• 한국수산과학회지
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• 제44권1호
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• pp.18-24
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• 2011

This study investigated the physicochemical and enzymatic properties of unmarketable cultured bastard halibut (Paralichthys olivaceus) of different weights as a potential source of surimi and surimi gel. The proximate composition of cultured bastard halibut of different weights did not differ significantly at P<0.05 (light weight (LBH) 400~500 g, medium weight (MBH) 600~800 g, and heavy weight (HBH) > 1,000 g). Compared to Alaska pollock muscle, the bastard halibut muscle had a 4% higher crude protein content and 6% lower moisture content. The collagen content of LBH bastard halibut muscle was 1.58 g/100 g, which was lower than or no different from bastard halibut weighing different amounts. Regardless of fish weight or pH, the enzymatic activities of crude fish extracts ranged from 0.34~0.48 U/mg for casein and hemoglobin, 11.0~12.7 U/mg for LeuPNA, 5.4~6.1 U/mg for ArgPNA, 2.3~2.9 U/mg for SAAPFNA, and 0.1~0.2 U/mg for BAPNA. The yield of surimi gel from LBH was 24.4%, which was similar to that from MBH and lower than that from HBH. The surimi gel from LBH was similar to that from HBH, while weaker than that from MBH. The surimi gel from LBH gel was stronger than grade SA gel from commercial Alaska pollock.

• 한국수산과학회지
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• 제44권3호
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• pp.191-196
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• 2011

In this study, we investigated the chemical and enzymatic properties of unmarketable cultured bastard halibut (UCBH) Paralichthys olivaceus harvested at different times (March, May, July, September, November, and January), and we examined the physical properties of surimi gel from UCBH as a potential source of surimi and surimi gel. The moisture and crude protein contents of UCBH harvested in July and January were >78% and <19%, respectively, which is greater than the moisture content in UCBH harvested in May, March, and September, but lower than the crude protein content. Regardless of the month of harvest, the UCBH had a higher crude protein content than Alaska pollock, which is the largest fishery biomass used for surimi and surimi gel, but a lower moisture content. Regardless of the month of harvest, the enzymatic activity in crude extracts of UCBH muscle ranged from 0.31-0.59 U/mg for casein (pH 6.0 and 9.0) and 11.7-12.7 U/mg for LeuPNA. These findings suggest that autolytic enzymes were unaffected by gel formation. Gel strength was highest in the surimi gel prepared from UCBH harvested in September, November, and January; second highest in that prepared from UCBH harvested in March and May; and lowest in that prepared from UCBH harvested in July. Compared to the gel strength of surimi gel from grade SA commercial Alaska pollock surimi, the strength of the surimi gels prepared from UCBH harvested in March, May, September, November, and January were superior, whereas that of the surimi gel prepared from UCBH harvested in July was similar.

• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5691-5696
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• 2014

Background: Many clinical trials have been conducted to evaluate sorafenib for the treatment of advanced NSCLC, but the results for efficacy have been inconsistent. The aim of this study was to evaluate the efficacy and safety of sorafenib in patients with advanced NSCLC in more detail by meta-analysis. Methods: This meta-analysis of randomized controlled trials (RCTs) was performed after searching PubMed, EMBASE, ASCO Abstracts, ESMO Abstracts, and the proceedings of major conferences for relevant clinical trials. Two reviewers independently assessed the quality of the trials. Outcomes analysis were disease control rate (DCR), progression- free survival (PFS), overall survival (OS) with 95% confidence intervals (CI) and major toxicity. Subgroup analysis was conducted according to sorafenib monotherapy, in combination with chemotherapy or EGFR-TKI to investigate the preferred therapy strategy. Results: Results reported from 6 RCTs involving 2, 748 patients were included in the analysis. Compared to sorafenib-free group, SBT was not associated with higher DCR (RR 1.31 (0.96- 1.79), p=0.09), PFS (HR 0.82 (0.66-1.02), p=0.07) and OS (HR 1.01 (0.92-1.12), p=0.77). In terms of subgroup results, sorafenib monotherapy was associated with significant superior DCR and longer PFS, but failed to show advantage with regard to OS. Grade 3 or greater sorafenib-related adverse events included fatigue, hypertension, diarrhea, oral mucositis, rash and HFSR. Conclusions: SBT was revealed to yield no improvement in DCR, PFS and OS. However, sorafenib as monotherapy showed some activity in NSCLC. Further evaluation may be considered in subsets of patients who may benefit from this treatment. Sorafenib combined inhibition therapy should be limited unless the choice of platinum-doublet regimen, administration sequence or identification of predictive biomarkers are considered to receive better anti-tumor activity and prevention of resistance mechanisms.

