• Journal of Ginseng Research
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• 제40권1호
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• pp.55-61
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• 2016

Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest. Previously, we have shown that activation of lysophosphatidic acid receptors (LPARs) via gintonin application potentiates synaptic transmission by the blockade of $K^+$ channels in the mature hippocampus. However, whether gintonin may exert any beneficial impact directly on cognition at the neural circuitry level and the behavioral level has not been investigated. Methods: In the current study, we took advantage of gintonin, a novel LPAR agonist, to investigate the effect of gintonin-mediated LPAR activation on cognitive performances. Hippocampus-dependent fear memory test, synaptic plasticity in the hippocampal brain slices, and quantitative analysis on synaptic plasticity-related proteins were used. Results: Daily oral administration of gintonin for 1 wk significantly improved fear memory retention in the contextual fear-conditioning test in mice.We also found that oral administration of gintonin for 1 wk increased the expression of learning and memory-related proteins such as phosphorylated cyclic adenosine monophosphate-response element binding (CREB) protein and brain-derived neurotrophic factor (BDNF). In addition, prolonged gintonin administration enhanced long-term potentiation in the hippocampus. Conclusion: Our observations suggest that the systemic gintonin administration could successfully improve contextual memory formation at the molecular and synaptic levels as well as the behavioral level. Therefore, oral administration of gintonin may serve as an effective noninvasive, nonsurgical method of enhancing cognitive functions.

• 전자공학회논문지SC
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• 제38권3호
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• pp.1-12
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• 2001

본 논문은 파라미터 불확실성을 갖는 비최소위상 시스템의 강인제어 문제를 고려한다. 먼저 불확실성을 갖는 비최소위상 시스템을 구간 최소위상 전달함수군과 Pade'근사화 형태로 시간지연 성분으로 변환하는 새로운 방법을 제시한다. 제안하게 될 제어기는 비최소위상 플랜트로 인한 시간지연 거동을 보상할 수 있도록 Smith 예측기 구조를 갖는 보상기로 구성된다. 최소위상 플랜트군의 피드백 제어기는 구조적 불확실성에 대해 주파수 영역의 설계사양의 강인 안정도를 만족하도록 QFT를 이용하여 설계되었다. 전체 시스템의 안정도와 성능은 예제를 통하여 입증한다.

• 항공우주기술
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• 제5권2호
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• pp.227-239
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• 2006

신뢰성 예측은 설계안 중 하나를 선택하거나, 적용되는 부품의 품질 수준, 부하경감(derating) 정도, 기존의 입증기술 또는 최신기술의 채택여부 등과 같은 사항을 설계시 결정하는 데에 합리적인 근거를 제공할 수 있으므로, 우주 시스템의 개발과정에 있어서 필수적인 사항으로 인식되고 있다. 신뢰성의 정량적인 표현을 위해서는 수치적인 정보와 그 정보를 생성하기 위한 기법의 정확성이 확보되어야 하며, 설계에 대한 평가를 돕고, 신뢰성 요구조건 할당, 시정조치 우선순위 결정 등의 기초자료로 적용하기 위하여 개념설계 초기 단계에서부터 수행되어야 한다. 대상품의 설계, 환경 요구조건, 운용환경 데이터, 고장률 데이터 또는 운용 프로파일의 변경이 발생할 때마다 업데이트되어야 한다. 본 논문에서는 우주시스템 개발과정에서 수행되는 신뢰성 예측을 위한 세부절차, 정량적 데이터의 도출 및 적용기법 등에 대하여 검토하였다.

• Tuberculosis and Respiratory Diseases
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• 제83권3호
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• pp.175-184
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• 2020

Quantitative sputum cytometry facilitates in assessing the nature of bronchitis associated with exacerbations of chronic obstructive pulmonary disease (COPD). This is not assessed in most clinical trials that evaluate the effectiveness of strategies to prevent or to treat exacerbations. While up to a quarter of exacerbations may be associated with raised eosinophil numbers, the vast majority of exacerbations are associated with neutrophilic bronchitis that may indicate airway infections. While eosinophilia may be a predictor of response to corticosteroids (oral and inhaled), the limited efficacy of anti-interleukin 5 therapies would suggest that eosinophils may not directly contribute to those exacerbations. However, they may contribute to airspace enlargement in patients with COPD through various mechanisms involving the interleukin 13 and matrix metalloprotease pathways. The absence of eosinophils may facilitate in limiting the unnecessary use of corticosteroids. The presence of neutrophiia could prompt an investigation for the specific pathogens in the airway. Additionally, sputum measurements may also provide insight into the mechanisms of susceptibility to airway infections. Iron within sputum macrophages, identified by hemosiderin staining (and by more direct quantification) may impair macrophage functions while the low levels of immunoglobulins in sputum may also contribute to airway infections. The assessment of sputum at the time of exacerbations thus would facilitate in customizing treatment and treat current exacerbations and reduce future risk of exacerbations.

