• Smart Structures and Systems
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• 제10권4_5호
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• pp.411-426
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• 2012

The Canton Tower (formerly named Guangzhou New TV Tower) of 610 m high has been instrumented with a long-term structural health monitoring (SHM) system consisting of over 700 sensors of sixteen types. Under the auspices of the Asian-Pacific Network of Centers for Research in Smart Structures Technology (ANCRiSST), an SHM benchmark problem for high-rise structures has been developed by taking the instrumented Canton Tower as a host structure. This benchmark problem aims to provide an international platform for direct comparison of various SHM-related methodologies and algorithms with the use of real-world monitoring data from a large-scale structure, and to narrow the gap that currently exists between the research and the practice of SHM. This paper first briefs the SHM system deployed on the Canton Tower, and the development of an elaborate three-dimensional (3D) full-scale finite element model (FEM) and the validation of the model using the measured modal data of the structure. In succession comes the formulation of an equivalent reduced-order FEM which is developed specifically for the benchmark study. The reduced-order FEM, which comprises 37 beam elements and a total of 185 degrees-of-freedom (DOFs), has been elaborately tuned to coincide well with the full-scale FEM in terms of both modal frequencies and mode shapes. The field measurement data (including those obtained from 20 accelerometers, one anemometer and one temperature sensor) from the Canton Tower, which are available for the benchmark study, are subsequently presented together with a description of the sensor deployment locations and the sensor specifications.

• 한국정보통신학회논문지
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• 제21권11호
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• pp.2052-2060
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• 2017

SOLAS 선박은 SFI group 코드 기준으로 적어도 83종의 장비를 탑재해야 하고, 각각의 장비는 다시 수 개에서 수십 개의 컴포넌트로 구성이 된다. 선박 운항 중에는 이러한 장비의 정상적인 운영이 보장되어야 하고, 문제 발생시 즉각적인 수리를 위하여 원격유지보수의 요구사항이 높다. 본 연구는 항해통신장비의 원격유지보수에 적합한 장비의 분류체계를 제시하고, 적절한 데이터베이스 구조를 도출하고자 했다. 연구 결과, 선박 항해통신장비의 원격유지보수를 위하여, 장비의 분류체계는 장비의 종류, 모델, 컴포넌트로 계층화되어야 하고, 고장모드와 영향분석, 질의응답, 수리이력, 상태정보와 예방정비 등의 테이블을 장비 모델 기준으로 구축하는 것이 효과적임을 알게 되었다. 140개의 항해통신장비 모델과 750개의 컴포넌트에 대하여 데이터베이스를 구축하였고, 실질적인 효과를 평가하기 위하여 선박장비 수리전문가가 클라우드 앱을 이용하여 검색 결과의 유용성을 평가하였다.

• Journal of Genetic Medicine
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• 제4권1호
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• pp.22-37
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• 2007

The autosomal dominant spinocerebellar ataxias (SCAs) are a group of neurodegenerative diseases, clinically and genetically heterogeneous, characterized by degeneration of spinocerebellar pathways with variable involvement of other neural systems. At present, 27 distinct genetic forms of SCAs are known: SCA1-8, SCA10-21, SCA23, SCA25-28, DRPLA (dentatorubral-pallidoluysian atrophy), and 16q-liked ADCA (autosomal dominant cerebellar ataxia). Epidemiological data about the prevalence of SCAs are restricted to a few studies of isolated geographical regions, and most do not reflect the real occurrence of the disease. In general a prevalence of about 0.3-2 cases per 100,000 people is assumed. As SCA are highly heterogeneous, the prevalence of specific subtypes varies between different ethnic and continental populations. Most recent data suggest that SCA3 is the commonest subtype worldwide; SCA1, SCA2, SCA6, SCA7, and SCA8 have a prevalence of over 2%, and the remaining SCAs are thought to be rare (prevalence <1%). In this review, we highlight and discuss the SCA7. The hallmark of SCA7 is the association of hereditary ataxia and visual loss caused by pigmentary macular degeneration. Visual failure is progressive, bilateral and symmetrical, and leads irreversibly to blindness. This association represents a distinct disease entity classified as autosomal dominant cerebellar ataxia (ADCA) type II by Harding. The disease affectsprimarily the cerebellum and the retina by the moderate to severe neuronal loss and gliosis, but also many other central nervous system structures as the disease progresses. SCA7 is caused by expansion of an unstable trinucleotide CAG repeat in the ATXN7 gene encoding a polyglutamine (polyQ) tract in the corresponding protein, ataxin-7. Normal ATXN7 alleles contain 4-35 CAG repeats, whereas pathological alleles contain from 36->450 CAG repeats. Immunoblott analysis demonstrated that ataxin-7 is widely expressed but that expression levels vary among tissues. Instability of expanded repeats is more pronounced in SCA7 than in other SCA subtypes and can cause substantial lowering of age at onset in successive generations termed ‘anticipation’ so that children may become diseased even before their parents develop symptoms. The strong anticipation in SCA7 and the rarity of contractions should have led to its extinction within a few generations. There is no specific drug therapy for this neurodegenerative disorder. Currently, therapy remains purely symptomatic. Cellular models and SCA7 transgenic mice have been generated which constitute valuable resources for studying the disease mechanism. Understanding the pathogenetic mechanisms of neurodegeneration in SCAs should lead to the identification of potential therapeutic targets and ultimately facilitate drug discovery. Here we summarize the clinical, pathological, and genetic aspects of SCA7, and review the current understanding of the pathogenesis of this disorder. Further, we also review the potential therapeutic strategies that are currently being explored in polyglutamine diseases.

