• 대한한방내과학회지
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• 제39권4호
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• pp.570-591
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• 2018

Objective: This study was designed to investigate the correlation between gastric emptying measurement by ultrasonography and the findings of various questionnaires of functional dyspepsia (FD) or in Korean medicine to explore the possibility of quantification of questionnaires. Methods: Eighty-eight patients (44 patients with FD and 44 healthy controls) were recruited from October 2016 to November 2017. Gastric emptying half-time (T1/2) was measured by ultrasonography at fasting, and at 0, 15, 30, 45, 60, 90, and 120 min after meals (apple juice, 500 ml, 224 kcal). The average half-time (average T1/2) was calculated by averaging all measured half-times. A visual analogue scale (VAS), food retention questionnaire (FRQ), damum questionnaire (DQ), cold and heat questionnaire (CHQ), deficiency and excess questionnaire (DEQ), spleen-qi deficiency questionnaire (SQDQ), Nepean dyspepsia index-Korean version (NDI-K), and quality of life of NDI (NDI-QoL) were filled out by all participants. Correlation between the average T1/2 and questionnaires were analyzed for 79 patients (37 patients with FD and 42 healthy controls) after excluding missing and erroneous data. Results: The FRQ, DEQ, SQDQ, NDI-K, and NDI-QoL scores, especially for some gastrointestinal symptoms and general weakness-related symptoms, showed statistically significant correlations with average T1/2. Conclusions: Our results suggest that gastric emptying measurement by ultrasonography may be a quantitative substitute method for some Korean medical questionnaires or for some dyspepsia-related and deficiency-related items among them. However, further studies using various measurements of gastric emptying will be needed.

• The Korean Journal of Pain
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• 제35권2호
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• pp.191-201
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• 2022

Background: This study aimed to assess the efficacy of the adductor canal block (ACB) in comparison to intra-articular steroid-lidocaine injection (IASLI) to control chronic knee osteoarthritis (KOA) pain. Methods: A randomized, single-blinded trial in an outpatient rehabilitation clinic recruiting chronic KOA with pain ≥ 6 months over one year. Following randomization, subjects received either a single ACB or IASLI under ultrasound guidance. Numerical rating scale (NRS) scores for pain, and Knee Injury and Osteoarthritis Outcome Scores (KOOS) were recorded at baseline, 1 hour, 1 month, and 3 months postinjection. Results: Sixty-six knees were recruited; 2 were lost to follow-up. Age was normally distributed (P = 0.463), with more female subjects in both arms (P = 0.564). NRS scores improved significantly for both arms at 1 hour, with better pain scores for the IASLI arm (P = 0.416) at 1st month and ACB arm at 3rd month (P = 0.077) with larger effect size (Cohen's d = 1.085). Lower limb function improved significantly in the IASLI arm at 1 month; the ACB subjects showed greater functional improvement at 3 months (Cohen's d = 0.3, P = 0.346). Quality of life (QoL) improvement mirrored the functional scores whereby the IASLI group fared better at the 1st month (P = 0.071) but at the 3rd month the ACB group scored better (Cohen's d = 0.08, P = 0.710). Conclusions: ACB provides longer lasting analgesia which improves function and QoL in chronic KOA patients up to 3 months without any significant side effects.

• 농촌의학ㆍ지역보건
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• 제40권1호
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• pp.21-31
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• 2015

본 연구는 우리나라 성인 당뇨병환자의 삶의 질을 평가하고, 당뇨병이 다른 만성질환이나 정상 건강인에 비해 삶의 질이 얼마나 다른지 알아보고, 이에 영향을 미치는 요인들을 분석하고자 하였다. 연구의 대상자는 제5기(2010-2012) 국민건강영양조사 자료 중 건강 설문조사와 검진조사에 모두 응답한 자로서 분석 변수에 결측치가 없는 만 19세 이상 성인 17,655명으로 하였다. 만성질환군 및 정상 건강군에 비해 당뇨병환자에서 삶의 질의 모든 하부영역에 '문제 있다'라고 응답한 분율이 더 높았다. 당뇨병환자에서 삶의 질의 하부 영역 중 운동능력(36.4%)에 문제가 있다고 한 사람이 가장 많았으며, 그 다음으로 통증/불편감(35.4%)이었다. 당뇨병환자와 만성질환군 및 정상 건강군간 삶의 질의 5가지 하부 영역을 비교하기 위해 다중로지스틱회귀분석을 이용하여 당뇨병환자를 기준으로 '문제 있음'에 대한 교차비와 신뢰구간을 계산한 결과 운동능력은 당뇨병 환자에 비해 만성질환군의 OR(95%CI)값이 0.77(0.66-0.91), 정상 건강군이 0.61(0.50-0.75)이었고, 자기관리는 0.68(0.55-0.83), 0.69(0.51-0.94)이었고, 일상활동은 0.85(0.72-0.99), 0.79(0.62-0.98)로 당뇨병환자에 비해 만성질환군과 정상 건강군이 운동능력, 자기관리, 일상활동에 문제가 있을 가능성이 낮았다. 당뇨병환자의 질적인 삶을 영위하기 위해서는 삶의 질과 관련된 다양한 변인 연구들이 꾸준히 이루어져야 할 것이며, 삶의 질에 영향을 미치는 사회 인구학적, 건강관련 특성을 반영한 다양한 건강프로그램이나 복지정책을 개발, 발전하여 지속적으로 관리해야 한다고 사료된다.

