• Asian Pacific Journal of Cancer Prevention
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• v.17 no.8
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• pp.4149-4154
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• 2016

Background: Cervical carcinoma is one of the main causes of mortality in women worldwide as well as in India. It occurs as a result of various molecular events that develop from the combined influences of an individual's genetic predisposition and external agents such as smoking and menstrual hygiene, for example. However, infection with human papillomavirus (HPV) is the established major risk factor. The aim of the current study was to investigate p16 CpG island methylation and establish any correlation with mRNA expression in north Indian population. Materials and Methods: We analyzed 196 woman volunteer out of which 98 were cases and 98 healthy controls. For the analysis of methylation pattern, DNA extracted from blood samples was modified with a bisulfate kit and used as template for methylation specific PCR (MSP). Quantitative real-time PCR (QRT-PCR) was performed to check mRNA expression. Results: Correlation between methylation status of p16 gene and poor menstrual hygiene was significant (p=0.006), high parity cases showed methylation of p16 gene (p=0.031) with increased risk up to 1.86 times for cervical cancer and smoking was a strong risk factor associated with cervical cancer. We analyzed methylation pattern and found 60.3% methylation in cases with low mRNA expression level (0.014) as compare to controls (1.24). It was also observed that promoter methylation of p16 gene was significantly greater in FIGO stage III. Conclusions: We conclude that p16 methylation plays an important role in cervical cancer in the north Indian population and its methylation decreases mRNA expression. It can be used as an important and consistent blood biomarker in cervical cancer patients.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.1
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• pp.751-758
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• 2021

Munitions must be analyzed to identify any risks for quality assurance in development and mass production. Risk identification for parts, compositions, and systems is carried out through failure mode effects analysis (FMEA) as one of the most reliable methods. FMEA is a design tool for the failure mode of risk identification and relies on the RPN (risk priority number). FMEA has disadvantages because its severity, occurrence, and detectability are rated at the same level. Fuzzy FMEA applies fuzzy logic to compensate for the shortcomings of FMEA. The fuzzy logic of Fuzzy FMEA is to express uncertainties about the phenomenon and provides quantitative values. In this paper, Fuzzy FMEA is applied to the failure mode of a rotorcraft landing system. The Fuzzy rule and membership functions were conducted in the Fuzzy model to study the RPN in the failure mode of a landing system. This method was selected to demonstrate crisp values of severity, occurrence, and detectability. In addition, the RPN was obtained. The results of Fuzzy FMEA for the landing system were analyzed for the RPN and ranking by fuzzy logic. Finally, Fuzzy FMEA confirmed that it could use the data in quality assurance activities for rotorcraft.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.15 no.3
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• pp.207-221
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• 2020

This study conducted a meta-analysis on the effects of innovation, risk-taking, and enterprising on entrepreneurship. From 2013 to 2020, 392 papers, which were judged as quantitative research from doctoral and master thesis, and academic journals published in Korea were selected as research subjects. 28 duplicates of thesis and thesis are excluded. A total of 52 papers were finally selected, excluding 312 papers that were insufficient to be used as research data because there were no statistical values such as correlation coefficients. For the 52 selected papers, the homogeneity of the variables was first verified. As a result of the homogeneity test, the innovativeness, risk-taking, initiative, and entrepreneurship education all showed great effects on heterogeneity, and the average effect size was analyzed by random effect model. The average effect size analyzed was 0.38 ~ 0.49, and all four variables showed moderate average effect size. As a result of analyzing the average effect size by forest plot, all showed proper results. From the results of funnel plot analysis of entrepreneurship education, published errors were confirmed asymmetric. Research data on entrepreneurship education shows that it cannot represent the whole. It is a structural equation model with entrepreneurship and entrepreneurial intention as a parameter. Iinnovation and risk-taking have an impact on entrepreneurship by taking entrepreneurship education as a parameter. Initiative had an effect on the entrepreneurial intention a business, regardless of entrepreneurship education. In a number of studies, university entrepreneurship education has had an impact on the entrepreneurial intention. It should be changed to entrepreneurship education that combines theory and practice. Entrepreneurship education should be transformed into continuous and field-oriented education.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.9
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• pp.131-141
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• 2021

