• Journal of Periodontal and Implant Science
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• v.43 no.1
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• pp.24-29
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• 2013

Purpose: Matrix metalloproteinases (MMPs) are capable of degrading extracellular matrix, and they are inducible enzymes depending on an inflammatory environment such as periodontitis and bacterial infection in periodontal tissue. Gingival inflammation has been postulated to be correlated with the production of MMP-2 and MMP-9. The objective of this study was to quantify the expression and activity of MMP-9 and -2, and to determine the correlation between activity and expression of these MMPs in human gingival tissues with periodontitis. Methods: The gingival tissues of 13 patients were homogenized in $500{\mu}L$ of phosphate buffered saline with a protease inhibitor cocktail. The expression and activity of MMP-2 and -9 were measured by enzyme-linked immunosorbent assay and Western blot analysis, and quantified by a densitometer. For the correlation line, statistical analysis was performed using the Systat software package. Results: MMP-9 was highly expressed in all gingival tissue samples, whereas MMP-2 was underexpressed compared with MMP-9. MMP-9 activity increased together with the MMP-9 expression level, with a positive correlation (r=0.793, P=0.01). The correlation was not observed in MMP-2. Conclusions: The expression of MMP-2 and -9 might contribute to periodontal physiological and pathological processes, and the degree of MMP-9 expression and activity are predictive indicators relevant to the progression of periodontitis.

• Journal of Korean society of Dental Hygiene
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• v.12 no.5
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• pp.1059-1069
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• 2012

Objectives : The purpose of this study was to examine the knowledge of orthodontic patients about oral health knowledge and their actual oral hygiene care, which affected the oral hygiene of orthodontic patients. It's specifically meant to provide information on the prevention of the possible side effects of orthodontic treatment and the promotion of the oral health of orthodontic patients. Methods : This study were 227 orthodontic patients of dental clinics specialized in orthodontics. The collected data were analyzed by the statistical package SPSS WIN 18.0. Results : 1.As for Oral health knowledge, they had the best knowledge about smoking and dental checkup among the subfactors of oral health knowledge. 2. As to actual oral hygiene care, what they did best was doing toothbrushing before sleeping and what they did worst was avoiding eating food injurious to teeth. 3. They scored highest in the right toothbrushing(3.85), the use of oral hygiene supplies(3.62), the prevention of periodontal diseases(3.13) in the subfactors of actual oral hygiene care. They scored lowest in dental checkup and diet(2.99). 4. There were significant differences among the patients in oral health knowledge according to age(F=2.95, p<.05). Those who received another treatment during orthodontic treatment had a better oral health knowledge than the others who didn't, and the gap between the two was statistically significant(t=2.26, p<.05). 5. There were differences among the patients in actual health hygiene care according to gender(t=2.71, p<.01), age(F=4.40, p<.01), educational experiences about oral hygiene care(t=3.06, p<.01) and experience of receiving another treatment during orthodontic treatment(t=2.56, p<.05). 6. There was a positive correlation between oral health knowledge and oral hygiene care(r=.261, p<.001). Conclusions :The above-mentioned findings suggest that more education of diet and toothbrushing should be provided for orthodontic patients to improve their oral health care.

• Proceedings of the KAIS Fall Conference
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• 2010.11b
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• pp.904-906
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• 2010

