• Analytical Science and Technology
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• v.29 no.4
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• pp.179-185
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• 2016

An effective analytical method has been developed for the determination of β-blockers(atenolol, metoprolol and propranolol) and 6 β-lactams(amoxicillin, penicillin G, cefaclor, cefadroxil, cephalexin and cephradine) in water samples using two different cartridges. The samples were extracted by solid-phase extraction (SPE) with the usage of polymeric hydrophile-lipophile balance(HLB cartridges) and strong cation-exchange mixed-mode polymeric sorbent (MCX cartridges). A XDB-C₁₈ column(1.8 μm; 3.0 mm × 100 mm) was used for the sufficient chromatographic resolution. The calibration curves showed good linearity with high correlation coefficients (>0.995). The method detection limits (MDL) and the limits of quantification(LOQ) were from 1.1 to 3.9 ng/L and from 5 to 13 ng/L, respectively. The method was applied for the determination of the target compounds in tributaries and raw water of the Han River and these were found at N.D. to 0.209 μg/L.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.23 no.2
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• pp.151-158
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• 2012

This paper proposes a H-plane 8-way rectangular waveguide power divider using Y-junction. A general N-way power divider can be composed of multi-stage T-junctions. However, if the distances of output ports are close, the matching characteristic is not improved by using only T-junctions because of space limitation. In this case, since other types of 3-port junctions should be used to final output stage, Y-junctions are used with T-junctions in this paper. The proposed Y-junction uses the tapered-line impedance transformer and inductive irises to improve impedance matching characteristic. The 8-way power divider using Y-junction is fabricated and measured. The measured return loss and insertion loss from input port to output port are -30.8 dB and -9.3 dB at operating frequency, respectively. The measured maximum phase difference is about $1^{\circ}$. Therefore, the proposed power divider will be useful to apply to various microwave systems, which need to divide the input power equally, such as feed networks for array antennas.

• Microbiology and Biotechnology Letters
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• v.29 no.3
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• pp.181-185
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• 2001

The naturally occurring chemical indole-3-carbinol (13C), found in vegetables of the Brassica genus, is a promising anticancer agent that was shown previ- ously to induce a Gl cell cycle arrest of human breast cancer cell lines, independent of estrogen receptor signaling. The anticancer activity of 13C and the possible mechanisms of its action were explored in a human hepatocellular carcinoma cell line, HepG2. Treatment of HepG2 cells with 13C suppressed the growth of the cells. The growth sup- pression caused by 13C ($IC_{50}$/: 444$\mu$M) was found to be partially due to its ability to stop the cell cycle in HepG2 cells. Western blot analysis for the Gl phase artiest demonstrated that the expression-levels of cyclin-dependent kinase (Cdk4, Cdk6) and cyclic D were reduced strongly after treatment of Hep72 cells with 13C (4007M) for 24- 72 hrs. Furthermore, I3C selectively abolished the expression of Cdk6 in a dose- and time-dependent manner, and accordingly, inhibited the phosphorylation of retinoblastoma. Interestingly, after the HepG2 cells reached their max- imal growth arrest, the level of the p21, a well-known Cdk inhibitor, increased significantly. Therefore, it could be considered that the Gl arrest of HepG2 cells treated with 13C was due to the indirect inhibition of Cdk4/6 activities by p21 Western blot analysis for G2/M phase arrest of demonstrated the levels of Cdc2 and cyclin Bl werer reduced dramatically after the treatment of HepG2 cells with 13C ($40\mu$M) for 24-72 hrs. flow cytometry of propidium iodide-stained HepG2 cells revealed that 13C induces a Gl (53%,72hr incubation) and G2 (25%,24hr incubation) cell cycle arrest. Thus, our observations have uncovered a previously undefined antiproliferative pathway for r3C that implicates Cdk4/6 and Cdc2 as a target for cell cycle control in human HepG2 cells. However, the 13C-medi- ated cell cycle arrest and repression of Cdk4/6 production did not affect the apoptotic induction of HepG2 cell.

