• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10355-10361
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• 2015

Background: MicroRNAs (miRNAs) are small non-coding RNA molecules found in multicellular eukaryotes which are implicated in development of cancer, including cutaneous squamous cell carcinoma (cSCC). Expression is controlled by transcription factors (TFs) that bind to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to messenger RNA. Interactions result in biological signal control networks. Materials and Methods: Molecular components involved in cSCC were here assembled at abnormally expressed, related and global levels. Networks at these three levels were constructed with corresponding biological factors in term of interactions between miRNAs and target genes, TFs and miRNAs, and host genes and miRNAs. Up/down regulation or mutation of the factors were considered in the context of the regulation and significant patterns were extracted. Results: Participants of the networks were evaluated based on their expression and regulation of other factors. Sub-networks with two core TFs, TP53 and EIF2C2, as the centers are identified. These share self-adapt feedback regulation in which a mutual restraint exists. Up or down regulation of certain genes and miRNAs are discussed. Some, for example the expression of MMP13, were in line with expectation while others, including FGFR3, need further investigation of their unexpected behavior. Conclusions: The present research suggests that dozens of components, miRNAs, TFs, target genes and host genes included, unite as networks through their regulation to function systematically in human cSCC. Networks built under the currently available sources provide critical signal controlling pathways and frequent patterns. Inappropriate controlling signal flow from abnormal expression of key TFs may push the system into an incontrollable situation and therefore contributes to cSCC development.

• 한국실내디자인학회논문집
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• 제25권3호
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• pp.90-101
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• 2016

The Homeshare program, which was introduced in 2012, has been implemented with the purpose of reduction of housing costs for young students and economic support for the senior to prevent isolation and help themselves. Nonetheless, the program has not being activated and the research about it has not progressed well. Therefore, this study as a basic research of the program aims to analyze and evaluate the program in progress in district offices to push it forward. This study was undertaken on documentary research and interviews, which analyzed advanced researches and open materials from the websites of district offices. The interviews were conducted in 4 gu-district offices (Nowon-gu, Gwangjin-gu, Seodaemun-gu, and Seongdong-gu) and did interviews with officials in charge on July in 2015. The result of this study is as follows. First, the Homeshare is being activated around the university town, which has advantage of housing welfare aspects for young students and social welfare aspects for the senior. Second, the support structures of the Homeshare can be categorized as the gu-districts offices, local resources and different structures funded by the Seoul City. Third, the process of the Homeshare takes 5 steps consisted of advertisement, reception/counseling, matching, contract, follow-up management. Fourth, the matching makes it a rule to match the same gender considering safety. In the case of the participation of the official in charge, it has a advantage of solving problems that can occur when the matching, which can lead to smooth progress. Fifth, joint consultation is divided into the contract among participants and the contract between participants and the gu-district office. Sixth, the follow-up management takes rather passive approaches such as calls once or twice a month and visits when necessary. For the activation of the Homeshare, it is required to improve it through the various methods such as regular visits, satisfaction researches and so on. This study resulted from investigating and analyzing the Homeshare operation system between generations will be considered to be a reference to the underlying management.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2010년도 춘계학술대회 초록집
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• pp.88.1-88.1
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• 2010

