• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.454-456
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• 2002

The evaluation of interval changes between temporally sequential chest radiographs is necessary for the detection of new abnormalities or interval changes, such as pulmonary nodules and interstitial disease. For interstitial lung disease, the interval changes are very important for diagnosis and treatment. Especially, interstitial lung disease may show rapid changes in the radiographs, show changes in the entire lung field in minute detail, or show changes in multiple parts depending on the type. It is therefore difficult to have an accurate grasp of the condition of the disease only with conventional radiographs. The temporal subtraction technique which was developed at the University of Chicago, provides a subtraction image of the current warped image and the previous image. A temporal subtraction image, shows only differences and changes between the two images, can be very useful for a diagnosis of interstitial lung disease. However, the evaluation of the temporal subtraction technique for interstitial lung disease using receiver operating characteristic(ROC) studies has not been reported yet. Therefore, we have evaluated the clinical usefulness of a temporal subtraction technique for detection of interval changes of interstitial lung disease by ROC analysis.

• Tuberculosis and Respiratory Diseases
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• 제41권1호
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• pp.36-41
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• 1994

저자들은 호흡곤란을 주소로 내원한 44세 남자에서 기관지 내시경검사, 흉막생검, 복부초음파검사, 흉부단층촬영을 시행한 결과 흉막삼출을 동반하는 폐의 전이성 맥관육종을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6219-6225
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• 2014

Background: Increasing evidence from animal, epidemiological and clinical investigations suggest that dietary anthocyanins have potential to prevent chronic diseases, including cancers. It is also noteworthy that human epidermal growth factor receptor 2 (ErbB2) protein overexpression or ErbB2 gene amplification has been included as an indicator for metastasis and higher risk of recurrence for breast cancer. Materials and Methods: The present experiments investigated the anti-metastasis effects of black rice anthocyanins (BRACs) on ErbB2 positive breast cancer cells in vivo and in vitro. Results: Oral administration of BRACs (150 mg/kg/day) reduced transplanted tumor growth, inhibited pulmonary metastasis, and decreased lung tumor nodules in BALB/c nude mice bearing ErbB2 positive breast cancer cell MDA-MB-453 xenografts. The capacity for migration, adhesion, motility and invasion was also inhibited by BRACs in MDA-MB-453 cells in a concentration dependent manner, accompanied by decreased activity of a transfer promoting factor, urokinase-type plasminogen activator (u-PA). Conclusions: Together, our results indicated that BRACs possess anti-metastasis potential against ErbB2 positive human breast cancer cells in vivo and in vitro through inhibition of metastasis promoting molecules.

• 대한수의학회지
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• 제30권4호
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• pp.441-446
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• 1990

Encephalomyocarditis virus infection in pigs, characterized by severe reproductive failure in sows and sudden death in less than 7 day-old-piglets, a period of several months from October to December of 1989, in Korea was occurred. The most outstanding gross lesions at necropsy were found in the heart which were consisted of pale, yellow brown necrotic foci of varying size in myocardium. In some cases, pulmonary edema and liver congestion were observed. Histopathology of the heart revealed the interstitial myocarditis, endocarditis and epicarditis with lymphocytic, plasmacytic and macrophage cell infiltration and, in some cases, calcification of the necrotic myocardial muscle fibers. In some cases of brain, the perivascular cuffing and glial nodules were observed. In the liver and the lacrimal gland varying degrees of multifocal necrosis were seen. The virus was isolated from the heart and the brain in a stillborn piglet and a mummified fetus. This outbreak represents the first case of encephalomyocarditis virus infection of pigs in Korea.

