• Biomolecules & Therapeutics
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• v.5 no.3
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• pp.316-322
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• 1997

CJ-50001 is a recombinant granulocyte-colony stimulating factor (rG-CSF) synthesized by recombi-nant DNA technology using E. coli as an expression system. The general pharmacological properties of CJ-50001 were evaluated in mice, rats, dogs and isolated guinea pig ileum. The doses are 100, 300 and 1, 0007g/kg, i.v. for mice and rats, 1, 10 and 100$\mu$g/kg, 1.v. for dogs and 1 and 10$\mu$g/ml for isolated guinea pig ileum. Intravenous administration of CJ-50001 at this dose range did not affect general behavior, central nervous system, smooth muscles, gastrointestinal system, cardiovascular and respiratory system and water and electro-lytes excretion. In summary, CJ-50001 had no harmful pharmacological erect in these studies even up to the 200-fold expected clinical dose, 2507g/man.

• Proceedings of the KIEE Conference
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• 1998.07f
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• pp.2076-2078
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• 1998

This paper presents STATCON(Static Condenser) control schemes for voltage regulation, power factor correction and harmonics mitigation. Each control scheme can be applied in the system depending on the system requirements. The 20KVA STATCON is developed and tested in the reduced system model for the verification of three different control algorithms. The results of proposed controls are compared for power factor correction and voltage regulation algorithms. For each algorithm, harmonic mitigation scheme is adopted as a part of control. Finally verification of STATCON for the transient response is implemented by voltage flicker test.

• Communications of the Korean Mathematical Society
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• v.36 no.1
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• pp.27-39
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• 2021

We discuss the condition that every nonzero right annihilator of an element contains a nonzero ideal, as a generalization of the insertion-of-factors-property. A ring with such condition is called right AP. We prove that a ring R is right AP if and only if Dn(R) is right AP for every n ≥ 2, where Dn(R) is the ring of n by n upper triangular matrices over R whose diagonals are equal. Properties of right AP rings are investigated in relation to nilradicals, prime factor rings and minimal order.

• Journal of the Korean Association of Geographic Information Studies
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• v.19 no.4
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• pp.130-145
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• 2016

Soil erosion processes are affected by weather factors, such as rainfall, temperature, wind, and humidity. Among these factors, rainfall directly influences soil erosion by breaking away soil particles. The kinetic energy of rainfall and water flow caused by rain entrains and transports soil particles downstream. Therefore, in order to estimate soil erosion, it is important to accurately determine the rainfall erosivity factor(R) in RUSLE(Revised Universal Soil Loss Equation). The objective of this study is to evaluate the average annual R using 14 years(2002~2015) of 1 minute rainfall data from 55 KMA(Korea Meteorological Administration) weather stations. The R results from 1 min rainfall were compared with previous R studies using 1 h rainfall data. The determination coefficients($R^2$) between R calculated using 1 min rainfall data and annual rainfall were 0.70-0.98. The estimation of 30 min rainfall intensity from 1 min rainfall data showed better $R^2$ results than results from 1 h rainfall data. For estimation of physical spatial rain erosivity(R), distribution of annual rainfall was estimated by IDW(Inverse Distance Weights) interpolation, taking elevation into consideration. Because of the computation burden, the R calculation process was programmed using the python GUI(Graphical User Interface) tool.

• Proceedings of the Microbiological Society of Korea Conference
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• 2008.05a
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• pp.23-25
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• 2008

