• 한국식품영양학회지
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• 제32권6호
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• pp.738-744
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• 2019

Recently, the prevalence of hyperlipidemia has been increasing, and consequently, the need to identify safe and effective treatments to control this chronic disease has also increased. The beneficial effects of probiotics have been revealed by several studies over the past few years, including their effects on hypertriglyceridemia. However, the mechanisms of action of probiotics are still unclear. The anti-obesity effects of Lactobacillus plantarum Q180 on lipid accumulation have already been demonstrated using an in vitro HepG2 cell model, and therefore, we investigated its efficacy and mechanism of action. Lipid accumulation was induced in HepG2 cells by palmitic acid treatment and then the cells were incubated with L. plantarum Q180 lysate or supernatant to investigate changes in lipid accumulation and expression of lipid metabolism-related genes. The results showed that the L. plantarum Q180-treated group exhibited significantly lower levels of lipid accumulation and mRNA expression of lipid synthesis- and adipogenesis-related genes than the palmitic acid-treated group did. These results indicate that L. plantarum Q180 may contribute to alleviating hypertriglyceridemia by inhibiting lipid synthesis.

• 한국전기전자재료학회논문지
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• 제18권6호
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• pp.532-537
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• 2005

In order to develop a tunable resonator which can be easily operated by DC bias and applied for microwave tunable filters and devices using ferroelectric thin or thick films, the non conductor backed-and conductor backed- coplanar stripline resonators have been designed and analyzed. They have been designed to be operated at 25 GHz which involve coplanar stripline input and output ports. The resonators have been simulated and analyzed using Ansoft HFSS. The research has been focused on the Quality factor of the coplanar stripline resonator. The conductor Q, box Q, and radiation Q of the resonators have been analyzed and calculated according to the substrate thickness & conductor width of the resonators. From these parameters, the loss factors of the coplanar stripline resonator have been investigated. The conducting Q of the coplanar stripline resonator has no relation with the thickness of dielectric substrate and increases as the conductor width increases. The box Q has no much relation with the thickness of substrate and the conductor width, which is above 2000. The radiation loss increases as the thickness of substrate and the conductor width increase. To decrease the radiation loss of the coplanar stripline resonator, a conductor backed coplanar stripline resonator has been proposed which has the unloaded Q of 170.

• Annals of Rehabilitation Medicine
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• 제42권6호
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• pp.884-887
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• 2018

We report a female proband carrying a de novo 5q34-q35.2 deletion breakpoint, and review the unique skeletal phenotype and possible genotype related to this mutation. The patient presented with a persistent head tilt and limited head rotation. Non-contrast-enhanced three-dimensional computed tomography of the cervical spine revealed several malformations including a bone cleft in the right pars interarticularis, a bone defect in both C5 lamina and the transverse foramen at C2-C3, agenesis of the right articular process of C5, bony fusion of C4-C5, and subluxation of the craniocervical joints. Several deformities of the cervical spine seen in this patient have not been associated with the 5q deletion. A review of 5q-related mutations suggests that abnormalities associated with MSX2 gene might cause cervical spine abnormalities.

• 대한간호학회지
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• 제48권6호
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• pp.679-691
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• 2018

Purpose: This study was aimed at identifying the types of perceptions of ethical issues among perioperative nurses. Methods: Q-methodology focusing on individual subjectivity was used with data collected in November 2016. Thirty-four Q-statements were selected and scored by the 35 participants on a 9-point scale with normal distribution. Participants were perioperative nurses working in advanced general hospitals and general hospitals. The data were analyzed using the PC-QUANL program. Results: A total of 35 perioperative nurses were classified into 4 factors based on the following viewpoints: self-centered (type 1), onlooking and avoiding (type 2), patient-centered (type 3), and problem-centered (type 4). The 4 factors accounted for 57.84% of the total variance. Individual contributions of factors 1, 2, 3, and 4 were 41.80%, 7.18%, 5.20%, and 3.66%, respectively. Conclusion: The major contribution of this study is the clarification of perioperative nurses' subjective perceptions of ethical issues. These findings can be used in formulating effective strategies for nursing educators, professional nurses, and nursing administrators to improve ethical decision-making abilities and to perform ethical nursing care by the appropriate management of ethical issues in everyday nursing practice.

