• Bulletin of the Korean Chemical Society
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• v.30 no.4
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• pp.938-940
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• 2009

• Bulletin of the Korean Chemical Society
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• v.27 no.4
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• pp.484-488
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• 2006

The solid-phase synthesis of new series of 1,6,8-trisubstituted tetrahydro-2H-pyrazino[1,2-a]pyrimidine-4,7-diones as bicyclic $\beta$-turn mimetics is described. Their NF-kB inhibition activities were tested and the effect of substituents on bicyclic ring was investigated. Among the prepared compounds, the fluorobenzyl and methoxybenzyl group substituted compounds 26 and 27 at C-1 and C-8 position showed more inhibitory activities than the others. Tested at a concentration of 10 uM, these two compounds showed a 60% inhibition against the target NF kB 549.

• Proceedings of the PSK Conference
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• 2001.04a
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• pp.105.2-105.2
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• 2001