• 한국동물위생학회지
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• 제37권3호
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• pp.197-202
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• 2014

Dirofilaria immitis infection is one of the most important parasitic diseases in dogs and public health. It often elicits nodules in the pulmonary parenchyma and in the subcutaneous tissues of human. In this study, we investigated the prevalence of D. immitis infection among 754 dogs in Seoul area from April to December 2012. The infection rate of 754 dogs was 9.8% (74/754) by the antigen test (canine SNAP 4Dx). The infection rates of D. immitis in dogs at the age of < 2, 2~4, 5~7, 8~10, and > 10 years were 3.7% (7/189), 12.9% (30/233), 15.0% (19/127), 9.8% (18/184), and 0% (0/21), respectively. The infection rates in the female and male dogs were 9.7% (33/340) and 9.9% (41/414), respectively. The regional infection rates in northern and southern Han river region of Seoul were 10.7% (44/410) and 8.7% (30/344), respectively. In order to confirm D. immitis infection, we performed PCR on serum samples of 74 dogs which tested positive for D. immitis antigen by the antigen test and we detected a specific gene ITS-2 in 59 serum samples. In conclusion, this study suggests that treatment and preventive care on the D. immitis infection should be considered in dogs of Seoul area.

• 한국임상수의학회지
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• 제29권2호
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• pp.194-197
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• 2012

호흡곤란과 기침을 주 증상으로 보이는 세마리 개가 내원하였다. 신체검사, 혈액검사와 더불어 영상학적 검사가 진행되었다. 한마리 개에서는 흉부 방사선 사진상 연부조직 밀도를 보이는 종괴가 폐엽에서 확인 되었고 CT 검사를 통해 종양 가능성이 배제되었다. 두마리 개에서 폐에 기관지 확장증이 동반된 기관지 간질 침윤이 확인되었고 세 마리 개 모두 조직병리학적 검사 혹은 세포학적 검사를 통해 호산구성 기관지폐병증이 진단되었다. 약 처방 후 임상 증상은 신속히 개선되었고 영상검사상에서 병변의 감소가 뚜렷하게 관찰되었다.

• Tuberculosis and Respiratory Diseases
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• 제43권2호
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• pp.285-290
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• 1996

저자들은 특징적인 임상 증상과 함께 전형적인 흉부 x-선 및 고해상 흉부 전산화 단층 촬영을 보이는 미만성 법세기관지염 환자에서 흉강경을 이용한 폐생검으로 확진하여 erythromycin 소량 투여로 임상적 효과를 얻은 1예를 문헌 고찰과 함께 보고는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제44권6호
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• pp.1396-1402
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• 1997

저자 등은 폐 및 간의 다발성 결절을 보인 26세의 화학과 대학원생 남자 환자에서 경기관지 폐생검으로 진단된 유상피 세포성 혈관내피종 1예를 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제63권1호
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• pp.88-93
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• 2007

저자 등은 단일 폐종괴로 발견되어 결핵이나 종양과의 감별이 쉽지 않아 개흉 조직검사를 통해 Wegener 육아종증을 진단 후 면역 억제 치료를 하였으나 폐렴 및 호흡부전이 발생한 증례를 경험하였기에 보고하는 바이다.

• 대한방사선기술학회지:방사선기술과학
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• 제44권5호
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• pp.473-480
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• 2021

This study was purpose to method that applies for improving the image quality in CT and X-ray scan, especially in the lung region. Also, we researched the parameters of the image before and after applying for Histogram Equalization (HE) such as mean, median values in the histogram. These techniques are mainly used for all type of medical images such as for Chest X-ray, Low-Dose Computed Tomography (CT). These are also used to intensify tiny anatomies like vessels, lung nodules, airways and pulmonary fissures. The proposed techniques consist of two main steps using the MATLAB software (R2021a). First, the technique should apply for the process of normalization for improving the basic image more correctly. In the next, the technique actively rearranges the intensity of the image contrast. Second, the Contrast Limited Adaptive Histogram Equalization (CLAHE) method was used for enhancing small details, textures and local contrast of the image. As a result, this paper shows the modern and improved techniques of HE and some advantages of the technique on the traditional HE. Therefore, this paper concludes that various techniques related to the HE can be helpful for many processes, especially image pre-processing for Machine Learning (ML), Deep Learning (DL).