인체탐험캠프의 목적은 청소년들에게 인체와 의학에 대한 올바른 지식을 전달하고 이와 더불어 건강에 대한 올바른 가치관을 정립하는 데 있다. 본 연구에서는 2009년에 개최된 제11회 인체탐험캠프에 참가한 초등학생을 대상으로 사전, 사후, 추후 설문조사를 통하여 만족도, 지식이해도 및 태도 간의 상관관계와 교육효과의 지속 여부를 조사하였다. 설문문항은 참가자의 일반적 특성, 지식이해도 및 태도로 구분하여 개발하였으며, 총 60문항이다. 설문조사는 캠프가 시작하기 직전 및 직후, 그리고 추후(3개월 후)로 나누어 총 3회 실시하였다. 조사 대상은 참가자 중 초등학생 61명이다. 본 연구의 수집된 자료는 SPSS(Statistical Package for the Social Science) WIN 13.0 프로그램을 이용하여 분석하였다. 초등학생의 지식이해도는 사전 11.34${\pm}$2.79, 사후 17.25${\pm}$2.31, 추후 14.23${\pm}$3.65로 사전과 사후, 사전과 추후를 비교한 결과 유의하게 증가한 것을 알 수 있었다(p<0.001). 태도 변화는 사전 3.87${\pm}$0.51, 사후 4.03${\pm}$0.49, 추후 3.96${\pm}$0.47로 사전과 사후(p<0.001), 사전과 추후(p<0.05)에서 유의하게 증가한 것을 알 수 있었다. 캠프에 대한 만족도는 태도 변화와 밀접한 관련이 있는 것으로 나타났다(r=.737, p<.001). 그러나 지식이해도와 태도변화 사이에는 통계적인 상관관계를 보이지 않았다. 결론적으로 인체탐험캠프는 의학 분야의 실험실습 중심의 체험학습 프로그램을 제공하여 초등학생들의 인체와 건강에 대한 지식이해도를 향상시켰으며, 긍정적인 태도변화를 유도하였다. 이는 인체탐험캠프가 학생들의 지식향상 뿐만 아니라 건강에 대한 올바른 가치관 확립에도 이바지 할 수 있는 유익한 프로그램이며, 점차 참여대학 및 관련기관시행기관이 확대될 것으로 기대된다.

• Journal of Technologic Dentistry
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• v.23 no.2
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• pp.105-119
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• 2002

This study was designed to grasp the degree of job stress affecting dental technicians and the degree of the symptoms of their job stress. With this in mind, the researcher selected a total of 170 dental technicians living in Seoul and Incheon, conducting a research in a period ranging from August 1,2001, to August 20, 2001. The researcher made use of a structured questionnaire whose reliability and feasibility are proved. The questionnaire is composed of a total of 55 questions: thirteen questions related to the subjects' general characteristics; 28 questions connected to the measurement of job stress and fourteen questions linked with the measurement of job-stress symptoms. The researcher analyzed the findings with the aid of SPSS(Statistical Package for Social Sciences). The research came to draw the following conclusions on the basis of frequency, percentage, T-test, and F-test, multiple regression. I. The analysis into the job stress of the subjects indicates that there is a significant difference in difficult questions among their work places, working hours, academic background, job satisfaction and jobs(P<.05). The job stress stands at 3.48 on the average, and the area of conflict among too much work and job performance turns out to be highly perceived. 2. The analysis into the degree of the symptoms of the job stress of the subjects shows that there is a significant difference in work place, working hours, job satisfaction and the continual maintenance of job(P<.05). The symptoms of job stress accounts for 2.65 on the average. Physical symptoms turn out to be highly perceived; The response 'My arms and legs are killing me' proves to stand for 3.03. 3. The correlation between job stress and the symptoms of job stress turns out to be significant(r=0.519, P<0.001), and there is a significant correlation between the average points of each job-stress area and the average points of the symptoms of job stress. All in all, it is necessary that dental technicians themselves should make positive efforts to control and relieve stress and that more efficient programs should be implemented with a view to dealing with stress.

