• Asian Pacific Journal of Cancer Prevention
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• 제15권21호
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• pp.9523-9527
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• 2014

The incidence of colorectal cancer (CRC) is increasing in many Asian countries and microRNAs have already been proven to be associated with tumorigenesis. Currently, microRNA-376a (miR-376a) expression and association with clinical factors in CRC remains unclear. In this study, real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was carried out on 53 matched pairs of CRC and adjacent normal mucosa to investigate the expression levels of miR-376a. According to the high or low expression of miR-376a, patients were divided into two groups. The relationship between miR-376a expression and clinicopathological factors of 53 patients was evaluated. Survival analysis of 53 CRC patients was performed with clinical follow-up information and survival curves were assessed by the Kaplan-Meier method. Immunohistochemistry (IHC) staining was performed on sections of paraffin-embedded tissue to investigate the vascular endothelial growth factor (VEGF) expression. MiR-376a showed low expression in cancer tissues compared to the adjacent normal tissues and altered high miR-376a expression tended to be positively correlated with advanced lymph node metastasis and shorter patient survival. VEGF IHC positivity was significantly more common in patients with high expression levels of miR-376a.Those results demonstrated that miR-376a may be a meaningful prognostic biomarker and potential therapeutic target in colorectal cancer.

• Wind and Structures
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• 제23권4호
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• pp.313-350
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• 2016

Taipei 101 Tower, which has 101 stories with height of 508 m, is located in Taipei where typhoons and earthquakes commonly occur. It is currently the second tallest building in the world. Therefore, the dynamic performance of the super-tall building under strong wind actions requires particular attentions. In this study, Large Eddy Simulation (LES) integrated with a new inflow turbulence generator and a new sub-grid scale (SGS) model was conducted to simulate the wind loads on the super-tall building. Three-dimensional finite element model of Taipei 101 Tower was established and used to evaluate the wind-induced responses of the high-rise structure based on the simulated wind forces. The numerical results were found to be consistent with those measured from a vibration monitoring system installed in the building. Furthermore, the equivalent static wind loads on the building, which were computed by the time-domain and frequency-domain analysis, respectively, were in satisfactory agreement with available wind tunnel testing results. It has been demonstrated through the validation studies that the numerical framework presented in this paper, including the recommended SGS model, the inflow turbulence generation technique and associated numerical treatments, is a useful tool for evaluation of the wind loads and wind-induced responses of tall buildings.

• 대한간호학회지
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• 제30권1호
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• pp.137-147
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• 2000

The purpose of this study was to investigate characteristics of teenagers' perceptions to bullies according to the classification types of Q-methodology. The results of the analysis were classified in 5 types. Type 1, which was the type geared foward solution, showed that they expressed a strong attitude of sympathy and protection towards the victim. However, they had harbored rage and hostile feelings against the assaulter. For example, when they witnessed the bully in action, they positively intervened in the situation. Type 2, which was the observer type, showed that they thought the victims were to blame for their misfortune. Also, when a friend who was left out in the cold by his classmates, they were just watched without showing any special interest. Type 3, which was the type of conflict, indicated that they believed that the both the victim and the assaulter should have responsibility. In contrast to the previous type, they had sympathy for the friend who was left out in the cold by his classmates, they had the dual feeling that intended to use the bully under the situation with his friend. Type 4, which was the type of assenting, indicated that they assumed an indifferent attitude to the situation, while they implied assenting to the situation of the friend who had a bad relationship with them. Type 5, which was the negative type, showed that they had the negative view to the situation of bully itself so that they did not recognize the bully as the method of revenge for whatever reason. The results of the study showed that the bully increased the factor of stress to school life of the victim or assaulter, even in the subjective position. The perception of the bully should change according to the characteristics of the types of people and it is necessary to study how to cope with the situations.

• 한국전기전자재료학회논문지
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• 제25권7호
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• pp.516-520
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• 2012

In this paper, we have theoretically analyzed and designed a dielectric multi-layer sensor with a SPR (surface plasmon resonance) using analytical calculation and FDTD (finite difference time-domain) methods. The proposed structure is composed of periodic layer and thin metal film. It has many advantages. One of that is a high sensitivity of the SPR. Another is a high Q-factor of the characteristics in the PhC (photonic crystals) micro-cavity structure. The incident light has double resonance characteristics, because the filtered light by PhC structure, dielectric multi-layer, is met the thin metal film for SPR effect. We have also observed the change of resonance characteristics according to the variation of effective index on the metal film.

