• Bulletin of the Korean Chemical Society
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• v.35 no.7
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• pp.1956-1964
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• 2014

To provide the scientific corroboration of the traditional uses of Akebia quinata (Thunb.) Decne., a detailed analytical examination of A. quinata stems was carried out using a reversed-phase high performance liquid chromatography (RP-HPLC) method coupled to photodiode array detector (PDA) for the simultaneous determination of four phenolic substances; cuneataside D (1), 2-(3,4-dihydroxyphenyl)ethyl-O-${\beta}$-D-glucopyranoside (2), 3-caffeoylquinic acid (3) and calceolarioside B (4). Particular attention was focused on the main compound, 3-caffeoylquinic acid (3), which has a range of biological functions. In addition, 2-(3,4-dihydroxyphenyl)ethyl-O-${\beta}$-D-glucopyranoside (2) was considered as a discernible marker of A. quinata from its easy confuse plants. The contents of compounds 2 and 3 ranged from 0.72 to 2.68 mg/g and from 1.66 to 5.64 mg/g, respectively. The validation data indicated that this HPLC/PDA assay was used successfully to quantify the four phenolic compounds in A. quinata from different locations using relatively simple conditions and procedures. The pattern-recognition analysis data from 53 samples classified them into two groups, allowing discrimination between A. quinata and comparable herbs. The results suggest that the established HPLC/PDA method is suitable for quantitation and pattern-recognition analyses for a quality evaluation of this medicinal herb.

• Journal of the Korean Society of Clothing and Textiles
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• v.40 no.3
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• pp.456-464
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• 2016

A new combat uniform is improved for added combat safety with various functions such as survivability, battle conformity and a camouflage performance system. Camouflage performance is an important factor in terms of combat survivability since it makes identification difficult and provide security. The combat uniform is worn under extreme conditions (exposure to ultraviolet light, sweat and friction) and an excellent color fastness to repeated washing is required. In this study, we investigated the color management, durability and discoloration of new combat uniform fabric with a digital pattern for camouflage performance to provide preliminary color management data. We examined color differences between standard fabric and mass-produced combat uniform fabrics, color differences between each military supply contract firm and color changes in combat uniforms after 60 washing cycles. The slight color differences between standard fabric and mass-produced combat uniform fabrics were tolerable under quality criteria of Republic of Korea Ministry of National Defense. However, the differences between the military supply contract firms were recognizable to the naked eye and increased with repeated washing. Continuous research on color fastness under repeated washing and color management is required to standardize reliability from each military supply contract firm for the daytime performance of a combat uniform's camouflage.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.16 no.1
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• pp.207-225
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• 2013

Current ecological stream restoration is focusing on recovery of physical characteristic and ecological functions of individual stream. For effective stream restoration, the relationship between stream environment and riparian flora should be investigated. The purpose of this study is to analyze the relationship between disturbance of hydromorphological structures and naturalized plants ratio in small to mid-sized streams. For the study sites, Gwanpyeong stream, Dongdal stream, and Yongchoo streams were chosen as 'reference stream' while, Gunnam stream, Anchang stream, and Hwa stream were chosen as 'damaged stream'. The hydromorphological structures of streams were evaluated with LAWA and flora of the streams were completely enumerated to calculate naturalized plants ratio. The result showed that there was a significant correlation between the outcome of LAWA and naturalized plants ratio(r=0.675, p<0.01). The result of factor analysis of LAWA identified three factors, 'River front and land use', 'River bed materials and structures', and 'Crossing structure and bar'. Among the factors of hydromorphological structures given by the result of factor analysis, 'river front and land use' and 'bed materials and structures' have statistically significant relationship with naturalized plants ratio($R^2$=0.470, p<0.01). Given this results, quantitative analysis on the relationship between disturbance of hydromorphological structures of streams and naturalized plants ratio could provide some essential information for stream restoration. Also, as this study figured out major factors of hydromorphological structures that affect naturalized plants ratio, it might help monitor ecological states and current problems of small and mid-sized streams.