• 헤리티지:역사와 과학
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• 제53권1호
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• pp.34-51
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• 2020

성남 고등동 회곽묘는 한 지역에서 다른 시기에 제작된 6기의 회곽묘가 발굴되었으며, 회곽묘 조성에 사용된 삼물회의 다양한 제작 기법이 확인되었다. 삼물회의 제작 기법을 규명하기 위하여 고문헌 기록을 바탕으로 석회 원료와 제작 기법 및 배합 방법을 고찰하였다. 조선시대 고문헌에는 석회의 원료 중 저품위 석회석을 사용한 기록과 배합 재료로 황토와 백토, 기와 가루 등과 같은 석회의 강도를 향상시킬 수 있는 포졸란 물질 사용에 대한 기록이 남아있다. 또한 삼물회의 다양한 배합 방법이 기록되어 있어 이에 대한 재현 실험을 바탕으로 석회 원료, 배합 재료, 배합 비율에 따른 삼물회 제작 기법 분석이 요구되었다. 조선시대 전기에는 석회를 다방면으로 사용하였으나 공급이 적고 기술적인 미숙함으로 지속적인 문제가 발생하였으며, 조선시대 후기에 이르러 대량 생산됨과 함께 석회 제작 기술이 발달하였다. 16세기와 18세기 회곽묘 삼물회의 제작 기법 분석을 바탕으로 고문헌에 기록된 배합비와 배합 방법들이 적용된 것을 알 수 있었으며, 회곽묘 삼물회는 시기에 따라 석회의 품질이 변화하였고 배합 재료 또한 변화됨에 따라 배합 비율이 다르게 나타나는 것으로 판단된다. 회곽묘 삼물회의 배합 비율은 시기에 따라서 변화하였으며, 주례와 가례를 기준으로 정해진 배합 방법으로 제작되었기 때문에 회곽묘 삼물회의 제작 기법에 대한 과학적 분석 자료가 지속적으로 구축된다면 회곽묘 편년 연구에 도움이 될 것으로 기대된다.

• 한국수산과학회지
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• 제43권6호
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• pp.598-605
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• 2010

This study investigated the physicochemical and enzymatic properties of unmarketable bastard halibut (Paralichthys olivaceus) cultured in different regions (i.e., Jeju, Wando, and Geoje) as a potential source of surimi and surimi gel. The proximate composition of unmarketable bastard halibut cultured in different regions did not differ significantly at P<0.05. Compared to Alaska pollock muscle, all of the unmarketable bastard halibut muscle had a 4% higher crude protein content and 5% lower moisture content. The collagen content of bastard halibut muscle cultured in Jeju was 1.96 g/100 g, which was higher than in fish cultured in other regions. Regardless of the region where cultured or pH, the enzymatic activities of the crude extracts from unmarketable bastard halibut muscle ranged from 0.30.0.48 U/mg for casein and hemoglobin, 11.9.13.7 U/mg for LeuPNA, 5.6.6.7 U/mg for ArgPNA, 2.8.4.7 U/mg for SAAPFNA, and 0.1.0.2 U/mg for BAPNA. Regardless of region, no mercury or lead was found in any of the unmarketable bastard halibut muscle, except for lead in fish cultured in Geoje. The strength of surimi gels from unmarketable bastard halibut cultured in Jeju, Geoje, and Wando was 1059, 988, and 900 g${\times}$cm, respectively. The surimi gel from unmarketable bastard halibut cultured in Jeju was stronger than commercial Alaska pollock surimi, which was grade SA.

• Journal of Animal Science and Technology
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• 제47권4호
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• pp.555-564
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• 2005