• 한국조경학회지
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• 제28권6호
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• pp.62-76
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• 2001

This study is to offer the basic information and materials for the restoration of the urban forest and the ecologically healthy and continuous green belt through the investigation and the analysis on the vegetation in Hwasan Park, Chonju-City. The flora of Hwasan Neighborhood park was composed of 86 families 230 genera, 261 species, 35 varieties, 1 formae or 298 Taxa. Among them, calculation of Pte-Q Index represented 0.60, Fisher's Index. Some characteristics of the plants in this area have represented such as Th-D1-R5 type in biological type, erect form(64.6%) in growth type, 30 taxa in naturalized plants. The life form spectra investigated from Hwasan neighborhood park was recognized as the following M"17.4%, N:11.4%, E:0.3%, Ch:0%, H:29.8%, G:6.7%, HH:0%, Th:34.2%. By the Z-M method 5 plant communities and 3 afforestation were recognized; Quercus variabilis community, Q.acutissima community, Q.serrata community, Sorbus alnifolia community, Pinus densiflora community, P.rigida afforestation, Robinia pseudo-acacia afforestation and Larix leptolepis afforestation. The actual vegetation map constructed on the grounds of the communities classified and other data. The pattern of successional trend of tree species might be suggested: L. leptoleipis, P. rigida and P. densifloralongrightarrowQ.variabilis and Q.acutissimalongrightarrowS.alnifolia and Q.serratalongrightarrowCarpinus tschonoskii community. Three measurements of species diversity (richness index(SR), Shannon-Wiener index(H'), evenness index(J')) and their relationship with community type were studied in the surveyed plant communities. Q.serrata community was higher in SR, H', J' than the other communities, whereas R.pseduo-acacia afforestation was low. Finally, The vegetation of the Hwasan neighborhood park must not allowed any more. Nothing ca be better than native states in preserving the ecosystems.tems.

• BMB Reports
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• 제40권6호
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• pp.899-910
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• 2007

Extracellular Regulated Kinases (ERK) and Protein Kinase B (Akt) are intermediaries in relaying extracellular growth signals to intracellular targets. Each pathway can become activated upon stimulation of G protein-coupled receptors mediated by $G_q$ and $G_{i/o}$ proteins subjected to regulation by RGS proteins. The goal of the study was to delineate the specificity in which cardiac RGS proteins modulate $G_{q^-}$ and $G_{i/o}$-induced ERK and Akt phosphorylation. To isolate $G_{q^-}$ and $G_{i/o}$-mediated effects, we exclusively expressed muscarinic $M_2$ or $M_3$ receptors in COS-7 cells. Western blot analyses demonstrated increase of phosphorylation of ERK 1.7-/3.3-fold and Akt 2.4-/6-fold in $M_{2^-}/M_{3^-}$ expressing cells through carbachol stimulation. In co-expressions, $M_3/G_q$-induced activation of Akt was exclusively blunted through RGS3s/RGS3, whereas activation of ERK was inhibited additionally through RGS2/RGS5. $M_2/G_{i/o}$ induced Akt activation was inhibited by all RGS proteins tested. RGS2 had no effect on $M_2/G_{i/o}$-induced ERK activation. The high degree of specificity in RGS proteins-depending modulation of $G_{q^-}$ and $G_{i/o}$-mediated ERK and Akt activation in the muscarinic network cannot merely be attributed exclusively to RGS protein selectivity towards $G_q$ or $G_{i/o}$ proteins. Counter-regulatory mechanisms and inter-signaling cross-talk may alter the sensitivity of GPCR-induced ERK and Akt activation to RGS protein regulation.

• Bulletin of the Korean Chemical Society
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• 제29권5호
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• pp.915-920
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• 2008

In this paper the electrochemical behaviors of hydroquinone ($H_2Q$) were investigated on a carbon paste electrode using room temperature ionic liquid N-butylpyridinium hexafluorophosphate ($BPPF_6$) as binder (ILCPE) and further applied to $H_2Q$ determination. In pH 2.5 phosphate buffer solution (PBS), the electrochemical response of H2Q was greatly improved on the IL-CPE with a pair of well-defined quasi-reversible redox peaks appeared, which was attributed to the electrocatalytic activity of IL-CPE to the $H_2Q$. The redox peak potentials were located at 0.340 V (Epa) and 0.240 V (Epc) (vs. the saturated calomel electrode, SCE), respectively. The formal potential ($E^0$') was calculated as 0.290 V and the peak-to-peak separation (${\Delta}E_p$) was 0.100 V. The electrochemical parameters of $H_2Q$ on the IL-CPE were further calculated by cyclic voltammetry. Under the selected conditions the anodic peak current was linear with $H_2Q$ concentration over the range from $5.0\;{{\times}}\;10^{-6}$ to $5.0\;{\times}\;10^{-3}\;mol\;L^{-1}$ with the detection limit as $2.5\;{\times}\;10^{-6}\;mol\;L^{-1}$ (3$\sigma$ ) by cyclic voltammetry. The proposed method was successful applied to determination of $H_2Q$ content in a synthetic wastewater sample without the interferences of commonly coexisting substances.

