• 응용통계연구
• /
• 제19권2호
• /
• pp.231-240
• /
• 2006

일반적으로 쌍체 비교(paired comparison 또는 paired t test)가 효과적인 쌍으로의 구획을 통하여 소위 독립비교(group comparison)라고 일컫는 독립 이표본 t 검정(two-sample t test)보다 정밀한 결과를 제공하는 것으로 알려져 있다. 본 논문에서는 이와 같은 사실을 통계적으로 됫받침하기 위하여 두 방법의 정밀도를 보다 정량적으로 비교하였다. 독립 비교와 쌍체 비교가 각각 일원배치법과 이원배치법 (특히, 임의화 블록 설계법)의 특수한 경우이므로 각각에 상응하는 신뢰구간의 길이의 비로 정의된 비교 통계량은 분산분석의 통계량으로 표현된다. 다시 말해서, 이 통계량은 t 와 F 분포함수로 표현되므로 쉽게 독립비교와 쌍체비교의 정밀도를 비교할 수 있다. 실제로, 자주 쓰이는 유의수준에서는 쌍체표본 내에 구획 간의 유의한 변동이 있으면 쌍체비교가 독립비교보다 정밀할 가능성이 더 높다.

• 한국지구과학회지
• /
• 제31권6호
• /
• pp.656-670
• /
• 2010

이 연구의 목적은 기능이 극대화된 국립자연사박물관을 설립하기 위한 방안을 제시하는 데 있다. 이를 위하여 1987년부터 2009년까지 국내외 자연사박물관에 대한 방문 조사와 학술적 연구를 통하여 자연사와 자연사박물관의 기원과 변천 과정을 정리하였으며, 국내 자연사 관련 박물관의 질적 양적 수준을 국제적으로 비교 하였다. 한국의 자연사박물관 수는 세계 100위권 밖에 머물러 있고 학문적 연구 능력과 표본 관리 능력 및 출판 능력은 초보적인 수준에 머물러 있다. 특히 연구원의 수가 너무 적고 연구 기반이 구축되어 있지 않으며, 전시-교육 전문가도 턱없이 부족하여 연구 결과물과 학술지를 발간하지 못하고 있다. 이러한 문제점을 해결하고 최적화된 국립자연사박물관을 건립하기 위해서는 국립자연사박물관 설립 전에 연구-표본 관리-출판-전시-교육 기능을 활성화해야 한다.

• BMB Reports
• /
• 제45권2호
• /
• pp.96-101
• /
• 2012

Urea-based nitrogen fertilizer was widely utilized in maize production, but transporters involved in urea uptake, translocation and cellular homeostasis have not been identified. Here, we isolated three maize aquapoin genes, ZmNIP2;1, ZmNIP2;4 and ZmTIP4;4, from a cDNA library by heterogous complementation of a urea uptake-defective yeast. ZmNIP2;1 and ZmNIP2;4 belonged to the nodulin 26-like intrinsic proteins (NIPs) localized at plasma membrane, and ZmTIP4;4 belonged to the tonoplast intrinsic protein (TIPs) at vacuolar membrane. Quantitative RT-PCR revealed that ZmNIP2;1 was expressed constitutively in various organs while ZmNIP2;4 and ZmTIP4;4 transcripts were abundant in reproductive organs and roots. Expression of ZmTIP4;4 was significantly increased in roots and expanded leaves under nitrogen starvation, while those of ZmNIP2;1 and ZmNIP2;4 remained unaffected. Functions of maize aquapoin genes in urea transport together with their distinct expression manners suggested that they might play diverse roles on urea uptake and translocation, or equilibrating urea concentration across tonoplast.

• BMB Reports
• /
• 제45권11호
• /
• pp.629-634
• /
• 2012

The human glycoprotein, stanniocalcin 2 (STC2) plays multiple roles in several tumor types, however, its function and clinical significance in hepatocellular carcinoma (HCC) remain unclear. In this study, we detected STC2 expression by quantitative real-time PCR and found STC2 was upregulated in HCC tissues, correlated with tumor size and multiplicity of HCC. Ectopic expression of STC2 markedly promoted HCC cell proliferation and colony formation, while silencing of endogenous STC2 resulted in a reduced cell growth by cell cycle delay in G0/G1 phase. Western blot analysis demonstrated that STC2 could regulate the expression of cyclin D1 and activate extracellular signal-regulated kinase 1/2 (ERK1/2) in a dominant-positive manner. Transwell chamber assay also indicated altered patterns of STC2 expression had an important effect on cell migration. Our findings suggest that STC2 functions as a potential oncoprotein in the development and progression of HCC as well as a promising molecular target for HCC therapy.