• Journal of Korean Society of Water and Wastewater
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• v.34 no.4
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• pp.251-258
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• 2020

Sewer deterioration models are needed to forecast the remaining life expectancy of sewer networks by assessing their conditions. In this study, the serious defect (or condition state 3) occurrence probability, at which sewer rehabilitation program should be implemented, was evaluated using four probability distribution functions such as normal, lognormal, exponential, and Weibull distribution. A sample of 252 km of CCTV-inspected sewer pipe data in city Z was collected in the first place. Then the effective data (284 sewer sections of 8.15 km) with reliable information were extracted and classified into 3 groups considering the sub-catchment area, sewer material, and sewer pipe size. Anderson-Darling test was conducted to select the most fitted probability distribution of sewer defect occurrence as Weibull distribution. The shape parameters (β) and scale parameters (η) of Weibull distribution were estimated from the data set of 3 classified groups, including standard errors, 95% confidence intervals, and log-likelihood values. The plot of probability density function and cumulative distribution function were obtained using the estimated parameter values, which could be used to indicate the quantitative level of risk on occurrence of CS3. It was estimated that sewer data group 1, group 2, and group 3 has CS3 occurrence probability exceeding 50% at 13th-year, 11th-year, and 16th-year after the installation, respectively. For every data groups, the time exceeding the CS3 occurrence probability of 90% was also predicted to be 27th- to 30th-year after the installation.

• Journal of the Korean Wood Science and Technology
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• v.35 no.4
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• pp.52-60
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• 2007

Plant can detoxify the effect of the volatile organic compounds (VOC) such as formaldehyde and toluene, however, mechanisms of VOC detoxification are largely unknown in plant system. This study was performed to investigate phenotypic changes of Arabidopsis seedlings upon treatment of either formalin or toluene. Formalin treatment up to twenty four hours didn't cause any significant phenotypic damages on the leaf surface of 27 DAG Arabidopsis seedlings. However, the protein profile of formalin-treated seedlings was significantly different from that of mock control. Using automated electrophoresis system, the molecular weight of each formaldehyde-responsive protein (FRP) was predicted and its formaldehyde-dependent expression was confirmed at transcription level by quantitative real-time RT-PCR analysis. Four FRPs isolated in this study are the novel proteins with unknown functions but highly homologous to the stress-related proteins.

• Earthquakes and Structures
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• v.11 no.6
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• pp.925-942
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• 2016

With ongoing development of earthquake engineering research and the lessons learnt from a series of strong earthquakes, the seismic design concept of "resilience" has received much attention. Resilience describes the capability of a structure or a city to recover rapidly after earthquakes or other disasters. As one of the main features of urban constructions, tall buildings have greater impact on the sustainability and resilience of major cities. Therefore, it is important and timely to quantify their seismic resilience. In this work, a quantitative comparison of the seismic resilience of two tall buildings designed according to the Chinese and US seismic design codes was conducted. The prototype building, originally designed according to the US code as part of the Tall Building Initiative (TBI) Project, was redesigned in this work according to the Chinese codes under the same design conditions. Two refined nonlinear finite element (FE) models were established for both cases and their seismic responses were evaluated at different earthquake intensities, including the service level earthquake (SLE), the design-based earthquake (DBE) and the maximum considered earthquake (MCE). In addition, the collapse fragility functions of these two building models were established through incremental dynamic analysis (IDA). Based on the numerical results, the seismic resilience of both models was quantified and compared using the new-generation seismic performance assessment method proposed by FEMA P-58. The outcomes of this study indicate that the seismic resilience of the building according to the Chinese design is slightly better than that according to the US design. The conclusions drawn from this research are expected to guide further in-depth studies on improving the seismic resilience of tall buildings.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.1887-1890
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• 2016

