• 제목/요약/키워드: Pyridazino[3,4-b]quinoxaline

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새로운 1,2-Diazepino[3,4-b]quinoxaline과 Pyridazino[3,4-b]quinoxaline (Synthesis of Novel 1,2-Diazepino[3,4-b]quinoxaline and Pyridazino[3,4-b]quinoxaline Derivatives)

  • 김호식;정극
    • 대한화학회지
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    • 제43권3호
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    • pp.302-306
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    • 1999

  • Quinoxaline 4-oxide 10을 2-chloroacrylonitrile과 반응시켜 1,3-쌍극성 고리화 첨가반응으로 2,3-dihydro-1H-1,2-diazepino[3,4-b]quinoxaline류 11a, b를 합성하였고, 이들을 2,3,4,6-tetrahydro-1H-1,2-diazepino-[3,4-b]quinoxaline 12로 변환시켰다. 그리고 ??嵐?11a를 아세트산/물 용매에서 SeO2와 반응시켜서 고리변환에 의해 1,4-dihydro-4-oxopyridazino[3,4-b]quinoxaline 13을 합성하였다.

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새로운 1,2-다이아제피노 [3,4-b]퀴녹살린류와 피리다지노 [3,4-b] 퀴녹살린류의 합성 (Synthesis of Novel 1,2-Diazepino[3,4-b] quinoxalines and pyridazino[3,4-b] quinoxalines)

  • 김호식;이성욱;정극;이만길
    • 약학회지
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    • 제44권4호
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    • pp.325-333
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    • 2000

  • The 1,3-dipolar cycloaddition reaction of the quinoxaline 4-oxides 2 with 2-chloroacrylonitrile gave the 2,3-dihydro-1H-1,2-diazepino[3,4-b]quinoxalines 3, which were converted into the 2,3,4,6-tetrahydro-1H-1,2-diazepino[3,4-b]quinoxalines 5-7. The reaction of compounds 3 with selenium dioxide in acetic acid/water resulted in ring transformation to give the 1,4-dihydro-4-oxopyridazino[3,4-b]quinoxalines 8.

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