• Tuberculosis and Respiratory Diseases
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• 제60권4호
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• pp.397-403
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• 2006

연구배경: 만성폐쇄성폐질환은 질병의 중증도를 추정 정상치에 대한 $FEV_1$의 백분율을 기준으로 분류해 왔다. 그러나, 같은 폐기능 검사소견을 보이는 환자들 사이에서도 환자가 느끼는 주관적 호흡곤란에는 차이가 있다. 본 연구에서는 호흡곤란이 $FEV_1$를 비롯하여, 건강관련 삶의 질, 주변으로부터 받는 도움의 정도, 직업 등에 영향을 받는지에 대해 알아보고자 하였다. 방법: 2002년 6월부터 2004년 5월까지 경북대학교병원 호흡기 내과에서 만성폐쇄성폐질환으로 추적관찰 중이며, 임상적으로 안정되어 있고 비가역적인 폐쇄성 폐기능 장애를 가진 환자 36명을 대상으로 하였다. 만성 폐쇄성 폐질환의 병기는, GOLD 병기를 따랐으며, 호흡곤란 척도는 MRC 호흡곤란 척도를 사용하였다. 건강 관련 삶의 질은 한국어 St. Goerge's respiratory questionnaire(SGRQ)를 사용하였다. 결과: 환자들의 평균 $FEV_1$은 추정 정상치의 32.0%였다. GOLD 병기와 호흡곤란 정도사이에 유의한 상관관계는 없었다(p=0.114). 호흡곤란이 심할수록 SGRQ 값의 증상(symptom)(p=0.041), 활동력(activity)(p=0.004), 영향력(impact)(p=0.001), 총점(total)(p<0.001) 수치 모두에서 의미있게 높은 수치를 보였다. 호흡곤란 정도와 직업간에 의미있는 상관관계는 없었으며(p=0.259), 호흡곤란이 심할수록 환자가 주변으로부터 받는 도움 정도는 적다고 느끼는 상관관계가 뚜렷하였다(p=0.011). 결론: 만성폐쇄성폐질환자의 진료에서 환자가 느끼는 주관적인 호흡곤란은 $FEV_1$에 따른 병기 외에도 건강관련 삶의 질 및 주변의 지지 정도와 더 연관성을 가질 수 있다는 점이 고려되어야 할 것으로 사료된다.

• 대한한방내과학회지
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• 제45권3호
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• pp.519-531
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• 2024

Objectives: This case study reports the effectiveness of Korean medical treatment in a patient with cyclic vomiting syndrome. Methods: A 29-year-old female Korean patient with cyclic vomiting syndrome received acupuncture, electroacupuncture, herbal medicine, and moxibustion for 2 weeks in hospital. Changes in symptoms were evaluated using the Gastrointestinal Symptom Rating Scale (GSRS), Visual Analog Scale (VAS), Index for Nausea, Vomiting, and Retching (INVR), Nausea Severity Scale (NSS), Nepean Dyspepsia Index-Korean version (NDI-K), quality of life using the Functional Dyspepsia Related Quality of Life questionnaire (FD-QoL), and gastric motility using electrogastrography (EGG). Results: Post-treatment, the patient showed high satisfaction and improvement in symptoms of nausea and vomiting. The following changes were observed in scores: GSRS: 23 to 19; VAS of nausea: 88 to 95; VAS of dyspepsia: 95 to 12; INVR: 13 to 1; NSS: 17 to 5; NDI-K: 107 to 78; and FD-QoL 84 to 27. We also found positive results in Channel 3 of EGG parameters, implying the improvement of gastric motility disorder. Conclusion: Korean medical treatment can be a therapeutic option for cyclic vomiting syndrome.