• Korean Journal of Health Education and Promotion
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• v.22 no.1
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• pp.17-40
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• 2005

This study was aimed to analyze the status of the a health education and the health behavior, and to identify the effected factors of health promotion behavior based on Green's PRECEDE Model among high school students The data was collected by interview survey with self-administration questionnaire from the selected high school students during the end of the second semester, 2001, and 1,591 students are analyzed. The statistical method of the analysing for effected factors of health promotion behavior was used the Multiple Linear Regression Analysis by SPSS package program. The results of this study are as fellows. 1. The index of the health educational contents shows the 18.14 points per 86 points, 18.96 points in girl students, 17.53 points in boy students. 2. In the index of health promotion behaviors was 84.9 points per 140 full points in all average; 61 points per 100 points. The experienced rate of smoking was $35\%$ of all students, $38.5\%$ of boy students, $30.6\%$ of girl students each. The experienced rate of drinking was $62.2\%$ of all students, $61.6\%$ of boy students, $69.4\%$ of girl students. 3. The effected factors of the health promotions behaviors to analyse by multiple linear regression model was sports activity, the degree of satisfaction of their school life, the academic records of school, the present health conditions, their awareness for hazard of smoking for their health, the experiences of the smoking, their stresses(R$^2$ =0.174). and the factors as the experiences of drinking, their stresses, and the indexes for the health education contents in their school were added in girls students.

• Journal of the Korean Society of Clothing and Textiles
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• v.27 no.11
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• pp.1338-1349
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• 2003

The color of apparels has the close interdependency on the skin colors of the wearers. This study was carried out to group the skin colors of Korean males into several similar skin colors and to analyze their preference colors. The skin colors were measured quantitatively and classified into several clusters that has similar hue, value and chroma with Munsell color system that is internationally used to communicate the colors. Sample size was 420 Korean males. With color spectrometer, JX-777, 4 points of the body were measured. All subjects had been shown with 40 color chips and answered their preference colors. Data were analysed by K-means Cluster analysis, Duncan test, Frequency and Chi square test using SPSS WIN 10 statistical package. Findings were as follows: 1. The skin colors of Korean males were mixed with skin colors of YR, R, and Y. 2. 420 subjects who have YR color were clustered in 3 kinds of skin color groups. 3. The average face color of total subjects was 4.81YR 5.91/4.97 in Munsell color system, 60.74 in L value, 13.71 in a value, 24.54 in b value. 136 observations out of 420 subjects were composed of Type 1: 4.50YR 6.35/4.87 and 192 observations were composed of Type 2: 4.62YR 5.86/5.12 and 92 observations were composed of Type 3: 5.67YR 5.37/4.79. 4. The average skin color of total 420 subjects was 6.26YR 6.07/4.41 and 62.33 in L value, 10.64 in a value, 23.48 in b value. The average skin color of Type 1 was 6.27YR 6.44/4.27 and of Type 2 was 6.15YR 5.91/4.49 and of Type 3 was 6.49YR 5.84/4.43 respectively. 5. 3 groups showed that the most preference color of sport$.$casual was 2.5Y 8/16 and 7.5PB 4/16 and the most preference color to their skins was 7.5PB 4/16 and 7.5YR 7/16.

• Journal of the Korean Data and Information Science Society
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• v.25 no.2
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• pp.327-336
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• 2014

Recurrent event data occurs when a subject experiences same type of event repeatedly and is found in various areas such as the social sciences, Economics, medicine and public health. To analyze recurrent event data either a total time or a gap time is adopted according to research interest. In this paper, we analyze recurrent event data with incomplete observation gap using a gap time scale. That is, some subjects leave temporarily from a study and return after a while. But it is not available when the observation gaps terminate. We adopt an interval censoring mechanism for estimating the termination time. Furthermore, to model the association among gap times of a subject, a frailty effect is incorporated into a model. Programs included in Survival package of R program are implemented to estimate the covariate effect as well as the variance of frailty effect. YTOP (Young Traffic Offenders Program) data is analyzed with both proportional hazard model and a weibull regression model.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.95-100
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• 2016

