• Journal of Dental Anesthesia and Pain Medicine
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• 제22권6호
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• pp.405-417
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• 2022

Oral lichen planus (OLP) is a chronic inflammatory immune-mediated condition that has been identified as a potentially malignant oral disorder. Various therapies have been proposed for its management as alternative to corticosteroids. However, no definitive treatment has been identified that can result in complete remission or minimal recurrence. Hyaluronic acid has recently been used as an alternative therapy for the management of OLP. This study aimed to systematically review the effectiveness of Hyaluronic acid in the management of symptomatic OLP. Online electronic databases and manual searches were performed for randomized controlled trials (RCTs) published in English between January 2010 and April 2022. RCTs were identified that compared the efficacy of hyaluronic acid and other interventional therapies at baseline and during follow-up. The Cochrane Risk of Bias tool was used to assess the quality of the included studies. Visual analog scale (VAS) scores, Thongprasom sign scores, lesion size, degree of erythema, clinical severity, and disease severity were assessed both quantitatively and qualitatively. Seven studies were analyzed. Five studies reported a high risk of bias while the remaining two studies reported an unclear risk of bias. The overall quantitative assessment of size, symptoms, degree of erythema, and sign score in OLP lesions treated with HA was not statistically significant compared to that in the control group (P > 0.05). In addition, subgroup analysis comparing HA with placebo or corticosteroids did not yield statistically significant (P > 0.05) results. Qualitatively, both HA and tacrolimus resulted in an effective reduction in signs and symptoms. Clinical/disease severity index/scores were inconsistent. A high degree of heterogeneity was observed among the included studies. None of the included studies reported the side effects of HA. These findings suggest that corticosteroids, tacrolimus, placebo, and HA could be equally effective in OLP management. The clinical/disease severity index or score reduction cannot be determined with certainty. Thus, OLP can be treated with HA as an alternative therapy. Owing to limited clinical trials on HA, high heterogeneity, and high risk of bias in the included studies, definitive conclusions cannot be derived.

• 국제학술발표논문집
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• The 6th International Conference on Construction Engineering and Project Management
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• pp.213-216
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• 2015

Despite the significant increase of Korean contractors in the international construction market, many SMCCs (Small & Medium Construction Companies) have suffered in the global financial crisis, and some of them have been kicked out of the international market after experiencing huge losses on projects. SMCCs face obstacles in the international market, such as an insufficient ability to gather information and inappropriate management of associated risks, which lead to difficulties in establishing effective business strategies. In other words, making immature decisions without an effective business strategy may cause not only the failure of one project but also the bankruptcy of the SMCC. To overcome this, the research presented herein aims to propose a decision support system for SMCCs, which would screen projects and make a go/no-go decision at the early stages of international projects. The proposed system comprises a double axis: (1) a profit prediction model, which evaluates 10 project properties using an objective methodology based on a historical project performance database and roughly suggests expected profit rate, and (2) a feasibility assessment model, which evaluates 17 project environment factors in a subjective and quantitative methodology based on experience and supervision. Finally, a web-based system is established to enhance the practical usability, which is expected to be a good reference for inexperienced SMCCs to make proper decisions and establish effective business strategies.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 정기총회 및 추계학술대회 논문집
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• pp.711-716
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• 2011

Ministry of Land, Transportation and Maritime Affairs of Korea has started a research project on verification process and safety assessment of Communication Based Train Control (CBTC) system for metropolitan railroad control as a 3-year project starting from 2010. As a number of companies has made efforts in securing the technologies for domestic production of CBTC systems, the purpose of the project is to develop the specification for interoperability with the considerations for local environments including metropolitan train operations and wireless communications. And the developed systems and the RAMS related outcomes from the participating companies are subject to Independent Safety Assessment (ISA) performed by a foreign specialized agency and the corresponding certificates are to be issued as a part of the project. In this paper, the RAMS management for verification and commercialization of metropolitan railroad CBTC systems has been studied. The study includes response strategy for the requirements of international standards, responsibility and authority of the related institute and the companies, quantitative RAMS objectives, and risk management strategies in project fulfillment.

