. In this sense, DEA(Data Envelopment Analysis) has been regarded as one of the most widely accepted methods to measure the relative efficiency of productivity of R&D programs. DEA is a methodology to measure and to evaluate the relative efficiency of a homogeneous set of decision-making units(DMUs) in a process which uses multiple inputs to produce multiple outputs. However, the sample of the R&D programs could consist of two or more naturally occurring subsets, thus exhibiting clear signs of heterogeneity such as different objectives. In such situations, the fairness of DEA is limited, for the nature of the relative efficiency of a DMU is likely to be influenced by its membership in a particular subset of the sample. In this study, we propose a methodology AI-DEA(attainment index DEA) allowing for reflecting decision maker's subjective judgement on difference among different subsets of R&D programs which have heterogeneous objectives. This methodology combines AHP and Delphi in order to decide the attainmnet index of each DMU for each outputs, and apply them to DEA model. We illustrate the proposed approach with a pilot evaluation of 13 programs involving 6 different subsets of Korean National R&D programs and compares the results of the original DEA model and AI-DEA model.

• 대한물리치료과학회지
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• 제28권3호
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• pp.53-65
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• 2021

Background: The purpose of this study was to a comparison of physical fitness according to the body mass index (BMI) of Chinese college students. Design: Cross-sectional study. Methods: According to the BMI, the research objects are divided into four types: underweight, normal weight, overweight, and obesity. This research took 26,976 college students who participated in Jiujiang College. It examines BMI, 50m, vital capacity, standing long jump, sitting forward bend, sit-up (female), pull-up (male), 800m (female), 1000m (male) which is to research the correlation between different BMI and other indicators. Results: The physical qualities of students with normal weight are significantly better than those with other BMI groups. Pearson correlation analysis showed that male BMI was positively correlated with vital capacity (r=0.07, p<0.01), 50m (r=0.15, p<0.01) and 1000m (r=0.14, p<0.01), and negatively correlated with standing long jump (r=-0.12, p<0.01), sitting forward bend (r=-0.06, p<0.01) and pull-up (r=-0.13, p<0.01); Female BMI was positively correlated with vital capacity (r=0.03, p<0.01), 50m (r=0.21, p<0.01) and 800m (r=0.18, p<0.01), and negatively correlated with standing long jump (r=-0.07, p<0.01), sitting forward bend (r=-0.11, p<0.01) and sit-up (r=-0.10, p<0.01). Conclusion: Overweight and underweight will affect the physical quality of college students. Students should keep their BMI within the normal range for their health.

• 기술혁신학회지
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• 제8권1호
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• pp.277-295
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• 2005

The objective of the study is to verify the discriminatory power of valuation indexes in predicting IT small and medium sized manufacturing firms' going concern or firms' failure. The result of the study is expected to be useful in loan evaluation, investment decision, internal management decision making and business improvement. The results of study is as follows. First, we find that at least six valuation index elements are significant ex-ante variable which are discriminating between firms' going concern and firms' failure in IT small and medium sized manufacturing firms in various analysis' results. Second, these index elements are composed of 2 indexes-the ability of technology R&D, the efficient strategy of market penetration and six index elements explain 46% of the total variance. This explainable power of these indexed is similar to that of the existing 16 index elements. Finally, we find that the most important success factor of IT small and medium sized manufacturing firms are the ability of technology R&D and the efficient strategy of market penetration.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2007년도 춘계학술대회
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• pp.347-351
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• 2007

The main objective of this paper is to provide analysis of obesity index of residents in six metropolitan cities. According to analysis of $R{\ddot{o}}hrer$ Index, there was significant difference regionally between men and women in metropolitan cities. Through analysis of Drop Value, it was found that there were significant differences regionally between men and women in metropolitan cities on circumferences of chest, waist and buttocks. The result of this research can be utilized in manufacturing and design of uniforms and equipments for safety.

• 대한안전경영과학회지
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• 제9권4호
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• pp.113-119
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• 2007

Recently, due to economic growth, living environment has been convenient and comfortable and so human activities were decreased. Consequently energy consumption was also decreased. Also the habit of food intake has been changed and the tendency of obesity has been increased. The main objective of this paper is to provide analysis of obesity index of residents in six metropolitan cities. According to analysis of $R\"{o}hrer$ Index, there were significant differences regionally between men and women in metropolitan cities. Through analysis of Drop Value, it was found that there were significant differences regionally between men and women in metropolitan cities on circumferences of chest, waist and buttocks. The result of this research can be utilized in manufacturing and design of uniforms and equipments for safety.