• 융합보안논문지
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• 제11권2호
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• pp.25-33
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• 2011

범죄의 양적 증가와 질적 심각성은 공경비만으로는 범죄예방에 한계가 있기 때문에 민간경비의 역할이 기대되고 있다. 결국 민간경비가 범죄예방의 소임을 다하기 위해서는 그 구성원의 우수한 자질과 능력이 선행되어야 한다. 이러한 치안환경의 변화는 시큐리티 분야에 전문성을 요구하게 되었고 나아가 전문자격증의 필요성이 대두되는 계기가 되었다. 이를 위해서는 첫째, 경비협회의 공신력을 제고하고, 자격증을 활성화 시킬 수 있어야 한다. 둘째, 자격은 교육과 노동시장을 연계시켜주는 기능을 하기 때문에 많은 자격취득자는 노동시장인 경비업계가 이를 반영하고 활용할 수 있는 방향을 재고해야 한다. 셋째, 신변보호사 자격제도가 국가에서 공인해주는 자격제도로 인정받을 수 있도록 자격증의 활용 실적이니 미비한 관리체계를 적극적으로 보완해야 한다.

• 디지털콘텐츠학회 논문지
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• 제11권4호
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• pp.463-471
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• 2010

하수 처리장은 화학적, 물리적, 생물학적 처리가 복합적으로 연계된 공정으로 구성 되는데, 각각의 단위공정과 전체시스템의 처리 성능 및 운영 상태의 정도를 파악 하려면 처리공정의 수학적 모델을 빠르게 연산 할 수 있는 컴퓨터 시뮬레이터를 이용하면 편리하다. 주어진 물리적 환경에서 처리공정의 오염물질, 화학물질, 생물학적 매체의 질량 수지를 계산하는 컴퓨터 시뮬레이터는 데이터의 입출력 과정과 수학모델의 연산과정을 효율적으로 수행하는 응용 소프트웨어로써 처리조 내부에서 일어나는 반응의 상태를 정량적으로 추산하는 도구이다. 이러한 시뮬레이션 소프트웨어는 처리시설의 성능 및 효율을 예측하여 운용자에게 최적 관리를 위한 의사결정의 타당성을 제공하게 되는데, 시뮬레이션 소프트웨어를 처리시설에 적합하도록 시나리오를 설정하고 데이터 수집 시스템에 연결하면 실시간으로 처리시설의 분석이 가능한 자동화 운영 시스템의 역할을 수행한다. 본 논문에서는 통합전산망에서 수집되는 데이터를 시뮬레이션 소프트웨어에서 운용, 실제 운영 상태와 시뮬레이션 결과를 실시간 비교, 분석하여 최적의 운전인자를 도출할 수 있는 시나리오 운영 소프트웨어 "WEC-Sim"의 설계 및 구현에 대하여 논한다.

• Clinical and Experimental Reproductive Medicine
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• 제26권3호
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• pp.383-387
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• 1999

Objective: There is increasing evidence for the expression of rat in gene in several extrapituitary sites including testis and ovary. We also have demonstrated that the local LH expression in the rat epididymis and uterus, the major accessory sex organs in male and female reproductive system, respectively. Design: The present study was undertaken to elucidate whether the gene for LH receptor is expressed in rat uterus and whether the expressions of uterine LH and its receptor are differentially regulated during estrous cycle. Presence of the transcripts for rat LH receptor in the rat uterine tissue were confirmed by touchdown reverse transcription-polymerase chain reaction (RT-PCR). Results: In $LH{\beta}$ semi-quantitative RT-PCR, the highest expression level was shown in estrus stage. The level of ill receptor transcripts was also fluctuated during estrous cycle. In ovariectomized rats (OVX + Oil), the expressions of both uterine LH and LH-R were markedly reduced when compared to those from normal rats. Supplement with estradiol $17{\beta}$ to the ovariectomized rats (OVX + $E_2$) restored the expression levels of LH and its receptor to the levels in uteri from normal rats. Conclusion: Our findings indicated that 1) LH and its receptor gene are expressed in the rat uterus from cycling rats, 2) the expression of uterine LH and its receptor is mainly, if not all, under the control of ovarian sex steroid(s). These results suggested that the uterine LH may act as a local regulator with auto and/or paracrine manner, though the posibility that the pituitary LH may act directly on the regulation of uterine functions could not be discarded.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제26권3호
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• pp.143-148
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• 2015

