• Asian-Australasian Journal of Animal Sciences
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• v.29 no.3
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• pp.343-351
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• 2016

Although the chemical, physical, and nutritional properties of bovine milk have been extensively studied, only a few studies have attempted to characterize milk-synthesizing genes using RNA-seq data. RNA-seq data was collected from 21 Holstein samples, along with group information about milk production ability; milk yield; and protein, fat, and solid contents. Meta-analysis was employed in order to generally characterize genes related to milk production. In addition, we attempted to investigate the relationship between milk related traits, parity, and lactation period. We observed that milk fat is highly correlated with lactation period; this result indicates that this effect should be considered in the model in order to accurately detect milk production related genes. By employing our developed model, 271 genes were significantly (false discovery rate [FDR] adjusted p-value<0.1) detected as milk production related differentially expressed genes. Of these genes, five (albumin, nitric oxide synthase 3, RNA-binding region (RNP1, RRM) containing 3, secreted and transmembrane 1, and serine palmitoyltransferase, small subunit B) were technically validated using quantitative real-time polymerase chain reaction (qRT-PCR) in order to check the accuracy of RNA-seq analysis. Finally, 83 gene ontology biological processes including several blood vessel and mammary gland development related terms, were significantly detected using DAVID gene-set enrichment analysis. From these results, we observed that detected milk production related genes are highly enriched in the circulation system process and mammary gland related biological functions. In addition, we observed that detected genes including caveolin 1, mammary serum amyloid A3.2, lingual antimicrobial peptide, cathelicidin 4 (CATHL4), cathelicidin 6 (CATHL6) have been reported in other species as milk production related gene. For this reason, we concluded that our detected 271 genes would be strong candidates for determining milk production.

• Reproductive and Developmental Biology
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• v.29 no.1
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• pp.43-48
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• 2005

To search of a new porcine pheromonal odorants for biostimulation control system technologies to offer a potentially useful and practical way to improve reproductive efficiency in livestock species, the holographic quantitative structure activity relationship (HQSAR) model between odorants, 2-phenoxytetrahydrofurane (A), 2-cyclohexyl-oxytetrahydrofurane (B), derivatives and binding affinity constants (p[Od.]/sub 50/) for porcine odorant-binding protein (pOBP) as receptor of pig pheromones were derivated and disscused. The binding affinity constants of cyclohexyl substituents (A) for pOBP were higher (A>B) than that of phenyl substituents (B). It was revealed that the optimum HQSAR model XI using PLS analyses had a fragment length (5∼8) with chirality at 5 components and hologram length 97 bin, which had a cross-validated q²(predictablities) of 0.916, and a conventional correlation coefficient r² (fitness) of 0.988, respectively. From the atomic contribution, the C3 and C5 atom in 2-oxyfuryl group contributed to binding affinity constants, whereas the central carbon atom in tert-butyl group on the cyclohexyl ring and the C4 atom of furyl group parts showed no contribution.

• International Commerce and Information Review
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• v.18 no.3
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• pp.275-306
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• 2016

This paper investigates the success and failure factors of technology commercialization for SMEs developing public sector technologies. The 2014 Korea Technology Transfer Commercialization Status Report states that only 30% of the technologies that are transferred are being used and the rest are neglected. The objective of this paper is to determine the relationship between quantitative variables and the success rate of technology commercialization of 1,222 SMEs in Korea by using three analyzes (cross tabulation, process and logistic) methodologies to increase the success of public technology commercialization. The outcome shows that the number of successful technology deployment cases and the number of IPR registration cases have a positive impact on the success rate of public technology commercialization. The statistical outcome also verifies that unnecessary technology development, more attempts and failures of technology development, and longer lead time in the planning phase have a negative impact on the success rate of the public technology development and commercialization. For policy implications, the government should be selective in supporting public technology commercialization and development for SMEs as not all technology attempts exert positive effects.