본 연구는 비육돈에 대한 황토의 주성분인 zeolite의 첨가효과를 구명하기 위하여 증체량, 사료요구율, 육질, 악취제거 및 경제성 등을 조사하였으며 생후 93일령의 비육돈 120두(4처리$\time$3반복$\time$10두)를 공시하여 출하시까지 70일간 사양시험을 실시하였다. 일당증체량은 비육돈 전기의 경우 zeolite 4% 첨가구가 1.00kg으로서 대조구의 0.8kg에 비하여 약 25%로 크게 향상되었다(P<0.05). 그러나 비육돈 후기의 일당 증체량은 대조구(0.78kg)를 포함한 모든 처리구에서 0.74-0.83kg으로서 유의한 차이는 없었다. 사료요구율은 시험 전기간 동안 대조구에서는 3.43으로서 가장 높았으며, 그 다음은 zeolite 1%구와 2%로서 각각 3.24와 3.13이었으며 zeolite 3% 첨가구는 3.00으로서 약 7.4%의 개선효과가 나타났다(P<0.05). 시험 전기간 동안의 $NH_3$ 가스 발생량은 zeolite 4% 첨가구가 대조구에 비하여 약 33.9-53.9%의 개선효과가 나타났다(P<0.05). 도체중과 등지방 두께는 대조구와 zeolite 첨가구 간에 차이가 없었으며, A등급 출현율은 zeolite 4% 첨가구가 60.00%로서 대조구의 36.67%에 비하여 높게 나타났다. 경제성 분석 결과, 증체 kg당 사료비는 zeolite 4% 첨가구는 910원, 2% 첨가구는 919원, 1% 첨가구는 941원 및 대조구는 982원으로서 zeolite를 4% 첨가함으로써 개선효과가 크게 나타났다. 이상의 결과, 비육돈에 대하여 zeolite를 4% 수준으로 첨가․급여하면 사료요구율, 육질 A등급 출현율, 분내 암모니아가스 발생량 및 경제성면에서 효과적인 것으로 사료된다.

• 대한족부족관절학회지
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• 제15권4호
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• pp.232-239
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• 2011

Purpose: Diabetic foot ulcer is one of the most important diabetic complications because it increases the risk of amputations. Moreover, it lowers the quality of patients' life and increases the social medical expenses. Authors analyzed risk factors of intractable diabetic foot ulcer using retrospective study. Materials and Methods: From January 2007 to December 2010, 40 patients who could not achieve complete healing despite more than 12 weeks of proper management among who had been diagnosed and treated as diabetic foot ulcer at our hospital were included and evaluated retrospectively. We compared the risk factors between two groups who were finally treated by amputation and non-amputation. Results: The sample was composed of 31 male patients (77.5%) and 9 female patients (22.5%). Comorbidity including hypertension and hyperlipidemia were 77.5% and 80% each. By Wagner classification, 30 patients (80%) had ulcerative lesion over the grade 3. From bacteriology results, 29 patients (72.5%) had polybacteria infection. 35 patients (87.5%) had neuropathy and 26 patients (65%) had vascular stenosis at least one level. The mean initial ankle-brachial index and toe-brachial index were 0.982 and 0.439. In comparison between amputation group and non-amputation group, ulcer severity, number of stenotic vessel and initial ankle-brachial index/toe-brachial index had statistical significance. Conclusion: The most commonly risk factor of intractable diabetic foot ulcer was peripheral neuropathy reaching 87.5% of cases. In comparison with non-amputation group, ulcer severity according to Wagner classification, number of stenotic vessel and initial ankle-brachial index/toe-brachial index were demonstrated as a risk factor of amputation in intractable diabetic foot ulcer.

• The Plant Pathology Journal
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• 제17권3호
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• pp.141-148
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• 2001

Postharvest decay of onion bulbs was examined by inspecting the commercial packages in the market or in storage. Bulb rot incidence was unexpectedly high, and onion bulbs with 1st quality grade were rotten most severely by 51%, followed by 32% for 2nd and 21% for 3rd grades. This indicates that larger bulbs had higher incidences of bulb rots. Major pathogens associated with basal and neck rots were Fusarium oxysporum and Aspergillus sp. or Botrytis allii, respectively, of which basal rot was most prevalent and damaging during storage. Among the epiphytic microorgani는 from onion plants, several Bacillus and Paenibacillus spp. and previously selected Pseudomonas putida and Trichoderma harzianum had inhibitory efficacy against bulb rot pathogens. Among these B. amyloliquefaciens BL-3, Paenibacillus polymyxa BL-4, and P. putida Cha 94 were highly inhibitory to conidial germination of F. oxysporum and B. allii. P. putida Cha 94, B. amyloliquefaciens BL-3, P. polymyxa BL-4, and T. harzianum TM were applied in the rhizoplane of onion at transplanting. Initially antagonist populations decreased rapidly during the first one month. However, among these antagonists, rhizoplane population densities of BL-3, Cha 94, and TM were consistently high thereafter, maintaining about 10$^4$-10$^{5}$ cells or spores per gram of onion root up to harvest time. The other bacterial antagonist BL-4 survived only for two months. TM was the most effective biocontrol agent against basal rot, with the number of rotten bulbs recorded at 4%, while that of the control was 16%. Cha 94 was effective for the first 20 days, but basal rot increased thereafter and had about the same control efficacy as that of BL-3 and BL-4. When the antagonists were applied to the topping areas of onion bulbs at harvest, TM was the most effective in protecting the stored onion bulbs from neck rotting. The second effective antagonist was BL-3. TM and BL-3 completely suppressed the neck rot in another test, suggesting that biocontrol of postharvest decay of onion using these microorganisms either at the time of transplanting or at harvesting may be promising.

