• 한국경제지리학회지
• /
• 제19권1호
• /
• pp.1-17
• /
• 2016

본 논문은 내국인 특허출원 자료에서 복수 발명자들의 주소지들을 파악하고 가산자료의 특성을 통제할 수 있는 영과잉 음이항 회귀모형을 사용하여 230개 시군구 간 발명자 네트워크의 공간구조와 그것의 결정요인을 분석한다. 발명자 네트워크의 공간적 연계에 영향을 미치는 몇 가지 요인들이 확인된다. 이출지역이 민간 R&D, 고등교육수준, 인구규모, 특허 생산성 등과 같은 R&D 관련 지역 특수적 자산들을 많이 보유하면 동태적인 수요효과를 통해 공간적 연계는 다른 지역으로 확대된다. 그리고 물리적 거리뿐만 아니라 기술적 거리에서도 거리조락현상이 나타난다. 이입지역이 R&D 관련 지역 특수적 자산을 많이 보유하면 유사한 논리로 공간적 연계에서 정(+)의 효과가 발생한다.

• Molecules and Cells
• /
• 제40권7호
• /
• pp.495-502
• /
• 2017

The $5-HT_6R$ has been considered as an attractive therapeutic target in the brain due to its exclusive expression in the brain. However, the mechanistic linkage between $5-HT_6Rs$ and brain functions remains poorly understood. Here, we examined the effects of $5-HT_6R$-mediated cell morphological changes using immunocytochemistry, Western blot, and live-cell imaging assays. Our results showed that the activation of $5-HT_6Rs$ caused morphological changes and increased cell surface area in HEK293 cells expressing $5-HT_6Rs$. Treatment with 5-HT specifically increased RhoA-GTP activity without affecting other Rho family proteins, such as Rac1 and Cdc42. Furthermore, live-cell imaging in hippocampal neurons revealed that activation of $5-HT_6Rs$ using a selective agonist, ST1936, increased the density and size of dendritic protrusions along with the activation of RhoA-GTP activity and that both effects were blocked by pretreatment with a selective $5-HT_6R$ antagonist, SB258585. Taken together, our results show that $5-HT_6R$ plays an important role in the regulation of cell morphology via a RhoA-dependent pathway in mammalian cell lines and primary neurons.

• 한국정보통신학회논문지
• /
• 제19권11호
• /
• pp.2609-2614
• /
• 2015

국가연구개발 사업을 계획하고 관리하는 기관에서는 연구개발비 오 남용 및 부정 집행을 방지하기 위하여 다양한 대책을 마련하여 시행하고 있으나 연구개발비의 오 남용을 방지하는 데는 한계를 드러내고 있다[1,2]. 본 논문에서는 이상거래에 대한 사후 적발로 인한 연구개발비 오 남용을 방지하고자 연구개발비 집행계획 단계부터 정보를 수집하여 이상거래를 탐지할 뿐만 아니라 그 결과를 주관연구기관, 전문기관, 신용카드사 간의 상호 실시간 연동으로 공유하여 활용하도록 하였다. 이를 위해 데이터 품질진단 기법 중 연구개발 관련 규정 및 매뉴얼, Q&A, FAQ, 담당자 인터뷰 결과 등과 같은 다양한 정보로부터 업무규칙을 도출하는 아웃사이드인(Outside-In) 분석 방법을 이용하였다.

• Journal of Plant Biotechnology
• /
• 제42권4호
• /
• pp.284-289
• /
• 2015

Powdery mildew (Podosphaera xanthii) commonly occurs in cultivated fields of melon (Cucumis melo L.). It inflicts a lot of damages. Therefore, breeding resistant lines is essential. Development of a resistant line by integrating resistance gene takes a long time. In addition, break down of developed resistance by generating new virulent fungus strains increases disease susceptibility. This phenomenon was related to races of powdery mildew. Therefore, it is important to develop a DNA marker to genetically analyze race-specific resistance genes of melon powdery mildew to breed resistant lines. To date, a total of 28 races of Podosphaera xanthii have been reported in the literature. In Japan, 10 races have been reported in the Ibaraki region. We developed a system to characterize the races of Podosphaera xanthii and confirmed eight out of those 10 races in the Ibaraki region. In Korea, only one race has been characterized to date. However, some different races were detected. Through genetic analysis of resistant lines and susceptible lines of powdery mildew, resistance genes of race1 (Pm-X, PXB, and Pm-R 1), race N1 (PXA), race 2 (Pm-w and Pm-R 2), race 3 (Pm-X3), and race 5 (Pm-X5 and Pm-R5) were identified in melon. These related genes of race 1, 3, N1, 5, and race 1, 2, 5 were located at linkage group II and V, respectively. In race 1, resistance gene was located in the linkage group XII. In addition, each race-specific marker related to specific resistance gene was developed. Using race information and race selection system obtained in this study, resistant line can be bred to develop resistant cultivar for several areas. Furthermore, this will make it more easily and economically to breed resistant lines by using selected markers.