• 한국멀티미디어학회논문지
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• 제7권7호
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• pp.944-955
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• 2004

현대 사회는 고도의 정보화 사회로서 평생 교육을 강조하며, 학교 현장에서는 학습자의 창의적 학습의 강조와 더불어 다양한 교수-학습 방법을 요구한다. 이러한 요구사항을 만족시키는 학습중의 하나가 웹을 활용한 자기 주도적 교수-학습 방법이다. 그러나 현재까지 개발된 대부분의 학습 자료는 단순 학습을 위한 웹 기반 교수-학습 자료이거나 단순한 문제 은행 시스템이 개발되어 있으며, 이러한 기존 학습 시스템들은 문제 해결 학습을 자기 주도적으로 수행할 수 있는 학습을 지원하기는 미흡하다. 그러므로 본 논문에서는 웹에서 문제 해결 학습과 자기 주도적 학습을 함께 활용하는 학습 시스템을 제안한다. 제안한 학습 시스템을 이용하여 학습자는 교과의 기본 개념과 원리를 학습한 후, 문제를 기반으로 하여 학습자의 사고력을 배양하고 스스로 학습 수준의 조정을 통하여 효율적인 학습을 수행한다. 제안한 학습 시스템은 중등학교 수학 교육에 적용을 보였으며, 학습자 스스로 문제 은행으로부터 선택한 문제를 이용하여 시험과 학력 수준의 파악 및 교수자와 온라인 게시판을 통하여 의문점 해결을 지원한다. 또한 자료실과 묻고 답하기를 이용한 학습자와 학습자, 교수자와 학습자간의 상호 정보를 공유함으로써 학습의 효율성을 높일 수 있는 것으로 확인하였다.

• Journal of Korean Vacuum Science & Technology
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• 제6권2호
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• pp.55-57
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• 2002

Metal-vapor-vacuum-arc ion source is an ideal source for both high current metal ion implanter and high current plasma thin-film deposition systems. It uses the direct evaporation of metal from surface of cathode by vacuum arc to produce a very high flux of ion plasmas. The MEVVA ion source, the high-current metal-ion implanter and high-current magnetic-field-filtered plasma thin-film deposition systems developed in Beijing Normal University are introduced in this paper.

• Toxicological Research
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• 제17권
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• pp.59-69
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• 2001

Arsenic exposure is associated with several human diseases, including cancers, atherosclerosis, hypertension, and cerebrovascular diseases. In cultured cells, arsenite, an inorganic arsenic com-pound, was demonstrated to interfere with many physiological functions, such as enhancement of oxidative stress, delay of cell cycle progression, and induction of structural and numerical changes of chromosomes. The objective of this study is to investigate the effects of arsenic exposure on gene expression profiles by colorimetric cDNA microarray technique. HFW (normal human diploid skin fibroblasts), CL3 (human lung adenocarcinoma cell line), and HaCaT (immortalized human keratinocyte cell line) were treated with 5 $\mu\textrm{M}$ or 10 $\mu\textrm{M}$ sodium arsenite for 6 or 16 h, respectively. By a dual-color detection system, the expression profile of arsenite-treated cultures was compared to that of control cultures. Several genes expressed differentially were identified on the microarray membranes. For example, MDM2, SWI/SNF, ubiquitin specific protease 4, MAP3K11, RecQ protein-like 5, and Ribosomal protein Ll0a were consistently induced in all three cell types by arsenite, whereas prohibitin, cyclin D1, nucleolar protein 1, PCNA, Nm23, and immediate early protein (ETR101) were apparently inhibited. The present results suggest that arsenite insults altered the expression of several genes participating in cellular responses to DNA damage, stress, transcription, and cell cycle arrest.