With the rapid development of the Internet, online shopping has grown so fast that almost any good or service can be sold online today. The popularity and rapid growth of e-commerce signal a huge market opportunity for e-retailers. From the organizational perspective, it is necessary to evaluate and explore what drives customers to buy their products or to use their services. This study, therefore, aims to explain the online purchase intention and its determinants of Vietnamese customers for cosmetics and personal care products. Quantitative data was collected from an online survey conducted among university students, then was put into SPSS and AMOS for further analysis. Descriptive statistics, Cronbach's alpha test, exploratory factor analysis (EFA), regression analysis, and SEM were used to examine data from 434 valid answers. The research findings reveal that four factors positively affect purchase intention: Shopping enjoyment has the most significant impact, followed by trust, benefit, and website quality. On the other hand, perceived risk negatively influences purchase intention. While the cosmetics and personal care industry is thriving with a huge number of producers and consumers throughout the world, this study contributes to the existing literature in terms of capturing customers' needs and developing effective strategies to attract more online users.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.34 no.4
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• pp.90-116
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• 2021

Objectives : This study covers the effects of burn treatments using oriental herbal medicine. Methods : The relevant literature was extensively investigated through domestic and international databases and finally 14 papers was selected. The literatures were systematically reviewed and 10 papers capable of quantitative analysis were meta-analyzed. Results : Oriental herbal medicines had a effect on reducing wound healing time, pain and the risk of infection and skin transplantation. Conclusions : We found that oriental herbal medicine was effective and safe for burn treatment.

• Journal of Dental Anesthesia and Pain Medicine
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• v.21 no.1
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• pp.15-27
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• 2021

This systematic review aimed to qualitatively and quantitatively evaluate the effectiveness of cryotherapy in the reduction of postendodontic pain. The review question was, "What will be the success rate of cryotherapy technique among human patients with postendodontic pain?". The review protocol was framed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Six studies were included in the review, and quantification of five studies was performed through a meta-analysis. In the forest plot representation of the studies comparing the control and cryotherapy groups in terms of the success rate in the management of postendodontic pain, the combined risk ratio (RR) was 0.80 (95% CI: 0.56 to 1.13) with a P value of 0.20. Based on the quantitative analysis, it can be suggested that intracanal cryotherapy does not play a significant role in reducing postendodontic pain.

• Korean Journal of Organic Agriculture
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• v.29 no.2
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• pp.159-171
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• 2021

The purpose of this paper is to analyze the relationship between the level of satisfaction of domestic Environment-friendly agricultural products and purchase intent of imported organic products. To accomplish the objective of the study a consumer survey was administered for quantitative analysis regarding consumption patterns. The bivariate probit with sample selection model was employed for empirical analysis on the relationship. The estimation results showed that to increase continuously the consumption, it is necessary to improve the quality satisfaction compared to the price, and that it is also necessary to increase the reliability of the certification system and the awareness that the consumption is helpful for health promotion to increase the quality satisfaction compared to price. In addition, it was concluded that in order to induce the purchase of domestic organic products rather than imported organic products, efforts to improve the safety of domestic products, remove the risk of residual pesticides, and increase the reliability of domestic products compared to imported products are needed. Therefore, to reduce the proportion of purchases of imported organic products and increase the consumption of domestic products, raising awareness that the consumption is conducive to health promotion, enhancing the safety of domestic products, and providing accurate information on the safety of imported products are required.

• Physical Therapy Rehabilitation Science
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• v.12 no.1
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• pp.12-18
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• 2023

Objective: Chemotherapy is usually given to inhibit cancer progression. It is the most common side effect of chemotherapyinduced peripheral neuropathy (CIPN) after chemotherapy, and its symptoms include pain such as paresthesia, dysesthesia, allodynia, hyperalgesia, and electrical stimulation. Therefore, in this review, randomized controlled trials (RCTs) were combined to analyze the effect qualitatively and quantitatively in order to find out the effect of manual therapy on patients with CIPN through a meta-analysis. Design: A systematic review and meta-analysis Methods: This review conducted a literature search through international databases (CINAHL, Embase, MEDLINE, Web of Science) in December 2022 to synthesize the effect of manual therapy on the symptomatic improvement of CIPN. Qualitative evaluation (risk of bias) and quantitative evaluation using ReVMan provided by the Cochrane Group were expressed as a random effect model and standardized mean difference (SMD). Results: In four RCTs 165 patients with CIPN were evaluated for symptoms of neuropathy. The experimental group consisting of manual therapy and its subcategories showed significant improvement compared to the control group. The results analyzed through the random effects model were SMD=-1.11; 95% confidence interval, -1.97 to -0.24. Conclusions: We came to the conclusion that manual therapy could significantly contribute to improving the symptoms of CIPN, and since it may vary depending on the technique of manual therapy, further studies on manual therapy suitable for neuropathy are needed.