• Journal of Animal Science and Technology
• /
• 제56권8호
• /
• pp.28.1-28.6
• /
• 2014

This study was conducted to estimate the effective population size using SNPs data of 240 Jeju horses that had raced at the Jeju racing park. Of the total 61,746 genotyped autosomal SNPs, 17,320 (28.1%) SNPs (missing genotype rate of >10%, minor allele frequency of <0.05 and Hardy-Weinberg equilibrium test P-value of < $10^{-6}$) were excluded after quality control processes. SNPs on the X and Y chromosomes and genotyped individuals with missing genotype rate over 10% were also excluded, and finally, 44,426 (71.9%) SNPs were selected and used for the analysis. The measures of the LD, square of correlation coefficient ($r^2$) between SNP pairs, were calculated for each allele and the effective population size was determined based on $r^2$ measures. The polymorphism information contents (PIC) and expected heterozygosity (HE) were 0.27 and 0.34, respectively. In LD, the most rapid decline was observed over the first 1 Mb. But $r^2$ decreased more slowly with increasing distance and was constant after 2 Mb of distance and the decline was almost linear with log-transformed distance. The average $r^2$ between adjacent SNP pairs ranged from 0.20 to 0.31 in each chromosome and whole average was 0.26, while the whole average $r^2$ between all SNP pairs was 0.02. We observed an initial pattern of decreasing $N_e$ and estimated values were closer to 41 at 1 ~ 5 generations ago. The effective population size (41 heads) estimated in this study seems to be large considering Jeju horse's population size (about 2,000 heads), but it should be interpreted with caution because of the technical limitations of the methods and sample size.

• 기술혁신학회지
• /
• 제8권1호
• /
• pp.183-208
• /
• 2005

In recent years, national R&D programs tend to become larger and more complicated, which necessitates strengthening the overall coordination of national R&D programs at the inter-ministerial level from the program planning stage. This paper looks into the status and problems of Korea's national R&D programs and proffers ways to improve the current system It highlights the problems shown in the process of the 2004 overall coordination and their rectification. First, various ad-hoc private-led committee brought about inefficiency in decision making process. Therefore, it is necessary to streamline such committees and strengthen the function of the Office of Science and Technology Innovation, Second, in view of the implementation of the overall coordination system, it is necessary to identify the problems in full detail that were raised in the course of the previous year's overall coordination so that new projects can be allotted minimal grades and follow-up activities can be efficiently put into execution. Third, it is necessary to establish standing committees for constant review and efficient utilization that will be devoted to reviewing programs overlapped and their linkage. Fourth, priority of investment regarding the nation's strategic policy direction should be reflected. Fifth, given the lack of performance-based evaluation system, it is necessary to develop macro and micro evaluation indices in conjunction with enacting the tentatively named "Performance-based Law." The overall coordination system of national R&D programs should be supplemented and further developed in relation to the aforementioned problems and their rectification in order to enhance the expertise, fairness, and efficiency of the nation's R&D coordination system.

• The Journal of Korean Physical Therapy
• /
• 제13권3호
• /
• pp.509-527
• /
• 2001