• International Journal of Industrial Entomology and Biomaterials
• /
• 제27권1호
• /
• pp.159-165
• /
• 2013

Bone morphogenetic proteins (BMPs) belong to the transforming growth factor (TGF-${\beta}$) superfamily and are involved in osteoblastic differentiation. The largest TGF-${\beta}$ superfamily subgroup shares genetic homology with human BMPs (hBMPs) and silkworm decapentaplegic (dpp). In addition, hBMPs are functionally interchangeable with Drosophila dpp. Bombyx mori dpp may induce bone formation in mammalian cells. To test this hypothesis, we synthesized the 1,285-base pairs cDNA of full-length B. mori dpp using total RNAs obtained from the fat body of 3-day-old of the $5^{th}$ instar larvae and cloned the cDNA into the pCEP4 mammalian expression vector. Next, B. mori dpp was expressed in C3H10T1/2 cells. The target cells transfected with the pCEP4-Bm dpp plasmid showed biological functions similar to those of osteogenic differentiation induction growth factors such as hBMPs. We determined the relative mRNA expression rates of Runt-related transcription factor 2 (RUNX2), osterix, osteocalcin, and alkaline phosphatase (ALP) to validate the osteoblast-specific differentiation effects of B. mori dpp by performing quantitative real-time RT-PCR. Interestingly, mRNA expression levels of the 3 marker genes except RUNX2, in cells expressing B. mori dpp were much higher than those in control cells and C3H10T1/2 cells transfected with pCEP4. These results suggested that B. mori dpp signaling regulates osterix expression during osteogenic differentiation via RUNX2-independent mechanisms.

• 자원환경지질
• /
• 제28권3호
• /
• pp.271-277
• /
• 1995

공간통계를 바탕으로 한 지질정보의 정량적 처리및 분석을 위한 여러 응용방법들이 최근에 광물탐사문제와 관련되어 연구되고 있다. 본 연구에서는 지화학자료와 관련된 이상점판단(outlier detection)과 방향성 상호 변이도 측정의 적용성을 검토하였고, 아울러 태백지역내의 광물탐사를 위한 지화학자료에 에 대한 사례연구를 수행하였다. 이상점판단방법으로는 이동창(moving window)통계법이 이용되었다. 한편 상호 변이도는 공간적 연속성 측정을 위한 통계적 방법으로 알려져 있으나, 본 연구에서는 이 개념을 자료의 공간적 상관도 문제로 확장하였다. 한편 다섯가지 행태의 변이도 표현식을 이상점처리전후의 결과와 연관하여 비교하였다. 이러한 비교연구의 결과로 이 두가지 공간 통계법에 의한 자료처리과정및 분석방법은 실제의 결정판단단계에서 결정적인 영향을 미치는 것으로 나타났으며, 광역적 광물탐사에서 유용한 해석보조자료로 제공될 수 있을 것으로 생각된다.

• 한국콘텐츠학회논문지
• /
• 제17권10호
• /
• pp.576-586
• /
• 2017

본 논문은 청소년을 대상으로 한 영상 커뮤니케이션 교육 프로그램 LTP(Litracy Through Photography)의 성과를 바탕으로 이미지와 텍스트의 결합에 대해 연구한 결과다. 현재는 디지털 영상 시대를 맞아 올바른 커뮤니케이션 교육이 필요한 시점이지만 아직 텍스트 위주의 교육이 다수인 건 사실이다. 이에 이미지의 커뮤니케이션 기능을 강조한 LTP 프로그램을 제시하고 청소년들에게 시각 커뮤니케이션에 대한 능력 향상을 위해 실시한 교육결과를 소개한다. 그리고 교육참여 청소년들의 LTP 작품분석과 설문조사와 질적조사를 실시한다. 청소년들의 창작 이미지는 바르트(Barthes)의 텍스트와 이미지의 상호 관계를 세 분류로 정의한 정박, 중계, 삽화를 기준으로 분석된다. 설문조사는 LTP 교육전후 실시한 영상 커뮤니케이션 능력에 대한 양적조사와 질적조사로 이뤄졌다. 그 결과 LTP 교육에서 텍스트보다 이미지를 활용했을 때 청소년의 커뮤니케이션에 대한 성취가 높음이 밝혀졌다. 본 연구는 이러한 조사와 연구결과가 정책적으로 문화예술교육에 반영되는 것을 주장한다. 결론적으로 본 연구는 청소년들의 LTP 작품과 설문조사를 커뮤니케이션 관점에서 고찰함으로써 창의성 제고를 위한 이미지 활용교육에 의미를 부여하고 LTP를 새로운 교육으로 제시한다.