• 한국터널지하공간학회 논문집
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• 제20권1호
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• pp.11-22
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• 2018

철도터널의 방재시설 계획 시 터널의 안전성을 정량적 위험도 평가에 의해서 정량화하여 방재시설의 적정성 여부를 판단하도록 하고 있다. 이에 본 연구에서는 터널화재에 대한 정량적 위험도 평가 시 결과에 크게 영향을 미치는 화재열차의 터널 내 정차확률을 예측하는 방법을 제시하였다. 이를 위해서 열차의 주행저항계수를 고려하여 타력운전거리를 계산하기 위한 모델을 개발하였으며, 타력운전특성과 비상제동거리를 고려하여 몬테카를로 시뮬레이션 기법에 의해 터널연장 및 경사도, 초기주행속도를 변수로 하여 화재열차가 터널에 정차할 확률을 예측하였다. 타력운전거리의 예측을 위한 운동방정식은 KTX II의 주행저항계수를 반영하여 분석하였다. KTX II 열차의 경우, 타력운전거리는 상향경사의 터널에서는 경사도가 증가할수록 감소하나 하향경사구간에서는 정지하지 않고 계속하여 주행이 가능하다. 화재열차의 터널 내 정차확률은 열차의 주행속도가 증가할수록, 경사도가 낮을수록 감소하며, 고속열차(주행속도 250 km/h 이상)는 인적오류를 고려하지 않는 경우, 경사도 0.5% 이하의 터널에서는 화재 시 열차가 터널에 정차할 확률은 0%이고, 경사도가 증가하고 터널연장이 증가하면 정차확률은 급격하게 증가하는 것으로 나타났다.

• 한국환경보건학회지
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• 제49권4호
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• pp.218-227
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• 2023

Background: Since 2019, the Ministry of Environment has implemented a seasonal fine dust management system from December to March, targeting high PM_2.5 levels with the aim of reducing PM_2.5 concentrations and protecting public health. The focus of improving the seasonal management system lies in the atmospheric PM_2.5 levels. Considering the primary goal of protecting public health, it is necessary to analyze the policy effects from an exposure perspective rather than a concentration-based approach. Objectives: This study aims to quantitatively assess the improvement of indoor PM_2.5 levels and the health impacts of the seasonal management system by comparing the periods before and during its implementation in residential environments. Methods: PM_2.5 concentrations within residential environments in a metropolitan area were measured using an optical particle counter (IAQ-C7, K-weather, Ltd, Korea) at one-minute intervals during the pre-implementation period (November 21~25, 2022) and during the implementation period (December 19~23, 2022). Based on the measured PM_2.5 concentrations, a quantitative evaluation of cancer and mortality risks was conducted according to age and gender. Results: The results of comparing indoor and outdoor PM_2.5 concentrations before and during the implementation of the seasonal management system showed a decrease of approximately 56.6% and 47.9%, respectively. Health risk assessments revealed that both the safety-limit-based and safety-target-based Hazard Quotients (HQ) exceeded the threshold of 0.1 for children under 19 years of age, both before and after the implementation. The mortality risk decreased by approximately 47.9% after the implementation, with children aged 0-9 showing the highest mortality risk at 0.9%. Conclusions: The findings of this study confirmed the positive health impacts of the seasonal management system across all age groups, particularly children under 19 who are more vulnerable to fine dust exposure.