The Sun's ray is composed of Infrared(49%), Visible light(40%) and Ultra violet(11%), however the ray getting to the earth is FIR(Far infrared; 60%), IR(Infrared; 20%), and UV(Ultra Violet; 20%). Human beings has utilized FIR already from time immemorial. Hershel found out Infrared for the first time. in the Industrial Revolution the Infrared and FIR had been begun to use making products. In these days, with contemporary science FIR would be begun to clear up the implication in the human body and organic compound. IR classified by wavelength three parts NlR, MIR, FIR. There is FIR which is radiated from healthy human body the wave length is 8-l4m. The human body is composed of proteins which get easily changed by a thermal factor (about 42 $^{\circ}$C over). FIR with low temperature can deeply penetrate on the human body composed things without troublesomes, since FIR has effectively operated on the human body at low temperature (35-40 $^{\circ}$C). When FlR penetrated on the human body. it would inhibit the abnormal genes and cells expression, and then information of DNA and RNA would be reexpressed for arranging DNA and RNA abnormal state. As FlR's receptors in the body, it could be presumed that N-glycosyl linkage of purine and deoxyribose, RNA splicing process, and Heat shock protein. To take the FIR which was a optimized wavewlength and strength, at first, we induced the characteristic algorithm and the computerized programing. Then we formed that the formular of optimized FIR with physical, mathematical logic and theory. especially, Plank, Kirchhoff, Wien, Stefan-Boltzmann's logic and law. In the long run, the formular was induced with integration mathematical, since we had to know the molecular wavelength. Based on the induced formular as above, we programmed the optimized FlR radiating computerized program. In this research, we designed the eletronic circuit f3r interfacing with human body to diagnosis and treatment with FIR sensor which radiated FIR wavelength optimized.

• 기술혁신학회지
• /
• 제18권4호
• /
• pp.561-589
• /
• 2015

그동안 과학기술정책은 연구개발 투자규모를 늘여서 논문이나 특허 같은 연구성과물을 창출해내는데 집중되어 왔다. 하지만, 과학기술의 경제적 역할이 강조되고 창조경제가 부각되면서, 기술사업화에 대한 정책적 관심이 높아지고 있다. 정부가 추진하는 기술사업화란 공공연구기관의 연구성과물이 민간 기업에서 상용화될 수 있도록 지원하는 일련의 혁신과정을 일컫는데, 조직 외부로의 지식(공공기술)의 흐름과 확산을 수반한다는 점에서 유출-개방형 기술혁신과 그 맥을 같이한다고 볼 수 있다. 본고는 이러한 견지에서, 주요 경제부처(미래창조과학부, 산업통상자원부, 중소기업청)의 기술사업화 예산사업에 대한 분석을 하였다. 이를 통해 현재의 기술사업화 정책현황을 진단하고 향후 정책과제를 도출하였다. 본고는 기술사업화 예산사업이 (1) 부처별로 특화되고, (2) 기술이전에 대한 지원을 강화하며, (3) 통합적 연계를 통해 지원 스펙트럼을 확대하고, (4) 엑셀러레이터 같은 민간 전문가 그룹을 육성하는 방향으로 추진될 것을 정책제언으로 제시하였다.

• 한국문헌정보학회지
• /
• 제56권1호
• /
• pp.405-423
• /
• 2022

본 연구는 국가 연구개발의 전주기를 확립하고 이를 위한 연구지원서비스 방안을 제안하는 것을 목적으로 한다. 특히 연구지원서비스를 제공하는 측면에서 국가적 연구지원시스템인 IRIS와 NTIS를 연계하여 서비스하는 방안을 제안하였다. 연구의 목적을 달성하기 위해 IRIS와 NTIS의 현황을 분석하고 각 시스템의 역할에 따른 연계방안을 제안하였으며, 국내외 선행연구와 사례를 분석하여 국가 연구개발의 전주기를 확립하였다. 연구개발의 현황 및 사례분석을 통해 연구개발 전주기의 각 단계에서 제공할 수 있는 연구지원서비스를 제안하였다.

• Animal cells and systems
• /
• 제5권4호
• /
• pp.341-346
• /
• 2001

Hypertension is a complex disease with strong genetic influences. Essential hypertension has been shown to be associated with insulin resistance. To clarify the genetic basis of insulin resistance in Hypertension, case-control association studies were performed to examine candidate genes for insulin resistance in hypertension. Polymorphisms investigated were the BstO I polymorphism of the $\beta$3-adrenergic receptor (ADRB3) gene, the Xba I Polymorphism of the glycogen synthase (GSY) gene, the Dde I polymorphism of the protein phosphatase 1 G subuit (PP1G) gene, the BstE II polymorphism of the glucagon receptor (GCG-R) gene, the Pst 1 polymorphism of the insulin (INS) gene and the Acc I polymorphism of the glucokinase (GCK) gene. No significant differences were observed in the distribution of alleles and genotypes of the ADRB3, GSY PP1G, GCG-R, INS, and GCK genes between hypertensive and normotensive groups. Although the frequencies in each of these polymorphisms were not significantly different between essential hypertensive and normotensive individuals, our results may provide additional information for linkage analysis and associative studies of disorders in carbohydrate metabolism or in cardiovascular disease.