• 산업식품공학
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• 제13권2호
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• pp.117-121
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• 2009

쇠고기의 저장 중 발생되는 부패취를 특수 관능기법인 R-index를 적용하여 부패취 검지분석을 하고, Pseudomonas 의 증식과 비교분석 하였다. 패널에게 사전훈련을 통하여 signal reference(37$^{\circ}C$, 48시간 동안 저장한 쇠고기)과 noise reference(-2$^{\circ}C$, 저장 시간이 없는 신선한 쇠고기)를 구별이 가능하도록 하였다. Stimuli samples(저장 온도 및 시간 별 쇠고기)와 noise reference를 같이 제공하여 부패취 발생 여부의 확신도에 따라 4가지 구간(signal sure(S), signal unsure(S?), noise unsure(N?), noise sure(N))으로 평가하게 하도록 하였다. 상온인 25$^{\circ}C$ 저장과 냉장 온도인 5$^{\circ}C$의 두가지 시료 모두 저장 시간이 증가함에 따라 R-index가 증가하였다. 25$^{\circ}C$의 경우 저장 36시간까지 급격한 변화를 보이다가 36시간 이후 완만한 변화를 보였으며, 5$^{\circ}C$는 전구간 매우 완만하게 점차적으로 변화하였다. 패널 개인별 Rindex가 유의수준 $\alpha$=0.05 및 $\alpha$=0.01에서의 경계점을 넘는 시점인 부패취 발생 검지시간을 구하였다. 부패취 발생 검지시간은 $\alpha$=0.05의 경우 25$^{\circ}C$에서 30.92${\pm}$3.47시간, 5$^{\circ}C$에서 169.80${\pm}$11.27시간, $\alpha$=0.01의 경우는 25$^{\circ}C$에서 34.80${\pm}$4.01시간, 5$^{\circ}C$에서 176.41${\pm}$9.89시간으로 산출되었다. 부패취가 발생되었다고 검지된 저장 시간의 Pesudomonas의 수는 저장 온도별 차이가 있었고, 부패하였다고 판단되는 6-7 log CFU/g에 근접한 수치였다. 이는 미생물이 쇠고기의 부패취 발생의 기여도는 있지만, 그 밖에 유통환경의 오염, 지방의 산패, 내인성 효소 등의 요인도 부패취 발생에 기여한다는 것을 시사한다.

• 대한간호학회지
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• 제7권2호
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• pp.11-21
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• 1977