• Journal of Power Electronics
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• 제9권3호
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• pp.343-353
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• 2009

In this paper, a nonlinear controller is proposed for Doubly-Fed Induction Machine (DFIM) drives. The nonlinear controller is designed based on an adaptive backstepping control technique, using a fifth order model of an induction machine in the synchronous d & q axis rotating reference frame, whose d axis coincides with the space voltage vector of the main AC supply, and using the rotor current and stator flux components as state variables. The nonlinear controller can perfectly track the torque reference signal measured in the stator terminals under the condition of unity power factor regulation, in spite of the stator and rotor resistance variations. In order to make the drive system capable of operating in the motoring and generating modes below and above the synchronous speed, two level Space-Vector PWM (SV-PWM) back-to-back voltage source inverters are employed in the rotor circuit. It is confirmed through computer simulation results that the proposed control approach is effective and valid.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2002년도 하계학술대회 논문집 Vol.3 No.2
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• pp.541-544
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• 2002

In this study, a new LTCC material using $ZnWO_4$-LiF system was attempted with respect to use as a capacitor layer in Front-End Module. Pure $ZnWO_4$ must be sintered above $1050^{\circ}C$ in order to obtain up to 98% of full density. It's measured dielectric constant, quality factor, and temperature coefficient of resonant frequency were 15.5, 74380GHz, and $-70ppm/^{\circ}C$, respectively. LiF addition resulted in an liquid phase formation at $810^{\circ}C$ due to interaction between $ZnWO_4$ and LiF. Therefore $ZnWO_4$ with 0.5~1.5wt% LiF could be densified at $850^{\circ}C$. Addition of LiF slightly lowered the dielectric constant from 15.5 to 14.2~15. In the given LiF addition range, the sintering shrinkage increased with increasing LiF content. $Q{\times}fo$ value, however, decreased with increasing LiF content(or increasing densification). This is originated from the interaction between the liquid phase and $ZnWO_4$ and inhomogeneity of grain morphology.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2012년도 추계학술대회 논문집
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• pp.88-90
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• 2012

A study on an integrated single stage AC/DC converter is presented in this paper. The input current can be controlled by the auxiliary winding($L_{aux}$), auxiliary primary winding($N_3$), and the boost inductor($L_B$) which are designed to operate in discontinuous conduction mode(DCM) to reduced the total harmonic distortion(THD) of input current. The auxiliary primary winding($N_3$) is critically selected in order to compress the input capacitor voltage($V_{in}$) as well as to reduce the current stress of the switch(Q). Low total harmonic distortion(THD), low input voltage($V_{in}$) in universal input voltage($V_{AC}$), low current stress at the switching device and high efficiency are the main consideration keys in this design to achieve high performance system with low cost of single stage AC/DC converter. A 30W single stage AC/DC prototype converter is under study.

• 한국막학회:학술대회논문집
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• 한국막학회 2002년도 춘계 총회 및 학술발표회
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• pp.81-85
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• 2002

Small angle light scattering and field emission scanning electron microscope have been used to quantify the kinetics of liquid-liquid separation behavior during water vapor(RH52%[$\pm$3%] at 27$^{\circ}C$) quenching (non-solvent induced phase separation, NIPS) of polysulfone/NMP/Alcohol and CPVC/THF/Alcohol, respectively. Time dependence of the position of the light scattering maximum was observed at polysufone dope solutions, confirming spinodal secomposition (SD). while CPVC dope solutions showed a decreased scattered light intensity with a increased q-valuel, indicating nucleation & growth (NG). For the each system, domain growth rate in the intermediate and late stage of phase separation decreased with increasing the number of carbon of alcohol used as additive (non-solvent). Also, in the early stage for SD, the scattering intensity with time was in accordance with Cahns linear theory of spinodal decomposition,[1-3] regardless of types of non-solvent additive.