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검색결과 210건 처리시간 0.025초

In Vitro Antifungal Activities of Amphotericin B, Fluconazole, Itraconazole, Terbinafine, Caspofungin, Voriconazole, and Posaconazole against 30 Clinical Isolates of Cryptococcus neoformans var. neoformancs

  • Lee, Young-Ki;Fothergill, Annette W.
    • Mycobiology
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    • 제31권2호
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    • pp.95-98
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    • 2003
  • Aantifungal agents were tested against 30 clinical isolates of Cryptococcus neoformans var. neoformans using the NCCLS method(M27-A2). Posaconazole, itraconazole and amphotericin B had lower MIC than the remaining four antifungal agents. The MIC result for posaconazole was over 220-fold lower active than fluconazole. Fluconazole MICs for most isolates fell within the dose-dependant range. The overall MIC ranges and $MIC_{50}s$ were amphotericin B(0.03-0.25; 0.25), fluconazole(0.5-64; 16), itraconazole(0.015-1; 0.125), terbinafine(0.06->2; 1), caspofungin(8-32; 32), voriconazole(0.015-0.5; 0.25), and posaconazole(0.015-0.25; 0.06 ${\mu}g/ml$), respectively. In conclusion, the $MIC_{50}s$ of these drugs did not exhibit any sign of an upward shift with the exception of fluconazole and tendency cross-resistance between the seven drugs was not observed. We conclude that in vitro resistance to antifungal agents has not significantly changed despite the recent wide-spread use of triazoles for long-term treatment of Cryptococcal meningitis.

An Identity-based Ring Signcryption Scheme: Evaluation for Wireless Sensor Networks

  • Sharma, Gaurav;Bala, Suman;Verma, Anil K.
    • IEIE Transactions on Smart Processing and Computing
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    • 제2권2호
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    • pp.57-66
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    • 2013
  • Wireless Sensor Networks consist of small, inexpensive, low-powered sensor nodes that communicate with each other. To achieve a low communication cost in a resource constrained network, a novel concept of signcryption has been applied for secure communication. Signcryption enables a user to perform a digital signature for providing authenticity and public key encryption for providing message confidentiality simultaneously in a single logical step with a lower cost than that of the sign-then-encrypt approach. Ring signcryption maintains the signer's privacy, which is lacking in normal signcryption schemes. Signcryption can provide confidentiality and authenticity without revealing the user's identity of the ring. This paper presents the security notions and an evaluation of an ID-based ring signcryption scheme for wireless sensor networks. The scheme has been proven to be better than the existing schemes. The proposed scheme was found to be secure against adaptive chosen ciphertext ring attacks (IND-IDRSC-CCA2) and secure against an existential forgery for adaptive chosen message attacks (EF-IDRSC-ACMA). The proposed scheme was found to be more efficient than scheme for Wireless Sensor Networks reported by Qi. et al. based on the running time and energy consumption.

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Towards Key Issues of Disaster Aid based on Wireless Body Area Networks

  • Liu, Jianqi;Wang, Qinruo;Wan, Jiafu;Xiong, Jianbin;Zeng, Bi
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제7권5호
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    • pp.1014-1035
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    • 2013
  • With recent advances in wireless communication and low-power miniaturized biomedical sensor and semiconductor technologies, wireless body area networks (WBAN) has become an integral part of the disaster aid system. Wearable vital sign sensors can track patients' status and location, thus enhancing disaster rescue efficiency. In the past few years, most of the literatures in the area of disaster aid system based on WBAN have focused on issues concerning wireless sensor design, sensor miniaturization, energy efficiency and communication protocols. In this paper, we will give an overview of disaster aid, discuss about the types of network communication as well as outline related issues. We will emphasize on analyzing six key issues in employing the disaster aid system. Finally, we will also highlight some of the challenges that still need to be addressed in the future in order to help the disaster aid system be truly and widely accepted by the public.