• Journal of the Korean Ceramic Society
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• v.41 no.8
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• pp.623-627
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• 2004

Phase formation and electrical conduction behavior of Ba-doped LaBaGa $O_4$ layered perovskite were studied. Orthorhombic single phase of $K_2$Ni $F_4$-type structure was observed for the composition range of 0$\leq$x$\leq$0.2 in the La$\_$1＋x/Ba$\_$1＋x/Ga $O_4$$\_$4-$\delta$/ system by X-ray analysis. In the dry atmosphere, La$\_$0.8/Ba$\_$1.2/Ga$\_$3.9/ exhibited mixed conduction of oxygen ion and hole (p-type) at high p( $O_2$). However, in water vapor containing atmosphere, it showed proton conduction due to the incorporation of water into oxygen vacancies. As the temperature decreased, the contribution of proton conductivity to the total conduction increased and proton conduction was dominant below 350$^{\circ}C$. The activation energy for proton conduction was calculated as 0.72 eV.

• Journal of Mechanical Science and Technology
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• v.20 no.12
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• pp.2292-2314
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• 2006

Efficient numerical method is developed for the prediction of aerodynamic noise generation and propagation in low Mach number flows such as aeolian tone noise. The proposed numerical method is based on acoustic/viscous splitting techniques of which acoustic solvers use simplified linearised Euler equations, full linearised Euler equations and nonlinear perturbation equations as acoustic governing equations. All of acoustic equations are forced with immersed surface dipole model which is developed for the efficient computation of aerodynamic noise generation and propagation in low Mach number flows in which dipole source, originating from unsteady pressure fluctuation on a solid surface, is known to be more efficient than quadrupole sources. Multi-scale overset grid technique is also utilized to resolve the complex geometries. Initially, aeolian tone from single cylinder is considered to examine the effects that the immersed surface dipole models combined with the different acoustic governing equations have on the overall accuracy of the method. Then, the current numerical method is applied to the simulation of the aeolian tones from twin cylinders aligned perpendicularly to the mean flow and separated 3 diameters between their centers. In this configuration, symmetric vortices are shed from twin cylinders, which leads to the anti-phase of the lift dipoles and the in-phase of the drag dipoles. Due to these phase differences, the directivity of the fluctuating pressure from the lift dipoles shows the comparable magnitude with that from the drag dipoles at 10 diameters apart from the origin. However, the directivity at 100 diameters shows that the lift-dipole originated noise has larger magnitude than, but still comparable to, that of the drag-dipole one. Comparison of the numerical results with and without mean flow effects on the acoustic wave emphasizes the effects of the sheared background flows around the cylinders on the propagating acoustic waves, which is not generally considered by the classic acoustic analogy methods. Through the comparison of the results using the immersed surface dipole models with those using point sources, it is demonstrated that the current methods can allow for the complex interactions between the acoustic wave and the solid wall and the effects of the mean flow on the acoustic waves.

• Clean Technology
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• v.11 no.3
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• pp.117-122
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• 2005

N-vinyl caprolactam (NVCL), a kind of N-vinyl amide monomer, must be dissolved in continuous phase ($scCO_2$) for dispersion polymerization in supercritical carbon dioxide. Phase behavior of $CO_2$+NVCL is very important and necessary for determining initial polymerization condition and for monomer extraction from final polymer. There is the limitation of experimental method for obtaining pure properties of the monomer because of the possibility of polymerization. And N-methyl caprolactam (NMCL) is the useful solvent for the gas treating process. In the viewpoint of molecular thermodynamics, NVCL and NMCL have same functional group i.e. ${\varepsilon}$-caprolactam. In the case of NVCL, hydrogen of amide group is substituted with vinyl group and for NMCL, hydrogen of amide group is substituted with methyl group. We suggested modified group contribution method for this ${\varepsilon}$-caprolactam derivatives. This new group contribution parameter was applied to correlate $CO_2$ + N-vinyl caprolactam or N-methyl caprolactam system.

• Bulletin of the Korean Chemical Society
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• v.24 no.5
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• pp.559-565
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• 2003