• 복식
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• 제42권
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• pp.91-112
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• 1999

This study mainly focuses on the dissatisfaction of the post-purchase behavior regarding the consumer dissatisfaction complaining behavior and repurchase intention In the literature study approach it was hypothe-sized that dissatisfaction variables was consisted of the cognitive process and emotion. And the dissatisfaction variables and the individual vari-ables and situational variables were set up to contribute to form the complaining behavior. In the process of the complaining behavior the first thing the consumers would do when they would seek for redress or not. Consumers who sought redress and actually received the fair treatment from a store practiced positive word-of-mouth. However consumers who received unfair treat-ment practived negative word-of-mouth exit behavior or the third party complaining Behavior. And consumers who did not seek any redress either showed exit behavior practiced negative word-of-mouth or no complaining behavior at all. Therefore. complaining behavior process consists of redress seeking process and non-redress seeking process. For the empirical study the survey method was used and two other researches were previously conducted. First of all the research was designed to comprehend consumer complaining behaviors process Secondly it was conducted for measuring validity and reliability: Cronbach's q. The sqmple was 569 women aged 2-'s to 5-'s living in Seoul and other suburban areas. The various methods were used to analyze the date such as frequency, percentage and multiple regression analysis. Overall the results were verified. 1) The dissatisfaction variables and individual variables influenced situational variables. 2) The complaining behavior intention was affected by dissatisfaction variables indivi-dual variables and situational variables. 3) The repurchase intention occurred more when the justice was performed Consequently the complaining behavior proce-dure was consisted of the redress seeking and non-redress seeking. And dissatisfaction vari-ables and individual variables were verified to influnce situational variables. These complaining behavior variables affected complaining behavior Especially in a case of redress seeking process complaining behavior and repurchase rate were highly affected by the perceived justice from a store.

• 한국정보처리학회논문지
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• 제6권6호
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• pp.1532-1541
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• 1999

본 연구에서는 웹을 기반으로 웹 클라이언트 간의 의사소통과 협동 작업을 가능하게 하는 웹 기반 협동 시스템의 구축에 필요한 상위레벨의 지식들과 재상용 컴포넌트들인 자바 애플릿과 어플리케이션들을 컴포넌트로 갖는 객체지향 프레임워크를 개발하였다. 프레임워크의 부품들은 재사용을 지원하기 위해서 설계 정보, 소스, 코드, 실행 코드 등을 포함한다. 연관된 연구를 통해서 얻어진 영역 프레임워크 구축 프로세스를 통해서 웹 협동 시스템 프레임워크를 구축하였다. 웹 클라이언트 간의 의사소통과 협동 작업을 지원하기 위해서 웹 기반 협동 시스템의 서브 시스템으로 사용자 관리 시스템, 채팅, 게시판, 질의 응답 시스템, 전자 게시판 등을 정의하였다. 프레임워크의 사용성을 높이기 위해서 지원 도구로 소스 코드 생성기, 클래스 편집기, 이해지원 도구 등의 비주얼 도구를 개발하였다.

• Ocean and Polar Research
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• 제39권2호
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• pp.149-158
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• 2017

The opsin family of light sensitive proteins family makes up are the universal photoreceptor molecules of all visual systems in the vertebrates including teleosts. They can change their conformation from a resting state to a signaling state upon light absorption, which activates the G-protein coupled receptor, thereby resulting in a signaling cascade that produces physiological responses. However, this species is poorly characterized at molecular level due to little sequence information available in public databases. We have investigated the opsin family of nocturnal cutlass fish using the whole transcriptome sequencing method. The opsin genes were cloned and its expression in the tissues and organs were examined by qPCR. We cloned 6 opsin genes (RRH, Opn4, Rh1, Rh2, VA-opsin, and Opn3) in retina and brain tissue. It contained the seven presumed transmembrane domains that are characteristic of the G-protein-coupled receptor family. However, short wavelength sensitive pigment (SWS) and long wavelength sensitive pigment (LWS) were not detected in this study. The mRNA expression of the 6 photoreceptor genes were detected in retina and peripheral tissue. Our studies will lead to further investigation of the photic entrainment mechanism at molecular and cellular levels in cutlass fish and can be used in comparative studies of other fishes.