Background: Survival time of lymphoma patients can be estimated with the help of microarray technology. In this study, with the use of iterative Bayesian Model Averaging (BMA) method, survival time of Mantle Cell Lymphoma patients (MCL) was estimated and in reference to the findings, patients were divided into two high-risk and low-risk groups. Materials and Methods: In this study, gene expression data of MCL patients were used in order to select a subset of genes for survival analysis with microarray data, using the iterative BMA method. To evaluate the performance of the method, patients were divided into high-risk and low-risk based on their scores. Performance prediction was investigated using the log-rank test. The bioconductor package "iterativeBMAsurv" was applied with R statistical software for classification and survival analysis. Results: In this study, 25 genes associated with survival for MCL patients were identified across 132 selected models. The maximum likelihood estimate coefficients of the selected genes and the posterior probabilities of the selected models were obtained from training data. Using this method, patients could be separated into high-risk and low-risk groups with high significance (p<0.001). Conclusions: The iterative BMA algorithm has high precision and ability for survival analysis. This method is capable of identifying a few predictive variables associated with survival, among many variables in a set of microarray data. Therefore, it can be used as a low-cost diagnostic tool in clinical research.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2171-2174
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• 2012

Background: Pancreatic cancer is a distressing disease with a miserable prospects and early recognition remains a challenge due to ubiquitous symptomatic presentation, deep anatomical location, and aggressive etiology. False positives and problems in distinguishing pancreatitis from adenocarcinoma limit the use of CA 19-9 as both disorders can present with similar symptoms and share radiographic physiognomies. This study aimed to assess the relative increase in accuracy of diagnosing the patients with chronic pancreatitis, benign neoplasm of pancreas and adenocarcinomas with CA 19-9, haptoglobin, and serum amyloid A in comparison to CA 19-9 alone. Materials and Methods: This hospital based case control study was carried out in the Departments of Medicine and Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal, between $1^{st}$ January 2010 and $31^{st}$ December 2011. The variables assessed were age, gender, serum CA19-9, serum haptoglobulin, serum Amyloid A. The data were analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. Results: Out of 197 cases of pancreatic disease, maximum number of assumed cases were of adenocarcinoma of pancreas (95). Number of males (59) were more than females (36) in assumed cases of adenocarcinoma of pancreas. The mean values of CA19-9 raised considerably in cases of chronic pancreatitis, benign neoplasm and adenocarcinoma of pancreas when compared to controls. The highest augmention in CA19-9 values were in cases of adenocarcinoma of pancreas. The p-value indicates that in cases of chronic pancreatitis, there was not significant increase in precision of diagnosis. Conclusions: These statistics established that haptoglobin and SAA are useful in discriminating cancer from benign conditions as well as healthy controls.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.1031-1033
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• 2014

Aim: To investigate the effect of hyperglycemia and hyperinsulinemia on prostate cancer risk. Materials and Methods: This hospital based study was carried out using data retrieved from the register maintained in the Department of Biochemistry of a tertiary care hospital of Kathmandu, Nepal between $31^{st}$ December, 2011 and $31^{st}$ October, 2013. The variables collected were age, serum cholesterol, serum calcium, PSA, fasting blood glucose, serum insulin. Analysis was performed by descriptive statistics and testing of hypothesis using Excel 2003, R 2.8.0, Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. Results: Of the total 125 subjects enrolled in our present study, 25 cases were of PCa and 100 were healthy controls. The mean value of fasting plasma glucose was 95.5 mg/dl in cases of prostatic carcinoma and the mean value of fasting plasma insulin was $5.78{\mu}U/ml$ (p value: 0.0001*). The fasting insulin levels ${\mu}U/ml$ were categorized into the different ranges starting from ${\leq}2.75$, >2.75 to ${\leq}4.10$, >4.10 to ${\leq}6.10$, > $6.10{\mu}U/ml$. The maximum number of cases of prostatic carcinoma of fasting insulin levels falls in range of > $6.10{\mu}U/ml$. The highest insulin levels (> $6.10{\mu}U/ml$) were seen to be associated with an 2.55 fold risk of prostatic carcinoma when compared with fasting insulin levels of (< $2.75{\mu}U/ml$). Conclusions: Elevated fasting levels of serum insulin appear to be associated with a higher risk of prostate cancer.