• 동의신경정신과학회지
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• 제32권2호
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• pp.81-93
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• 2021

Objectives: Mild cognitive impairment (MCI) is condition of cognitive decline shown in transition from normal aging to dementia. Hominis placenta pharmacopuncture (HPP) is a treatment that combines effects of medication and acupuncture by injecting Hominis placenta into acupoints. The objective of this study was to evaluate the efficacy and safety of HPP for MCI. Methods: This was a randomized, double-blind, placebo-controlled, two-center clinical trial. Eligible patients were randomly allocated to either the HPP group or the placebo group. HPP or saline as placebo was administered to participants for eight weeks. Changes in symptoms were observed. The primary outcome was difference in mean change of Korean Version of the Montreal Cognitive Assessment (MoCA-K) score between the HPP group and the placebo group. Cognitive function, overall status of mood and sleep, and quality of life (QoL) were also assessed. Safety assessment and economic analysis were then conducted. Results: Thirty participants were enrolled. One participant in the placebo group dropped out. The score of MoCA-K increased after treatment. Its mean change was smaller in the HPP group than in the control group. HPP ameliorated Global Deterioration Scale and Korean Dementia Rating Scale subtests for attention, organization, and memory compared to the placebo. However, none of them was significantly different between the two groups. Mood, sleep, and QoL all improved more in the HPP group than in the placebo group, although differences between the two groups were not statistically significant. There was no adverse event probably related to the drug. HPP treatment needed KRW 345,000 more than the placebo group in improving Geriatric Quality of Life scale-Dementia score by one point for one year. Conclusions: Although HPP treatment did not significantly improve cognition, it changed behavioral and psychological symptoms in MCI.

• 재활복지
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• 제21권2호
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• pp.247-259
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• 2017

출혈성 뇌졸중 후 인지기능의 저하는 장기적 기능회복에 영향을 주는 주요한 인자이다. 이에 저자들은 출혈성 뇌졸중 환자에서 주요 회복시기에 따른 인지기능의 변화와 일상생활활동 독립수준 및 삶의 질의 변화를 추적하고, 인지 기능 변화와 관련된 연관 요인을 파악하며, 이를 통한 향후 관리방안 제시를 위한 기초자료를 마련하고자 이 연구를 시행하였다. 1개 상급종합병원에 입원한 초발 출혈성 뇌졸중 환자 25명의 환자를 대상으로 발병 후 7일, 발병 후 3개월, 발병 후 6개월, 발병 후 12개월 시점에 Glasgow Coma Scale (GCS), 한국형 정신상태 간이검사(K-MMSE), 한국판 수정바델 지수(K-MBI), 건강관련 삶의 질 지수(EQ-5D)를 사용하여 연구 대상자의 인지기능을 포함한 전반적인 기능 변화와 관련한 평가를 시행하였다. K-MMSE는 발병 후 7일 $13.32{\pm}11.80$점, 3개월 15점, 6개월 17점, 12개월에 18점으로 의미 있는 회복을 보였으며(p=0.007), GCS, K-MBI, EQ-5D와 같은 다른 기능평가에서도 시간의 경과에 따라 의미 있는 개선을 보였다(p<0.01). 발병 12개월의 인지기능에 영향을 미치는 요인 분석에서 발병 당시의 연령 및 출혈성 뇌졸중의 유형, 발병 7일의 GCS이 통계적으로 유의한 연관성을 나타내었다. 본 연구를 통해 출혈성 뇌졸중 환자에 있어서 지속적으로 인지 기능을 포함한 전반적인 기능 회복이 발병 후 1년까지도 이루어짐을 확인하였고, 이에 관련된 연관 요인을 확인함으로써, 출혈성 뇌졸중 환자의 기능회복에 대한 이해와 그에 대한 지속적인 관리 및 치료의 필요성을 높일 수 있는 근거가 될 수 있을 것으로 보인다.

