• Journal of Korean Society of Rural Planning
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• v.22 no.3
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• pp.119-129
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• 2016

The aim of this study is to suggest the quantitative standard of a marginal village. For the purpose, the study selected 43 villages with the population of 50 or less, the classification of a marginal village in accordance with advanced research and 47 villages with the population over 50 in Buyeo-gun region. The common reason of occurrence of a marginal village suggested by advanced research is a characteristic of a village or decline and extinction of a village rather than a simple index of population or aging rate. Therefore, the study assumed that decline of functions of the village would be caused by decline a function of communities consisting of the villagers. The study then assumed that the relatively low or 0 number or rate of participants would result in community functions. The study conducted t-test on basis of population and aging rate and an analysis to find the range with relatively large differences in the number of communities, participants and the rate of the participants, etc. The result showed that the community function began to decline when the population was less than 60~70 and the aging rate over 75%~85%. As the decline of functions of communities began in population of 70, the critical point was met when the population was 40 or less. With population of 40 or less, the young and the old group communities became extinct or showed rapid decrease in the number of participants. The study assumed that decline of functions of a village, a reason of occurrence of a marginal village would be decline of functions of communities, but there was no further analysis on decline or extinction of a village with population of 40 or less. There shall be further studies about whether a village of population of 40 or less is led to decline of a function or extinction of village communities.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.58 no.3
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• pp.444-449
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• 2009

This paper introduces a method to establish performance criteria of the in-house power supply system in nuclear power plants. The performance criteria of the system is presented in terms of the number of function failures and amount of the out-of-service time that can be allowed commensurate with the probabilistic safety assessment results of the nuclear power plants. To obtain the performance criteria such as reliability and availability, the functions of the system were analyzed and probabilistic assessment results were utilized. This method provides quantitative guidelines in selecting and monitoring system functions to determine an adequate level of maintenance quality in order to ensure the probabilistic goals for the safety of the nuclear power plants.

• Asia Pacific Journal of Corpus Research
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• v.2 no.2
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• pp.1-15
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• 2021

The study aims to explore the use of metadiscourse in the Bank Negara Malaysia Governor's speeches based on Hyland's Interpersonal Model of Metadiscourse. The corpus data consist of 343 speech texts, which were extracted from the Malaysian Corpus of Financial English (MacFE), amounting to 688,778 tokens. Adopting both quantitative and qualitative approaches to data analysis the study investigates (1) the overall use of metadiscourse in the Bank Negara Governor's speech texts and (2) the functions of the most prominent metadiscourse resources used and their functions in the speech texts. The findings reveal that the Governor's speech texts to be interactional rather than interactive, revealing a rich distribution of interactional metadiscourse resources, namely engagement markers, self-mention, hedges, boosters and attitude markers throughout the texts. The interactional metadiscourse resources function to establish speaker-audience engagement and alignment of views, as well as to express degree of uncertainty and certainty and attitudes. The study concludes that the speech texts are not merely informational or propositional, but rather interpersonal.

• Journal of ILASS-Korea
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• v.26 no.4
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• pp.182-188
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• 2021

In this paper, using a transfer function-based analytical model, major factors influencing the acoustics and combustion instability in a two-stage duct system composed of a nozzle and a combustor were derived and their quantitative effects were evaluated. From the acoustic analysis, it was confirmed that the change in reflection coefficient and mean flow could have a great influence on the instability growth rate, and the area ratio and speed of sound ratio between the nozzle and the combustor are also key parameters to determine combustion instability as well as flame transfer functions.

• Journal of KSNVE
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• v.10 no.1
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• pp.168-173
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• 2000

This paper deals with the theoretical study on the effect of the viscosity of an adjacent viscous fluid on the characteristics of the torsional vibration of a rod with fixed-free boundary conditions. Expressions for the natural frequency and damping factor have been obtained as functions of the viscosity of the fluid by exact and asymptotic analyses. The results provide quantitative information of the natural frequency reduction and damping rate affected by the fluid viscosity.

• Asia pacific journal of information systems
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• v.12 no.3
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• pp.1-20
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• 2002

For the last decade, some leading groups of corporations in Korea have integrated and managed their Information Systems(IS) functions. Each group established a separate System Management(SM) company to manage the IS and tried to get a synergy effect from the integration. These attempts, however, were not initiated by any one company. Rather they were group efforts. Moreover, the previous measuring tools evaluated IS with the scope of technical performance or quantitative user satisfaction using an absolute scale. Obscure criteria were used in an attempt to present improvements in IS function which were qualitatively weak. This study evaluates whether integration has been efficient and successful. For this purpose, we evaluate the performance efficiency of IS functions with Data Envelopment Analysis(DEA) methodology. In comparison with prior methods, DEA presents the rate of relative efficiency, the efficiency frontier for improving inefficiency, the degree of improvement(slack), and the guideline to construct any benchmark(reference set). For our DEA evaluation, this study selected a leading group of 23 companies in Korea. Our experimental results are as follows. First, efficiency was rated low on average. It also demonstrates that the motivation of performance efficiency of IS functions is deficient. Second, the result of the test to find the existence of economy of scale and scope shows that the growth of an organization and industrial characteristics do not affect IS performance efficiency from the perspective of user satisfaction. Finally, the comparison with other evaluation approaches informs us that DEA can be a complementary evaluation method which supports other measuring tools.