Organic dyes, because of their many advantages, such as high molar extinction coefficients, convenience of customized molecular design for desired photophysical and photochemical properties, inexpensiveness with no transition metals contained, and environment-friendliness, are suitable as photosensitizers for the Dye-sensitized Solar Cell (DSSC). The efficiency of DSSC based on metal-free organic dyes is known to be much lower than that of Ru dyes generally, but a high solar energy-to-electricity conversion efficiency of up to 8% in full sunlight has been achieved by Ito et al. using an indoline dye. This result suggests that smartly designed and synthesized metal-free organic dyes are also highly competitive candidates for photosensitizers of DSSCs with their advantages mentioned above. Recently, the performance of DSSC based on metal-free organic dyes has been remarkably improved by several groups. We had reported the novel organic dye with double electron acceptor chromophore, which was a new strategy to design an efficient photosensitizer for DSSC. To verify the strategy, we synthesized organic dyes whose geometries, electronic structures and optical properties were derived from preceding density functional theory (DFT) and time-dependent density functional theory (TD-DFT) calculations. In this paper, we successfully synthesized the chromophore containing multi-acceptor push-pull system from triphenylamine with thiophene moieties as a bridge unit. Organic dyes with a single electron acceptor and double acceptor system were also synthesized for comparison purposes. The photovoltaic performances of these dyes were compared, and the recombination dark current curves and the incident photon-to-current (IPCE) efficiencies were also measured in order to characterize the effects of the multi-anchoring groups on the open-circuit voltage and the short-circuit current. In order to match specifications required for practical applications to be implemented outdoors, light soaking and thermal stability tests of these DSSCs, performed under $100mWcm^{-2}$ and $60^{\circ}C$ for 1000h.

• 비파괴검사학회지
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• 제31권5호
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• pp.494-499
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• 2011

인체 근골격 시스템에 대한 다물체 동역학 모델을 이용한 동작중의 인체 내부의 생체역학 분석 및 평가 기술에 대하여 기술하였다. 의료영상과 사체실험 결과를 기본으로 하는 인체 다물체 동역학 모델과 3차원 동작분석 시스템을 이용한 인체 동작분석기술을 이용하여 생체내 발생하는 관절기구학, 관절모멘트 관절접촉력 및 근력을 예측하는 기술을 보행과 팔굽혀펴기 두 동작에 적용하였다. 본 연구에서 개발한 인체 다물체 동역학 모델링 기술과 3차원 동작분석기술은 다양한 동작을 수행하는 생체의 분석 및 평가 기술로 활용성이 높을 것으로 생각한다.

• 정보관리학회지
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• 제36권2호
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• pp.31-56
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• 2019

본 연구에서는 P대학도서관 이용자 만족도와 요구사항 등을 설문조사를 통해 파악하고자 하였다. 이를 바탕으로 CRM기법을 적용하여 이용자의 요구를 충족시킬 수 있는 방안을 마련하는 것을 목적으로 하였다. 이를 위하여 P대학 구성원을 대상으로 응답자 기본정보, 소장자료, 자료이용, 홈페이지, 이용자서비스, 시설/환경의 6가지 영역으로 구성하여 설문조사를 실시하여 분석하였다. 연구결과를 요약해 보면 첫째, 만족도조사에서 자료이용 부분이 가장 높게 나타났고, 시설환경 부분이 가장 낮게 나타났다. 자료이용에서는 희망도서 신청 자료를 신속히 구입 및 정리하여 제공하고, 예약도서에 대한 캠퍼스 간 대출이 필요하다. 둘째, 홈페이지에서는 OPAC의 검색시스템과 예약시스템 기능 개선이 필요하고, 자주 이용하는 기능에 대한 메뉴 재배치도 필요하다. 셋째, 이용자서비스에서는 도서관 행사를 더욱 확대하고, 문제점으로 지적되는 행사 안내와 홍보를 강화할 수 있는 방안(SMS, Push 등)을 마련할 필요가 있다. 넷째, 시설환경에서는 개인 및 그룹 학습공간의 부족, 사물함 부족, 환기 및 냉난방 관리 문제, 화장실 시설관리 불만 (휴지 부족 등) 도서관의 지리적 접근성 부족, 외부이용자 관리 등에 대한 불만을 개선할 수 있는 정책이 필요하다.