• Journal of Acupuncture Research
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• v.18 no.3
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• pp.56-68
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• 2001

Objective : Functional brain mapping study on acupuncture stimulation using the [14C]2-deoxyglucose([14C]2-DG) autoradiography provides quantitative data and visualized pathway in central nervous system(CNS). We aimed to investigate the neural pathway and spatial distribution of metabolic activity elicited in CNS on electroacupuncture stimulation using [14C]2-DG autoradiography. Methods : The study were divided into three groups by stimulation times. 45-mins stimulation group according to Sokoloffs method, 5-mins stimulation group according to Duncun's method, and 15-mins stimulation group. ;A venous catheter was equipped into right jugular vein. The rats (Sprague-Dawley rats, 230-260g) were kept fastened loosely on a holding platform without anesthesia. Electroacupuncture stimulation (5 ms, 2 Hz, 1~3 mA) were applied on the left Zusanli (ST36) acupoint and [14C]2-DG ($25{\mu}Ci/rat$) injection was performed through the catheter. After sacrifice, the brain and the spinal cord were made to sections for film image. The film images were digitalized as the isotope concentration based upon comparison of optical densities with that of the standards and normalized by the optical density of corpus callosum. Results : 1. 15-mins stimulation group was most effective among 3 experiments. 2. On 15-mins stimulation group, medial geniculate nucleus, intetpeduncular nucleus intermedius, ventral periolivary nucleus, caudal periolivary nucleus, medial superior olive, lateral paragigantocellular nucleus, including hypothalamic arcuate nucleus were increased by more than 25% (at least, p<0.05) by electroacupuncture stimulation. 3. Especially, the metabolism in hypothalamic arcuate nucleus was increased by 90% (p<0.05). 4. The fact that arcuate nucleus of hypothalamus might play a role of interconnection area between ascending and descending pathway of acupuncture stimulation was demonstrated visually. Conclusions : Advanced study on electroacupuncture stimulation elicited significant increase of metabolic activity in various nuclei of hypothalamus will provide the important experimental basis in research of the relationship between electroacupuncture stimulation and internal visceral functions.

• Journal of the Korean earth science society
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• v.24 no.7
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• pp.614-624
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• 2003

The purpose of this study was to examine the effectiveness of utilizing a concept map as an instructional strategy to promote student achievement through semantical learning in elementary school on volcanoes. To analyze student achievement in understanding the concept of volcano, quantitative and qualitative analyses were performed through a written test for two different groups that were composed of 80 sixth-grade students: a control group that attended class using the conventional strategy and an experimental group that attended class using concept maps. The results of this study were as follows: First, the use of concept maps in class is effective in learning because of the higher understanding of the group that was using concept maps in the achievement assessment. Second, in their post-instructional understandings, no significant differences are shown between middle- and low-ranking students statistically, but a significant difference is shown between high- and low-ranking students or between high- and middle-ranking students. This indicates that the use of concepts maps in a class is more effective for the middle- and low-ranking students than for the high-ranking students. Third, in the repetitions of classes, the students learning with an aid of concept maps became accustomed to structuring the concepts of their learning subject in categories of relationships, hierarchies, cross-links, and examples easily.

• Sleep Medicine and Psychophysiology
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• v.11 no.2
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• pp.100-105
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• 2004

Objectives: Major depression is associated with an increased risk of cardiovascular mortality. One possible explanation for this association is that major depression influences autonomic neurocardiac regulation. However, previous studies on the relationship between heart rate variability (HRV) and major depression have revealed conflicting results. The purpose of this study is to clarify that major depressive patients compared to healthy controls show a reduction in HRV as an expression of reduced modulation of vagal activity to the heart. Methods: According to DSM-IV, the time and frequency domain HRV indices (5-min resting study) of 30 patients with major depressive disorder were compared with those of 30 healthy controls. Standardized HRV tests enable quantitative estimation of autonomic nervous system function. Results: After controlling for age and gender, subjects with major depression showed a higher heart rate and significantly lower modulation of cardiovagal activity compared to controls. The total power (TP) band, very low frequency (VLF: 0.003-0.04 Hz) band, low frequency (LF: 0.04-0.15 Hz) band, and high frequency (HF: 0.15-0.4 Hz) band were significantly reduced in subjects with major depression compared to control subjects. Conclusion: Patients with major depression may suffer from functional disturbances in the interaction between the sympathetic and parasympathetic autonomic systems.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.45 no.6
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• pp.117-122
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• 2008