Many in nursing look back on Nursing Research history and proudly point to the fact that emphasis in nursing research has changed from studying the nurse to studying nursing practice. In recent years, much emphasis has been placed on seeking a method of evaluating the quality of nursing care. In spite of these attempts, however, an instrument for evaluating the quality of nursing care that is actually applicable in the clinical area has not been found. The Purposes of this study are as follows: 1) To develop the instrument to be used in evaluating the quality of nursing care provided in the Neuro - Surgery Constant Care Unit of Severance Hospital 2) To evaluate the quality of nursing care in the clinical area. 3) To provide the necessary information for improvement of quality of nursing care. The instrument for evaluating the quality of nursing care, developed by the investigator, was composed of 7 nursing goals and divided into 65 standards of nursing performance. The 7 nursing goal are as follows : 1) Maintenance of airway 2) Maintenance of fluid at electrolyte balance 3) Maintenance of elimination 4) Personal hygiene 5) Optimum activity 6) Prevention of accidents 7) Emotional care The study population defined was composed of all the case (51) who were admitted in the Neuro- Surgery Constant Care Unit of Severance Hospital from May 7-13, 1976. The observation method was used and the data was subjected to the %, X²-test, T-test, F-test and Correlation. The results of tile study were as follows : 1. Levels of nursing performance regarding nursing goals. Seven different nursing care indices were constructed in terms of nursing goals. The index scores were grouped arbitrarily into ,j categories such as "excellent", "good", "moderate", "incomplete", and "poor"based upon the investigator′s personal judgement. a. The nursing index of maintaining airway showed that 78% of the patients fell within the "excellent" and 22% of the patients, fell within the "good" category. b. The nursing index of maintaining fluid & electrolyte balance showed that 95% of the patients fell within the "excellent" and 5 % of the patients fell within the "good" category. c. The nursing index of maintaining elimination showed that 100% of the patients fell within the "excellent" category. d. The nursing index of personal hygiene revealed that 49% of the patients fell within the "excellent" and 51% of the patients fell within the "good" category. e. The nursing index of optimum activity showed that 63% of the patients fell within the "excellent" and 32% of the patients fell within tile "good" and 5% of patients fell within the "moderate" category. f. The nursing index of prevention of accidents showed that 100% of the patients foil within the "excellent" category. g. The nursing index of emotional cart revealed that 27% of the patients fell within the "excellent", 24 % of the patients fell within tile "good", 29 % of the patients fell within the "incomplete" category. From these findings it is disclosed that the quality of nursing care provided in the Neuro- Surgery Constant Care Unit of Severance Hospital was excellent. h. There were statistically significant differences between the nursing index of physical care and emotional care. (t=8.73, D. F. =100. p<0.01) It is revealed that more physical care then emotional care was carried out by nurses. 2. Levels of nursing performance regarding general characteristics of the patients. No significant differences were observed statistically with the nursing indices of nursing goals according to the sex (t=0.084, D. F. =12, p>0.05). Age (F=0.1251, D. F. : 3.18. p 〉0.05), absence or presence of operating experiences (t=0.6032, D. F. =12, p〉0.05, levels of consciousness (F=0.31, D. F. :3. 18, p >0.05) 3. Relationship between the levels of consciousness and the nursing index of each nursing goal. There was negative correlation between the levels of consciousness and the nursing index of maintaining airway (r=-0. 5449, p<0.01) and personal hygiene (r= -0.4075, p<0.01) There was positive correlation between the levels of consciousness and the nursing index of optimum activity (r=0.3936, p <0.01) and emotional care (r=0.7819, p〈0.01). There was slight correlation between the levels of consciousness and the nursing index of maintaining fluid & electrolyte balance (r=-0.3418, 0.010.05) and preventing accidents (r=0.1441, p>0.05.

• Journal of Chest Surgery
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• 제21권6호
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• pp.970-978
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• 1988

There is tendency of increasing number and decreasing age of patients who are indicated for Rastelli operation for their cyanotic congenital heart disease. So there is the need to find the criterion which saves the patients from early postoperative hemodynamic disturbances. We reviewed the 26 patients who had been performed Rastelli operation at Seoul national University Hospital from January 1981 to June 1988. mean age of the patients was 7.8*3.4 years[range 2.5-15years], mean body surface area[BSA] 0.79*0.25m2[range 0.49-1.51m2] and mean hematocrit 57.95*12%[range 48-80%]. We divided these patients into survived group and died group before postoperative 72 hours, and analyzed preoperative arterial oxygen saturation[SaO2], the ratio of diameter of right pulmonary artery to ascending aorta[RPA/AA], the ratio of both right and left pulmonary artery diameter to descending thoracic aorta[RPA+LPA/DTA], pulmonary artery index[PA index], cardiopulmonary bypass time, aorta cross-clamping time, postoperative perfusion state and total amount of dopamine infused postoperatively. The results showed that RPA+LPA/DTA and PA index were statistically significant factors to influence early postoperative cardiac death rate[P< 0.05]. Especially there were good linear correlations between PA index[X] and peripheral perfusion index[Y][Y= - 1.15+0.02 X, r=0.86, P<0.01]and between PA index[X] and total amount of dopamine infused before postoperative 72 hours[mg/kg, Y][Y=61.94 - 0.15 X, r=-0.80, P < 0.01]. Also there were tendencies that the higher RPA+LPA/DTA[Y], the better peripheral perfusion [X] and the lower need of dopamine[X], but no statistical significance.[Y=0.78+1.60 X, r =0. 49, P >0.05] And the discriminate analysis showed that patients with PA index over 221 mm2/BSA could undergo correction with 25 per cent of error rate. In conclusion, early postoperative hemodynamic states could be predicted by preoperatively measured PA index, and which can be used as a criterion for Rastelli operation performed on cyanotic congenital heart disease.