• Biomedical Science Letters
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• v.22 no.3
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• pp.107-114
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• 2016

Maintenance of fasting blood glucose levels is important for glucose homeostasis. Disruption of feedback mechanisms are a major reason for elevations of glucose level in blood, which is a risk factor for type 2 diabetes mellitus that is mainly caused by malfunction of pancreatic beta-cell and insulin. The fasting blood glucose level has been known to be influenced by genetic and environmental factors. Mitochondria have many functions for cell survival and death: glucose metabolism, fatty acid oxidation, ATP generation, reactive oxygen species (ROS) metabolism, calcium handling, and apoptosis regulation. In addition to these functions, mitochondria change their morphology dynamically in response to multiple signals resulting in fusion and fission. In this study, we aimed to examine association between fasting blood glucose levels and variants of the genes that are reported to have functions in mitochondrial dynamics, fusion and fission, using a cohort study. A total 416 SNPs from 36 mitochondrial dynamics genes were selected to analyze the quantitative association with fasting glucose level. Among the 416 SNPs, 4 SNPs of PRKACB, 13 SNPs of PPP3CA, 6 SNPs of PARK2, and 3 SNPs of GDAP1 were significantly associated. In this study, we were able to confirm an association of mitochondrial dynamics genes with glucose levels. To our knowledge our study is the first to identify specific SNPs related to fasting blood glucose level.

• KSBB Journal
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• v.30 no.5
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• pp.230-238
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• 2015

Abnormal glycosylation can significantly affect the intrinsic functions (i.e., stability and solubility) of proteins and the extrinsic protein interactions with other biomolecules. For example, recombinant glycoprotein therapeutics needs proper glycosylation for optimal drug efficacy. Therefore, there has been a strong demand for rapid, sensitive and high-through-put glycomics tools for real-time monitoring and fast validation of the biotherapeutics glycosylation. Although liquid chromatography tandem mass spectrometry (LC-MS/MS) is one of the most powerful tools for the characterization of glycan structures, it is generally time consuming and requires highly skilled personnel to collect the data and analyze the results. Recently, as an alternative method, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS), which is a fast, robust and easy-to-use instrumentation, has been used for quantitative glycomics with various chemical derivatization techniques. In this review, we highlight the recent advances in MALDI-MS based quantitative glycan analysis according to the chemical derivatization strategies. Moreover, we address the application of MALDI-MS for high-throughput glycan analysis in many fields of clinical and biochemical engineering.

• Journal of Plant Biotechnology
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• v.37 no.2
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• pp.196-204
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• 2010

With the completion of genome sequencing of several organisms, attention has been focused to determine the function and functional network of proteins by proteome analysis. The recent techniques of proteomics have been advanced quickly so that the high-throughput and systematic analyses of cellular proteins are enabled in combination with bioinformatics tools. Furthermore, the development of proteomic techniques helps to elucidate the functions of proteins under stress or diseased condition, resulting in the discovery of biomarkers responsible for the biological stimuli. Ultimate goal of proteomics orients toward the entire proteome of life, subcellular localization, biochemical activities, and their regulation. Comprehensive analysis strategies of proteomics can be classified as three categories: (i) protein separation by 2-dimensional gel electrophoresis (2-DE) or liquid chromatography (LC), (ii) protein identification by either Edman sequencing or mass spectrometry (MS), and (iii) quanitation of proteome. Currently MS-based proteomics turns shiftly from qualitative proteome analysis by 2-DE or 2D-LC coupled with off-line matrix assisted laser desorption ionization (MALDI) and on-line electrospray ionization (ESI) MS, respectively, to quantitative proteome analysis. Some new techniques which include top-down mass spectrometry and tandem affinity purification have emerged. The in vitro quantitative proteomic techniques include differential gel electrophoresis with fluorescence dyes, protein-labeling tagging with isotope-coded affinity tag, and peptide-labeling tagging with isobaric tags for relative and absolute quantitation. In addition, stable isotope labeled amino acid can be in vivo labeled into live culture cells through metabolic incorporation. MS-based proteomics extends to detect the phosphopeptide mapping of biologically crucial protein known as one of post-translational modification. These complementary proteomic techniques contribute to not only the understanding of basic biological function but also the application to the applied sciences for industry.

• Journal of Animal Science and Technology
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• v.48 no.2
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• pp.169-190
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• 2006

Researches in livestock are currently actively progressing to improve economically important traits using DNA markers. In cattle, the candidate genes have been selected based on their known functions in the target QTL (quantitative trait locus) region in order to identify QTN (quantitative trait nucleotide) for improving productivities. In this review, molecular genetic studies for the meat related traits, one of the major determinant of market prices, have been fully described. Also recent emerging microarray technique for identifying candidate genes in cattle has been discussed. In case of microarray, cDNA microarrays have been replaced to oligoarrays in order to minimize the experimental errors in cattle. Since the first draft of bovine genome sequences was appeared in the public domain, more markers in relation to the quantitative traits will be discovered in a short period of time and genes affecting difficult-to-measure traits, such as disease resistance, can also be selected for marker assisted selection in near future.