• 한국안전학회지
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• 제18권3호
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• pp.88-93
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• 2003

The Process Safety Management (PSM) by the Law of Industry, Safety and Health has been performed for preventing major accidents of chemical plants since 1996. In terms of preventing chemical accidents more precisely, it is essential to develop a tool for quantitative risk assessment. For this, KOSHA (Korea Occupational Safety and Health Agency) developed an Integrated Risk Management System (IRMS). The system is designed to assimilate data on chemical plant hazards from external database, to integrate these data with location information(topographic and demographic), and to make them user-friendly accessible. The system consists of several main functions: display of five major Korean petrochemical complex layout display of equipment layout with its information utilizing the external database, zonation of the hazard effected area with consequence analyses, the most probable accident scenario generation, accident/incident database and calculation of frequency of accident using equipment reliability database, etc. The highlight of IRMS is to provide the risk contours using GIS(Geographical Information System) technology. IRMS is intended to manage hazardous installation more systematically and effectively, to reduce the number of accident remarkably, further minimizing production loss in the plant. The system is now under application to about 500 PSM sites as well as and emergency authorities in Korea by KOSHA (Korea Occupational Safety and Health Agency)

• 한국IT서비스학회지
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• 제7권1호
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• pp.117-130
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• 2008

Multi-attribute risk assessments provide a useful framework for systematic quantitative risk assessment that the security manager can use to prioritize security requirements and threats. In the first step, the security managers identify the four significant outcome attributes(lost revenue, lost productivity, lost customer, and recovery cost). Next. the security manager estimates the frequency and severity(three points estimates for outcome attribute values) for each threat and rank the outcome attributes according to AHP(Analytic Hierarchy Process). Finally, we generate the threat index by using muiti-attribute function and make sensitivity analysis with simulation package(Crystal Ball). In this paper, we show how multi-attribute risk analysis techniques from the field of security risk management can be used by security managers to prioritize their organization's threats and their security requirements, eventually they can derive threat index. This threat index can help security managers to decide whether their security investment is consistent with the expected risks. In addition, sensitivity analysis allows the security manager to explore the estimates to understand how they affect the selection.

• 한국가스학회지
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• 제27권2호
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• pp.86-94
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• 2023

본 연구는 공동주택에 도시가스를 공급하기 위해 정압기 대신 설치하는 공용 압력조정기의 안전성 향상을 위한 대안을 마련하기 위한 목적으로 진행되었다. 먼저, 국내 압력조정기의 안전기준 및 설치 실태를 조사하여 문제점을 도출하고 해결방안을 제시하였다. 또한 정량적 위험성평가 솔루션인 DNV Phast-Safeti 프로그램을 이용해 공동주택에 설치되는 압력조정기와 주변 가스설비에 내포된 가스누출 등의 위험성을 개인적 위험도와 사회적 위험도로 구분하여 평가하고, 압력조정기의 설치와 관리 측면에서 위험성 감소를 위한 방안을 도출하였다.

• 산업경영시스템학회지
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• 제22권51호
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• pp.63-72
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• 1999

Many firms have applied flexible manufacturing systems as a means of increasing productivity, profitability, and quality. Therefore, the purpose of this paper is to develop the more efficient justification model through an analytical scoring model with the quantitative factors, flexibility factors, and safety factors under uncertainty. In this paper, the three factors for properly comparing and evaluating of flexible manufacturing systems are presented. Especially, this paper has emphasized the flexibility and safety factor; the one consists of organization assessment, process treatment function, products and products quantity, useful life assesment, and software function, the other presents risk assesment, Y2K problem, safety device analysis, total productive management system, safety management. Finally, a normalized scoring model by the new flexibility and safety factors can be used in real fields for flexible manufacturing systems project selection under uncertainty.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2023년도 가을학술발표대회논문집
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• pp.249-250
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• 2023

The vulnerability factor analysis and risk quantification model for aging buildings presented in this study can be utilized by governmental agencies such as the Facility Safety Foundation, the Ministry of Land, Infrastructure and Transport, and various local governments. Policymakers can use this to supplement inadequacies in existing checklists, and it is expected that they can proactively prevent risks by evaluating dangers based on specific aging characteristics of buildings.