• Tribology and Lubricants
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• 제30권1호
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• pp.52-58
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• 2014

Because food crops serve as the raw materials for biodiesel, the increasing use of biodiesel as an alternative fuel can lead to adverse effects such as food price inflation and may contribute to global starvation. To solve these problems, efforts are being made to explore various nonedible raw materials for producing biodiesel. Different raw materials impart different fuel characteristics to biodiesel. In this study, we synthesized pure fatty acid methyl ester (FAME), which is a biodiesel component, and then analyzed its fuel properties. The fuel properties of pure FAME would be useful in producing biodiesel from various new raw materials.

• 한국컴퓨터정보학회논문지
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• 제21권11호
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• pp.151-158
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• 2016

This study analyzes the stock market reaction of disclosure of technological information using events which are collected in the Korean stock market for the thirteen-year period between January 2002 and December 2014. We find that abnormal return on the disclosure day of full sample firms is positive and statistically significant. However, abnormal return of high R&D intensity subsample is a larger positive number than that of the low one. Using a longer window, it shows that low R&D intensity negatively decreases the long term performance after the adoption of new technological information. The empirical evidence of the studying is expected to serve as a good judging guide-line for the investors.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2003년도 추계학술대회 논문집 전력기술부문
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• pp.158-160
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• 2003

Recently, with the increasing use of power semiconductors and microprocessors which are very sensitive to little change of power quality and for coping positively with anticipating power quality disputes between power providers and consumers which are possible to occur by of power market being formed, the power quality problem has gained preponderance among the contemporary research areas. To serve these purposes, this paper is described the integrated system for power quality monitoring, which provides speedy and powerful functions by analyzing the Event data and diverse graphic interfaces for user.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.6129-6133
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• 2015

miR-129-2 is frequently downregulated in multiple cancers. However, how it is silenced in cancers remains unclear. Here we investigated the expression profile and potential biological function of miR-129-2 in glioblastoma (GBM), the most common and lethal form of brain tumors in adults. We showed that miR-129-2 is lost in GBM patient specimens and cultured cell lines. miR-129-2 expression could be restored upon treatment with a histone deadetylase inhibitor (trichostatin A) but not a DNA methylation inhibitor (5-Aza-2'-deoxycytidine), and more profound effect was observed with the treatment of these two drugs in combination. Furthermore, forced expression of miR-129-2 repressed the expression of major oncogenic genes such as PDGFRa and Foxp1 in GBMs. Consistently, expression of miR-129-2 significantly inhibits GBM cell proliferation in vitro. These results reveal that miR-129-2 is epigenetically regulated and functions as a tumor suppressor gene in GBMs, suggesting it may serve as a potential therapeutic target for GBM treatment.

• 대한화장품학회지
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• 제29권2호
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• pp.79-104
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• 2003

Introducing to the market place, safe and effective product is an important responsibility of clinical investigators as well as regulatory agencies in all developed countries. Products claiming to improve skin wrinkles are no exceptions. To date, Renova(R) (all-trans retinoic acid), Avage(R) (tazarotene), and Botox(R) (botulinum toxin) are the only agents FDA approved to ameliorate wrinkles associated with photoaged skin in the USA. For all three, clinical evaluation of wrinkle severity was the primary endpoint required for the approval process. No sophisticated instrument measurements of wrinkles were required, nor used in the pivotal studies. The Division of Dermatologic & Dental Products of the US FDA (Director, Jonathan Wilkin, MD) is not against the use of mechanical instruments in assessing wrinkle severity. Its position on this issue however, remains that any such device must be grounded in patients' or product users' perspective, which means that the evaluation instrument must be clinically relevant and clinically perceptible. Sophisticated devices that can detect minimal improvement, but imperceptible to the users are considered useless in the eyes of the US FDA. Two instruments that have been tried in some antiwrinkle studies in the USA are silicone replicas and Primos. Despite their sophistications, they have clear limitations; thus have never replaced clinical evaluations in these studies. At most, they have served as secondary measures to provide corroborative data on the clinical efficacy of antiwrinkle products. For the foreseeable future, at least in the USA, careful clinical assessment of wrinkles will continue to serve as the critical benchmark to determine whether an antiwrinkle product has enough efficacy to benefit its users. We must not lose sight of the fact that sophisticated devices are only to serve in generating supportive evidence, and not the primary evidence, in any clinical studies.