• 한국환경복원기술학회지
• /
• 제11권4호
• /
• pp.75-90
• /
• 2008

The golf course has many problems that are a pollution of river, a extinction of habitat by destructing a forest and a simplication of species composition. Therefore, this study was carried out to examine the ecological characteristics of vascular plants in construct-reserved site of golf course. The results were as follow. The vascular plants were summarized as 342 taxa; 86 families, 231 genera, 295 species, 42 varieties and 5 forma. In the results by the location environments of vegetation, Salix caprea community and wetland species like Persicaria thunbergii were appeared in the swamp. Especially, S. caprea will be made use of promoting a landscape. In the stream, Stephanandra incisa community has a functions like an ecological axis and a corridor of wild animals. The planting technique will be applied to using Atractylodes japonica and Ainsliaea acerifolia in the lower part of Pinus densiflora and Quercus mongolica. Because Rhododendron schlippenbachii and Convallaria keiskei grew by layer in Q. variabilis community, this will be made use of natural vegetation model. The rare plants were 2 taxa; Aristolochia contorta and Iris ensata var. spontanea. To preserve their community, we will prohibit a development and remove a threatening factor. The endemic plants were 4 taxa; Salix caprea, Clematis trichotma, Spiraea prunifolia for. simpliciflora and Weigela subsessilis. The naturalized plants were 19 taxa; Rumex crispus, Bildedykia dumetora and so on. To establish the quantitative management plan, we will obtain a ecological information about a naturalized plants in accumulating by season, community and land use pattern.

• The Korean Journal of Physiology and Pharmacology
• /
• 제20권6호
• /
• pp.565-571
• /
• 2016

Paeoniflorin (PAE) is the most abundant compound in Xuebijing injection widely used to treat sepsis. We aimed to investigate effect of PAE on expression of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in a rat model of sepsis. Wistar rats were divided into Normal, Model, and PAE groups (n=20 each). Endotoxin was administrated at 5 mg/ml/kg in Model and PAE rats to establish rat sepsis model. 1 h after endotoxin administration, PAE was administrated at 4 ml/kg in PAE group once per day for 3 days. Routine blood tests and biochemical indexes were assessed, including aspartate aminotransferase (AST) and creatine kinase-MB (CK-MB). The plasma sTREM-1 level was measured using quantitative ELISA. At the end of experiment, the small intestine, liver, kidney and lung were subjected to pathological examinations. A rat model of sepsis-induced multiple organ dysfunction syndrome (MODS) was established successfully with endotoxin administration (5 mg/ml/kg), evidenced by histo-pathological examinations, routine blood tests and biochemical indexes: platelet count decreased and white blood cell count increased (p<0.05), CK-MB and AST increased (p<0.05). PAE treatment significantly reduced the plasma levels of AST, CK-MB, and sTREM-1, compared to Model group (p<0.05). Meanwhile, sepsis-induced damages in the liver, lung, stomach and intestinal mucosa were also markedly ameliorated by PAE treatment. PAE demonstrated a significantly protective effect in a rat model of sepsis by decreasing plasma sTREM-1 level, reducing inflammation, preventing MODS and protecting organ functions.

• 대한의용생체공학회:의공학회지
• /
• 제35권6호
• /
• pp.227-233
• /
• 2014

In this paper, to quantitatively evaluate the degree of rehabilitation for the disabled of unilateral lower extremity, we compared the EMG pattern of normal and simulated abnormal gait. The EMG signal was measured at a rate of 1 kHz on the quadriceps and biceps femoris, the pressure sensor was attached to the sole in order to distinguish the gait cycle. Integrated EMG (IEMG) was obtained by the gait cycle, and classified four patterns that were the normal gait pattern, amplitude decrease pattern, reversed pattern, and irregular pattern. For comparison of the patterns, a curve fitting was performed using the trigonometric functions. The result of curve fitting, the method using a variable A that corresponds to the amplitude of the regression curve was able to distinguish the reverse pattern and remaining pattern. The coefficient of determination ($R^2$) representing coincidence of the pattern of the regression curve and EMG was confirmed the biggest value at the normal gait. Therefore, the degree of normal gait can be confirmed using the coefficient of determination. This results show that it is possible to quantitatively confirm the degree of unilateral lower extremity disabled rehabilitation, and it will be contributed to the study of efficient rehabilitation methods by objective analysis.