• Journal of Genetic Medicine
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• 제14권1호
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• pp.8-17
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• 2017

Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and is considered a marker of vascular damage. However, a genome-wide association study analyzing single nucleotide polymorphisms (SNPs) associated with brachial-ankle PWV (baPWV) has not been conducted in healthy populations. We performed this study to identify SNPs associated with baPWV in healthy populations in Korea. Materials and Methods: Genomic SNPs data for 2,407 individuals from three sites were analyzed as part of the Korean Genomic Epidemiologic Study. Without replication samples, we performed multivariable analysis as a post hoc analysis to verify the findings in site adjusted analysis. Healthy subjects aged between 40 and 70 years without self-reported history or diagnosis of hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and cancer were included. We excluded subjects with a creatinine level >1.4 mg/dL (men) and 1.2 mg/dL (women). Results: In the site-adjusted association analysis, significant associations (P<$5{\times}10^{-8}$) with baPWV were detected for only 5 SNPs with low minor allele frequency. In multivariable analysis adjusted by age, sex, height, body mass index, mean arterial pressure, site, smoking, alcohol, and exercise, 11 SNPs were found to be associated (P<$5{\times}10^{-8}$) with baPWV. The 5 SNPs (P<$5{\times}10^{-8}$) linked to three genes (OPCML, PRR35 and RAB40C) were common between site-adjusted analysis and multivariable analysis. However, meta-analysis of the result from three sites for the 11 SNPs showed no significant associations. Conclusion: Using the recent standard for genome-wide association study, we did not find any evidence of significant association signals with baPWV.

• 대한한방내과학회지
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• 제29권4호
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• pp.970-978
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• 2008

Objectives : This study aimed to clarify the relationship between the Oriental medical diagnosis and arteriosclerosis by measuring carotid-ankle vascular index(CAVI) in acute cerebral infarction patients. Method : One hundred thirty-one subjects were recruited from the patients admitted to the Internal Medical Department at Kyunghee University Oriental Medical Center from April 2007 to August 2008. We sorted cerebral infarction patients and assessed one hundred fourteen patients' CAVI data. We diagnosed dampness-phlegm by Oriental medical diagnosis and evaluated stroke type by single or multiple infarctions. then, we analyzed their characteristics with type of stroke, risk factor, lifestyle, metabolic syndrome and dampness-phlegm diagnosis. Result : 1. On the demographic variables of the patients, age, hypertension, hyperlipidemia, multiple infarction group and metabolic syndrome and dampness-phlegm group were significantly higher in the high CAVI score group than in the control. 2. According to the significant difference in the dampness-phlegm group, we analyzed dampness-phlegm related index for pattern identifications by CAVI score. As a result, dark circles, insomnia, headache, white coating tongue. slippery pulse, and rough pulse were significantly higher in the high CAVI score group then in the control. 3. In multivariate analysis, age, hypertension, multiple infarction and dampness-phlegm groups showed a close relationship with the high CAVI score group. Conclusions : According to the analysis, significance between dampness-phlegm diagnosed patients group and high CAVI score were clarified. Moreover, multiple location infarctions also have a relationship with high CAVI score in cerebral infarction patients. These results can be utilized in the future as a basis material.

• 대한한방내과학회지
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• 제29권4호
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• pp.1130-1137
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• 2008

Objectives : Oriental medical doctors usually use the three-finger pulse diagnosis method to observe disease. Since it is difficult to diagnose ischemic heart disease (IHD) objectively by this diagnostic method, we performed the study to diagnose it as soon as possible by using Yuk Bu Jung Wee Jin Mac(六部定位診脈) and electrocardiogram(ECG). Methods : Patients who had abdominal discomfort were observed by Yuk Bu Jung Wee Jin Mac(六部定位診脈) and we presumed they had heart disease and checked them with electrocardiogram(ECG). Results : We diagnosed it early by using Yuk Bu Jung Wee Jin Mac(六部定位診脈) and electrocardiogram (ECG). Conclusions : The study suggests that it is easy to diagnose IHD early using Yuk Bu Jung Wee Jin Mac(六部定位診脈) and ECG. More data related to IHD is needed.

• 한국음향학회지
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• 제23권4호
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• pp.268-273
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• 2004

본 연구에서는 원호의 내부벽면에 1열로 배열된 어레이 트랜스듀서를 이용한 반사-투과형 생체진단용 역산란 초음파 단층화상법을 제안하였다. 제안된 방법에서는 대상 물체의 배면에 반사판을 배치하여 경면효과를 이용하였고, 유한 대역을 갖는 펄스파를 송신파로 사용하여 다중 주파수 성분을 이용함으로써 데이터 관측 범위를 줄일 수 있었다. 제안된 방법의 성능 평가를 위하여 컴퓨터 시뮬레이션을 이용한 모의 생체 조직에 대한 유효성을 검토한 격과, 트랜스듀서군의 송수신 각도 범위가 30도로 극히 좁은 범위로 제한되었음에도 불구하고 정량적인 화상재현이 가능함을 확인할 수 있다.