• 지능정보연구
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• 제16권4호
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• pp.147-157
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• 2010

아이폰의 등장과 함께 스마트 폰에 대한 관심이 높아지고, 통신사업자를 통해야만 가능했던 다양한 서비스가 스마트 폰을 통해서 직접 제공할 수 있는 환경이 가능해졌다. 전세계적으로 해외 관광객이 증가하면서 관광가이드 없이 자신의 노력으로 여행을 다니는 개인관광객도 증가하고 있다. 그러나 우리나라를 방문하는 외국인들이 개인적으로 여행을 즐기기에는 언어소통이나 제공되는 정보의 부족으로 어려움을 느끼고 있다. 본 연구에서는 스마트 폰이 탑재하고 있는 GPS와 WiFi 또는 3G 무선망을 통해서 사전에 설정된 관광 정보 카테고리에 따라서 관광객의 위치에 따른 관련 정보를 자동으로 제공함으로써 관광객의 편의성을 높이는 서비스 기술을 개발하였다. 개발된 서비스는 인사동을 대상으로 시험하였으며, 사용자의 선택과 같은 불편함 없이 주변정보를 제공함으로써 관광에 대한 편의성을 최대한 높였다.

• International Journal of Railway
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• 제1권4호
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• pp.143-148
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• 2008

This paper is the output of a collaborative European project concerning the barrier free accessibility for disabled persons to regional and long distance trains in Europe. Disabled people represent around 13% of the population in Europe. This is approximately 63 million people. The range of disabilities includes people with reduced mobility including wheel chair users, viewing and hearing impaired people and other forms of impairment. Improving accessibility aims at contributing to the provision of public transport services to all citizens in an equitable way. The purpose of the project was to analyse and to evaluate the existing solutions at selected European railways for all required modules at the entrance (doors, information and safety solutions), to derive a design concept, to develop a mock-up in meeting the needs of rail travellers with the above mentioned impairments and to test it with user groups. The project also aims at deriving components for the determination of standards. The EUPAX Design Mock-up test was performed to verify the advantages of the layout of the train segment including the different modules such as access area (including the access door, gaps between platform and train as well as boarding aid devices), entrance vestibule, information systems inside and outside the train, emergency facilities, toilet with all conveniences and the additional test arrangements regarding push buttons, steps and emergency equipment. For this purpose a questionnaire was developed for the assessment of the EUPAX segment and the additional test arrangements. With the help of this questionnaire it was possible to execute a quantitative and qualitative evaluation. During three test phases 67 experts and handicapped persons from 6 countries have evaluated the Industrial Design mock-up based on this questionnaire. The test group covered persons from North (Denmark) to the South (Italy) and from the West (Spain) to the Middle of Europe (Germany). This is especially important for the generalization (harmonisation) of the results for all European countries. According to COST 335 the information for people with reduced mobility should be clear, concise, accurate and timely. So that all information can be received from persons, they must be transferred on at least two of the three possible ways (acoustical, visual, tactile), a so called "2-sense-principle". Based on the results ergonomic specifications/ solutions for the ergonomic design of the access area, the acoustic, visual and tactile information and the emergency devices including the emergency communication system were developed, related to the benefiting passenger groups.

• 한국항공우주학회지
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• 제33권10호
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• pp.60-67
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• 2005

현대의 고성능 전투기는 한계받음각 내에서 적절한 조종성(Controllability) 및 안정성(Stability)을 확보하고 있어야 한다. 고받음각에서 항공기가 이탈에 진입할 수 있는 한계값은 항공기 형상설계에 직결되는 문제이다. 하지만 현대의 고성능 전투기는 전기식 비행제어계통(Digital Fly-By-Wire Flight Control System)을 사용하여 고받음각 제어법칙을 설계함으로써 한계값 내에서 항공기의 안정성을 보장하고 있다. 현재, T-50 세로축 고받음각 제어법칙에는 (+)한계받음각 이상으로의 비행을 제한하는 받음각 제한기(Angle of Attack Limiter)가 설계되어 있다. 그러나 (-)한계받음각 이상으로 비행을 제한하는 받음각 제한기는 설계되어 있지 않아, 조종사의 과도한 (-)세로축 기동에 대해 항공기가 이탈에 진입할 수 있다. 그리고 T-50 비행시험에서 PA에서 과도한 (+)세로축 기동 시, 받음각(Angle of Attack)이 현재 설계되어 있는 한계받음각을 초과하는 문제점이 발생하였다. 본 논문에서는 고받음각 제어법칙을 일부 수정하여 한계받음각 내에서 항공기의 세로축 조종성능을 향상시키고, 항공기 안정성을 확보할 수 있는 제어법칙에 관한 연구를 수행하였다.

