• 한국한의학연구원논문집
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• 제13권2호통권20호
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• pp.59-63
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• 2007

The purpose of this study was to diagnosis that what patterns identification using the statistical method. Discriminant analysis using the medical specialist and resident pattern identification agree case in stroke patients within 1 month of onset. The agreement rate of dificiency of Gi(75%), heat-transformation(74%), dampphlegm syndrome(69%), deficiency of Eum(51%) and syndrome of blood stagnation(43%) are respectively 0.75, 0.74, 0.69, 0.51 and 0.43 in medical specialist and using linear discriminant function pattern identification are same. The study of inspection, pulse feeling and palpitation will be continued to evaluate concordance rate. Discrimination model will be make to get higher Accuracy and prediction, it means becomes the help in pattern identification diagnosis objectivity and scientific.

• Clinical Pain
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• 제19권1호
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• pp.23-27
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• 2020

Our objective is to evaluate the applicability of segmental phase angle (PhA) via bioelectrical impedance analysis (BIA) for post-stroke complex regional pain syndrome (CRPS). Due to its noninvasiveness and convenience, various studies have used BIA in clinical conditions. We measured segmental PhA in 4 patients at the time of CRPS diagnosis and repeated 4 weeks after 2 weeks of steroid pulse therapy. In 3 cases, the affected-to-unaffected ratio of the upper limb PhA decreased at the time of diagnosis. In 2 cases with improvement of more than 5 points in the CRPS severity score (CSS), increased ratios were observed. In other 2 cases with improvement of less than 4 points in the CSS, no remarkable changes in the ratios were found. We suggest that the segmental PhA can be helpful in assessment of post-stroke CRPS and its recovery.

• Journal of Genetic Medicine
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• 제14권1호
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• pp.8-17
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• 2017

Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and is considered a marker of vascular damage. However, a genome-wide association study analyzing single nucleotide polymorphisms (SNPs) associated with brachial-ankle PWV (baPWV) has not been conducted in healthy populations. We performed this study to identify SNPs associated with baPWV in healthy populations in Korea. Materials and Methods: Genomic SNPs data for 2,407 individuals from three sites were analyzed as part of the Korean Genomic Epidemiologic Study. Without replication samples, we performed multivariable analysis as a post hoc analysis to verify the findings in site adjusted analysis. Healthy subjects aged between 40 and 70 years without self-reported history or diagnosis of hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and cancer were included. We excluded subjects with a creatinine level >1.4 mg/dL (men) and 1.2 mg/dL (women). Results: In the site-adjusted association analysis, significant associations (P<$5{\times}10^{-8}$) with baPWV were detected for only 5 SNPs with low minor allele frequency. In multivariable analysis adjusted by age, sex, height, body mass index, mean arterial pressure, site, smoking, alcohol, and exercise, 11 SNPs were found to be associated (P<$5{\times}10^{-8}$) with baPWV. The 5 SNPs (P<$5{\times}10^{-8}$) linked to three genes (OPCML, PRR35 and RAB40C) were common between site-adjusted analysis and multivariable analysis. However, meta-analysis of the result from three sites for the 11 SNPs showed no significant associations. Conclusion: Using the recent standard for genome-wide association study, we did not find any evidence of significant association signals with baPWV.

• 전자공학회논문지SC
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• 제45권3호
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• pp.68-79
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• 2008

대동맥 증강지수는 심실의 부하뿐만 아니라 대동맥의 탄력성을 직접적으로 나타낼 수 있는 장점 때문에 동맥의 경직도를 평가하는 지표로 주목받고 있다. 하지만, 정확한 대동맥 증강지수를 계산하기 위해서는 직접 카테터를 피험자에 삽입하여 측정해야 하기 때문에 임상에 적용하기에는 한계가 존재한다. 이러한 문제점 때문에 전달함수를 이용하여 요골 동맥 맥파로부터 대동맥 맥파를 간접적으로 추정하는 방법이 이용되고 있다. 본 논문에서는 전달함수를 구하기 위하여 Millar 카테터를 이용한대동맥 맥파와 토노메트릭 방식의 압력센서를 이용하여 요골동맥 맥파를 측정하였다. 또한, 기존의 증강점 검출 알고리즘 대신단계적으로 미분 차수를 증가시키면서 증강점을 검출하는 새로운 알고리즘을 제안하였다. 10차 ARX 모델을 이용하여 전달함수를 구현하였으며, 잔차 분석을 통하여 모델을 검증하였다. 증강점 검출 알고리즘 검증을 위하여 네 가지 종류의 합성파를 만들어 제안된 알고리즘이 기존 알고리즘 보다 더 정확한 결과를 나타내는 것을 확인할 수 있었다. 본 연구는 쉽게 측정할 수 있는 요골동맥 맥파를 이용하여 대동맥의 경직도를 평가할 수 있는 방법을 제시하였으며 이를 통하여 다양한 심혈관 질환의 조기 진단에 기여할 수 있을 것이다.