Although the pulse diagnosis is the one of the most important diagnostic process to traditional medical doctors, there is no proper communication tool between experts and trainees. In this paper, we have developed a indentation training system which consists of a hardware measuring indent pressure on artificial arm quantitatively and a software providing a indentation training program. The hardware for measurement of indent pressure profile includes 3 load cells embedded in the artificial arm, signal amplification part and digitization part, NI-USB 6009 with 200Hz sampling rate. For setting up a relationship table between weights and output voltages, 8 standard weights were used. To evaluate this hardware, 3 oriental medical specialists were involved and their indent pressure profile were recorded three times respectively. From these, it was found that pulse diagnosis process could be divided into 3 periods and the maximum load were $500g{\cdot}f$ approximately while doctors perform a pulse diagnosis. The indentation training program was implemented with LabView and designed to monitor the differences between the pressure profile of a expert and that of a trainee so to offer some visual feedback to the trainee. Also, this program could provide the trends of training performances. With this developed system, the education of pulse diagnosis is expected to be more quantitative and effective.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.25 no.1
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• pp.34-39
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• 2013

In this study, the quantitative analysis and pattern analysis of the error bounds with respect to recording period were carried out using the wave climate data from coastal areas. Arbitrary recording periods were randomly sampled from one month to six years using the bootstrap method. Based on the analysis, for recording periods less than one year, it was found that the error bounds decreased rapidly as the recording period increased. Meanwhile, the error bounds were found to decrease more slowly for recording periods longer than one year. Assuming the absolute estimate error to be around 10% (${\pm}0.1m$) for an one meter significant wave height condition, the minimum recording period for reaching the estimate error for Sokcho and Geoje-Hongdo stations satisfied this condition with over two years of data, while Anmado station was found to satisfy this condition when using observational data of over three years. The confidence intervals of the significant wave height clearly show an increasing pattern when the percentile value of the wave height increases. Whereas, the confidence intervals of the mean wave period are nearly constant, at around 0.5 seconds except for the tail regions, i.e., 2.5- and 97.5-percentile values. The error bounds for 97.5-percentile values of the wave height necessary for harbor tranquility analysis were found to be 0.75 m, 0.5 m, and 1.2 m in Sokcho, Geoje-Hongdo, and Anmado, respectively.

• Economic and Environmental Geology
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• v.40 no.3 s.184
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• pp.295-306
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• 2007

In this study, we predicted areas vulnerable to ground subsidence near abandoned underground coal mine at Sam-cheok City in Korea using a probability (frequency ratio) model with Geographic Information System (GIS). To extract the factors related to ground subsidence, a spatial database was constructed from a topographical map, geo-logical map, mining tunnel map, land characteristic map, and borehole data on the study area including subsidence sites surveyed in 2000. Eight major factors were extracted from the spatial analysis and the probability analysis of the surveyed ground subsidence sites. We have calculated the decision coefficient ($R^2$) to find out the relationship between eight factors and the occurrence of ground subsidence. The frequency ratio model was applied to deter-mine each factor's relative rating, then the ratings were overlaid for ground subsidence hazard mapping. The ground subsidence hazard map was then verified and compared with the surveyed ground subsidence sites. The results of verification showed high accuracy of 96.05% between the predicted hazard map and the actual ground subsidence sites. Therefore, the quantitative analysis of ground subsidence near abandoned underground coal mine would be possible with a frequency ratio model and a GIS.

• Korean Journal of Food Science and Technology
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• v.41 no.6
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• pp.609-614
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• 2009

Sesame oil was sometimes replaced by mixed oil due to high price in Korean market. To find out authentic sesame oil, electronic nose (E-nose) based on mass spectrometer system was used. Sesame oil was blended with perilla oil at the ratio of 97:3, 94:6, 91:9, 88:12 and 85:15, respectively. Intensities of each fragment from sesame oil by E-nose based on MS were completely different from those of perilla oil. The obtained data was used for discriminant function analysis. For quantitative analysis, the partial least square algorithm was used. The added concentration of perilla oil to sesame oil was correlated with discriminant function first score (DF1) and second score (DF2). From this relationship it could be found out how much perilla oil added. DFA plot indicated a significant separation of pure sesame oil and pure perilla oil. The different geographical origin of sesame oil was used for blending with perilla oil were closed to that of sesame oil. Korean sesame oil mixture and Indian sesame oil one were well separated. And the correlation between mixing ratios and DF1 values was found at the ratio of 97:3, 91:9, and 85:15 (SE vs PE oil), respectively. But the added concentration of perilla oil to sesame oil was correlated with discriminant function first score (DF1). E-nose based on MS system could be used as an efficient method for purity of oil quality.