• 대한통합의학회지
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• 제6권4호
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• pp.39-45
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• 2018

Purpose : The purpose of this study is to investigate the effect of core motion pattern on abdominal muscle thickness on unstable support surface using sling suspension system and to provide an effective exercise program for therapeutic rehabilitation in clinical practice. Methods : In this study, we used the flank exercise using a sling. It was intended for 21 healthy men and 9 healthy women. Before and after the exercise of the subjects, abdominal muscles (EO, IO, TrA the thickness of the muscle) was determined using a diagnostic ultrasonic apparatus. The period of exercise was 3 times a week for 6 weeks. The exercise for each group started with 3 sets per week and 1 set per week was added. A description of the method and attitude of each exercise is as follows. First, the push-up flank 's exercise position is to put both feet on the sling and hold the floor with both hands. Second, the side flank's exercise postures take the side flanks, while the two legs hang on the sling and one arm supports the body with an articulated bend (about $90^{\circ}$). Third, the elbow flank's exercise position is to put the two legs on the sling, and take a flank posture with the arms bent and joint bending (about $90^{\circ}$). Results : There was a significant difference in the thickness of the muscle in the three flank movements after the exercise (p<.05). The most significant difference was in the change of the muscle thickness in the abdominal muscle, the outer muscle, and the stomach in the elbow flank exercise after exercise. There was a significant difference between the mean thickness of the abdominal muscles according to the flank type after exercise (p<.05). Conclusion : In flank exercise for core stabilization using sling, it is considered effective to strengthen the abdominal muscles by considering the support surface, difficulty level, change of movement pattern.

• 아동학회지
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• 제1권
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• pp.94-106
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• 1980

The issue presented in this paper are as follows: 1. Legislative actions of welfare-related law for the exceptional children. The legislative base for the evolution has been yet weak and ambigous at best for a formalization of what should be considered accepted practice and effective action in providing handicapped child and their parents educational rights and equal protection of the law. And they are under remote control of partial factor subject to social welfare law for children, and public law for education, promotion law for the exceptional child education, protection law for public aids. 2. Organization of government for the welfare services for the exceptional children. There is no sing of a push toward consolidation of effort for the welfare service of the exceptional children in this country that seeks to recapture a sense of unity, of coherence, of completeness from a reality made up of discontinuous fragments of humanitarian effora This presently that. as for the education of the exceptional child, by the section of the exceptional education in MOE (Ministry of Education), and/or as for welfare services and promotion actions, by the section of child welfare in MHSA (Ministry of Health and Social Affairs). One door type operation rooted in the specialization, and limited resources to evolve multi-purpose agencies that undertake to provide a broad range of tangible and concrete services, as well as supportive counselling and assessment, under a single management which plans and directs the allocations of resources, should be followed. 3. Facilities and recruitment of teachers for the exceptional children. In this country there are 54 facilities for special services, 56 schools for the exceptional education, and 3 colleges and equavalents that provide teacher training services leading to certification with IIO annual graduates. However, curriculum for exceptional children should be rearranged and reconstructed. Conclusion; Only as for social welfare institutions in community, this country produced a succession of specific purpose activities, over period of time, that accumulated to form the present network of hundreds of social welfare organizations and facilities Periodically major efforts were launched to revitalize or to improve the help-giving system. But they lack specialization to be effective, and the nature of multi-purpose center tends to be vague for the classified handicapped. Therefore, there, should be linkage between policy maker and community services to maintain some coherenty in preventive care, treatment, and after cares. At last, the effects of the current concept "the exceptional child" involved with their families, and their neighborhood should be considered in view of the people who consist about 25% of the total population.