• 한국측량학회지
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• 제34권4호
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• pp.413-423
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• 2016

Worldview-3 satellite sensor provides panchromatic image with high-spatial resolution and 8-band multispectral images. Therefore, an image-sharpening technique, which sharpens the spatial resolution of multispectral images by using high-spatial resolution panchromatic images, is essential for various applications of Worldview-3 images based on image interpretation and processing. The existing pansharpening algorithms tend to tradeoff between spectral distortion and spatial enhancement. In this study, we applied six pansharpening algorithms to Worldview-3 satellite imagery and assessed the quality of pansharpened images qualitatively and quantitatively. We also analyzed the effects of time lag for each multispectral band during the pansharpening process. Quantitative assessment of pansharpened images was performed by comparing ERGAS (Erreur Relative Globale Adimensionnelle de Synthèse), SAM (Spectral Angle Mapper), Q-index and sCC (spatial Correlation Coefficient) based on real data set. In experiment, quantitative results obtained by MRA (Multi-Resolution Analysis)-based algorithm were better than those by the CS (Component Substitution)-based algorithm. Nevertheless, qualitative quality of spectral information was similar to each other. In addition, images obtained by the CS-based algorithm and by division of two multispectral sensors were shaper in terms of spatial quality than those obtained by the other pansharpening algorithm. Therefore, there is a need to determine a pansharpening method for Worldview-3 images for application to remote sensing data, such as spectral and spatial information-based applications.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 1998년도 Proceedings of International Symposium on Remote Sensing
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• pp.236-241
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• 1998

The NOAA AVHRR remote sense SST data, collected by the National Fisheries Research and Development Institute (NFRDI), are analyzed in order to understand the spatial and temporal distributions of SST in the seas adjacent to Korea. Our study is based on 10-day SST images during last 7 years (1991-1997). For a time series analysis of multiple 557 images, all of images must be aligned exactly at the same position by adjusting the scales and positions of each SST image. We devised an algorithm which yields automatic detections of cloud pixels from multiple SST images. The cloud detection algorithm is based on a physical constraint that SST anomalies in the ocean do not exceed certain limits (we used $\pm$ 3$^{\circ}C$ as a criterion of SST anomalies). The remote sense SST data are tuned by comparing remote sense data with observed SST at coastal stations. Seasonal variations of SST are studied by harmonic fit of SST normals at each pixel. The SST anomalies are studied by statistical method. We found that the SST anomalies are rather persistent with time scales between 1 and 2 months. Utilizing the persistency of SST anomalies, we devised an algorithm for a prediction of future SST Model fit of SST anomalies to the Markov process model yields that autoregression coefficients of SST anomalies during a time elapse of 10 days are between 0.5 and 0.7. We plan to improve our algorithms of automatic cloud pixel detection and prediction of future SST. Our algorithm is expected to be incorporated to the operational real time service of SST around Korea.

• Transactions on Electrical and Electronic Materials
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• 제6권6호
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• pp.276-279
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• 2005

Influences of sustain pulse-width on electrical characteristics and luminous efficiency are experimentally investigated for surface discharge of AC-PDP. A square pulse with variable duty ratio and fixed rising time of 300 ns has been used in the experiment. It is found that the memory coefficient is significantly increased at the critical pulse-width. And the wall charges and wall voltages as well as capacitances are experimentally measured by Q- V analysis method along with the voltage margin relation, in terms of the sustain pulse-width in the range of $1{\mu}s$ to $5{\mu}s$ under driving frequency of 10 kHz to 180 kHz. And the luminous efficiency is also experimentally investigated in above range of sustain pulse-width with driving frequency of 10 kHz to 180 kHz. It is noted that the luminous efficiency for 10 kHz and 180 kHz are 1.29 1m/W and 0.68 1m/W respectively, since the power consumption for 10 kHz is much less than that for 180 kHz. It has been concluded that the optimal sustain pulse-width is in the range of $2.5 {\~}4.5{\mu}s$ under driving frequency range of 10 kHz and 60 kHz, and in the range of $1.5 {\~} 2.5{\mu}s$ under driving frequency range of 120 kHz and 180 kHz based on observation of memory coefficient, and wall voltage as well as luminous efficiency.