• Journal of The Korean Society of Agricultural Engineers
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• v.59 no.1
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• pp.81-96
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• 2017

Along with climate change, it is reported that the scale and the frequency of extreme climate events (e.g. heavy rain, typhoon, etc.) show unstable tendency of increase. In case of Korea, also, the frequency of heavy rainfall shows increasing tendency, thus causing natural disaster damage in downtown and agricultural areas by rainfall that exceeds the design criteria of hydraulic structures. In order to minimize natural disaster damage, it is necessary to analyze how extreme precipitation event changes under climate change. Therefore a new design criteria based on non-stationarity frequency analysis is needed to consider a tendency of future extreme precipitation event and to prepare countermeasures to climate change. And a quantitative and objective characteristic analysis could be a key to preparing countermeasures to climate change impact. In this study, non-stationarity frequency analysis was performed and inundation risk indices developed by 4 inundation characteristics (e.g. inundation area, inundation depth, inundation duration, and inundation radius) were assessed. The study results showed that future probable rainfall could exceed the existing design criteria of hydraulic structures (rivers of state: 100yr-200yr, river banks: 50yr-100yr) reaching over 500yr frequency probable rainfall of the past. Inundation characteristics showed higher value in the future compared to the past, especially in sections with tributary stream inflow. Also, the inundation risk indices were estimated as 0.14 for the past period of 1973-2015, and 0.25, 0.29, 1.27 for the future period of 2016-2040, 2041-2070, 2071-2100, respectively. The study findings are expected to be used as a basis to analyze future inundation damage and to establish management solutions for rivers with inundation risks.

• Journal of Korean Academy of Nursing
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• v.13 no.1
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• pp.7-21
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• 1983

For the flexible and rational distribution of limited existing health resources based on measurements of individual risk, the socalled Risk Approach is being proposed by the World Health Organization as a managerial tool in maternal and child health care program. This approach, in principle, puts us under the necessity of developing a technique by which we will be able to measure the degree of risk or to discriminate the future outcomes of pregnancy on the basis of prior information obtainable at prenatal care delivery settings. Numerous recent studies have focussed on the identification of relevant risk factors as the Prior infer mation and on defining the adverse outcomes of pregnancy to be dicriminated, and also have tried on how to develope scoring system of risk factors for the quantitative assessment of the factors as the determinant of pregnancy outcomes. Once the scoring system is established the technique of classifying the patients into with normal and with adverse outcomes will be easily de veloped. The scoring system should be developed to meet the following four basic requirements. 1) Easy to construct 2) Easy to use 3) To be theoretically sound 4) To be valid In searching for a feasible methodology which will meet these requirements, the author has attempted to apply the“Likelihood Method”, one of the well known principles in statistical analysis, to develop such scoring system according to the process as follows. Step 1. Classify the patients into four groups: Group $A_1$: With adverse outcomes on fetal (neonatal) side only. Group $A_2$: With adverse outcomes on maternal side only. Group $A_3$: With adverse outcome on both maternal and fetal (neonatal) sides. Group B: With normal outcomes. Step 2. Construct the marginal tabulation on the distribution of risk factors for each group. Step 3. For the calculation of risk score, take logarithmic transformation of relative proport-ions of the distribution and round them off to integers. Step 4. Test the validity of the score chart. h total of 2, 282 maternity records registered during the period of January 1, 1982-December 31, 1982 at Ewha Womans University Hospital were used for this study and the“Questionnaire for Maternity Record for Prenatal and Intrapartum High Risk Screening”developed by the Korean Institute for Population and Health was used to rearrange the information on the records into an easy analytic form. The findings of the study are summarized as follows. 1) The risk score chart constructed on the basis of“Likelihood Method”ispresented in Table 4 in the main text. 2) From the analysis of the risk score chart it was observed that a total of 24 risk factors could be identified as having significant predicting power for the discrimination of pregnancy outcomes into four groups as defined above. They are: (1) age (2) marital status (3) age at first pregnancy (4) medical insurance (5) number of pregnancies (6) history of Cesarean sections (7). number of living child (8) history of premature infants (9) history of over weighted new born (10) history of congenital anomalies (11) history of multiple pregnancies (12) history of abnormal presentation (13) history of obstetric abnormalities (14) past illness (15) hemoglobin level (16) blood pressure (17) heart status (18) general appearance (19) edema status (20) result of abdominal examination (21) cervix status (22) pelvis status (23) chief complaints (24) Reasons for examination 3) The validity of the score chart turned out to be as follows: a) Sensitivity: Group $A_1$: 0.75 Group $A_2$: 0.78 Group $A_3$: 0.92 All combined : 0.85 b) Specificity : 0.68 4) The diagnosabilities of the“score chart”for a set of hypothetical prevalence of adverse outcomes were calculated as follows (the sensitivity“for all combined”was used). Hypothetidal Prevalence : 5％ 10％ 20％ 30％ 40％ 50％ 60％ Diagnosability : 12% 23% 40% 53% 64% 75% 80%.