디스플레이 표집과 시각타성에 관한 연구 (A Study of Display Sampling and Visual Momentum)

  • 양리가
    • 디자인학연구
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    • 제20권3호
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    • pp.39-48
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    • 2007
  • 본 논문은 도시환경의 공공사인시스템의 효율극대화를 위하여 안구운동을 측정하는 공학 심리적 또는 인지 과학적 실험을 통하여 안구운동과 가로세로의 시각흐름 그리고 유전된 문화적. 선험적 도식 그리고 대뇌의 시각 시스템의 차별을 탐색하였다. 따라서 EMR 관측실험과 bitmap counting 방법을 대입함으로서 가장 효율적인 시각디자인 측정을 구할 수 있는 algorithm을 도출하였다. 본 논문에서는 과학적인 실험 Data가 인간의 $\ulcorner$Schema$\lrcorner$$\ulcorner$Sensory Qualia$\lrcorner$ 에 의해, 차별화와 시각표집(Visual Sampling)의 가변성(Momentum)이 상존함을 알게 되었다.

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3BC와 F2mECC를 이용한 MDIT(Mobile Digital Investment Trust) 에이전트 설계 및 보안 강화 (A MDIT(Mobile Digital Investment Trust) Agent design and security enhancement using 3BC and E2mECC)

  • 정은희;이병관
    • 인터넷정보학회논문지
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    • 제6권3호
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    • pp.1-16
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    • 2005
  • 본 논문은 모바일 전자 상거래 환경에서 투자 신탁을 위한 MDIT(Mobile Digital Investment Trust) 에이전트 설계를 제안하고 또한 이 MDIT에서 모바일 전자 상거래 환경이 가지고 있는 기억 장치 용량, CPU 처리 속도 문제, 그리고 보안 강화 문제점을 해결하기 위해, 비밀키 암호 알고리즘인 3BC(Bit, Byte end Block Cypher)와 공개키 알고리즘인 F2mECC 설계를 제안한다. 특히, MDIT는 모바일 전자상거래에 투자 신탁의 개념을 도입한 은행 업무 보안 프로토콜로서 공개키 알고리즘인 ECC를 이용해 공유 비밀키를 생성한 후, 이 값을 공유 비밀키를 대칭키로 사용하는 블록 암호화 기법인 3BC에 사용하여, 보안 기능을 강화시키고, 처리속도를 감소시킨 MDIT 보안 에이전트를 구축하였다.

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증강현실 기반의 인포메이션 실감체험을 위한 앱 콘텐츠 개발 (Development of App Contents for Information Realistic Experience based on AR)

  • 문희정
    • 한국멀티미디어학회논문지
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    • 제23권11호
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    • pp.1428-1434
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    • 2020
  • Virtual reality (VR) and augmented reality (AR) technologies can interact intuitively using virtual 3D images. Information signs on buildings that are frequently used by the public play a very important role in conveying information. However, the current information sign has different understanding and interpretation, and it is difficult to communicate quickly and intuitively for interaction. The purpose of this study is to increase the efficiency of information signing through information provision using mobile augmented reality. The InfoAR app not only guides you to the destination of the building, but also acts as a marker for the logo image. The logo image created based on the feature points recognizes the information of the destination. It is converted to AR through a mobile app, allowing users to easily find their destination by obtaining specific information. In addition, it presents interactions that can enlarge, reduce, move, and rotate information about virtual objects augmented through a function called AR. In the future, if user convenience and usability of the interface are added, research is conducted, and the level of completion is improved, such as using VR contents and promotions and business cards, it is expected that highly useful contents will be produced.

돼지 마이코플라즈마 폐렴 예방백신의 접종시기별 방어효과에 관한 연구 (Evaluation of vaccination against Mycoplasma hyopneumoniae in pigs at different vaccination time-points)

  • 이함희;제임스 라;한정희
    • 한국동물위생학회지
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    • 제31권3호
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    • pp.291-303
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    • 2008
  • This study was performed to evaluate the effect of commercial swine mycoplasma vaccine (M+$Pac^{(R)}$, Schering-Plough Animal HealthCo.) at different vaccination time points. Total 139 piglets were moved to experimental farm after weaning and were randomly allocated to 3 treatment groups and 1 control group. Piglets of 3 treatment groups (A, B and C) were vaccinated twice at 1 and 3 weeks (A group), 3 and 5 weeks (B), and 6 and 8 weeks (C), respectively. All vaccinates showed higher antibody titers compared with nonvaccinates, and maintained to finish (P<0.001). Performance and RBC/WBC count showed no significant difference between groups. Vaccinates at 6-8 weeks showed better effect on decrease of clinical sign compared with vaccinates at 1-3 weeks and 3-5 weeks and nonvaccinates. Also, lung lesion assessment showed significant difference between vaccinates at 3-5 weeks and 6-8 weeks, and nonvaccinates and vaccinates at 1-3 weeks (P<0.05). Vaccinates at 3-5 score in comparison with other groups. In conclusion, these results suggested that vaccination at 3-5 weeks or later may be more effective than earlier vaccination.