• 경영정보학연구
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• 제13권1호
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• pp.75-96
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• 2011

본 연구는 e-Commerce 산업의 미래 트랜드를 예측하기 위해 Coolhunting을 실시하였다. Coolhunting은 사회네트워크 분석을 통해 트렌드세터를 발견하고 이들의 집단지성을 통해 미래 트랜드인 Cool Trends를 읽어내는 방법이다. Coolhunting은 사회네트워크분석을 통해 실시되는데 본 연구에서는 사회 네트워크 분석 Tool 중 NodeXL을 활용하였다. e-Commerce 산업의 Cool Trends를 발견하기 위해 e-Commerce 기업, 상품, 고객서비스 유형, 고객응대직원, 고객간의 산업네트워크 연구모형을 설계하였다. 연구모형을 통해 e-Commerce 산업의 흐름을 분석하고, 네트워크 영향력을 나타내는 사이중앙값과 페이지랭크값 분석을 통해 트렌드세터들의 특성을 파악하였다. 본 연구의 결과 e-Commerce 산업 네트워크는 혼돈형태에서 현재 집단지성형태의 네트워크로 변화되고 있었다. 네트워크 영향력에 대한 분석결과 e-Commerce 시장의 Cool Trends가 VIP, 우수, 관리등급의 여성고객(트렌드세터)들을 중심으로 집단지성을 통한 상거래인 소셜커머스 시장이 활성화 될 것이고, 소셜커머스에서는 소비자들에게 시맨틱한 소비를 촉진시키고, 상품군 중 화장품/미용기구/향수 상품군에서 고객 들의 구매력이 집중될 것이라는 것을 발견하였다. 본 연구결과를 통해 e-Commerce 기업이 취해야 할 전략적 방향성을 제언하였고, 국내 e-Commerce 기업들에게 있어서 지속적 성장이 이루어지고, 고객들에게 있어서는 양질의 서비스가 제공되기를 바란다.

• 한국유기농업학회지
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• 제17권3호
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• pp.347-356
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• 2009

본 실험은 중부 지방에서 유기질 비료를 시용하여 두과 사료작물 초종의 생산성, 사료가치 및 가축사육능력을 조사하였고 그 결과를 요약하면 다음과 같다. 두과 사료작물의 생초 수량과 건물수량은 초종 간 차이가 인정되었으며 공시 초종 중에서 red clover가 생초수량 38.6 ton/ha, 건물수량 7.8 ton/ha, CP수량 1.0 ton/ha, TDN수량 4.6 ton/ha로 다른 초종보다 유의하게 많았다(p<0.05). NDF와 ADF는 수확시기가 늦을수록 높은 경향을 나타내서 galega와 cicer milkvetch가 가장 높았고 yellow suckling clover가 가장 낮았다. 상대사료가치(RFV)는 galega와 cicer milkvetch를 제외한 나머지 품종이 100 이상의 값을 나타내어 우수하였으며 특히, yellow suckling clover, yellow blossom sweet clover, crimson clover, hairy vetch 등은 151 이상으로 1등급에 속하였다. 가축사육능력은 초종 평균으로 Kcp(2.18 head/ha/yr) > KTDN(1.25 head/ha/yr) > K(0.04 head/ha/yr) 순으로 높았고, 초종별로는 red clover가 K 0.05 head/ha/yr, Kcp 6.84 head/ha/yr, KTDN 3.64 head/ha/yr로 공시작물 중 가장 높은 가축사육능력을 나타내었다. 이상의 결과로 볼 때 두과 사료작물 중에서 red clover가 생산성, 사료가치 및 가축사육능력이 가장 우수하여 중부지방에서 두과 사료작물 생산에 있어서 적절한 초종으로 판단되었다.