• 대한약침학회지
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• 제27권3호
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• pp.177-189
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• 2024

Objectives: Cupping therapy is a widely used complementary medicine for the treatment of migraine headaches globally. However, conflicting evidence exists on its effectiveness. To evaluate the safety and efficacy of cupping therapy in treating migraine headache disorder. Methods: Seven databases were systematically searched: PubMed/MEDLINE, Clinicaltrials.gov, Cochrane CENTRAL, ScienceDirect, ProQuest, SinoMed, and the National Science and Technology Library. The primary endpoints are the treatment success and the pain intensity reduction. The secondary endpoints were adverse events (AEs) risk and improvement in quality of life (QoL), which was based on the Migraine Disability Scale (MIDAS). Subgroup analyses were performed based on the cupping techniques (wet and dry cupping) and adjunctive complementary treatments (i.e. acupuncture and/or collateral pricking). Results: Eighteen trials out of 348 records were included, pooling 1,446 participants (n = 797 received cupping therapy). Treatment success was significantly higher among those with cupping therapy (risk ratio [RR] [95% CI] = 1.83 [1.52-2.21]); with significant improvement observed only with wet cupping (RR [95% CI] = 1.88 [1.53-2.30]). The adjunctive complementary therapy did not achieve a greater amplitude of treatment success compared to cupping therapy alone. Furthermore, cupping therapy showed significant pain reduction compared to baseline (standardized mean difference [SMD] [95% CI] = 0.55 [0.39-0.70]) and achieved fewer risks of AEs (RR [95% CI] = 1.88 [1.53-2.30]). However, cupping did not improve the overall QoL (MIDAS SMD [95% CI] = -0.79 [-3.55-1.98]). Conclusion: Cupping therapy was an effective complementary modality to treat migraine headaches. However, it did not demonstrate improvement in QoL (PROSPERO: CRD42024514509).

• 대한한의학회지
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• 제37권3호
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• pp.27-38
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• 2016

Objectives: According to Korean Medicine theory, the skin color of LU10 serves as a diagnostic clue to dyspeptic symptoms. The aims of this study were (1) to find the difference of skin color in LU10 region between functional dyspepsia (FD) and healthy control (HC) and (2) to examine the relationship between LU10 skin color parameters and dyspeptic symptoms. Methods: 39 participants (29 FD and 10 HC) have participated in this study. They were asked to complete gastrointestinal scale (GIS), gastrointestinal symptom rating scale (GSRS), Nepean dyspepsia index (NDI), functional dyspepsia-related quality of life (FD-QoL), visual analogue scale (VAS) for dyspeptic symptoms, food retention questionnaire (FRQ) and cold heat questionnaire (CHQ). $L^*$ (luminance), $a^*$ (red-green balance) and $b^*$ (yellow-blue balance) values of LU10 region were calculated through digital images of the participant's hand. Then we evaluated test-retest reliability of $L^*$, $a^*$ and $b^*$ values of LU10 region. Additionally, we compared $L^*$, $a^*$ and $b^*$ values of LU10 between FD and HC, and examined the relationship between LU10 color parameters and seven questionnaires scores. Results: Only $L^*$ values in LU10 region were significantly higher in FD compared with HC. GIS scores and the subset scores of NDI had a positive correlation with $L^*$ values significantly. Correlation coefficients of test-retest reliability of skin color measurement of LU10 ranged from 0.871 to 0.936 representing very strongly statistically significant (P<0.001). Conclusions: We confirmed the difference of skin color in LU10 region between FD and HC, and relationship between LU10 skin color parameters and dyspeptic symptoms.

• 대한조현병학회지
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• 제20권2호
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• pp.37-43
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• 2017

Objectives : This study was aimed to investigate the associations of childhood trauma with psychopathology and clinical characteristics in patients with schizophrenia. Methods : This study enrolled 66 inpatients with schizophrenia. Korean Childhood Trauma Questionnaire (K-CTQ) and Life Event Questionnaire (LEQ) were administered to assess childhood trauma. Psychopatholgy and clinical characteristics were assessed with the Positive and Negative Syndrome Scale (PANSS), Beck Depression Inventory (BDI), Korean Version of Internalized Stigma of Mental Illness (K-ISMI), Perceived Stress Scale (PSS), and visual analogue scale of EuroQoL-5 Dimension Index (EQ-5D). Results : Total scores on K-CTQ were positively associated with scores on the BDI, K-ISMI, PSS, and PANSS and negatively associated with the score on the EQ-5D. Among subscales of K-CTQ, emotional abuse was significantly associated with all measures for psychopathology and clinical characteristics. Patients with physical abuse (36.5%), emotional abuse (30.2%), or bullying (30.6%) according to the LEQ showed sighificanlty higher the ISMI score and lower EQ-5D score. Emotional abuse and bullying were also significantly associated with higher scores on BDI and/or PSS. Conclusion : Our results suggest that childhood trauma negatively influences on internalized stigma, depression, perceived stress and quality of life in patients with schizophrenia. Clinicians should carefully evalute and manage childhood traumatic experience of patients with schizophrenia.