Multiple myeloma presenting with a maxillary lesion as the first sign

  • Ramaiah, Kiran Kumar Kotagudda;Joshi, Vajendra;Thayi, Shilpa Ravishankar;Sathyanarayana, Pathalapate;Patil, Prashant;Ahmed, Zaheer
    • Imaging Science in Dentistry
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    • 제45권1호
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    • pp.55-60
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    • 2015
  • Multiple myeloma is a clonal neoplastic proliferation of terminally differentiated B-lymphocytes involving the skeletal system in a multifocal fashion. Its oral manifestations are less common in the maxilla than in the mandible due to the lower amount of hemopoietic bone marrow in the maxilla. We report the case of a 50-year-old man who presented with a mass in the left maxillary alveolar region with tooth mobility. The mass had become enlarged after the teeth were extracted 15 days previously. Radiographs demonstrated multiple punched-out radiolucent lesions in the skull and pelvic region. Computed tomography images showed a soft tissue density mass in the left maxilla, eroding the floor and walls of the maxillary sinus. Although several analytical techniques were used to characterize the lesion, it was finally confirmed as multiple myeloma through immunohistochemistry.

Breast Cancer Awareness among Saudi Females in Jeddah

  • Radi, Sahar Mahmoud
    • Asian Pacific Journal of Cancer Prevention
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    • 제14권7호
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    • pp.4307-4312
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    • 2013
  • Breast cancer is the most frequent malignancy of women worldwide. It is the leading cause of female cancer related disability and mortality. In Saudi Arabia breast cancer ranks first among cancerous diseases in females. In the Gulf region, and especially in Saudi Arabia, few studies have been conducted to address breast cancer awareness. The purpose of the current study was therefore to investigate the level of breast cancer awareness among Saudi females in Jeddah, focusing on knowledge of breast cancer warning signs, risk factors, screening programs and breast self-examination (BSE). The design of this study was an exploratory correlational analysis. The sample comprised 200 Saudi females aged 20 and older living in Jeddah. Data were collected using face-to-face interviews. Breast cancer awareness was measured using a modified Arabic version of the Breast Cancer Awareness Measure (Breast CAM) version 2. Descriptive statistical analysis, Pearson's Product Moment correlation coefficients and ANOVA test were used to answer study questions. Out of 200 participants, 50.5% were aware of breast lump as a warning sign of breast cancer, 57.5% claimed that family history was risk factor, 20.5% had undergone breast screening, 79% heard about BSE, and 47.5% knew how to perform BSE. Findings indicated that Saudi females level of awareness of breast cancer is very inadequate. Public awareness interventions are needed in order to overcome an ever-increasing burden of this disease among Saudi females.

화학물질에 대한 직업적 노출기준의 표기 항목 비교 (Comparison of Notation Items for Chemical Occupational Exposure Limits)

  • 피영규;김승원;하권철
    • 한국산업보건학회지
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    • 제30권2호
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    • pp.226-235
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    • 2020
  • Objectives: This study was to investigate the signs and notations of skin absorption, carcinogenicity, germ cell mutagenicity, and reproductive toxicity in the occupational exposure limits of Korea and of other advanced countries. Methods: Information on occupational exposure limits in Korea, the USA, the UK, Germany, and Japan was investigated through the Internet, and items marked as carcinogenicity and skin absorption were compared by country. Results: Legal occupational exposure limits have been greatly simplified. However, in the case of HSE WEL, skin absorption, carcinogenicity classification, sensitization, and in the case of DFG MAK, skin absorption, carcinogenicity, pregnancy risk group, germ cell mutagenicity, airway and skin sensitization, photo contact sensitization, and vapor pressure were provided. Conclusions: It is desirable to indicate the carcinogenicity and skin absorption within permissible limits, and to include information on critical effects in chemical substance exposure limits to uphold the right to know of industrial hygienists and workers in Korea. It is also necessary to clarify the precautions, limitations and protections for skin absorption.