• 한국콘텐츠학회논문지
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• 제21권1호
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• pp.227-242
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• 2021

공영방송 KBS를 비롯해 한국 언론인들의 전문직주의는 미성숙 상태라는 평가가 일반적이다. 본 연구는 Q 방법론을 활용하여, 기자의 직업적 성취에 대하여 KBS 기자들과 시민들이 형성하고 있는 주관성을 탐색하였다. 이를 통해 한국 언론전문직주의 미성숙 상태에 관한 언론인의 주관성 차원의 배경과 이유를 파악하고자 하였다. KBS 기자 30명과 4년제 대학 언론고시반 대학생 10명, 그리고 다양한 연령대의 일반인 40명, 총 80명을 상대로 기자의 직업적 성취와 관련된 내용의 95개의 진술문을 활용하여 '승진/발탁되는 기자'를 조건으로 소팅을 진행하여 총 3개의 Q 요인을 추출하였고, 이를 다시 각 요인별 양(+) 하부 요인과 음(-) 하부 요인으로 구분하여 총 6개의 기자에 대한 인식과 태도 유형을 발견하였다. 그 결과 KBS 기자의 직업적 성취에 관한 주관성은 '전문직형 기자', '모사꾼 기자', '조직충성형기자', '열혈기자', '입신양명기자', '착실한 직업인'으로 명명된 6개의 인식 유형으로 정리되었다. 본 연구는 기존 한국 기자의 직업 정체성 연구를 더욱 심화시키고 확장시켰다는 데 의의를 가질 수 있다.

• Parasites, Hosts and Diseases
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• 제55권6호
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• pp.601-606
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• 2017

Cystoisospora is responsible for morbidity in immunocompromised patients. PCR is sensitive for diagnosing Cystoisospora; however, it needs reevaluation for differential molecular diagnosis of cystoisosporiasis. We aimed at evaluating melting curve analysis (MCA) after real-time PCR (qPCR) in diagnosis and genotyping of Cystoisospora as an alternative to conventional PCR. We included 293 diarrheic stool samples of patients attending the Department of Clinical Oncology and Nuclear Medicine of Cairo University Hospitals, Egypt. Samples were subjected to microscopy, nested PCR (nPCR), and qPCR targeting the internal transcribed spacer 2 region (ITS2) of the ribosomal RNA (r RNA) gene followed by melting temperatures ($T_ms$) analysis and comparing the results to PCR-RFLP banding patterns. Using microscopy and ITS2-nPCR, 3.1% and 5.8% of cases were Cystoisospora positive, respectively, while 10.9% were positive using qPCR. Genotyping of Cystoisospora by qPCR-MCA revealed 2 genotypes. These genotypes matched with 2 distinct melting peaks with specified $T_ms$ at $85.8^{\circ}C$ and $88.6^{\circ}C$, which indicated genetic variation among Cystoisospora isolates in Egypt. Genotype II proved to be more prevalent (65.6%). HIV-related Kaposi sarcoma and leukemic patients harbored both genotypes with a tendency to genotype II. Genotype I was more prevalent in lymphomas and mammary gland tumors while colorectal and hepatocellular tumors harbored genotype II suggesting that this genotype might be responsible for the development of cystoisosporiasis in immunocompromised patients. Direct reliable identification and differentiation of Cystoisospora species could be established using $qPCR-T_ms$ analysis which is useful for rapid detection and screening of Cystoisospora genotypes principally in high risk groups.

• 대한전자공학회논문지TC
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• 제41권4호
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• pp.45-50
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• 2004

본 논문에서는 소자 결합 구조를 통해 발진전력이 합쳐지는 회로를 이용한 저전압, 고효율 Q-band MIMIC 발진기를 제안한다. 0.1 ㎛ GaAs PHEMTS와 CPW 전송라인을 사용하여 제안된 구조의 발진기를 성공적으로 집적화하였다. 제작된 발진기는 34.56 ㎓ 주파수에서 2.6 ㏈m의 출력 전력일때 19 %의 높은 효율특성을 가졌다. 이때 회로에 인가된 전압은 2.2 V로 현재까지 Q-band에서 발표된 발진기보다 낮은 구동전압 특성을 얻었다. 또한 최대 출력 전력은 34.56 ㎓ 주파수에서 6.7 ㏈m을 얻었다.