• 전기학회논문지
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• 제62권4호
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• pp.544-553
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• 2013

In this paper, we propose the pattern classifier of Radial Basis Function Neural Networks(RBFNNs) for diagnosis of 3-phase partial discharge. Conventional methods map the partial discharge/noise data on 3-PARD map, and decide whether the partial discharge occurs or not from 3-phase or neutral point. However, it is decided based on his own subjective knowledge of skilled experter. In order to solve these problems, the mapping of data as well as the classification of phases are considered by using the general 3-PARD map and PA method, and the identification of phases occurring partial discharge/noise discharge is done. In the sequel, the type of partial discharge occurring on arbitrary random phase is classified and identified by fuzzy clustering-based polynomial Radial Basis Function Neural Networks(RBFNN) classifier. And by identifying the learning rate, momentum coefficient, and fuzzification coefficient of FCM fuzzy clustering with the aid of PSO algorithm, the RBFNN classifier is optimized. The virtual simulated data and the experimental data acquired from practical field are used for performance estimation of 3-phase partial discharge pattern classifier.

• 대한한방내과학회지
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• 제36권3호
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• pp.228-235
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• 2015

Objectives: The aim of this study was to find an effective medical device to detect cold sensation of hands. Methods: Patients with cold sensation of hands (N=42) were recruited in July 2013. We surveyed patients’ general characteristics, severity of cold sensation, body temperature in Nogung (PC8) and Hyeopbaek (LU4) measured with a digital thermometer, digital infrared thermal imaging, and pulse wave velocity. Results: The relation between severity of cold sensation and temperature in Nogung (PC8) and Hyeopbaek (LU4) was statistically significant. The results showed a higher correlation of severity of cold sensation with Nogung (PC9) than with Hyeopback (LU4) temperature. No other indices were statistical significant. Conclusions: Measuring the Nogung (PC9) temperature is most reasonable for assessing the severity of cold sensation of hands. To generalize this result, however, a large-scale study is warranted.

• Transactions on Electrical and Electronic Materials
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• 제16권6호
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• pp.323-327
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• 2015

In this paper, parameters related with partial discharge (PD) were analyzed in SF₆ gas under AC and DC voltages. Three electrode systems (protrusion on conductor, protrusion on enclosure, and free particle) were fabricated to simulate PD defects in a gas-insulated switchgear (GIS). All electrode systems were filled with SF₆ gas at 0.5 MPa. PD pulses were detected using an oscilloscope and a data acquisition (DAQ) based on IEC 60270. To analyze the PD characteristics under AC and DC voltages, parameters such as discharge inception voltage (DIV), discharge extinction voltage (DEV), pulse magnitude, repetition rate, and T-F map were compared. From the experimental results, PD was revealed to have different characteristics under AC and DC, and these results may be useful for diagnosis of power facilities operated under HVDC.

• 한국전기전자재료학회논문지
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• 제11권11호
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• pp.1035-1042
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• 1998

After the 1990's, a computer-aided partial discharge(PD) measurement system was referred in part of aging diagnosis using digital signal processing as the new technology has been studied. The PD patterns and relevant information for pattern recognition are discussed in PD research area, because discharge quantity(q), the number of discharge pulse(n) and the applied boltage phase($\varphi$) was combined with the system information of the aging state. This paper investigates the discharge phase and quantity, as well as the number of discharge(n) with regard to discharge signals generated in power cable. therefore, according to characteristic analysis on the distribution of $\varphi$, q and n, it is able to apply in the aging analysis of power cable which visual observation is impossible and distribution change of discharge signals offers much information for risk degree on aging progress of insulation materials.

• 대한수의학회지
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• 제48권1호
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• pp.125-130
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• 2008

Mesenteric torsion was diagnosed in a 2-year-old, spayed female Miniature Schnauzer. The patient was presented with acute depression, vomiting, lethargy and hematochezia. On physical examination, severe dehydration, tachycardia, tachypnea, weak femoral pulse, delayed capillary refill time and pale mucous membrane were found and the dog was in shock. Radiography and ultrasonography revealed intestines distended with gas, ascites and the "C" shaped distended intestine. Medical treatments including fluid therapy, analgesics, antibiotics and lidocaine for reducing reperfusion injury were applied. And then, the mesenteric torsion was definitively diagnosed through exploratory laparotomy and intestinal resection and anastomosis were performed. The dog made an uneventful recovery and was free of clinical sign one week after surgery. Mesenteric torsion is an unusual and life-threatening disease in dogs. It has usually been described in the middle and large breed dogs, especially German Shepherds. However, the mesenteric torsion should be included in the differential diagnostic lists for acute abdomen even in small breed dog. The mortality rate of mesenteric torsion can be reduced through prompt diagnosis, proper preventive therapy for shock and reperfusion injury and emergency surgery.

• 대한한방내과학회지
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• 제11권1호
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• pp.1-13
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• 1990

We objerved the following results from The Yellow Emperior's Canon of Internal medicine through the investigation of literature about fever. 1. Fever is divieded two type asthenic fever sthenic heat and It accused two type of excess of Yang-exoganous heat, deficiency of Yin-internal fever 2. The cause of fever is divieded three type, exoganous cause, internal cause non-exoganouse and internal cause Among the cause of fever Exoganous cause is almost affected by cold-evil Internal cause is affected by deficiency of Yin and seven emotion caused by having sex after intoxigation or over-exertion, and non-exoganous and internal cause bring about the difference of a personal life and food and drink 3. The sympton produced by fever is appeared differently through-pulse and meridian and they are indication of Diagnosis 4. The theory of treatment about fever are as follows Drinking cold-water Practising acupuncture Trerating hot-evil by cold Dispel cold by warm Treating cold-evil by heat Promote vital energy circulation by cold Treating warm-evil by cold Promating circulation by cold Treating cold-evil by warm Promoting circulation by heat.