Breast cancer is the most common cause of cancer-related death among women in the whole world. MiR- 34a and let-7a are well known tumor suppressors that participate in the regulation of apoptosis, invasion and other cellular functions. In this study, expression of miR-34a, let-7a and apoptosis pathway genes such as Bcl-2, Caspase-3 and P53 were evaluated using quantitative real-time PCR in 45 paired samples of normal margin and tumor tissue collected from breast cancer patient at advanced stage (3-4). MiR-34a, let-7a, caspase-3 and P53 expression are reduced and Bcl-2 expression is increased within tumoral tissues in comparison with normal margin tissues. P53 expression directly or indirectly was correlated with miR-34a, let-7a, Bcl-2 and caspase-3 expression. In This study we found that MiR-34a and let-7a expression are reduced in the tumoral tissues. Down-regulation of these two molecules correlated with expression of genes associated with apoptosis. These results suggest that due to the correlation of miR-34a and let-7a with apoptotic and anti-apoptotic pathways these molecules could participate as regulators in advanced clinical stages of breast cancer and should be considered as markers for diagnosis, prognostic assessment and targeted therapy.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1077-1082
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• 2015

Recent studies have suggested that the RAS protein activator like-1 (RASAL1) functions as a tumor suppressor in vitro and may play an important role in the development of gastric cancer. However, whether or not RASAL1 suppresses tumor growth in vivo remains to be determined. In the present study, we investigated the role of RASAL1 in gastric carcinogenesis using an in vivo xenograft model. A lentiviral RASAL1 expression vector was constructed and utilized to transfect the human poorly differentiated gastric adenocarcinoma cell line, BGC-823. RASAL1 expression levels were verified by quantitative real-time RT-PCR and Western blotting analysis. Then, we established the nude mice xenograft model using BGC-823 cells either over-expressing RASAL1 or normal. After three weeks, the results showed that the over-expression of RASAL1 led to a significant reduction in both tumor volume and weight compared with the other two control groups. Furthermore, in xenograft tissues the increased expression of RASAL1 in BGC-823 cells caused decreased expression of p-ERK1/2, a downstream moleculein the RAS/RAF/MEK/ERK signal pathway. These findings demonstrated that the over-expression of RASAL1 could inhibit the growth of gastric cancer by inactivation of the RAS/RAF/MEK/ERK pathway in vivo. This study indicates that RASAL1 may attenuate gastric carcinogenesis.

• KIEAE Journal
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• v.11 no.6
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• pp.109-115
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• 2011

Recently the Elderly with dementia is increasing in Korea with rapid aging of the population. In addition to increasing a number of nuclear family and women's advancement in society, people are less capable of supporting family with dementia. In response, the Seoul city increased welfare facilities for the elderly with dementia about two times for one year. I think that the quantitative portion of facility get to meet the requirements but it is lack of qualitative one in fact. Therefore, the space for the elderly can keep up with the falloff of mental and physical functions, dementia and geriatric diseases according to aging and careful consideration about the space considering stability and convenience is required. At this point, this study has the purpose to plan a daycare center which reflects the characteristics of the elderly to protect them within the community safely and comfortably. As for the research method, case study was conducted to understand the overall situation on the space plan of the daycare center for 3 daycare centers located in Seoul and found out problems. From the generalization of the above study, a space plan for a daycare center considering the characteristics of the elderly was provided. The composition of Dementia welfare facility should be carefully planned to fit characteristics of the patient's behaviors.

• KIEAE Journal
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• v.12 no.1
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• pp.3-10
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• 2012

Recently, the increase of impervious area has been pointed out as a major cause of climate change and biotop area deterioration]. Therefore, quantitative indicators for environmental housing design and planning have been needed especially to control the impervious area. The Biotop Area Ratio(BAR) as the mostly applied environmental planning control instrument in Korea verifying the possibility of utilizing has been used effectively in various aspects. However, the fact that the space types are based on two dimension and ecological functions of spaces are simplified has shown the limitations of this planning instrument in the use as planning and evaluation indicator. In this study, classification criteria and the weighting of the space types in similar indicators Biotopflaechenfaktor (BFF, Berlin), Seattle Green Factor (SGF, Seattle), and Green Area Factor (GAF, Malmo) were analyzed. These indicators are similar in the sense that they apply weights to calculate the area and express a percentage of land area. The findings are as follows: The basic method that can estimate the vegetation volume is proposed to overcome the limitation of the BAR. It also was proven that the introduction of three-dimensional volume rate of biotops area was possible. Finally, the framework of space type classification criteria is proposed through linkages with relevant laws and regulations. With the improvement of the space types, the BAR is expected to be reasonable indicator in outdoor space evaluation in housing project.