• 융합신호처리학회논문지
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• 제22권2호
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• pp.45-50
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• 2021

최근 IT기술이 발달함에 따라 다양한 생체신호 측정 기기에 대한 연구 및 관심이 높아지고 있으나, 가장 대표적인 생체 신호 중 하나인 심전도, 특히 부정맥 신호 검출과 관련한 연구는 미비한 현실이다. 부정맥은 그 발병원인이 다양하며 발병이후 예후가 좋지 않으므로 조기진단을 통한 예방치료가 최선이다. 하지만 부정맥을 진단하기 위한 도구인 24시간 홀터 심전계는 사용지속시간의 제약, 일상생활로 인한 동잡음 분석의 어려움, 위험상황에서 사용자의 실시간 알람 기능에 단점을 보인다. 본 연구에서는 장시간 연속 측정이 가능한 심전도 및 맥박 모니터링 기기와 실시간 모니터링 앱, 분석용 소프트웨어를 개발하였으며, 측정한 값의 경향성을 확인하였다. 향후 연구에서는 심전도 신호 측정 분석의 정량적 결과 도출에 관한 연구가 필요하며, 이를 바탕으로 하는 부정맥 신호 검출 알고리즘 개발과 관련한 추가 연구를 진행해야 한다.

• 대한한방내과학회지
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• 제45권1호
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• pp.1-10
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• 2024

Objectives: This study investigated the pattern identification (PI) and clinical index of Parkinson's disease (PD) for personalized diagnosis and treatment. Methods: This prospective observational multi-center study recruited 100 patients diagnosed with PD from two Korean medicine hospitals. To cluster new subtypes of PD, items on a PI questionnaire (heat and cold, deficiency and excess, visceral PI) were evaluated along with pulse and tongue analysis. Gait analysis was performed and blood and feces molecular signature changes were assessed to explore biomarkers for new subtypes. In addition, unified PD rating scale II and III scores and the European quality of life 5-dimension questionnaire were assessed. Results: The clinical index obtained in this study analyzed the frequency statistics and hierarchical clustering analysis to classify new subtypes based on PI. Moreover, the biomarkers and current status of herbal medicine treatment were analyzed using the new subtypes. The results provide comprehensive data to investigate new subtypes and subtype-based biomarkers for the personalized diagnosis and treatment of PD patients. Ethical approval was obtained from the medical ethics committees of the two Korean medicine hospitals. All amendments to the research protocol were submitted and approved. Conclusions: An objective and standardized diagnostic tool is needed for the personalized treatment of PD by traditional Korean medicine. Therefore, we developed a clinical index as the basis for the PI clinical evaluation of PD. Trial Registration: This trial is registered with the Clinical Research Information Service (CRIS) (KCT0008677)

• 대한중풍순환신경학회지
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• 제12권1호
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• pp.50-60
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• 2011