An analytical method the determination of benzo(a)pyrene (BaP) and its hydroxylated metabolites, 1-hydroxybenzo(a)pyrene (1-OHBaP), 3-hydroxybenzo(a)pyrene (3-OHBaP), benzo(a)pyrene-4,5-dihydrodiol (4,5-diolBaP) and benzo(a)pyrene-7,8-dihydrodiol (7,8-diolBaP), in rat urine and plasma has been developed by HPLC/FLD and GC/MS. The derivatization with alkyl iodide was employed to improve the resolution and the detection of two mono hydroxylated metabolites, 1-OHBaP and 3-OHBaP, in LC and GC. BaP and its four metabolites in spiked urine were successfully separated by gradient elution on reverse phase ODS $C_{18}$ column (4.6 mm I.D., 100 mm length, particle size 5 ㎛) using a binary mixture of MeOH/H₂O (85/15, v/v) as mobile phase after ethylation at 90 ℃ for 10 min. The extraction recoveries of BaP and its metabolites in spiked samples with liquid-liquid extraction, which was better than solid phase extraction, were in the range of 90.3- 101.6% in n-hexane for urine and 95.7-106.3% in acetone for plasma, respectively. The calibration curves has shown good linearity with the correlation coefficients (R²) varying from 0.992 to 1.000 for urine and from 0.996 to 1.000 for plasma, respectively. The detection limits of all analytes were obtained in the range of 0.01-0.1 ng/mL for urine and 0.1-0.4 ng/mL for plasma, respectively. The metabolites of BaP were excreted as mono hydroxy and dihydrodiol forms after intraperitoneal injection of 20 mg/kg of BaP to rats. The total amounts of BaP and four metabolites excreted in dosed rat urine were 3.79 ng over the 0-96 hr period from adminstration and the excretional recovery was less than 0.065% of the injection amounts of BaP. The proposed method was successfully applied to the determination of BaP and its hydroxylated metabolites in rat urine and plasma for the pharmacokinetic studies.

• Korean Journal of Optics and Photonics
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• v.27 no.3
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• pp.106-113
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• 2016

In this paper, we deal with the wavefront compensation capability of a silicon carbide (SiC) deformable mirror (DM) with 37 actuators for adaptive optics. The wavefront compensation capability of the SiC DM is predicted by computer simulation and examined by actual experiments with a closed-loop adaptive optics system consistsing of a light source, a phase plate, a SiC DM, a high speed Shack-Hartmann sensor, and a control computer. Distortion of wavefront is caused by the phase plate in the closed-loop adaptive optics system. The distorted wavefront has a peak-to-valley (PV) wavefront error of $0.3{\mu}m{\sim}0.9{\mu}m$ and root-mean-square (RMS) error of $0.06{\mu}m{\sim}0.25{\mu}m$. The high-speed Shack-Hartmann sensor measures the wavefront error of the distortion caused by the phase plate, and the SiC DM compensates for the distorted wavefront. The compensated wavefront has residual errors lower than $0.1{\mu}m$ PV and $0.03{\mu}m$ RMS. Consequently, we conclude that we can compensate for the distorted wavefront using the SiC DM in the closed-loop adaptive optics system with an operating frequency speed of 500 Hz.

• Journal of Adhesion and Interface
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• v.11 no.4
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• pp.155-161
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• 2010

A series of ethylene vinyl acetate (EVA) based hot melt adhesives containing different types and compositions of tackifier resins were prepared to investigate their rheological behavior and T-peel adhesion strength on polyurethane (PU) elastomeric sheets. C5 aliphatic hydrocarbon resin (C5 resin), C9 aromatic hydrocarbon resin (C9 resin), hydrogenated dicyclopentadiene resin ($H_2$-DCPD resin), and dicyclopentadiene and acrylic monomer copolymer resin (DCPD-acrylic resin) were used as the tackifiers for the hot melt adhesives. To determine the polarity of the tackifiers, their oxygen contents were analyzed, and the DCPDacrylic resin was found to contain an oxygen content higher than the other tackifiers. Only the DCPD-acrylic resin showed complete miscibility with EVA and the homogeneous phase of the hot melt adhesive blends at all compositions. The T-peel adhesion strength between the hot melt adhesives and polyurethane elastomeric sheets was mainly affected by the polarity of the tackifier resins in the hot melt adhesives, rather than by the storage moduli, G', of the hot melt adhesives themselves.

• Journal of Korea Technology Innovation Society
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• v.16 no.4
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• pp.1032-1054
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• 2013

An increase of national R&D has brought the growth of research performance such as paper and patent quantitatively. However, the results of technology transfer and commercialization still leave much to be desired in Korea. Therefore, it has to be drawn up a plan for effective management & application of research performance created by public research institutes. We select four leading institutes (two universities, two government-funded research institutes) that performed efficient performance management & application. Then, we analyze the best practices and suggest contributions. The results show that four institutes build up a framework of performance management & application from research planning to technology transfer and commercialization. At an early planning phase, institutes set up definite needs-oriented goals, and prior review as well as prior art search is executed through experts. Besides, they systematically promote strategic patent management, technology marketing, post management, and so forth. For such a performance management & application process, capabilities have to be supported with regard to specialized organization, system, routine. This study can give an hint to improve performance management & application from public research institutes in Korea.