The purpose of this review was to investigate the relationship between aerobic exercise and cognitive function as well as synthesize the effect of aerobic exercise intervention studies centered on psychiatric symptoms associated with general cognitive deficit. Prospective studies on aerobic exercise and improvement of cognitive function were reviewed and synthesized. In addition, this literature review provides significant positive results on the relationship between aerobic exercise and general cognitive deficit associated with psychiatric symptoms. Review of this literature suggests that there is a positive relationship between participation in aerobic exercise and cognitive function. In this text, there are at least three general pathways by which aerobic exercise may facilitate executive function in children : 1) cognitive demands inherent in engaging in physical activity, 2) cognitive demands inherent in cooperation of complex motor tasks, and 3) physiological changes resulting from aerobic exercise. Another main finding of this review is that physical activity has a stronger influence on cognitive deficit, including attention-deficit hyperactivity disorder, depression, and anxiety. Development of cognitive function is the most important factor for children and youth. Therefore, future research should prove relationship between physical activity and cognitive function using a more scientific and quantitative approach design.

• 농업과학연구
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• 제32권1호
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• pp.81-94
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• 2005

This study is aimed at giving the basic information for individual farm households to make decisions for optimizing their farm sizes and for the government to implement farm size optimization policies through the identification of combinations among rice production factors in plain areas like Cheolwon district and the suggestion of the optimal farm sizes of individual farmers based on the scale of economy calculated. The data of agricultural production costs of 50 rice farmers in the plain area which is located in Dongsong-eup Cholwon district, Kangwon province were used in the analysis. The 'translog' cost function among various methods which is a flexible function type was adopted to calculate the scale of economy in rice production. Seemingly unrelated regression(SUR) method was used in forecasting functions and processing other statistics by SHAZAM which is one of the computer aid program for quantitative econometric analysis. In conclusion, the long-run average cost(LAC) curve showed 'U-shape' which was different from 'L-type' one which was shown in the previous studies by others. The lowest point of the LAC was 9.764ha and the concerned production cost amounted to 633 Won/kg. Based on these results, it have to be suggested that around 10 ha of paddy is the target size for policy assistances to save costs under the present level of farming practices and technology. The above results show that the rice production costs could be saved up to 10ha in Cheolwon plain area which is a typical paddy field. However, land use, land condition, land ownership and manager's ability which may affect scale of economy should be considered. Furthermore, reasonable management will have to be realized by means of labor saving technology and cost saving management skill like enlargement of farm size of rice.

• Journal of Ginseng Research
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• 제41권3호
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• pp.419-427
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• 2017

Background: Glycosylation of natural compounds increases the diversity of secondary metabolites. Glycosylation steps are implicated not only in plant growth and development, but also in plant defense responses. Although the activities of uridine-dependent glycosyltransferases (UGTs) have long been recognized, and genes encoding them in several higher plants have been identified, the specific functions of UGTs in planta remain largely unknown. Methods: Spatial and temporal patterns of gene expression were analyzed by quantitative reverse transcription (qRT)-polymerase chain reaction (PCR) and GUS histochemical assay. In planta transformation in heterologous Arabidopsis was generated by floral dipping using Agrobacterium tumefaciens (C58C1). Protein localization was analyzed by confocal microscopy via fluorescent protein tagging. Results: PgUGT72AL1 was highly expressed in the rhizome, upper root, and youngest leaf compared with the other organs. GUS staining of the promoter: GUS fusion revealed high expression in different organs, including axillary leaf branch. Overexpression of PgUGT72AL1 resulted in a fused organ in the axillary leaf branch. Conclusion: PgUGT72AL1, which is phylogenetically close to PgUGT71A27, is involved in the production of ginsenoside compound K. Considering that compound K is not reported in raw ginseng material, further characterization of this gene may shed light on the biological function of ginsenosides in ginseng plant growth and development. The organ fusion phenotype could be caused by the defective growth of cells in the boundary region, commonly regulated by phytohormones such as auxins or brassinosteroids, and requires further analysis.