Objectives : This study was aimed to clarify the relationship between the dampness-phlegm diagnosis and internal carotid artery stenosis by measuring carotid artery sonography in cerebral infarction patients. Methods : One hundred eighty subjects were recruited from the patients admitted to the Department of Internal Medicine at Kyunghee university oriental medical center from September 2008 to July 2010. We assessed one hundred eighty patients' carotid artery sonography data and diagnosed dampness-phlegm by oriental medical diagnosis. then, analyzed their characteristics, risk factor, lifestyle, metabolic syndrome, body mass index, Waist/Hip ratio(W/H ratio) and dampness-phlegm diagnosis. Results : On the demographic variables of the patients, age, smoking, W/H ratio and dampness-phlegm group were significantly higher in severe internal carotid artery(ICA) stenosis group than in the control group. According to the significant difference in dampness-phlegm group, we analyzed dampness-phlegm related index for pattern identifications by ICA stenosis. As a result, sputum, bowel sound, chest discomfort, slippery pulse were significantly higher in the severe ICA stenosis group than in the control group. In multivariate analysis, dampness-phlegm group showed close relationship with severe ICA stenosis group. Conclusion : According to the analysis, significance between dampness-phlegm diagnosed patients group and severe ICA stenosis were clarified. These results can be utilized in the future as a basis material.

• 대한한의학회지
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• 제20권2호
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• pp.37-42
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• 1999

In Oriental medicine, the subjective process of diagnosis often makes it difficult to explain the indications objectively, in spite of its excellent therapeutic value. The authors' objective Was to present more objective indications of Chongpesagan-tang(淸肺瀉肝湯), a prescription predominantly used to treat stroke in Oriental Medicine, We analyzed clinical symptoms of 105 patients who were hospitalized in the Department of Circulatory Internal Medicine, College of Oriental Medicine. Kyung Hee University, Seoul, who were given Chongpesagan-tang and improved without side effects, The symptoms analyzed included general symptoms which are usually checked in the process of Oriental Medicine Diagnosis: the so called Four Diagnosis(四診). We rearranged and selected symptoms which were predominantly found among other symptoms. We found some symptoms of which the patients frequently complained: sweating 84%, red tongue 74%, white tongue coat 65%, constipation 35%, tight pulse 21%, headache 20%, thirst 20%, chest discomport 17%, etc, We believe that these suggest an objective indication of Chongpesagantang.

• 대한의용생체공학회:의공학회지
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• 제30권5호
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• pp.401-411
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• 2009

In this paper, we correct pulse wave velocity(PWV) with heart-rate and derive regression equations to estimate intima-media thickness(IMT). Widely used methods for diagnosis of arteriosclerosis are IMT and PWV. Arterial wall stiffness determines the degree of energy absorbed by the elastic aorta and its recoil in diastole but there is not correlation between sclerosis and IMT in an existing study. In this study, we will correct PWV with heart-rate and get regression equation to estimate IMT using heart-rate correction index(HCI). We executed experiments for this study. Made up question of physical condition and measured electrocardiogram(ECG), photoplethysmogram (PPG) of finger-tip and toe-tip and ultrasound image of carotid artery. Calculated PWV and IMT using ECG, PPG and ultrasound image. We found that every p-value between PWV and IMT is not significant(<0.05). But p-value between IMT and HCI which is a corrected PWV using heart-rate is significant(>0.01). We use HCI and various measured parameter for estimating regression equation and apply backward estimation to select parameters for regression analysis. Result of backward estimation, found that only HCI is possible to derive proper regression equation of IMT. Relationship between PWV and IMT is the second order. Result of regression equation of E-H PWV is $R^2$=0.735, adj $R^2$=0.711. This is the best correlation value. We calculate error of its analysis for verification of earlobe PWV regression equation. Its result is RMSEP=0.0328, MAPE(%) = 4.7622. Like this regression analysis, we know that HCI is useful parameter and relationship between PWV, HCI and IMT. In addition, we are able to suggest possibility which is that we can get different parameter of prediction throughout just one measurement.

• 한국전기전자재료학회논문지
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• 제11권11호
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• pp.1035-1042
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• 1998

After the 1990's, a computer-aided partial discharge(PD) measurement system was referred in part of aging diagnosis using digital signal processing as the new technology has been studied. The PD patterns and relevant information for pattern recognition are discussed in PD research area, because discharge quantity(q), the number of discharge pulse(n) and the applied boltage phase($\varphi$) was combined with the system information of the aging state. This paper investigates the discharge phase and quantity, as well as the number of discharge(n) with regard to discharge signals generated in power cable. therefore, according to characteristic analysis on the distribution of $\varphi$, q and n, it is able to apply in the aging analysis of power cable which visual observation is impossible and distribution change of discharge signals offers much information for risk degree on aging progress of insulation materials.