Serum complement proteins comprise an important system that is responsible for several innate and adaptive immune defence mechanisms. There were three well described pathways known to lead to the generation of a C3 convertase, which catalyses the proteolysis of complement component C3, and leads to the formation of C3 opsonins (C3b, iC3b and C3d) that fix to bacteria. A pivotal step in the complement pathway is the assembly of a C3 convertase, which digests the C3 complement component to form microbial-binding C3 fragments recognized by leukocytes. The spleen clears microorganisms from the blood. Individuals lacking this organ are more susceptible to Streptococcus pneumoniae. Innate resistance to S. pneumoniae has previously been shown to involve complement components C3 and C4, however this resistance has only a partial requirement for mediators of these three pathways, such as immunoglobulin, factor B and mannose-binding lectin. Therefore it was likely that spleen and complement system provide resistance against blood-borne S. pneumoniae infection through unknown mechanism. To better understand the mechanisms involved, we studied Specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1. SIGN-R1, is a C-type lectin that is expressed at high levels by spleen marginal-zone macrophages and lymph-node macrophages. SIGN-R1 has previously been shown to be the main receptor for bacterial dextrans, as well as for the capsular pneumococcal polysaccharide (CPS) of S. pneumoniae. We examined the specific role of this receptor in the activation of complement. Using a monoclonal antibody that selectively downregulates SIGN-R1 expression in vivo, we show that in response to S. pneumoniae or CPS, SIGN-R1 mediates the immediate proteolysis of C3 and fixation of C3 opsonins to S. pneumoniae or to marginal-zone macrophages that had taken up CPS. These data indicate that SIGN-R1 is largely responsible for the rapid C3 convertase formation induced by S. pneumoniae in the spleen of mice. Also, we found that SIGN-R1 directly binds C1q and that C3 fixation by SIGN-R1 requires C1q and C4 but not factor B or immunoglobulin. Traditionally C3 convertase can be formed by the classical C1q- and immunoglobulin-dependent pathway, the alternative factor-B-dependent pathway and the soluble mannose-binding lectin pathway. Furthermore Conditional SIGN-R1 knockout mice developed deficits in C3 catabolism when given S. pneumoniae or its capsular polysaccharide intravenously. There were marked reductions in proteolysis of serum C3, deposition of C3 on organisms within SIGN-$R1^+$ spleen macrophages, and formation of C3 ligands. The transmembrane lectin SIGN-R1 therefore contributes to innate resistance by an unusual C3 activation pathway. We propose that in the SIGN-R1 mediated complement activation pathway, after binding to polysaccharide, SIGN-R1 captures C1q. SIGN-R1 can then, in association with several other complement proteins including C4, lead to the formation of a C3 convertase and fixation of C3. Therefore, this new pathway for C3 fixation by SIGN-R1, which is unusual as it is a classical C1q-dependent pathway that does not require immuno globulin, contributes to innate immune resistance to certain encapsulated microorganisms.

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.179.2-179.2
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• 2000

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 1998.03a
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• pp.178-183
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• 1998

This paper examines the crack growth behavior of 7075-T651 and 5052-H32 aluminum alloys for variable load within tensile load range condition. The cantilever beam type specimen with a chevron notch is used in this study. The crack growth and closure are investgated by compliance method. The applied initial stress ratio is R=0.3 and variable load are R=0.65, 0.46. Crack length, stress intensity factor range, ratio of effective stress intensity factor range and crack growth rate etc. are inspected with fracture mechanics estimate.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2006.03a
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• pp.151-158
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• 2006

Recently, as RC flat plate system is applied on high-rising building largely, necessity of all over research about lateral performance becomes a prominent. In this paper, It is estimated that performance of slab-column connection in flat plate system is inter-story drift index 3.6%. In addition, when R-factor is fixed in seismic design, it must be considered all system. Also Considering that plastic hinge propagation is not adjustable, R-factor should be applied bellow '5.5'.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.8 no.4
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• pp.254-259
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• 1979

Radiation data on south-facing surfaces required for the simplified design pro cedures for solar energy systems, have been computed using the method by Liu and Jordan. For the five localities of South Korea selected from reference 6, the factor R for the conversion of the monthly average daily total radiation on a horizontal surface to that on an inclined surface is presented in Table 5. For the other localities, the convession factor R can by computed using Table 2 through Table 4.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1513-1517
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• 2016

Background: A combination of rituximab to cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is one of the most effective front-line therapies to treat B-cell non-Hodgkin's lymphoma (NHL). The aim of this trial was to evaluate overall survival (OS), progression free survival (PFS) and toxicity of R-CHOP-14 compared to R-CHOP-21 in untreated stage III and IV B-cell NHL patients with Iranian ethnicity. Materials and Methods: In phase III trial, patients with previously untreated stage III and IV indolent and aggressive B-cell NHL were randomly assigned by using a minimization method to receive six to eight cycles of either R-CHOP-21 (administered every 21 days) or R-CHOP-14 (administered every 14 days with granulocyte colony-stimulating factor). Results: A total of 143 patients were randomly enrolled in our study (66 patients in R-CHOP-14 group and 77 patients in R-CHOP-21), between 2011 and 2014. The mean follow-up was 45 months at the time of treatment analysis. The 2-year and 5-year PFS rates for the R-CHOP-14 group were 83.6% vs 73.6% and for R-CHOP-21 group were 75% vs 54%. The 2-year and 5-year OS rates for R-CHOP-14 group were 98% vs 89% and for R-CHOP-21 group were 84.4% vs 67.5%. There was a significant correlation for PFS and OS in the two arms. There was no significant difference between adverse events with the two regimens. Conclusions: In our research improved survival was found with CHOP-14 as compared to CHOP-21. It is possible that drug metabolism in different races/ethnicities may be one important factor.