YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of Novel 1,2-Diazepino[3,4-b] quinoxalines and pyridazino[3,4-b] quinoxalines

새로운 1,2-다이아제피노 [3,4-b]퀴녹살린류와 피리다지노 [3,4-b] 퀴녹살린류의 합성

  • Kim, Ho-Sik (Department of Chemistry, Catholic University of Taegu-Hyosung) ;
  • Lee, Seong-Uk (Department of Chemistry, Catholic University of Taegu-Hyosung) ;
  • Jeong, Geuk (Department of Industrial Chemistry, Ulsan College) ;
  • Lee, Man-Kil (Department of Chemistry, Koshin University) ;
  • Kurasawa, Yoshihisa (School of Pharmaceutical Sciences, Kitasato University)
  • 김호식 (대구효성가톨릭대학교 화학과) ;
  • 이성욱 (대구효성가톨릭대학교 화학과) ;
  • 정극 (울산과학대학 공업화학과) ;
  • 이만길 (고신대학교 화학과) ;
  • Published : 2000.08.01
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Abstract

The 1,3-dipolar cycloaddition reaction of the quinoxaline 4-oxides 2 with 2-chloroacrylonitrile gave the 2,3-dihydro-1H-1,2-diazepino[3,4-b]quinoxalines 3, which were converted into the 2,3,4,6-tetrahydro-1H-1,2-diazepino[3,4-b]quinoxalines 5-7. The reaction of compounds 3 with selenium dioxide in acetic acid/water resulted in ring transformation to give the 1,4-dihydro-4-oxopyridazino[3,4-b]quinoxalines 8.

Keywords

References

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