• Biomolecules & Therapeutics
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• 제25권4호
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• pp.367-373
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• 2017

This study was performed to evaluate whether microRNAs (miRNAs) in circulating exosomes may serve as biomarkers of drug-induced liver, kidney, or muscle-injury. Quantitative PCR analyses were performed to measure the amounts of liver-specific miRNAs (miR-122, miR-192, and miR-155), kidney-specific miR-146a, or muscle-specific miR-206 in plasma and exosomes from mice treated with liver, kidney or muscle toxicants. The levels of liver-specific miRNAs in circulating plasma and exosomes were elevated in acetaminophen-induced liver injury and returned to basal levels by treatment with antioxidant N-acetyl-cysteine. Circulating miR-146a and miR-206 were increased in cisplatin-induced nephrotoxicity and bupivacaine-induced myotoxicity, respectively. Taken together, these results indicate that circulating plasma and exosomal miRNAs can be used as potential biomarkers specific for drug-induced liver, kidney or muscle injury.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6145-6149
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• 2012

Objective: To identify whether saliva supernatant miR-21 can serve as a novel potential biomarker in patients with esophageal cancer (EC). Methods: 32 patients with EC and 16 healthy controls were recruited in this study. Total RNA was extracted from saliva supernatant samples for measurement of miR-21 levels using RT-qPCR and relationships between miR-21 levels and clinical characteristics of EC patients were analyzed. Results: miR-21 was significantly higher in the EC than control groups. The sensitivity and specificity were 84.4% and 62.5% respectively. Supernatant miR-21 levels showed no significant correlation with cancer stage, differentiation and nodal metastasis. Conclusions: Saliva supernatant miR-21 may be a novel biomarker for EC.

• 센서학회지
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• 제22권6호
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• pp.379-386
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• 2013

The influences of the load resistance $R_L$ on the magnetoelectric (ME) characteristics of $NiZnFe_2O_4+PZT$ composite were investigated in the non-resonance frequency range. The ME coefficient peak increases with increasing $R_L$, but the frequency indicating the ME coefficient peak decreases with increasing $R_L$. The maximum output power peak is approximately $9.3{\times}10^{-10}mW/Oe$ near $R_L=3.3M{\Omega}$ at f=280 Hz, and the ME coefficient seems to be saturated at $R_L>20M{\Omega}$. This frequency shift effect of $R_L$ shows that the frequency range for an ME sensor application can be modulated with the appropriate value of $R_L$. The ME output voltage has a good linear response to the ac field Hac and shows fair stability over a range of temperatures. The measured non-linearity of this sample is approximately 0.8%. This sample will allow for a low-strength magnetic ac-field sensor. The result from this sample will serve as basic data for a signal-processing circuit system.

• 기술경영경제학회:학술대회논문집
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• 기술경영경제학회 2000년도 제17회 하계학술발표회 논문집
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• pp.153-173
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• 2000

This study is focused on measuring levels of science and technology aspect of ten strategic items in korea to serve as a guidance for the government R&D policy-making, and provide appropriate information for promoting the national R&D programs. The survey of the precise technology level for study applies functional and technical parameters. Functional parameters are used for measuring technology level of the specification and performance of emerging items such as 256M DRAM, TFT-LCD ect. in the present and / or near future; technical parameters, the element / core technologies on emerging items. The study suggests that the result of the survey should be applied for strategic technology planning to narrow the technology gap and draw the criteria for resource allocation in national R&D programs.

• 대한간호학회지
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• 제34권2호
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• pp.261-269
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• 2004

Purpose: This study was to exam me the correlations among management of menopause, marital satisfaction, and quality of life in middle-aged women. Method: The sample was 158 middle-aged women who were 40-64 years. Data were collected from June 14 to July 10, 2003 using questionnaires and were analyzed by using the SPSS 10.0 PC+ program. Result: The level of marital satisfaction was related positively to the level of quality of life(r=.504, p<.01) and management of menopause(r=.3l5, p<.0l). In addition, there were significant correlations between the level of quality of life and management of menopause(r=.251, p<.01). In stepwise multiple regression analysis, 25.9% of the variance in quality of life was explained by marital satisfaction. Conclusion: Marital satisfaction and management of menopause serve to improve the quality of life of middle-aged women. It is necessary to develop an effective intervention program to improve marital satisfaction and management of menopause.